SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5b3f'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OQ5_A_CELA701_2
(CARBONIC ANHYDRASE
II)		 5b3f PHOSPHORIBULOKINASE/
URIDINE KINASE
(Methanospirillum
hungatei) 		4 / 4 HIS A 123
VAL A  51
THR A 127
LEU A 133
 None
 1.08A 1oq5A-5b3fA:
undetectable		 1oq5A-5b3fA:
23.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SG9_B_SAMB302_0
(HEMK PROTEIN)		 5b3f PHOSPHORIBULOKINASE/
URIDINE KINASE
(Methanospirillum
hungatei) 		5 / 12 PHE A 243
THR A 270
GLY A 298
ILE A 296
SER A 197
 None
 0.98A 1sg9B-5b3fA:
2.2		 1sg9B-5b3fA:
22.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QD3_A_CHDA501_0
(FERROCHELATASE)		 5b3f PHOSPHORIBULOKINASE/
URIDINE KINASE
(Methanospirillum
hungatei) 		5 / 11 LEU A  87
LEU A  84
ARG A  91
ILE A  93
THR A 127
 None
 1.34A 2qd3A-5b3fA:
undetectable		 2qd3A-5b3fA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YGO_A_PCFA1213_0
(WNT INHIBITORY
FACTOR 1)		 5b3f PHOSPHORIBULOKINASE/
URIDINE KINASE
(Methanospirillum
hungatei) 		5 / 12 ILE A 274
ILE A 226
ILE A 305
ILE A 230
VAL A 212
 None
 1.06A 2ygoA-5b3fA:
undetectable		 2ygoA-5b3fA:
20.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZSE_A_PAUA600_0
(PANTOTHENATE KINASE)		 5b3f PHOSPHORIBULOKINASE/
URIDINE KINASE
(Methanospirillum
hungatei) 		4 / 7 TYR A 221
PHE A 223
ILE A 315
ASN A 319
 None
 0.98A 2zseA-5b3fA:
17.9		 2zseA-5b3fA:
22.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IB1_A_IMNA701_1
(LACTOTRANSFERRIN)		 5b3f PHOSPHORIBULOKINASE/
URIDINE KINASE
(Methanospirillum
hungatei) 		4 / 4 PRO A 113
THR A 114
GLY A  21
THR A 137
 None
 1.16A 3ib1A-5b3fA:
undetectable		 3ib1A-5b3fA:
19.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PGH_B_FLPB701_1
(CYCLOOXYGENASE-2)		 5b3f PHOSPHORIBULOKINASE/
URIDINE KINASE
(Methanospirillum
hungatei) 		5 / 11 VAL A  51
LEU A  80
VAL A  22
GLY A  24
ALA A  23
 None
 1.17A 3pghB-5b3fA:
undetectable		 3pghB-5b3fA:
20.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SU9_A_ACTA426_0
(UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE)		 5b3f PHOSPHORIBULOKINASE/
URIDINE KINASE
(Methanospirillum
hungatei) 		3 / 3 GLN A 281
GLU A   9
LYS A   6
 None
 1.04A 3su9A-5b3fA:
undetectable		 3su9A-5b3fA:
20.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V4T_E_ACTE502_0
(UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE)		 5b3f PHOSPHORIBULOKINASE/
URIDINE KINASE
(Methanospirillum
hungatei) 		3 / 3 LYS A  30
ARG A 173
LEU A 122
 SO4  A 401 (-2.7A)
None
None
 1.24A 3v4tE-5b3fA:
undetectable		 3v4tE-5b3fA:
20.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WG7_J_CHDJ101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 5b3f PHOSPHORIBULOKINASE/
URIDINE KINASE
(Methanospirillum
hungatei) 		4 / 6 ILE A  93
LEU A  87
TYR A  54
THR A  50
 None
 1.06A 3wg7A-5b3fA:
undetectable
3wg7J-5b3fA:
undetectable		 3wg7A-5b3fA:
18.04
3wg7J-5b3fA:
8.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C49_B_HCYB1384_1
(CORTICOSTEROID-BINDI
NG GLOBULIN)		 5b3f PHOSPHORIBULOKINASE/
URIDINE KINASE
(Methanospirillum
hungatei) 		5 / 12 THR A 282
PHE A  41
ARG A  35
ILE A  37
SER A 307
 None
 1.47A 4c49B-5b3fA:
undetectable		 4c49B-5b3fA:
23.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C49_D_HCYD1384_1
(CORTICOSTEROID-BINDI
NG GLOBULIN)		 5b3f PHOSPHORIBULOKINASE/
URIDINE KINASE
(Methanospirillum
hungatei) 		5 / 12 THR A 282
PHE A  41
ARG A  35
ILE A  37
SER A 307
 None
 1.38A 4c49D-5b3fA:
undetectable		 4c49D-5b3fA:
23.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J24_A_ESTA600_1
(ESTROGEN RECEPTOR
BETA)		 5b3f PHOSPHORIBULOKINASE/
URIDINE KINASE
(Methanospirillum
hungatei) 		5 / 12 LEU A  80
LEU A  79
ILE A 119
ILE A 117
LEU A 133
 None
 1.14A 4j24A-5b3fA:
undetectable		 4j24A-5b3fA:
20.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J24_B_ESTB600_1
(ESTROGEN RECEPTOR
BETA)		 5b3f PHOSPHORIBULOKINASE/
URIDINE KINASE
(Methanospirillum
hungatei) 		5 / 12 LEU A  80
LEU A  79
ILE A 119
ILE A 117
LEU A 133
 None
 1.15A 4j24B-5b3fA:
undetectable		 4j24B-5b3fA:
20.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IMS_B_ACTB713_0
(ACETOLACTATE
SYNTHASE CATALYTIC
SUBUNIT,
MITOCHONDRIAL)		 5b3f PHOSPHORIBULOKINASE/
URIDINE KINASE
(Methanospirillum
hungatei) 		3 / 3 GLY A 121
GLN A 184
LYS A  30
 None
None
SO4  A 401 (-2.7A)
 0.91A 5imsB-5b3fA:
undetectable		 5imsB-5b3fA:
20.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M50_E_TA1E502_1
(TUBULIN BETA-2B
CHAIN)		 5b3f PHOSPHORIBULOKINASE/
URIDINE KINASE
(Methanospirillum
hungatei) 		5 / 12 VAL A  51
ASP A  52
GLU A 120
HIS A 123
GLY A  27
 None
None
SO4  A 401 ( 4.2A)
None
SO4  A 401 (-3.2A)
 1.11A 5m50E-5b3fA:
undetectable		 5m50E-5b3fA:
22.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M5C_B_TA1B502_1
(TUBULIN BETA-2B
CHAIN)		 5b3f PHOSPHORIBULOKINASE/
URIDINE KINASE
(Methanospirillum
hungatei) 		5 / 12 VAL A  51
ASP A  52
GLU A 120
HIS A 123
GLY A  27
 None
None
SO4  A 401 ( 4.2A)
None
SO4  A 401 (-3.2A)
 1.15A 5m5cB-5b3fA:
3.2		 5m5cB-5b3fA:
22.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M5C_E_TA1E502_1
(TUBULIN BETA-2B
CHAIN)		 5b3f PHOSPHORIBULOKINASE/
URIDINE KINASE
(Methanospirillum
hungatei) 		5 / 10 VAL A  51
ASP A  52
GLU A 120
HIS A 123
GLY A  27
 None
None
SO4  A 401 ( 4.2A)
None
SO4  A 401 (-3.2A)
 1.13A 5m5cE-5b3fA:
undetectable		 5m5cE-5b3fA:
22.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YW0_A_ACTA409_0
(UNCHARACTERIZED
PROTEIN KDOO)		 5b3f PHOSPHORIBULOKINASE/
URIDINE KINASE
(Methanospirillum
hungatei) 		3 / 3 ASP A 141
PHE A 178
ARG A 144
 None
 1.00A 5yw0A-5b3fA:
undetectable		 5yw0A-5b3fA:
20.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DJZ_B_GMJB301_0
(SIGMA NON-OPIOID
INTRACELLULAR
RECEPTOR 1)		 5b3f PHOSPHORIBULOKINASE/
URIDINE KINASE
(Methanospirillum
hungatei) 		5 / 12 LEU A 130
ILE A 119
THR A 114
VAL A  17
LEU A  79
 None
 1.35A 6djzB-5b3fA:
undetectable		 6djzB-5b3fA:
19.19