SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5b2o'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)

Filter list by:

	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1JOL_B_FFOB361_0 (DIHYDROFOLATE REDUCTASE)	5b2o	CRISPR-ASSOCIATED ENDONUCLEASE CAS9 (Francisella tularensis)	5 / 12	ILE A 799 LEU A 668 ILE A 687 LEU A 683 PRO A 680	None	1.08A	1jolB-5b2oA: undetectable	1jolB-5b2oA: 6.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1LQT_B_ACTB1873_0 (FPRA)	5b2o	CRISPR-ASSOCIATED ENDONUCLEASE CAS9 (Francisella tularensis)	3 / 3	ASP A 495 ASP A 500 LYS A 846	None	0.89A	1lqtB-5b2oA: undetectable	1lqtB-5b2oA: 14.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1LQU_B_ACTB1430_0 (FPRA)	5b2o	CRISPR-ASSOCIATED ENDONUCLEASE CAS9 (Francisella tularensis)	3 / 3	ASP A 495 ASP A 500 LYS A 846	None	0.92A	1lquB-5b2oA: undetectable	1lquB-5b2oA: 14.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1SBR_A_VIBA502_1 (YKOF)	5b2o	CRISPR-ASSOCIATED ENDONUCLEASE CAS9 (Francisella tularensis)	4 / 6	PHE A 99 LEU A 98 ILE A 319 SER A 361	None	0.99A	1sbrA-5b2oA: undetectable 1sbrB-5b2oA: undetectable	1sbrA-5b2oA: 8.08 1sbrB-5b2oA: 8.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1SBR_B_VIBB504_1 (YKOF)	5b2o	CRISPR-ASSOCIATED ENDONUCLEASE CAS9 (Francisella tularensis)	4 / 6	PHE A 99 LEU A 98 ILE A 319 SER A 361	None	1.00A	1sbrA-5b2oA: undetectable 1sbrB-5b2oA: undetectable	1sbrA-5b2oA: 8.08 1sbrB-5b2oA: 8.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1VIF_A_FOLA1_0 (DIHYDROFOLATE REDUCTASE)	5b2o	CRISPR-ASSOCIATED ENDONUCLEASE CAS9 (Francisella tularensis)	3 / 3	GLN A1211 ILE A1208 TYR A1191	None	0.74A	1vifA-5b2oA: undetectable	1vifA-5b2oA: 2.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1YAT_A_FK5A108_1 (FK506 BINDING PROTEIN)	5b2o	CRISPR-ASSOCIATED ENDONUCLEASE CAS9 (Francisella tularensis)	5 / 11	PHE A1576 VAL A1561 ILE A1547 TYR A1549 ILE A1611	None	1.19A	1yatA-5b2oA: undetectable	1yatA-5b2oA: 5.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2BXP_A_P1ZA3001_1 (SERUM ALBUMIN)	5b2o	CRISPR-ASSOCIATED ENDONUCLEASE CAS9 (Francisella tularensis)	5 / 12	LEU A 12 LEU A 869 ALA A 870 ILE A 873 ALA A1096	None	1.02A	2bxpA-5b2oA: 1.7	2bxpA-5b2oA: 16.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2HZQ_A_STRA300_1 (APOLIPOPROTEIN D)	5b2o	CRISPR-ASSOCIATED ENDONUCLEASE CAS9 (Francisella tularensis)	4 / 7	THR A1598 ALA A1158 TYR A1150 PHE A1219	None	0.98A	2hzqA-5b2oA: undetectable	2hzqA-5b2oA: 6.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2J9C_C_ACTC1120_0 (HYPOTHETICAL NITROGEN REGULATORY PII-LIKE PROTEIN MJ0059)	5b2o	CRISPR-ASSOCIATED ENDONUCLEASE CAS9 (Francisella tularensis)	3 / 3	LYS A 780 TYR A 765 PRO A 775	None	1.34A	2j9cC-5b2oA: undetectable	2j9cC-5b2oA: 5.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2QD2_A_CHDA426_0 (FERROCHELATASE)	5b2o	CRISPR-ASSOCIATED ENDONUCLEASE CAS9 (Francisella tularensis)	4 / 4	LEU A 368 PRO A 367 LEU A 363 ARG A 312	None CL A1705 ( 3.9A) None None	1.42A	2qd2A-5b2oA: 2.8	2qd2A-5b2oA: 12.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2QEB_A_HSMA145_1 (D7R4 PROTEIN)	5b2o	CRISPR-ASSOCIATED ENDONUCLEASE CAS9 (Francisella tularensis)	4 / 7	ARG A 444 TYR A 392 PHE A 436 GLU A 423	None	1.14A	2qebA-5b2oA: undetectable	2qebA-5b2oA: 6.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2QEU_A_ACTA141_0 (PUTATIVE CARBOXYMUCONOLACTONE DECARBOXYLASE)	5b2o	CRISPR-ASSOCIATED ENDONUCLEASE CAS9 (Francisella tularensis)	3 / 3	VAL A 434 ASP A 435 GLU A 385	None	0.57A	2qeuA-5b2oA: 2.7	2qeuA-5b2oA: 6.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2QEU_C_ACTC141_0 (PUTATIVE CARBOXYMUCONOLACTONE DECARBOXYLASE)	5b2o	CRISPR-ASSOCIATED ENDONUCLEASE CAS9 (Francisella tularensis)	3 / 3	VAL A 434 ASP A 435 GLU A 385	None	0.56A	2qeuC-5b2oA: 2.6	2qeuC-5b2oA: 6.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2X45_A_HSMA1160_1 (ALLERGEN ARG R 1)	5b2o	CRISPR-ASSOCIATED ENDONUCLEASE CAS9 (Francisella tularensis)	4 / 6	SER A1210 TYR A1140 VAL A1143 ASP A1207	None	1.36A	2x45A-5b2oA: undetectable	2x45A-5b2oA: 5.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2YGO_A_PCFA1213_0 (WNT INHIBITORY FACTOR 1)	5b2o	CRISPR-ASSOCIATED ENDONUCLEASE CAS9 (Francisella tularensis)	5 / 12	LEU A1539 ILE A1544 ILE A1593 PHE A1576 VAL A1559	None	1.06A	2ygoA-5b2oA: undetectable	2ygoA-5b2oA: 7.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3AIA_A_SAMA206_0 (UPF0217 PROTEIN MJ1640)	5b2o	CRISPR-ASSOCIATED ENDONUCLEASE CAS9 (Francisella tularensis)	4 / 6	GLY A 398 LEU A 420 SER A 416 CYH A 421	EDO A1719 (-3.6A) None None None	0.67A	3aiaA-5b2oA: undetectable	3aiaA-5b2oA: 8.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3B2R_A_VDNA1_1 (CGMP-SPECIFIC 3',5'-CYCLIC PHOSPHODIESTERASE)	5b2o	CRISPR-ASSOCIATED ENDONUCLEASE CAS9 (Francisella tularensis)	5 / 12	ILE A1212 LEU A1185 ILE A1183 ILE A1124 PHE A1170	None	0.99A	3b2rA-5b2oA: undetectable	3b2rA-5b2oA: 12.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3B2R_B_VDNB1_1 (CGMP-SPECIFIC 3',5'-CYCLIC PHOSPHODIESTERASE)	5b2o	CRISPR-ASSOCIATED ENDONUCLEASE CAS9 (Francisella tularensis)	5 / 11	ILE A1212 LEU A1185 ILE A1183 ILE A1124 PHE A1170	None	1.00A	3b2rB-5b2oA: undetectable	3b2rB-5b2oA: 12.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3BRF_A_SORA2_0 (LIN-12 AND GLP-1 PHENOTYPE PROTEIN 1, ISOFORM A)	5b2o	CRISPR-ASSOCIATED ENDONUCLEASE CAS9 (Francisella tularensis)	3 / 3	LYS A 707 LYS A 697 VAL A 700	None	1.00A	3brfA-5b2oA: undetectable	3brfA-5b2oA: 14.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3BU1_A_HSMA301_1 (LIPOCALIN)	5b2o	CRISPR-ASSOCIATED ENDONUCLEASE CAS9 (Francisella tularensis)	4 / 7	SER A1210 TYR A1140 VAL A1143 ASP A1207	None	1.24A	3bu1A-5b2oA: undetectable	3bu1A-5b2oA: 6.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3D2T_B_1FLB500_1 (TRANSTHYRETIN)	5b2o	CRISPR-ASSOCIATED ENDONUCLEASE CAS9 (Francisella tularensis)	4 / 6	LYS A1222 LEU A 43 THR A 17 VAL A 19	None	0.37A	3d2tB-5b2oA: undetectable	3d2tB-5b2oA: 5.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3LOQ_A_ACTA277_0 (UNIVERSAL STRESS PROTEIN)	5b2o	CRISPR-ASSOCIATED ENDONUCLEASE CAS9 (Francisella tularensis)	3 / 3	ASP A1180 SER A1182 ARG A 620	None	0.87A	3loqA-5b2oA: 2.2	3loqA-5b2oA: 10.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3LOQ_A_ACTA277_0 (UNIVERSAL STRESS PROTEIN)	5b2o	CRISPR-ASSOCIATED ENDONUCLEASE CAS9 (Francisella tularensis)	3 / 3	ASP A1180 SER A1182 ARG A 625	None	1.02A	3loqA-5b2oA: 2.2	3loqA-5b2oA: 10.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3ME6_A_CGEA501_1 (CYTOCHROME P450 2B4)	5b2o	CRISPR-ASSOCIATED ENDONUCLEASE CAS9 (Francisella tularensis)	5 / 10	VAL A 19 ILE A 873 PHE A1095 ALA A1096 ILE A 893	None	1.08A	3me6A-5b2oA: undetectable	3me6A-5b2oA: 14.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3ONN_A_ACTA270_0 (PROTEIN SSM1)	5b2o	CRISPR-ASSOCIATED ENDONUCLEASE CAS9 (Francisella tularensis)	4 / 5	LEU A 363 ARG A 102 LEU A 368 PRO A 367	None G B 18 ( 3.4A) None CL A1705 ( 3.9A)	1.12A	3onnA-5b2oA: undetectable	3onnA-5b2oA: 10.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3OZK_B_T44B128_1 (TRANSTHYRETIN)	5b2o	CRISPR-ASSOCIATED ENDONUCLEASE CAS9 (Francisella tularensis)	4 / 7	LYS A1222 LEU A 43 THR A 17 VAL A 19	None	0.75A	3ozkB-5b2oA: undetectable	3ozkB-5b2oA: 6.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3SPK_A_TPVA100_1 (HIV-1 PROTEASE)	5b2o	CRISPR-ASSOCIATED ENDONUCLEASE CAS9 (Francisella tularensis)	5 / 11	ALA A1169 ASP A1165 ASP A 11 ILE A1212 PRO A 7	None None CA A1706 (-2.5A) None None	1.12A	3spkA-5b2oA: undetectable	3spkA-5b2oA: 5.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3VAW_A_FK5A114_1 (UBIQUITIN-LIKE PROTEIN SMT3,PEPTIDYL-PROLYL CIS-TRANS ISOMERASE)	5b2o	CRISPR-ASSOCIATED ENDONUCLEASE CAS9 (Francisella tularensis)	5 / 11	PHE A1576 VAL A1561 ILE A1547 TYR A1549 ILE A1611	None	1.25A	3vawA-5b2oA: undetectable	3vawA-5b2oA: 9.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3W67_D_VIVD301_0 (ALPHA-TOCOPHEROL TRANSFER PROTEIN)	5b2o	CRISPR-ASSOCIATED ENDONUCLEASE CAS9 (Francisella tularensis)	5 / 12	VAL A 350 LEU A 438 PHE A 336 ILE A 319 ILE A 357	None	1.12A	3w67D-5b2oA: undetectable	3w67D-5b2oA: 10.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4DRH_A_RAPA201_1 (PEPTIDYL-PROLYL CIS-TRANS ISOMERASE FKBP5)	5b2o	CRISPR-ASSOCIATED ENDONUCLEASE CAS9 (Francisella tularensis)	5 / 12	PHE A1576 VAL A1561 ILE A1547 TYR A1549 ILE A1611	None	1.23A	4drhA-5b2oA: undetectable	4drhA-5b2oA: 7.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4DRI_A_RAPA201_1 (PEPTIDYL-PROLYL CIS-TRANS ISOMERASE FKBP5)	5b2o	CRISPR-ASSOCIATED ENDONUCLEASE CAS9 (Francisella tularensis)	5 / 11	PHE A1576 VAL A1561 ILE A1547 TYR A1549 ILE A1611	None	1.25A	4driA-5b2oA: undetectable	4driA-5b2oA: 7.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4DZ2_A_FK5A200_1 (PEPTIDYL-PROLYL CIS-TRANS ISOMERASE)	5b2o	CRISPR-ASSOCIATED ENDONUCLEASE CAS9 (Francisella tularensis)	5 / 11	PHE A1576 VAL A1561 ILE A1547 TYR A1549 ILE A1611	None	1.24A	4dz2A-5b2oA: undetectable 4dz2B-5b2oA: undetectable	4dz2A-5b2oA: 5.48 4dz2B-5b2oA: 5.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4DZ2_B_FK5B200_1 (PEPTIDYL-PROLYL CIS-TRANS ISOMERASE)	5b2o	CRISPR-ASSOCIATED ENDONUCLEASE CAS9 (Francisella tularensis)	5 / 11	PHE A1576 VAL A1561 ILE A1547 TYR A1549 ILE A1611	None	1.26A	4dz2A-5b2oA: undetectable 4dz2B-5b2oA: undetectable	4dz2A-5b2oA: 5.48 4dz2B-5b2oA: 5.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4DZ3_A_FK5A201_1 (PEPTIDYL-PROLYL CIS-TRANS ISOMERASE)	5b2o	CRISPR-ASSOCIATED ENDONUCLEASE CAS9 (Francisella tularensis)	5 / 10	PHE A1576 VAL A1561 ILE A1547 TYR A1549 ILE A1611	None	1.28A	4dz3A-5b2oA: undetectable	4dz3A-5b2oA: 5.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4DZ3_B_FK5B201_1 (PEPTIDYL-PROLYL CIS-TRANS ISOMERASE)	5b2o	CRISPR-ASSOCIATED ENDONUCLEASE CAS9 (Francisella tularensis)	5 / 10	PHE A1576 VAL A1561 ILE A1547 TYR A1549 ILE A1611	None	1.30A	4dz3B-5b2oA: undetectable	4dz3B-5b2oA: 5.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4G19_D_ACTD302_0 (GLUTATHIONE TRANSFERASE GTE1)	5b2o	CRISPR-ASSOCIATED ENDONUCLEASE CAS9 (Francisella tularensis)	3 / 3	TYR A1249 PHE A1506 ARG A1362	None	1.18A	4g19D-5b2oA: undetectable	4g19D-5b2oA: 10.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4K4Y_A_ACTA502_0 (RNA-DEPENDENT RNA POLYMERASE)	5b2o	CRISPR-ASSOCIATED ENDONUCLEASE CAS9 (Francisella tularensis)	4 / 5	LYS A 486 LEU A 484 GLU A 483 LEU A 593	None	1.37A	4k4yA-5b2oA: undetectable	4k4yA-5b2oA: 14.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4K4Y_E_ACTE503_0 (RNA-DEPENDENT RNA POLYMERASE)	5b2o	CRISPR-ASSOCIATED ENDONUCLEASE CAS9 (Francisella tularensis)	4 / 4	LYS A 486 LEU A 484 GLU A 483 LEU A 593	None	1.40A	4k4yE-5b2oA: undetectable	4k4yE-5b2oA: 14.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4K4Y_I_ACTI503_0 (RNA-DEPENDENT RNA POLYMERASE)	5b2o	CRISPR-ASSOCIATED ENDONUCLEASE CAS9 (Francisella tularensis)	4 / 5	LYS A 486 LEU A 484 GLU A 483 LEU A 593	None	1.36A	4k4yI-5b2oA: undetectable	4k4yI-5b2oA: 14.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4KR4_C_AICC401_1 (OUTER MEMBRANE PROTEIN F)	5b2o	CRISPR-ASSOCIATED ENDONUCLEASE CAS9 (Francisella tularensis)	4 / 8	LYS A 980 ARG A1131 ARG A1085 ASP A1180	None	1.08A	4kr4C-5b2oA: undetectable	4kr4C-5b2oA: 11.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4NNR_A_FK5A201_1 (PEPTIDYL-PROLYL CIS-TRANS ISOMERASE FKBP2)	5b2o	CRISPR-ASSOCIATED ENDONUCLEASE CAS9 (Francisella tularensis)	5 / 12	PHE A1576 VAL A1561 ILE A1547 TYR A1549 ILE A1611	None	1.20A	4nnrA-5b2oA: undetectable 4nnrB-5b2oA: undetectable	4nnrA-5b2oA: 6.44 4nnrB-5b2oA: 6.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4NNR_B_FK5B201_1 (PEPTIDYL-PROLYL CIS-TRANS ISOMERASE FKBP2)	5b2o	CRISPR-ASSOCIATED ENDONUCLEASE CAS9 (Francisella tularensis)	5 / 10	PHE A1576 VAL A1561 ILE A1547 TYR A1549 ILE A1611	None	1.17A	4nnrB-5b2oA: undetectable	4nnrB-5b2oA: 6.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4QOP_B_HQEB503_1 (CATALASE)	5b2o	CRISPR-ASSOCIATED ENDONUCLEASE CAS9 (Francisella tularensis)	5 / 9	ILE A 357 PHE A 336 LEU A 98 LEU A 340 ASP A 324	None	0.93A	4qopB-5b2oA: undetectable	4qopB-5b2oA: 14.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4QT2_A_RAPA202_1 (FK506-BINDING PROTEIN (FKBP)-TYPE PEPTIDYL-PROPYL ISOMERASE)	5b2o	CRISPR-ASSOCIATED ENDONUCLEASE CAS9 (Francisella tularensis)	5 / 10	PHE A1576 VAL A1561 ILE A1547 TYR A1549 ILE A1611	None	1.21A	4qt2A-5b2oA: undetectable	4qt2A-5b2oA: 5.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4R20_A_AERA602_1 (CYTOCHROME P450 FAMILY 17 POLYPEPTIDE 2)	5b2o	CRISPR-ASSOCIATED ENDONUCLEASE CAS9 (Francisella tularensis)	4 / 8	ALA A 907 ILE A 868 THR A1091 SER A 899	None None EDO A1727 ( 4.0A) EDO A1727 (-3.1A)	0.78A	4r20A-5b2oA: undetectable	4r20A-5b2oA: 14.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4UBS_A_DIFA503_1 (PENTALENIC ACID SYNTHASE)	5b2o	CRISPR-ASSOCIATED ENDONUCLEASE CAS9 (Francisella tularensis)	4 / 7	LEU A 683 ALA A 803 LEU A 668 ILE A 799	None	0.82A	4ubsA-5b2oA: undetectable	4ubsA-5b2oA: 12.25
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	5B2O_A_ACTA1728_0 (CRISPR-ASSOCIATED ENDONUCLEASE CAS9)	5b2o	CRISPR-ASSOCIATED ENDONUCLEASE CAS9 (Francisella tularensis)	5 / 5	GLN A 92 THR A1458 TRP A1459 ASP A1460 ASN A1462	U B 49 (-3.1A) ACT A1728 (-3.3A) ACT A1728 (-4.0A) ACT A1728 (-4.9A) ACT A1728 (-4.0A)	0.00A	5b2oA-5b2oA: 52.9	5b2oA-5b2oA: 100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	5B2O_B_ACTB120_0 (CRISPR-ASSOCIATED ENDONUCLEASE CAS9 GUIDE RNA)	5b2o	CRISPR-ASSOCIATED ENDONUCLEASE CAS9 (Francisella tularensis)	4 / 4	ASN A1248 SER A1368 ARG A1370 PRO A1444	NA A1703 ( 3.4A) None U B 24 (-3.8A) U B 45 ( 4.1A)	0.00A	5b2oA-5b2oA: 52.9	5b2oA-5b2oA: 100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	5B2P_A_ACTA1728_0 (CRISPR-ASSOCIATED ENDONUCLEASE CAS9)	5b2o	CRISPR-ASSOCIATED ENDONUCLEASE CAS9 (Francisella tularensis)	5 / 5	GLN A 92 THR A1458 TRP A1459 ASP A1460 ASN A1462	U B 49 (-3.1A) ACT A1728 (-3.3A) ACT A1728 (-4.0A) ACT A1728 (-4.9A) ACT A1728 (-4.0A)	0.06A	5b2pA-5b2oA: 36.5	5b2pA-5b2oA: 100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	5B2P_B_ACTB120_0 (CRISPR-ASSOCIATED ENDONUCLEASE CAS9 GUIDE RNA)	5b2o	CRISPR-ASSOCIATED ENDONUCLEASE CAS9 (Francisella tularensis)	4 / 4	ASN A1248 SER A1368 ARG A1370 PRO A1444	NA A1703 ( 3.4A) None U B 24 (-3.8A) U B 45 ( 4.1A)	0.06A	5b2pA-5b2oA: 36.5	5b2pA-5b2oA: 100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	5B2Q_A_ACTA1728_0 (CRISPR-ASSOCIATED ENDONUCLEASE CAS9)	5b2o	CRISPR-ASSOCIATED ENDONUCLEASE CAS9 (Francisella tularensis)	3 / 3	ASN A1248 SER A1368 ARG A1370	NA A1703 ( 3.4A) None U B 24 (-3.8A)	0.04A	5b2qA-5b2oA: undetectable	5b2qA-5b2oA: 99.82
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	5B2Q_A_ACTA1729_0 (CRISPR-ASSOCIATED ENDONUCLEASE CAS9)	5b2o	CRISPR-ASSOCIATED ENDONUCLEASE CAS9 (Francisella tularensis)	5 / 5	GLN A 92 THR A1458 TRP A1459 ASP A1460 ASN A1462	U B 49 (-3.1A) ACT A1728 (-3.3A) ACT A1728 (-4.0A) ACT A1728 (-4.9A) ACT A1728 (-4.0A)	0.05A	5b2qA-5b2oA: 51.1	5b2qA-5b2oA: 99.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5HWC_A_FK5A201_1 (FK506-BINDING PROTEIN 1A)	5b2o	CRISPR-ASSOCIATED ENDONUCLEASE CAS9 (Francisella tularensis)	5 / 11	PHE A1576 VAL A1561 ILE A1547 TYR A1549 ILE A1611	None	1.18A	5hwcA-5b2oA: undetectable	5hwcA-5b2oA: 5.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5IWU_A_ACTA402_0 (MACROLIDE 2'-PHOSPHOTRANSFERAS E II)	5b2o	CRISPR-ASSOCIATED ENDONUCLEASE CAS9 (Francisella tularensis)	4 / 6	PHE A 607 VAL A 611 TYR A 615 ASP A 549	None	1.15A	5iwuA-5b2oA: 2.1	5iwuA-5b2oA: 10.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5LJE_A_RTLA201_0 (RETINOL-BINDING PROTEIN 1)	5b2o	CRISPR-ASSOCIATED ENDONUCLEASE CAS9 (Francisella tularensis)	5 / 12	LEU A1364 LEU A1316 ARG A1262 ILE A1273 LEU A1293	None	1.12A	5ljeA-5b2oA: undetectable	5ljeA-5b2oA: 6.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5MXB_A_ML1A222_1 (CLASS 10 PLANT PATHOGENESIS-RELATED PROTEIN)	5b2o	CRISPR-ASSOCIATED ENDONUCLEASE CAS9 (Francisella tularensis)	5 / 10	VAL A1561 ILE A1600 LEU A1594 GLY A1543 ALA A1545	None	0.96A	5mxbA-5b2oA: undetectable	5mxbA-5b2oA: 4.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5O96_D_SAMD501_0 (RIBOSOMAL RNA SMALL SUBUNIT METHYLTRANSFERASE E)	5b2o	CRISPR-ASSOCIATED ENDONUCLEASE CAS9 (Francisella tularensis)	5 / 10	ARG A 32 ILE A1183 GLY A1184 GLY A 27 ALA A1174	None	1.03A	5o96C-5b2oA: undetectable 5o96D-5b2oA: undetectable	5o96C-5b2oA: 8.94 5o96D-5b2oA: 8.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5ODI_D_ACTD202_0 (METHYL-VIOLOGEN REDUCING HYDROGENASE, SUBUNIT D)	5b2o	CRISPR-ASSOCIATED ENDONUCLEASE CAS9 (Francisella tularensis)	3 / 3	HIS A 702 GLU A 701 TRP A 698	None	0.99A	5odiD-5b2oA: 2.4	5odiD-5b2oA: 6.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5ODI_D_ACTD202_0 (METHYL-VIOLOGEN REDUCING HYDROGENASE, SUBUNIT D)	5b2o	CRISPR-ASSOCIATED ENDONUCLEASE CAS9 (Francisella tularensis)	3 / 3	HIS A1255 GLU A1326 TRP A1267	None	0.87A	5odiD-5b2oA: 2.4	5odiD-5b2oA: 6.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5ODQ_D_ACTD202_0 (METHYL-VIOLOGEN REDUCING HYDROGENASE, SUBUNIT D)	5b2o	CRISPR-ASSOCIATED ENDONUCLEASE CAS9 (Francisella tularensis)	3 / 3	HIS A1255 GLU A1326 TRP A1267	None	0.84A	5odqD-5b2oA: undetectable	5odqD-5b2oA: 6.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5ODR_D_ACTD202_0 (METHYL-VIOLOGEN REDUCING HYDROGENASE, SUBUNIT D)	5b2o	CRISPR-ASSOCIATED ENDONUCLEASE CAS9 (Francisella tularensis)	3 / 3	HIS A 702 GLU A 701 TRP A 698	None	0.90A	5odrD-5b2oA: undetectable	5odrD-5b2oA: 6.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5ODR_D_ACTD202_0 (METHYL-VIOLOGEN REDUCING HYDROGENASE, SUBUNIT D)	5b2o	CRISPR-ASSOCIATED ENDONUCLEASE CAS9 (Francisella tularensis)	3 / 3	HIS A1255 GLU A1326 TRP A1267	None	0.87A	5odrD-5b2oA: undetectable	5odrD-5b2oA: 6.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5X6Y_A_SAMA902_1 (MRNA CAPPING ENZYME P5)	5b2o	CRISPR-ASSOCIATED ENDONUCLEASE CAS9 (Francisella tularensis)	3 / 3	TYR A1104 ASP A1115 ASP A 648	None	0.79A	5x6yA-5b2oA: undetectable	5x6yA-5b2oA: 19.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6DJZ_B_GMJB301_0 (SIGMA NON-OPIOID INTRACELLULAR RECEPTOR 1)	5b2o	CRISPR-ASSOCIATED ENDONUCLEASE CAS9 (Francisella tularensis)	5 / 12	TYR A 24 LEU A 33 ILE A1183 HIS A1177 LEU A 6	None None None None EDO A1725 ( 4.5A)	1.26A	6djzB-5b2oA: 1.2	6djzB-5b2oA: 8.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6MKE_C_FK5C201_1 (PEPTIDYLPROLYL ISOMERASE)	5b2o	CRISPR-ASSOCIATED ENDONUCLEASE CAS9 (Francisella tularensis)	5 / 10	PHE A1576 VAL A1561 ILE A1547 TYR A1549 ILE A1611	None	1.16A	6mkeC-5b2oA: undetectable	6mkeC-5b2oA: 3.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6MKE_D_FK5D201_1 (PEPTIDYLPROLYL ISOMERASE)	5b2o	CRISPR-ASSOCIATED ENDONUCLEASE CAS9 (Francisella tularensis)	5 / 10	PHE A1576 VAL A1561 ILE A1547 TYR A1549 ILE A1611	None	1.18A	6mkeD-5b2oA: undetectable	6mkeD-5b2oA: 3.69

[["DrReposER ID","Desc.","Hit PDB","Hit molecule","Hit organism","Res. no.","Interface","HETATM","RMSD","Z-score","Seq ID"],["1JOL_B_FFOB361_0","DIHYDROFOLATE REDUCTASE","5b2o","CRISPR-ASSOCIATED ENDONUCLEASE CAS9","Francisella tularensis",5,"ILE A 799;LEU A 668;ILE A 687;LEU A 683;PRO A 680","None","1.08A","1jolB-5b2oA:undetectable","1jolB-5b2oA:6.94"],["1LQT_B_ACTB1873_0","FPRA","5b2o","CRISPR-ASSOCIATED ENDONUCLEASE CAS9","Francisella tularensis",3,"ASP A 495;ASP A 500;LYS A 846","None","0.89A","1lqtB-5b2oA:undetectable","1lqtB-5b2oA:14.10"],["1LQU_B_ACTB1430_0","FPRA","5b2o","CRISPR-ASSOCIATED ENDONUCLEASE CAS9","Francisella tularensis",3,"ASP A 495;ASP A 500;LYS A 846","None","0.92A","1lquB-5b2oA:undetectable","1lquB-5b2oA:14.10"],["1SBR_A_VIBA502_1","YKOF;YKOF","5b2o","CRISPR-ASSOCIATED ENDONUCLEASE CAS9","Francisella tularensis",4,"PHE A  99;LEU A  98;ILE A 319;SER A 361","None","0.99A","1sbrA-5b2oA:undetectable;1sbrB-5b2oA:undetectable","1sbrA-5b2oA:8.08;1sbrB-5b2oA:8.08"],["1SBR_B_VIBB504_1","YKOF;YKOF","5b2o","CRISPR-ASSOCIATED ENDONUCLEASE CAS9","Francisella tularensis",4,"PHE A  99;LEU A  98;ILE A 319;SER A 361","None","1.00A","1sbrA-5b2oA:undetectable;1sbrB-5b2oA:undetectable","1sbrA-5b2oA:8.08;1sbrB-5b2oA:8.08"],["1VIF_A_FOLA1_0","DIHYDROFOLATE REDUCTASE","5b2o","CRISPR-ASSOCIATED ENDONUCLEASE CAS9","Francisella tularensis",3,"GLN A1211;ILE A1208;TYR A1191","None","0.74A","1vifA-5b2oA:undetectable","1vifA-5b2oA:2.98"],["1YAT_A_FK5A108_1","FK506 BINDING PROTEIN","5b2o","CRISPR-ASSOCIATED ENDONUCLEASE CAS9","Francisella tularensis",5,"PHE A1576;VAL A1561;ILE A1547;TYR A1549;ILE A1611","None","1.19A","1yatA-5b2oA:undetectable","1yatA-5b2oA:5.40"],["2BXP_A_P1ZA3001_1","SERUM ALBUMIN","5b2o","CRISPR-ASSOCIATED ENDONUCLEASE CAS9","Francisella tularensis",5,"LEU A  12;LEU A 869;ALA A 870;ILE A 873;ALA A1096","None","1.02A","2bxpA-5b2oA:1.7","2bxpA-5b2oA:16.11"],["2HZQ_A_STRA300_1","APOLIPOPROTEIN D","5b2o","CRISPR-ASSOCIATED ENDONUCLEASE CAS9","Francisella tularensis",4,"THR A1598;ALA A1158;TYR A1150;PHE A1219","None","0.98A","2hzqA-5b2oA:undetectable","2hzqA-5b2oA:6.96"],["2J9C_C_ACTC1120_0","HYPOTHETICAL NITROGEN REGULATORY PII-LIKE PROTEIN MJ0059","5b2o","CRISPR-ASSOCIATED ENDONUCLEASE CAS9","Francisella tularensis",3,"LYS A 780;TYR A 765;PRO A 775","None","1.34A","2j9cC-5b2oA:undetectable","2j9cC-5b2oA:5.82"],["2QD2_A_CHDA426_0","FERROCHELATASE","5b2o","CRISPR-ASSOCIATED ENDONUCLEASE CAS9","Francisella tularensis",4,"LEU A 368;PRO A 367;LEU A 363;ARG A 312","None; CL A1705 ( 3.9A);None;None","1.42A","2qd2A-5b2oA:2.8","2qd2A-5b2oA:12.58"],["2QEB_A_HSMA145_1","D7R4 PROTEIN","5b2o","CRISPR-ASSOCIATED ENDONUCLEASE CAS9","Francisella tularensis",4,"ARG A 444;TYR A 392;PHE A 436;GLU A 423","None","1.14A","2qebA-5b2oA:undetectable","2qebA-5b2oA:6.32"],["2QEU_A_ACTA141_0","PUTATIVE CARBOXYMUCONOLACTONE DECARBOXYLASE","5b2o","CRISPR-ASSOCIATED ENDONUCLEASE CAS9","Francisella tularensis",3,"VAL A 434;ASP A 435;GLU A 385","None","0.57A","2qeuA-5b2oA:2.7","2qeuA-5b2oA:6.75"],["2QEU_C_ACTC141_0","PUTATIVE CARBOXYMUCONOLACTONE DECARBOXYLASE","5b2o","CRISPR-ASSOCIATED ENDONUCLEASE CAS9","Francisella tularensis",3,"VAL A 434;ASP A 435;GLU A 385","None","0.56A","2qeuC-5b2oA:2.6","2qeuC-5b2oA:6.75"],["2X45_A_HSMA1160_1","ALLERGEN ARG R 1","5b2o","CRISPR-ASSOCIATED ENDONUCLEASE CAS9","Francisella tularensis",4,"SER A1210;TYR A1140;VAL A1143;ASP A1207","None","1.36A","2x45A-5b2oA:undetectable","2x45A-5b2oA:5.44"],["2YGO_A_PCFA1213_0","WNT INHIBITORY FACTOR 1","5b2o","CRISPR-ASSOCIATED ENDONUCLEASE CAS9","Francisella tularensis",5,"LEU A1539;ILE A1544;ILE A1593;PHE A1576;VAL A1559","None","1.06A","2ygoA-5b2oA:undetectable","2ygoA-5b2oA:7.37"],["3AIA_A_SAMA206_0","UPF0217 PROTEIN MJ1640","5b2o","CRISPR-ASSOCIATED ENDONUCLEASE CAS9","Francisella tularensis",4,"GLY A 398;LEU A 420;SER A 416;CYH A 421","EDO A1719 (-3.6A);None;None;None","0.67A","3aiaA-5b2oA:undetectable","3aiaA-5b2oA:8.98"],["3B2R_A_VDNA1_1","CGMP-SPECIFIC 3',5'-CYCLIC PHOSPHODIESTERASE","5b2o","CRISPR-ASSOCIATED ENDONUCLEASE CAS9","Francisella tularensis",5,"ILE A1212;LEU A1185;ILE A1183;ILE A1124;PHE A1170","None","0.99A","3b2rA-5b2oA:undetectable","3b2rA-5b2oA:12.31"],["3B2R_B_VDNB1_1","CGMP-SPECIFIC 3',5'-CYCLIC PHOSPHODIESTERASE","5b2o","CRISPR-ASSOCIATED ENDONUCLEASE CAS9","Francisella tularensis",5,"ILE A1212;LEU A1185;ILE A1183;ILE A1124;PHE A1170","None","1.00A","3b2rB-5b2oA:undetectable","3b2rB-5b2oA:12.31"],["3BRF_A_SORA2_0","LIN-12 AND GLP-1 PHENOTYPE PROTEIN 1, ISOFORM A","5b2o","CRISPR-ASSOCIATED ENDONUCLEASE CAS9","Francisella tularensis",3,"LYS A 707;LYS A 697;VAL A 700","None","1.00A","3brfA-5b2oA:undetectable","3brfA-5b2oA:14.89"],["3BU1_A_HSMA301_1","LIPOCALIN","5b2o","CRISPR-ASSOCIATED ENDONUCLEASE CAS9","Francisella tularensis",4,"SER A1210;TYR A1140;VAL A1143;ASP A1207","None","1.24A","3bu1A-5b2oA:undetectable","3bu1A-5b2oA:6.58"],["3D2T_B_1FLB500_1","TRANSTHYRETIN","5b2o","CRISPR-ASSOCIATED ENDONUCLEASE CAS9","Francisella tularensis",4,"LYS A1222;LEU A  43;THR A  17;VAL A  19","None","0.37A","3d2tB-5b2oA:undetectable","3d2tB-5b2oA:5.75"],["3LOQ_A_ACTA277_0","UNIVERSAL STRESS PROTEIN","5b2o","CRISPR-ASSOCIATED ENDONUCLEASE CAS9","Francisella tularensis",3,"ASP A1180;SER A1182;ARG A 620","None","0.87A","3loqA-5b2oA:2.2","3loqA-5b2oA:10.59"],["3LOQ_A_ACTA277_0","UNIVERSAL STRESS PROTEIN","5b2o","CRISPR-ASSOCIATED ENDONUCLEASE CAS9","Francisella tularensis",3,"ASP A1180;SER A1182;ARG A 625","None","1.02A","3loqA-5b2oA:2.2","3loqA-5b2oA:10.59"],["3ME6_A_CGEA501_1","CYTOCHROME P450 2B4","5b2o","CRISPR-ASSOCIATED ENDONUCLEASE CAS9","Francisella tularensis",5,"VAL A  19;ILE A 873;PHE A1095;ALA A1096;ILE A 893","None","1.08A","3me6A-5b2oA:undetectable","3me6A-5b2oA:14.14"],["3ONN_A_ACTA270_0","PROTEIN SSM1","5b2o","CRISPR-ASSOCIATED ENDONUCLEASE CAS9","Francisella tularensis",4,"LEU A 363;ARG A 102;LEU A 368;PRO A 367","None;  G B  18 ( 3.4A);None; CL A1705 ( 3.9A)","1.12A","3onnA-5b2oA:undetectable","3onnA-5b2oA:10.52"],["3OZK_B_T44B128_1","TRANSTHYRETIN","5b2o","CRISPR-ASSOCIATED ENDONUCLEASE CAS9","Francisella tularensis",4,"LYS A1222;LEU A  43;THR A  17;VAL A  19","None","0.75A","3ozkB-5b2oA:undetectable","3ozkB-5b2oA:6.06"],["3SPK_A_TPVA100_1","HIV-1 PROTEASE","5b2o","CRISPR-ASSOCIATED ENDONUCLEASE CAS9","Francisella tularensis",5,"ALA A1169;ASP A1165;ASP A  11;ILE A1212;PRO A   7","None;None; CA A1706 (-2.5A);None;None","1.12A","3spkA-5b2oA:undetectable","3spkA-5b2oA:5.35"],["3VAW_A_FK5A114_1","UBIQUITIN-LIKE PROTEIN SMT3,PEPTIDYL-PROLYL CIS-TRANS ISOMERASE","5b2o","CRISPR-ASSOCIATED ENDONUCLEASE CAS9","Francisella tularensis",5,"PHE A1576;VAL A1561;ILE A1547;TYR A1549;ILE A1611","None","1.25A","3vawA-5b2oA:undetectable","3vawA-5b2oA:9.39"],["3W67_D_VIVD301_0","ALPHA-TOCOPHEROL TRANSFER PROTEIN","5b2o","CRISPR-ASSOCIATED ENDONUCLEASE CAS9","Francisella tularensis",5,"VAL A 350;LEU A 438;PHE A 336;ILE A 319;ILE A 357","None","1.12A","3w67D-5b2oA:undetectable","3w67D-5b2oA:10.22"],["4DRH_A_RAPA201_1","PEPTIDYL-PROLYL CIS-TRANS ISOMERASE FKBP5","5b2o","CRISPR-ASSOCIATED ENDONUCLEASE CAS9","Francisella tularensis",5,"PHE A1576;VAL A1561;ILE A1547;TYR A1549;ILE A1611","None","1.23A","4drhA-5b2oA:undetectable","4drhA-5b2oA:7.39"],["4DRI_A_RAPA201_1","PEPTIDYL-PROLYL CIS-TRANS ISOMERASE FKBP5","5b2o","CRISPR-ASSOCIATED ENDONUCLEASE CAS9","Francisella tularensis",5,"PHE A1576;VAL A1561;ILE A1547;TYR A1549;ILE A1611","None","1.25A","4driA-5b2oA:undetectable","4driA-5b2oA:7.39"],["4DZ2_A_FK5A200_1","PEPTIDYL-PROLYL CIS-TRANS ISOMERASE;PEPTIDYL-PROLYL CIS-TRANS ISOMERASE","5b2o","CRISPR-ASSOCIATED ENDONUCLEASE CAS9","Francisella tularensis",5,"PHE A1576;VAL A1561;ILE A1547;TYR A1549;ILE A1611","None","1.24A","4dz2A-5b2oA:undetectable;4dz2B-5b2oA:undetectable","4dz2A-5b2oA:5.48;4dz2B-5b2oA:5.48"],["4DZ2_B_FK5B200_1","PEPTIDYL-PROLYL CIS-TRANS ISOMERASE;PEPTIDYL-PROLYL CIS-TRANS ISOMERASE","5b2o","CRISPR-ASSOCIATED ENDONUCLEASE CAS9","Francisella tularensis",5,"PHE A1576;VAL A1561;ILE A1547;TYR A1549;ILE A1611","None","1.26A","4dz2A-5b2oA:undetectable;4dz2B-5b2oA:undetectable","4dz2A-5b2oA:5.48;4dz2B-5b2oA:5.48"],["4DZ3_A_FK5A201_1","PEPTIDYL-PROLYL CIS-TRANS ISOMERASE","5b2o","CRISPR-ASSOCIATED ENDONUCLEASE CAS9","Francisella tularensis",5,"PHE A1576;VAL A1561;ILE A1547;TYR A1549;ILE A1611","None","1.28A","4dz3A-5b2oA:undetectable","4dz3A-5b2oA:5.48"],["4DZ3_B_FK5B201_1","PEPTIDYL-PROLYL CIS-TRANS ISOMERASE","5b2o","CRISPR-ASSOCIATED ENDONUCLEASE CAS9","Francisella tularensis",5,"PHE A1576;VAL A1561;ILE A1547;TYR A1549;ILE A1611","None","1.30A","4dz3B-5b2oA:undetectable","4dz3B-5b2oA:5.48"],["4G19_D_ACTD302_0","GLUTATHIONE TRANSFERASE GTE1","5b2o","CRISPR-ASSOCIATED ENDONUCLEASE CAS9","Francisella tularensis",3,"TYR A1249;PHE A1506;ARG A1362","None","1.18A","4g19D-5b2oA:undetectable","4g19D-5b2oA:10.25"],["4K4Y_A_ACTA502_0","RNA-DEPENDENT RNA POLYMERASE","5b2o","CRISPR-ASSOCIATED ENDONUCLEASE CAS9","Francisella tularensis",4,"LYS A 486;LEU A 484;GLU A 483;LEU A 593","None","1.37A","4k4yA-5b2oA:undetectable","4k4yA-5b2oA:14.71"],["4K4Y_E_ACTE503_0","RNA-DEPENDENT RNA POLYMERASE","5b2o","CRISPR-ASSOCIATED ENDONUCLEASE CAS9","Francisella tularensis",4,"LYS A 486;LEU A 484;GLU A 483;LEU A 593","None","1.40A","4k4yE-5b2oA:undetectable","4k4yE-5b2oA:14.71"],["4K4Y_I_ACTI503_0","RNA-DEPENDENT RNA POLYMERASE","5b2o","CRISPR-ASSOCIATED ENDONUCLEASE CAS9","Francisella tularensis",4,"LYS A 486;LEU A 484;GLU A 483;LEU A 593","None","1.36A","4k4yI-5b2oA:undetectable","4k4yI-5b2oA:14.71"],["4KR4_C_AICC401_1","OUTER MEMBRANE PROTEIN F","5b2o","CRISPR-ASSOCIATED ENDONUCLEASE CAS9","Francisella tularensis",4,"LYS A 980;ARG A1131;ARG A1085;ASP A1180","None","1.08A","4kr4C-5b2oA:undetectable","4kr4C-5b2oA:11.64"],["4NNR_A_FK5A201_1","PEPTIDYL-PROLYL CIS-TRANS ISOMERASE FKBP2;PEPTIDYL-PROLYL CIS-TRANS ISOMERASE FKBP2","5b2o","CRISPR-ASSOCIATED ENDONUCLEASE CAS9","Francisella tularensis",5,"PHE A1576;VAL A1561;ILE A1547;TYR A1549;ILE A1611","None","1.20A","4nnrA-5b2oA:undetectable;4nnrB-5b2oA:undetectable","4nnrA-5b2oA:6.44;4nnrB-5b2oA:6.44"],["4NNR_B_FK5B201_1","PEPTIDYL-PROLYL CIS-TRANS ISOMERASE FKBP2","5b2o","CRISPR-ASSOCIATED ENDONUCLEASE CAS9","Francisella tularensis",5,"PHE A1576;VAL A1561;ILE A1547;TYR A1549;ILE A1611","None","1.17A","4nnrB-5b2oA:undetectable","4nnrB-5b2oA:6.44"],["4QOP_B_HQEB503_1","CATALASE","5b2o","CRISPR-ASSOCIATED ENDONUCLEASE CAS9","Francisella tularensis",5,"ILE A 357;PHE A 336;LEU A  98;LEU A 340;ASP A 324","None","0.93A","4qopB-5b2oA:undetectable","4qopB-5b2oA:14.56"],["4QT2_A_RAPA202_1","FK506-BINDING PROTEIN (FKBP)-TYPE PEPTIDYL-PROPYL ISOMERASE","5b2o","CRISPR-ASSOCIATED ENDONUCLEASE CAS9","Francisella tularensis",5,"PHE A1576;VAL A1561;ILE A1547;TYR A1549;ILE A1611","None","1.21A","4qt2A-5b2oA:undetectable","4qt2A-5b2oA:5.41"],["4R20_A_AERA602_1","CYTOCHROME P450 FAMILY 17 POLYPEPTIDE 2","5b2o","CRISPR-ASSOCIATED ENDONUCLEASE CAS9","Francisella tularensis",4,"ALA A 907;ILE A 868;THR A1091;SER A 899","None;None;EDO A1727 ( 4.0A);EDO A1727 (-3.1A)","0.78A","4r20A-5b2oA:undetectable","4r20A-5b2oA:14.96"],["4UBS_A_DIFA503_1","PENTALENIC ACID SYNTHASE","5b2o","CRISPR-ASSOCIATED ENDONUCLEASE CAS9","Francisella tularensis",4,"LEU A 683;ALA A 803;LEU A 668;ILE A 799","None","0.82A","4ubsA-5b2oA:undetectable","4ubsA-5b2oA:12.25"],["5B2O_A_ACTA1728_0","CRISPR-ASSOCIATED ENDONUCLEASE CAS9","5b2o","CRISPR-ASSOCIATED ENDONUCLEASE CAS9","Francisella tularensis",5,"GLN A  92;THR A1458;TRP A1459;ASP A1460;ASN A1462","  U B  49 (-3.1A);ACT A1728 (-3.3A);ACT A1728 (-4.0A);ACT A1728 (-4.9A);ACT A1728 (-4.0A)","0.00A","5b2oA-5b2oA:52.9","5b2oA-5b2oA:100.00"],["5B2O_B_ACTB120_0","CRISPR-ASSOCIATED ENDONUCLEASE CAS9;GUIDE RNA","5b2o","CRISPR-ASSOCIATED ENDONUCLEASE CAS9","Francisella tularensis",4,"ASN A1248;SER A1368;ARG A1370;PRO A1444"," NA A1703 ( 3.4A);None;  U B  24 (-3.8A);  U B  45 ( 4.1A)","0.00A","5b2oA-5b2oA:52.9","5b2oA-5b2oA:100.00"],["5B2P_A_ACTA1728_0","CRISPR-ASSOCIATED ENDONUCLEASE CAS9","5b2o","CRISPR-ASSOCIATED ENDONUCLEASE CAS9","Francisella tularensis",5,"GLN A  92;THR A1458;TRP A1459;ASP A1460;ASN A1462","  U B  49 (-3.1A);ACT A1728 (-3.3A);ACT A1728 (-4.0A);ACT A1728 (-4.9A);ACT A1728 (-4.0A)","0.06A","5b2pA-5b2oA:36.5","5b2pA-5b2oA:100.00"],["5B2P_B_ACTB120_0","CRISPR-ASSOCIATED ENDONUCLEASE CAS9;GUIDE RNA","5b2o","CRISPR-ASSOCIATED ENDONUCLEASE CAS9","Francisella tularensis",4,"ASN A1248;SER A1368;ARG A1370;PRO A1444"," NA A1703 ( 3.4A);None;  U B  24 (-3.8A);  U B  45 ( 4.1A)","0.06A","5b2pA-5b2oA:36.5","5b2pA-5b2oA:100.00"],["5B2Q_A_ACTA1728_0","CRISPR-ASSOCIATED ENDONUCLEASE CAS9","5b2o","CRISPR-ASSOCIATED ENDONUCLEASE CAS9","Francisella tularensis",3,"ASN A1248;SER A1368;ARG A1370"," NA A1703 ( 3.4A);None;  U B  24 (-3.8A)","0.04A","5b2qA-5b2oA:undetectable","5b2qA-5b2oA:99.82"],["5B2Q_A_ACTA1729_0","CRISPR-ASSOCIATED ENDONUCLEASE CAS9","5b2o","CRISPR-ASSOCIATED ENDONUCLEASE CAS9","Francisella tularensis",5,"GLN A  92;THR A1458;TRP A1459;ASP A1460;ASN A1462","  U B  49 (-3.1A);ACT A1728 (-3.3A);ACT A1728 (-4.0A);ACT A1728 (-4.9A);ACT A1728 (-4.0A)","0.05A","5b2qA-5b2oA:51.1","5b2qA-5b2oA:99.82"],["5HWC_A_FK5A201_1","FK506-BINDING PROTEIN 1A","5b2o","CRISPR-ASSOCIATED ENDONUCLEASE CAS9","Francisella tularensis",5,"PHE A1576;VAL A1561;ILE A1547;TYR A1549;ILE A1611","None","1.18A","5hwcA-5b2oA:undetectable","5hwcA-5b2oA:5.67"],["5IWU_A_ACTA402_0","MACROLIDE 2'-PHOSPHOTRANSFERASE II","5b2o","CRISPR-ASSOCIATED ENDONUCLEASE CAS9","Francisella tularensis",4,"PHE A 607;VAL A 611;TYR A 615;ASP A 549","None","1.15A","5iwuA-5b2oA:2.1","5iwuA-5b2oA:10.80"],["5LJE_A_RTLA201_0","RETINOL-BINDING PROTEIN 1","5b2o","CRISPR-ASSOCIATED ENDONUCLEASE CAS9","Francisella tularensis",5,"LEU A1364;LEU A1316;ARG A1262;ILE A1273;LEU A1293","None","1.12A","5ljeA-5b2oA:undetectable","5ljeA-5b2oA:6.92"],["5MXB_A_ML1A222_1","CLASS 10 PLANT PATHOGENESIS-RELATED PROTEIN","5b2o","CRISPR-ASSOCIATED ENDONUCLEASE CAS9","Francisella tularensis",5,"VAL A1561;ILE A1600;LEU A1594;GLY A1543;ALA A1545","None","0.96A","5mxbA-5b2oA:undetectable","5mxbA-5b2oA:4.18"],["5O96_D_SAMD501_0","RIBOSOMAL RNA SMALL SUBUNIT METHYLTRANSFERASE E","5b2o","CRISPR-ASSOCIATED ENDONUCLEASE CAS9","Francisella tularensis",5,"ARG A  32;ILE A1183;GLY A1184;GLY A  27;ALA A1174","None","1.03A","5o96C-5b2oA:undetectable;5o96D-5b2oA:undetectable","5o96C-5b2oA:8.94;5o96D-5b2oA:8.94"],["5ODI_D_ACTD202_0","METHYL-VIOLOGEN REDUCING HYDROGENASE, SUBUNIT D","5b2o","CRISPR-ASSOCIATED ENDONUCLEASE CAS9","Francisella tularensis",3,"HIS A 702;GLU A 701;TRP A 698","None","0.99A","5odiD-5b2oA:2.4","5odiD-5b2oA:6.54"],["5ODI_D_ACTD202_0","METHYL-VIOLOGEN REDUCING HYDROGENASE, SUBUNIT D","5b2o","CRISPR-ASSOCIATED ENDONUCLEASE CAS9","Francisella tularensis",3,"HIS A1255;GLU A1326;TRP A1267","None","0.87A","5odiD-5b2oA:2.4","5odiD-5b2oA:6.54"],["5ODQ_D_ACTD202_0","METHYL-VIOLOGEN REDUCING HYDROGENASE, SUBUNIT D","5b2o","CRISPR-ASSOCIATED ENDONUCLEASE CAS9","Francisella tularensis",3,"HIS A1255;GLU A1326;TRP A1267","None","0.84A","5odqD-5b2oA:undetectable","5odqD-5b2oA:6.54"],["5ODR_D_ACTD202_0","METHYL-VIOLOGEN REDUCING HYDROGENASE, SUBUNIT D","5b2o","CRISPR-ASSOCIATED ENDONUCLEASE CAS9","Francisella tularensis",3,"HIS A 702;GLU A 701;TRP A 698","None","0.90A","5odrD-5b2oA:undetectable","5odrD-5b2oA:6.54"],["5ODR_D_ACTD202_0","METHYL-VIOLOGEN REDUCING HYDROGENASE, SUBUNIT D","5b2o","CRISPR-ASSOCIATED ENDONUCLEASE CAS9","Francisella tularensis",3,"HIS A1255;GLU A1326;TRP A1267","None","0.87A","5odrD-5b2oA:undetectable","5odrD-5b2oA:6.54"],["5X6Y_A_SAMA902_1","MRNA CAPPING ENZYME P5","5b2o","CRISPR-ASSOCIATED ENDONUCLEASE CAS9","Francisella tularensis",3,"TYR A1104;ASP A1115;ASP A 648","None","0.79A","5x6yA-5b2oA:undetectable","5x6yA-5b2oA:19.60"],["6DJZ_B_GMJB301_0","SIGMA NON-OPIOID INTRACELLULAR RECEPTOR 1","5b2o","CRISPR-ASSOCIATED ENDONUCLEASE CAS9","Francisella tularensis",5,"TYR A  24;LEU A  33;ILE A1183;HIS A1177;LEU A   6","None;None;None;None;EDO A1725 ( 4.5A)","1.26A","6djzB-5b2oA:1.2","6djzB-5b2oA:8.17"],["6MKE_C_FK5C201_1","PEPTIDYLPROLYL ISOMERASE","5b2o","CRISPR-ASSOCIATED ENDONUCLEASE CAS9","Francisella tularensis",5,"PHE A1576;VAL A1561;ILE A1547;TYR A1549;ILE A1611","None","1.16A","6mkeC-5b2oA:undetectable","6mkeC-5b2oA:3.69"],["6MKE_D_FK5D201_1","PEPTIDYLPROLYL ISOMERASE","5b2o","CRISPR-ASSOCIATED ENDONUCLEASE CAS9","Francisella tularensis",5,"PHE A1576;VAL A1561;ILE A1547;TYR A1549;ILE A1611","None","1.18A","6mkeD-5b2oA:undetectable","6mkeD-5b2oA:3.69"]]