SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5b37'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FOH_A_IPHA802_0
(PHENOL HYDROXYLASE)		 5b37 TRYPTOPHAN
DEHYDROGENASE
(Nostoc
punctiforme) 		5 / 10 GLY A 112
MET A 295
VAL A 133
ILE A 110
GLY A  41
 None
 1.40A 1fohA-5b37A:
undetectable		 1fohA-5b37A:
19.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FOH_B_IPHB802_0
(PHENOL HYDROXYLASE)		 5b37 TRYPTOPHAN
DEHYDROGENASE
(Nostoc
punctiforme) 		5 / 10 GLY A 112
MET A 295
VAL A 133
ILE A 110
GLY A  41
 None
 1.41A 1fohB-5b37A:
undetectable		 1fohB-5b37A:
19.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FOH_C_IPHC802_0
(PHENOL HYDROXYLASE)		 5b37 TRYPTOPHAN
DEHYDROGENASE
(Nostoc
punctiforme) 		5 / 10 GLY A 112
MET A 295
VAL A 133
ILE A 110
GLY A  41
 None
 1.43A 1fohC-5b37A:
undetectable		 1fohC-5b37A:
19.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MZ9_A_VDYA1002_4
(CARTILAGE OLIGOMERIC
MATRIX PROTEIN)		 5b37 TRYPTOPHAN
DEHYDROGENASE
(Nostoc
punctiforme) 		4 / 5 LEU A 195
VAL A 174
ALA A 255
CYH A 233
 None
 1.14A 1mz9D-5b37A:
undetectable		 1mz9D-5b37A:
9.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PN0_A_IPHA6012_0
(PHENOL
2-MONOOXYGENASE)		 5b37 TRYPTOPHAN
DEHYDROGENASE
(Nostoc
punctiforme) 		5 / 10 GLY A 112
MET A 295
VAL A 133
ILE A 110
GLY A  41
 None
 1.38A 1pn0A-5b37A:
undetectable		 1pn0A-5b37A:
19.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PN0_C_IPHC6032_0
(PHENOL
2-MONOOXYGENASE)		 5b37 TRYPTOPHAN
DEHYDROGENASE
(Nostoc
punctiforme) 		5 / 10 GLY A 112
MET A 295
VAL A 133
ILE A 110
GLY A  41
 None
 1.44A 1pn0C-5b37A:
2.7		 1pn0C-5b37A:
19.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PN0_D_IPHD6042_0
(PHENOL
2-MONOOXYGENASE)		 5b37 TRYPTOPHAN
DEHYDROGENASE
(Nostoc
punctiforme) 		5 / 10 GLY A 112
MET A 295
VAL A 133
ILE A 110
GLY A  41
 None
 1.43A 1pn0D-5b37A:
2.7		 1pn0D-5b37A:
19.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DU8_A_BEZA352_0
(D-AMINO-ACID OXIDASE)		 5b37 TRYPTOPHAN
DEHYDROGENASE
(Nostoc
punctiforme) 		4 / 6 LEU A 270
TYR A 277
ILE A 252
GLY A 237
 None
 0.69A 2du8A-5b37A:
3.8		 2du8A-5b37A:
22.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DU8_B_BEZB1352_0
(D-AMINO-ACID OXIDASE)		 5b37 TRYPTOPHAN
DEHYDROGENASE
(Nostoc
punctiforme) 		4 / 6 LEU A 270
TYR A 277
ILE A 252
GLY A 237
 None
 0.74A 2du8B-5b37A:
3.7		 2du8B-5b37A:
22.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F78_A_BEZA1003_0
(HTH-TYPE
TRANSCRIPTIONAL
REGULATOR BENM)		 5b37 TRYPTOPHAN
DEHYDROGENASE
(Nostoc
punctiforme) 		4 / 7 VAL A 282
LEU A 335
PHE A 318
THR A 328
 None
 1.08A 2f78A-5b37A:
undetectable		 2f78A-5b37A:
24.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F78_B_BEZB1004_0
(HTH-TYPE
TRANSCRIPTIONAL
REGULATOR BENM)		 5b37 TRYPTOPHAN
DEHYDROGENASE
(Nostoc
punctiforme) 		4 / 7 VAL A 282
LEU A 335
PHE A 318
THR A 328
 None
 1.08A 2f78B-5b37A:
undetectable		 2f78B-5b37A:
24.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OPX_A_DXCA1003_0
(ALDEHYDE
DEHYDROGENASE A)		 5b37 TRYPTOPHAN
DEHYDROGENASE
(Nostoc
punctiforme) 		4 / 5 ILE A 317
LEU A 314
ASP A 280
ALA A 332
 None
 1.01A 2opxA-5b37A:
3.4		 2opxA-5b37A:
25.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QL8_B_BEZB143_0
(PUTATIVE REDOX
PROTEIN)		 5b37 TRYPTOPHAN
DEHYDROGENASE
(Nostoc
punctiforme) 		4 / 6 ARG A 333
TYR A 281
THR A 328
ALA A 331
 None
 1.24A 2ql8A-5b37A:
undetectable
2ql8B-5b37A:
undetectable		 2ql8A-5b37A:
16.62
2ql8B-5b37A:
16.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A2Q_A_ACAA601_1
(6-AMINOHEXANOATE-CYC
LIC-DIMER HYDROLASE)		 5b37 TRYPTOPHAN
DEHYDROGENASE
(Nostoc
punctiforme) 		4 / 7 GLY A 176
ALA A 205
VAL A 216
ILE A 222
 None
 0.79A 3a2qA-5b37A:
undetectable		 3a2qA-5b37A:
23.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BSZ_E_RTLE177_0
(PLASMA
RETINOL-BINDING
PROTEIN)		 5b37 TRYPTOPHAN
DEHYDROGENASE
(Nostoc
punctiforme) 		5 / 11 LEU A 288
ALA A  70
ALA A  69
VAL A 291
MET A  65
 None
 1.31A 3bszE-5b37A:
undetectable		 3bszE-5b37A:
20.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HS6_B_EPAB1_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 5b37 TRYPTOPHAN
DEHYDROGENASE
(Nostoc
punctiforme) 		5 / 12 GLY A 153
ILE A 283
ALA A 143
SER A 147
GLY A 149
 None
 0.91A 3hs6B-5b37A:
undetectable		 3hs6B-5b37A:
18.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUD_C_SUEC1201_1
(NS3 PROTEASE, NS4A
PROTEIN)		 5b37 TRYPTOPHAN
DEHYDROGENASE
(Nostoc
punctiforme) 		5 / 12 GLY A 181
ILE A 310
GLY A 254
ALA A 255
ALA A 285
 None
 1.01A 3sudC-5b37A:
undetectable		 3sudC-5b37A:
20.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UA5_B_06XB501_1
(CYTOCHROME P450 2B6)		 5b37 TRYPTOPHAN
DEHYDROGENASE
(Nostoc
punctiforme) 		4 / 7 ILE A 154
GLU A 190
LEU A 195
VAL A 193
 None
 0.65A 3ua5B-5b37A:
undetectable		 3ua5B-5b37A:
21.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AN2_A_EUIA1382_2
(DUAL SPECIFICITY
MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE 1)		 5b37 TRYPTOPHAN
DEHYDROGENASE
(Nostoc
punctiforme) 		4 / 4 ASN A 309
SER A 147
LEU A 148
THR A 313
 None
 1.48A 4an2A-5b37A:
undetectable		 4an2A-5b37A:
23.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EAT_B_BEZB1000_0
(BENZOATE-COENZYME A
LIGASE)		 5b37 TRYPTOPHAN
DEHYDROGENASE
(Nostoc
punctiforme) 		5 / 9 ALA A 255
ALA A 285
GLY A 287
GLY A 149
ILE A 310
 None
 1.01A 4eatB-5b37A:
5.8		 4eatB-5b37A:
21.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X1K_D_LOCD502_2
(TUBULIN BETA CHAIN)		 5b37 TRYPTOPHAN
DEHYDROGENASE
(Nostoc
punctiforme) 		5 / 12 CYH A 233
LEU A 184
ALA A 173
ALA A 231
ILE A 222
 None
 1.11A 4x1kD-5b37A:
undetectable		 4x1kD-5b37A:
21.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YJI_A_TYLA502_1
(ARYL ACYLAMIDASE)		 5b37 TRYPTOPHAN
DEHYDROGENASE
(Nostoc
punctiforme) 		4 / 7 LEU A 276
THR A 328
GLY A 325
ALA A 321
 None
 0.65A 4yjiA-5b37A:
undetectable		 4yjiA-5b37A:
23.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DNU_A_BEZA319_0
(SHKAI2IB)		 5b37 TRYPTOPHAN
DEHYDROGENASE
(Nostoc
punctiforme) 		4 / 5 GLN A 306
HIS A 308
ILE A 289
ILE A 145
 None
 1.03A 5dnuA-5b37A:
undetectable		 5dnuA-5b37A:
21.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DNV_A_BEZA304_0
(SHKAI2IB)		 5b37 TRYPTOPHAN
DEHYDROGENASE
(Nostoc
punctiforme) 		4 / 5 GLN A 306
HIS A 308
ILE A 289
ILE A 145
 None
 0.96A 5dnvA-5b37A:
undetectable		 5dnvA-5b37A:
21.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TE8_B_08JB602_1
(CYTOCHROME P450 3A4)		 5b37 TRYPTOPHAN
DEHYDROGENASE
(Nostoc
punctiforme) 		4 / 8 ALA A  72
THR A 313
ALA A 332
LEU A 335
 None
 0.76A 5te8B-5b37A:
undetectable		 5te8B-5b37A:
21.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FGD_A_ACTA817_0
(GEPHYRIN)		 5b37 TRYPTOPHAN
DEHYDROGENASE
(Nostoc
punctiforme) 		3 / 3 THR A 327
ALA A 271
LYS A 273
 None
 0.76A 6fgdA-5b37A:
3.6		 6fgdA-5b37A:
23.23