SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5b3n'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1H8S_A_AICA1000_1
(MUTANT AL2 6E7P9G)		 5b3n ANTI-H4K20ME1_SCFV
(Mus
musculus) 		7 / 12 TYR A 178
GLN A 231
LEU A 238
PHE A 240
VAL A  39
ALA A  99
TRP A 113
 None
 0.69A 1h8sA-5b3nA:
21.8		 1h8sA-5b3nA:
30.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Z11_A_8MOA501_0
(CYTOCHROME P450,
FAMILY 2, SUBFAMILY
A, POLYPEPTIDE 6)		 5b3n ANTI-H4K20ME1_SCFV
(Mus
musculus) 		6 / 11 PHE A  31
ASN A  76
GLY A  57
THR A  60
ILE A  72
LEU A  81
 None
 1.40A 1z11A-5b3nA:
undetectable		 1z11A-5b3nA:
17.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q6K_A_ADNA699_1
(CHLORINASE)		 5b3n ANTI-H4K20ME1_SCFV
(Mus
musculus) 		4 / 7 ASP A 236
TYR A  61
TYR A  62
PRO A  63
 None
 1.35A 2q6kA-5b3nA:
undetectable		 2q6kA-5b3nA:
22.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XN7_A_T44A1355_1
(THYROXINE-BINDING
GLOBULIN)		 5b3n ANTI-H4K20ME1_SCFV
(Mus
musculus) 		5 / 10 LEU A  88
LEU A 119
SER A  23
LEU A  22
LEU A  20
 None
 1.11A 2xn7A-5b3nA:
undetectable
2xn7B-5b3nA:
undetectable		 2xn7A-5b3nA:
20.60
2xn7B-5b3nA:
7.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3APW_B_DP0B190_1
(ALPHA-1-ACID
GLYCOPROTEIN 2)		 5b3n ANTI-H4K20ME1_SCFV
(Mus
musculus) 		5 / 12 VAL A 151
ILE A 248
GLU A 223
ARG A 203
TYR A 228
 None
 1.24A 3apwB-5b3nA:
undetectable		 3apwB-5b3nA:
21.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ARU_A_PNXA608_1
(CHITINASE A)		 5b3n ANTI-H4K20ME1_SCFV
(Mus
musculus) 		4 / 6 TRP A 113
SER A  37
ALA A  35
HIS A 101
 None
 1.38A 3aruA-5b3nA:
6.3		 3aruA-5b3nA:
19.35
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3LS4_H_TCIH220_2
(HEAVY CHAIN OF
ANTIBODY FAB
FRAGMENT
LIGHT CHAIN OF
ANTIBODY FAB
FRAGMENT)		 5b3n ANTI-H4K20ME1_SCFV
(Mus
musculus) 		4 / 5 TYR A 178
GLN A 231
LEU A 238
PHE A 240
 None
 0.28A 3ls4L-5b3nA:
21.2		 3ls4L-5b3nA:
63.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OU6_B_SAMB300_1
(SAM-DEPENDENT
METHYLTRANSFERASE)		 5b3n ANTI-H4K20ME1_SCFV
(Mus
musculus) 		3 / 3 TYR A  61
ASP A 108
ASP A 111
 None
 0.67A 3ou6B-5b3nA:
undetectable		 3ou6B-5b3nA:
22.10
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3QXV_A_MTXA2000_1
(ANTI-METHOTREXATE
CDR1-4 GRAFT VHH)		 5b3n ANTI-H4K20ME1_SCFV
(Mus
musculus) 		6 / 12 VAL A   4
ALA A  26
MET A  36
ARG A  74
ASN A  76
TYR A 112
 None
 1.09A 3qxvA-5b3nA:
20.6		 3qxvA-5b3nA:
58.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RXH_A_HSMA7_1
(CATIONIC TRYPSIN)		 5b3n ANTI-H4K20ME1_SCFV
(Mus
musculus) 		4 / 5 ASP A 168
SER A 173
SER A 194
GLY A 210
 None
 0.83A 3rxhA-5b3nA:
undetectable		 3rxhA-5b3nA:
24.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_T_BEZT801_0
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 2
BEZ-LEU-LEU)		 5b3n ANTI-H4K20ME1_SCFV
(Mus
musculus) 		4 / 5 SER A  37
ALA A  51
HIS A 101
LEU A 238
 None
 1.32A 5dzkf-5b3nA:
undetectable
5dzkt-5b3nA:
undetectable		 5dzkf-5b3nA:
22.42
5dzkt-5b3nA:
1.04
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6CJK_B_ACTB302_0
(IMMUNOGLOBULIN FAB
HEAVY CHAIN)		 5b3n ANTI-H4K20ME1_SCFV
(Mus
musculus) 		3 / 3 TYR A  62
GLY A  68
THR A  71
 None
 0.20A 6cjkB-5b3nA:
19.9		 6cjkB-5b3nA:
37.40