SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5b3j'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FM6_U_9CRU502_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 5b3j NMDA GLUTAMATE
RECEPTOR SUBUNIT
(Xenopus
laevis) 		5 / 12 ALA A 283
LEU A 280
ALA A 279
VAL A 385
ILE A 374
 None
 0.91A 1fm6U-5b3jA:
undetectable		 1fm6U-5b3jA:
21.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AVS_B_MK1B902_1
(POL POLYPROTEIN)		 5b3j NMDA GLUTAMATE
RECEPTOR SUBUNIT
(Xenopus
laevis) 		5 / 12 GLY A 120
VAL A 306
ILE A  29
GLY A  30
VAL A  32
 None
 0.88A 2avsA-5b3jA:
undetectable		 2avsA-5b3jA:
12.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F78_A_BEZA1001_0
(HTH-TYPE
TRANSCRIPTIONAL
REGULATOR BENM)		 5b3j NMDA GLUTAMATE
RECEPTOR SUBUNIT
(Xenopus
laevis) 		5 / 9 LEU A 228
LEU A 225
PHE A 218
LEU A 242
ILE A 166
 None
 0.99A 2f78A-5b3jA:
undetectable		 2f78A-5b3jA:
21.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F78_B_BEZB1002_0
(HTH-TYPE
TRANSCRIPTIONAL
REGULATOR BENM)		 5b3j NMDA GLUTAMATE
RECEPTOR SUBUNIT
(Xenopus
laevis) 		5 / 9 LEU A 228
LEU A 225
PHE A 218
LEU A 242
ILE A 166
 None
 0.99A 2f78B-5b3jA:
undetectable		 2f78B-5b3jA:
21.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F7A_A_BEZA1003_0
(HTH-TYPE
TRANSCRIPTIONAL
REGULATOR BENM)		 5b3j NMDA GLUTAMATE
RECEPTOR SUBUNIT
(Xenopus
laevis) 		5 / 9 LEU A 228
LEU A 225
PHE A 218
LEU A 242
ILE A 166
 None
 0.94A 2f7aA-5b3jA:
undetectable		 2f7aA-5b3jA:
21.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F8D_A_BEZA1002_0
(HTH-TYPE
TRANSCRIPTIONAL
REGULATOR BENM)		 5b3j NMDA GLUTAMATE
RECEPTOR SUBUNIT
(Xenopus
laevis) 		5 / 10 LEU A 228
LEU A 225
PHE A 218
LEU A 242
ILE A 166
 None
 0.99A 2f8dA-5b3jA:
undetectable		 2f8dA-5b3jA:
21.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F8D_B_BEZB1003_0
(HTH-TYPE
TRANSCRIPTIONAL
REGULATOR BENM)		 5b3j NMDA GLUTAMATE
RECEPTOR SUBUNIT
(Xenopus
laevis) 		5 / 10 LEU A 228
LEU A 225
PHE A 218
LEU A 242
ILE A 166
 None
 0.99A 2f8dB-5b3jA:
undetectable		 2f8dB-5b3jA:
21.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PNJ_B_CHDB501_0
(FERROCHELATASE,
MITOCHONDRIAL)		 5b3j NMDA GLUTAMATE
RECEPTOR SUBUNIT
(Xenopus
laevis) 		5 / 12 LEU A  33
PHE A  42
ILE A  90
VAL A 355
VAL A 309
 None
 1.31A 2pnjB-5b3jA:
4.3		 2pnjB-5b3jA:
22.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RK8_A_PPFA3969_1
(PHOSPHOENOLPYRUVATE
CARBOXYKINASE,
CYTOSOLIC [GTP])		 5b3j NMDA GLUTAMATE
RECEPTOR SUBUNIT
(Xenopus
laevis) 		4 / 8 HIS A 146
SER A 145
ASP A 366
ALA A 175
 None
 1.27A 2rk8A-5b3jA:
undetectable		 2rk8A-5b3jA:
19.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AQI_A_CHDA1_0
(FERROCHELATASE)		 5b3j NMDA GLUTAMATE
RECEPTOR SUBUNIT
(Xenopus
laevis) 		5 / 11 LEU A  33
PHE A  42
ILE A  90
VAL A 355
VAL A 309
 None
 1.37A 3aqiA-5b3jA:
4.2		 3aqiA-5b3jA:
22.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LSL_A_PZIA802_0
(GLUTAMATE RECEPTOR 2)		 5b3j NMDA GLUTAMATE
RECEPTOR SUBUNIT
(Xenopus
laevis) 		3 / 3 ASP A 366
ASN A 362
SER A 126
 None
 0.90A 3lslA-5b3jA:
1.2
3lslD-5b3jA:
1.4		 3lslA-5b3jA:
20.87
3lslD-5b3jA:
20.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MDR_B_GJZB506_1
(CHOLESTEROL
24-HYDROXYLASE)		 5b3j NMDA GLUTAMATE
RECEPTOR SUBUNIT
(Xenopus
laevis) 		4 / 6 PHE A 342
ILE A 313
ALA A 312
ALA A 305
 None
 1.02A 3mdrB-5b3jA:
undetectable		 3mdrB-5b3jA:
23.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NYA_A_JTZA1203_1
(BETA-2 ADRENERGIC
RECEPTOR, LYSOZYME)		 5b3j FAB, HEAVY CHAIN
(Mus
musculus) 		5 / 12 VAL E 172
VAL E 190
SER E 188
ASN E 205
ASN E 164
 None
 1.41A 3nyaA-5b3jE:
undetectable		 3nyaA-5b3jE:
18.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P2K_A_SAMA6735_0
(16S RRNA METHYLASE)		 5b3j NMDA GLUTAMATE
RECEPTOR SUBUNIT
(Xenopus
laevis) 		5 / 12 GLY A 263
GLY A 265
ALA A 256
ALA A 257
TRP A 402
 None
 1.01A 3p2kA-5b3jA:
undetectable		 3p2kA-5b3jA:
20.57
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3QEL_D_QELD2_1
(NMDA GLUTAMATE
RECEPTOR SUBUNIT
GLUTAMATE [NMDA]
RECEPTOR SUBUNIT
EPSILON-2)		 5b3j NMDA GLUTAMATE
RECEPTOR SUBUNIT
(Xenopus
laevis) 		4 / 5 THR A 110
PHE A 113
ARG A 115
LEU A 135
 None
 0.93A 3qelC-5b3jA:
50.8		 3qelC-5b3jA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3QEL_D_QELD2_1
(NMDA GLUTAMATE
RECEPTOR SUBUNIT
GLUTAMATE [NMDA]
RECEPTOR SUBUNIT
EPSILON-2)		 5b3j NMDA GLUTAMATE
RECEPTOR SUBUNIT
(Xenopus
laevis) 		4 / 5 TYR A 109
THR A 110
PHE A 113
ARG A 115
 None
 0.39A 3qelC-5b3jA:
50.8		 3qelC-5b3jA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UJ7_B_SAMB302_0
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE)		 5b3j NMDA GLUTAMATE
RECEPTOR SUBUNIT
(Xenopus
laevis) 		5 / 12 ILE A  83
GLY A  30
ILE A 116
ASP A  81
LEU A  33
 None
 1.07A 3uj7B-5b3jA:
undetectable		 3uj7B-5b3jA:
22.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UJ7_B_SAMB302_0
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE)		 5b3j NMDA GLUTAMATE
RECEPTOR SUBUNIT
(Xenopus
laevis) 		5 / 12 ILE A 374
GLY A 271
GLY A 289
ILE A 241
ILE A 288
 None
 0.95A 3uj7B-5b3jA:
undetectable		 3uj7B-5b3jA:
22.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V3O_B_T1CB405_1
(TETX2 PROTEIN)		 5b3j NMDA GLUTAMATE
RECEPTOR SUBUNIT
(Xenopus
laevis) 		5 / 12 PHE A 137
GLY A 365
PRO A 117
ALA A 111
GLY A 112
 None
 1.18A 3v3oB-5b3jA:
4.0		 3v3oB-5b3jA:
20.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W1W_B_CHDB504_0
(FERROCHELATASE,
MITOCHONDRIAL)		 5b3j NMDA GLUTAMATE
RECEPTOR SUBUNIT
(Xenopus
laevis) 		5 / 12 LEU A  33
PHE A  42
ILE A  90
VAL A 355
VAL A 309
 None
 1.34A 3w1wB-5b3jA:
4.4		 3w1wB-5b3jA:
22.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A6N_A_T1CA392_1
(TETX2 PROTEIN)		 5b3j NMDA GLUTAMATE
RECEPTOR SUBUNIT
(Xenopus
laevis) 		5 / 11 PHE A 137
GLY A 365
PRO A 117
ALA A 111
GLY A 112
 None
 1.35A 4a6nA-5b3jA:
3.6		 4a6nA-5b3jA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QWP_B_GCSB307_1
(CHITOSANASE)		 5b3j FAB, HEAVY CHAIN
(Mus
musculus) 		4 / 7 THR E 117
GLY E  10
THR E 119
HIS E 208
 None
 1.00A 4qwpB-5b3jE:
undetectable		 4qwpB-5b3jE:
20.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R29_C_SAMC301_0
(UNCHARACTERIZED
PROTEIN)		 5b3j NMDA GLUTAMATE
RECEPTOR SUBUNIT
(Xenopus
laevis) 		5 / 12 ALA A 370
GLY A 390
PHE A 388
TYR A 372
GLU A 272
 None
 1.21A 4r29C-5b3jA:
undetectable		 4r29C-5b3jA:
19.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RVG_A_SAMA503_0
(D-MYCAROSE
3-C-METHYLTRANSFERAS
E)		 5b3j NMDA GLUTAMATE
RECEPTOR SUBUNIT
(Xenopus
laevis) 		5 / 12 THR A 140
ILE A  29
PRO A 117
VAL A 309
ILE A 313
 None
 0.92A 4rvgA-5b3jA:
5.5		 4rvgA-5b3jA:
21.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JSD_A_1GNA607_1
(PHIAB6 TAILSPIKE)		 5b3j FAB, HEAVY CHAIN
(Mus
musculus) 		3 / 3 THR E  28
SER E  31
TYR E  32
 None
 0.81A 5jsdA-5b3jE:
2.5		 5jsdA-5b3jE:
16.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JSD_B_1GNB618_1
(PHIAB6 TAILSPIKE)		 5b3j FAB, HEAVY CHAIN
(Mus
musculus) 		3 / 3 THR E  28
SER E  31
TYR E  32
 None
 0.82A 5jsdB-5b3jE:
undetectable		 5jsdB-5b3jE:
16.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JSD_C_1GNC608_1
(PHIAB6 TAILSPIKE)		 5b3j FAB, HEAVY CHAIN
(Mus
musculus) 		3 / 3 THR E  28
SER E  31
TYR E  32
 None
 0.81A 5jsdC-5b3jE:
undetectable		 5jsdC-5b3jE:
16.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JSE_A_1GNA608_1
(PHIAB6 TAILSPIKE)		 5b3j FAB, HEAVY CHAIN
(Mus
musculus) 		3 / 3 THR E  28
SER E  31
TYR E  32
 None
 0.84A 5jseA-5b3jE:
2.5		 5jseA-5b3jE:
16.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JSE_B_1GNB611_1
(PHIAB6 TAILSPIKE)		 5b3j FAB, HEAVY CHAIN
(Mus
musculus) 		3 / 3 THR E  28
SER E  31
TYR E  32
 None
 0.83A 5jseB-5b3jE:
undetectable		 5jseB-5b3jE:
16.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JSE_C_1GNC611_1
(PHIAB6 TAILSPIKE)		 5b3j FAB, HEAVY CHAIN
(Mus
musculus) 		3 / 3 THR E  28
SER E  31
TYR E  32
 None
 0.83A 5jseC-5b3jE:
undetectable		 5jseC-5b3jE:
16.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TE8_A_08JA602_1
(CYTOCHROME P450 3A4)		 5b3j NMDA GLUTAMATE
RECEPTOR SUBUNIT
(Xenopus
laevis) 		4 / 7 ARG A 367
ALA A 307
ILE A 302
LEU A  91
 None
 0.97A 5te8A-5b3jA:
undetectable		 5te8A-5b3jA:
21.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X2S_I_PEMI202_1
(HEMOGLOBIN SUBUNIT
ALPHA
HEMOGLOBIN SUBUNIT
BETA)		 5b3j NMDA GLUTAMATE
RECEPTOR SUBUNIT
(Xenopus
laevis) 		4 / 8 PRO A 104
THR A 122
THR A 123
TYR A 128
 None
 1.23A 5x2sI-5b3jA:
undetectable
5x2sJ-5b3jA:
undetectable
5x2sK-5b3jA:
undetectable		 5x2sI-5b3jA:
18.26
5x2sJ-5b3jA:
17.80
5x2sK-5b3jA:
18.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CDU_A_EY4A502_0
(CHIMERIC ALPHA1GABAA
RECEPTOR)		 5b3j NMDA GLUTAMATE
RECEPTOR SUBUNIT
(Xenopus
laevis) 		4 / 7 ALA A 111
THR A 110
TYR A 109
VAL A 118
 None
 0.84A 6cduA-5b3jA:
undetectable
6cduE-5b3jA:
undetectable		 6cduA-5b3jA:
21.73
6cduE-5b3jA:
21.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CDU_H_EY4H500_0
(CHIMERIC ALPHA1GABAA
RECEPTOR)		 5b3j NMDA GLUTAMATE
RECEPTOR SUBUNIT
(Xenopus
laevis) 		4 / 7 VAL A 118
ALA A 111
THR A 110
TYR A 109
 None
 0.86A 6cduH-5b3jA:
undetectable
6cduI-5b3jA:
undetectable		 6cduH-5b3jA:
21.73
6cduI-5b3jA:
21.73