SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5b47'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DLS_A_MTXA188_1
(DIHYDROFOLATE
REDUCTASE)		 5b47 2-OXOACID--FERREDOXI
N OXIDOREDUCTASE
ALPHA SUBUNIT
(Sulfurisphaera
tokodaii) 		5 / 12 ILE A 384
ALA A 411
SER A 263
ILE A 266
ASN A 269
 None
 1.21A 1dlsA-5b47A:
undetectable		 1dlsA-5b47A:
15.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1H7X_A_URFA1033_1
(DIHYDROPYRIMIDINE
DEHYDROGENASE)		 5b47 2-OXOACID--FERREDOXI
N OXIDOREDUCTASE
ALPHA SUBUNIT
(Sulfurisphaera
tokodaii) 		4 / 6 ASN A  37
ILE A 602
ASN A 572
SER A 522
 None
 1.20A 1h7xA-5b47A:
2.1		 1h7xA-5b47A:
21.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1H7X_B_URFB1033_1
(DIHYDROPYRIMIDINE
DEHYDROGENASE)		 5b47 2-OXOACID--FERREDOXI
N OXIDOREDUCTASE
ALPHA SUBUNIT
(Sulfurisphaera
tokodaii) 		4 / 6 ASN A  37
ILE A 602
ASN A 572
SER A 522
 None
 1.20A 1h7xB-5b47A:
3.3		 1h7xB-5b47A:
21.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1H7X_C_URFC1033_1
(DIHYDROPYRIMIDINE
DEHYDROGENASE)		 5b47 2-OXOACID--FERREDOXI
N OXIDOREDUCTASE
ALPHA SUBUNIT
(Sulfurisphaera
tokodaii) 		4 / 6 ASN A  37
ILE A 602
ASN A 572
SER A 522
 None
 1.19A 1h7xC-5b47A:
undetectable		 1h7xC-5b47A:
21.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1H7X_D_URFD1033_1
(DIHYDROPYRIMIDINE
DEHYDROGENASE)		 5b47 2-OXOACID--FERREDOXI
N OXIDOREDUCTASE
ALPHA SUBUNIT
(Sulfurisphaera
tokodaii) 		4 / 6 ASN A  37
ILE A 602
ASN A 572
SER A 522
 None
 1.18A 1h7xD-5b47A:
2.3		 1h7xD-5b47A:
21.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MXG_A_ACRA444_1
(ALPHA AMYLASE)		 5b47 2-OXOACID--FERREDOXI
N OXIDOREDUCTASE
ALPHA SUBUNIT
(Sulfurisphaera
tokodaii) 		4 / 7 TYR A  50
ASN A 412
TYR A 414
GLY A 235
 None
 1.35A 1mxgA-5b47A:
undetectable		 1mxgA-5b47A:
22.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MXG_A_ACRA444_1
(ALPHA AMYLASE)		 5b47 2-OXOACID--FERREDOXI
N OXIDOREDUCTASE
ALPHA SUBUNIT
(Sulfurisphaera
tokodaii) 		4 / 7 TYR A 414
HIS A  81
TYR A  50
GLY A  10
 None
 1.28A 1mxgA-5b47A:
undetectable		 1mxgA-5b47A:
22.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NH8_A_HISA289_0
(ATP
PHOSPHORIBOSYLTRANSF
ERASE)		 5b47 2-OXOACID--FERREDOXI
N OXIDOREDUCTASE
BETA SUBUNIT
(Sulfurisphaera
tokodaii) 		4 / 5 ASP B 192
LEU B 175
ALA B 165
LEU B 153
 None
 0.96A 1nh8A-5b47B:
1.5		 1nh8A-5b47B:
23.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PJ7_A_FFOA2887_1
(N,N-DIMETHYLGLYCINE
OXIDASE)		 5b47 2-OXOACID--FERREDOXI
N OXIDOREDUCTASE
BETA SUBUNIT
(Sulfurisphaera
tokodaii) 		3 / 3 ASP B 266
THR B 269
GLU B 277
 None
 0.63A 1pj7A-5b47B:
undetectable		 1pj7A-5b47B:
15.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A1N_A_CAMA1422_0
(CYTOCHROME P450-CAM)		 5b47 2-OXOACID--FERREDOXI
N OXIDOREDUCTASE
BETA SUBUNIT
(Sulfurisphaera
tokodaii) 		5 / 11 TYR B 121
GLY B  97
VAL B 115
ASP B  90
VAL B  88
 TPP  B 402 (-4.2A)
None
None
MG  B 403 ( 3.1A)
None
 1.04A 2a1nA-5b47B:
undetectable		 2a1nA-5b47B:
19.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CP4_A_CAMA416_0
(CYTOCHROME P450-CAM)		 5b47 2-OXOACID--FERREDOXI
N OXIDOREDUCTASE
BETA SUBUNIT
(Sulfurisphaera
tokodaii) 		5 / 10 TYR B 121
GLY B  97
VAL B 115
ASP B  90
VAL B  88
 TPP  B 402 (-4.2A)
None
None
MG  B 403 ( 3.1A)
None
 1.10A 2cp4A-5b47B:
undetectable		 2cp4A-5b47B:
19.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DM6_A_IMNA1401_1
(NADP-DEPENDENT
LEUKOTRIENE B4
12-HYDROXYDEHYDROGEN
ASE)		 5b47 2-OXOACID--FERREDOXI
N OXIDOREDUCTASE
BETA SUBUNIT
(Sulfurisphaera
tokodaii) 		5 / 10 ILE B 179
ALA B 182
ILE B  33
GLU B  24
ILE B  28
 None
 1.16A 2dm6A-5b47B:
3.5
2dm6B-5b47B:
3.6		 2dm6A-5b47B:
25.89
2dm6B-5b47B:
25.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IGT_A_SAMA1001_0
(SAM DEPENDENT
METHYLTRANSFERASE)		 5b47 2-OXOACID--FERREDOXI
N OXIDOREDUCTASE
BETA SUBUNIT
(Sulfurisphaera
tokodaii) 		5 / 12 ALA B 165
ALA B 189
PRO B 224
GLY B 253
TRP B 222
 None
 1.09A 2igtA-5b47B:
4.0		 2igtA-5b47B:
22.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IGT_C_SAMC1003_0
(SAM DEPENDENT
METHYLTRANSFERASE)		 5b47 2-OXOACID--FERREDOXI
N OXIDOREDUCTASE
BETA SUBUNIT
(Sulfurisphaera
tokodaii) 		5 / 12 ALA B 165
ALA B 189
PRO B 224
GLY B 253
TRP B 222
 None
 1.08A 2igtC-5b47B:
4.1		 2igtC-5b47B:
22.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IJ7_C_TPFC2471_1
(CYTOCHROME P450 121)		 5b47 2-OXOACID--FERREDOXI
N OXIDOREDUCTASE
BETA SUBUNIT
(Sulfurisphaera
tokodaii) 		4 / 8 VAL B 115
VAL B 191
PHE B 101
ALA B 156
 None
 1.13A 2ij7C-5b47B:
undetectable		 2ij7C-5b47B:
20.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OGY_B_C2FB4000_0
(5-METHYLTETRAHYDROFO
LATE CORRINOID/IRON
SULFUR PROTEIN
METHYLTRANSFERASE)		 5b47 2-OXOACID--FERREDOXI
N OXIDOREDUCTASE
ALPHA SUBUNIT
(Sulfurisphaera
tokodaii) 		5 / 12 GLU A 619
ILE A 515
LEU A 534
GLY A 610
ILE A 614
 None
 1.33A 2ogyB-5b47A:
undetectable		 2ogyB-5b47A:
19.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PKM_A_ADNA501_1
(ADENOSINE KINASE)		 5b47 2-OXOACID--FERREDOXI
N OXIDOREDUCTASE
ALPHA SUBUNIT
(Sulfurisphaera
tokodaii) 		5 / 12 SER A 214
ALA A 175
GLY A 174
GLY A 211
PHE A 144
 None
 0.75A 2pkmA-5b47A:
undetectable		 2pkmA-5b47A:
20.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0G_A_LEUA1887_0
(AMINOACYL-TRNA
SYNTHETASE)		 5b47 2-OXOACID--FERREDOXI
N OXIDOREDUCTASE
ALPHA SUBUNIT
2-OXOACID--FERREDOXI
N OXIDOREDUCTASE
BETA SUBUNIT
(Sulfurisphaera
tokodaii;
Sulfurisphaera
tokodaii) 		4 / 8 ASP B  90
SER B 129
TYR B 121
TYR A 254
 MG  B 403 ( 3.1A)
None
TPP  B 402 (-4.2A)
TPP  B 402 (-4.6A)
 1.34A 2v0gA-5b47B:
undetectable		 2v0gA-5b47B:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BGD_A_PM6A302_1
(THIOPURINE
S-METHYLTRANSFERASE)		 5b47 2-OXOACID--FERREDOXI
N OXIDOREDUCTASE
ALPHA SUBUNIT
(Sulfurisphaera
tokodaii) 		4 / 6 THR A 340
GLN A 251
LEU A 392
LEU A 248
 None
 0.89A 3bgdA-5b47A:
undetectable		 3bgdA-5b47A:
17.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BGD_B_PM6B302_1
(THIOPURINE
S-METHYLTRANSFERASE)		 5b47 2-OXOACID--FERREDOXI
N OXIDOREDUCTASE
ALPHA SUBUNIT
(Sulfurisphaera
tokodaii) 		4 / 7 THR A 340
GLN A 251
LEU A 392
LEU A 248
 None
 0.92A 3bgdB-5b47A:
undetectable		 3bgdB-5b47A:
17.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_B_SVRB512_2
(PHOSPHOLIPASE A2)		 5b47 2-OXOACID--FERREDOXI
N OXIDOREDUCTASE
BETA SUBUNIT
(Sulfurisphaera
tokodaii) 		4 / 7 VAL B  84
ILE B  33
GLY B  32
ARG B  29
 None
 0.76A 3bjwB-5b47B:
undetectable		 3bjwB-5b47B:
18.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_H_SVRH511_3
(PHOSPHOLIPASE A2)		 5b47 2-OXOACID--FERREDOXI
N OXIDOREDUCTASE
BETA SUBUNIT
(Sulfurisphaera
tokodaii) 		4 / 7 VAL B  84
ILE B  33
GLY B  32
ARG B  29
 None
 0.75A 3bjwH-5b47B:
undetectable		 3bjwH-5b47B:
18.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3C6G_A_VD3A701_1
(CYTOCHROME P450 2R1)		 5b47 2-OXOACID--FERREDOXI
N OXIDOREDUCTASE
ALPHA SUBUNIT
(Sulfurisphaera
tokodaii) 		5 / 12 LEU A 364
GLY A 317
THR A 313
VAL A 337
ILE A 327
 None
 0.93A 3c6gA-5b47A:
undetectable		 3c6gA-5b47A:
21.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G1U_B_ADNB438_2
(ADENOSYLHOMOCYSTEINA
SE)		 5b47 2-OXOACID--FERREDOXI
N OXIDOREDUCTASE
ALPHA SUBUNIT
(Sulfurisphaera
tokodaii) 		3 / 3 THR A 448
GLU A 472
HIS A 470
 None
 0.76A 3g1uB-5b47A:
3.2		 3g1uB-5b47A:
22.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NU4_B_478B401_1
(PROTEASE)		 5b47 2-OXOACID--FERREDOXI
N OXIDOREDUCTASE
ALPHA SUBUNIT
(Sulfurisphaera
tokodaii) 		5 / 9 ILE A 403
GLY A 367
PRO A 401
VAL A 337
ILE A 339
 None
 0.97A 3nu4A-5b47A:
undetectable		 3nu4A-5b47A:
10.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3O7W_A_SAMA801_0
(LEUCINE CARBOXYL
METHYLTRANSFERASE 1)		 5b47 2-OXOACID--FERREDOXI
N OXIDOREDUCTASE
BETA SUBUNIT
(Sulfurisphaera
tokodaii) 		5 / 12 ALA B  70
GLY B  93
GLY B  97
ILE B  96
VAL B  88
 None
 1.10A 3o7wA-5b47B:
3.7		 3o7wA-5b47B:
22.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3R9S_C_BEZC264_0
(CARNITINYL-COA
DEHYDRATASE)		 5b47 2-OXOACID--FERREDOXI
N OXIDOREDUCTASE
ALPHA SUBUNIT
(Sulfurisphaera
tokodaii) 		4 / 6 ALA A 240
ILE A 266
LEU A 244
ALA A 388
 None
 0.88A 3r9sC-5b47A:
undetectable		 3r9sC-5b47A:
19.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3R9T_B_BEZB264_0
(ECHA1_1)		 5b47 2-OXOACID--FERREDOXI
N OXIDOREDUCTASE
BETA SUBUNIT
(Sulfurisphaera
tokodaii) 		4 / 7 ILE B  85
LEU B 114
ALA B  23
MET B  54
 None
 0.79A 3r9tB-5b47B:
undetectable		 3r9tB-5b47B:
22.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V3O_A_T1CA404_1
(TETX2 PROTEIN)		 5b47 2-OXOACID--FERREDOXI
N OXIDOREDUCTASE
BETA SUBUNIT
(Sulfurisphaera
tokodaii) 		5 / 12 PHE B 101
HIS B 103
GLY B  99
ALA B 154
ASN B 151
 None
 1.04A 3v3oA-5b47B:
undetectable		 3v3oA-5b47B:
20.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V3O_B_T1CB405_1
(TETX2 PROTEIN)		 5b47 2-OXOACID--FERREDOXI
N OXIDOREDUCTASE
BETA SUBUNIT
(Sulfurisphaera
tokodaii) 		5 / 12 PHE B 101
HIS B 103
GLY B  99
ALA B 154
ASN B 151
 None
 1.20A 3v3oB-5b47B:
undetectable		 3v3oB-5b47B:
20.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_B_W9TB501_1
(HEMOLYTIC LECTIN
CEL-III)		 5b47 2-OXOACID--FERREDOXI
N OXIDOREDUCTASE
BETA SUBUNIT
(Sulfurisphaera
tokodaii) 		4 / 5 SER B  47
GLY B  48
TRP B  11
ASP B  10
 TPP  B 402 (-3.0A)
None
None
None
 1.13A 3w9tB-5b47B:
undetectable		 3w9tB-5b47B:
20.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_C_W9TC1003_1
(HEMOLYTIC LECTIN
CEL-III)		 5b47 2-OXOACID--FERREDOXI
N OXIDOREDUCTASE
BETA SUBUNIT
(Sulfurisphaera
tokodaii) 		4 / 5 SER B  47
GLY B  48
TRP B  11
ASP B  10
 TPP  B 402 (-3.0A)
None
None
None
 1.13A 3w9tC-5b47B:
undetectable		 3w9tC-5b47B:
20.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_D_W9TD501_1
(HEMOLYTIC LECTIN
CEL-III)		 5b47 2-OXOACID--FERREDOXI
N OXIDOREDUCTASE
BETA SUBUNIT
(Sulfurisphaera
tokodaii) 		4 / 5 SER B  47
GLY B  48
TRP B  11
ASP B  10
 TPP  B 402 (-3.0A)
None
None
None
 1.14A 3w9tD-5b47B:
undetectable		 3w9tD-5b47B:
20.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BQF_B_QPSB951_1
(ALPHA-GLUCAN
PHOSPHORYLASE 2,
CYTOSOLIC)		 5b47 2-OXOACID--FERREDOXI
N OXIDOREDUCTASE
ALPHA SUBUNIT
(Sulfurisphaera
tokodaii) 		4 / 8 ARG A 431
ARG A 310
GLU A 396
GLU A 430
 None
 1.10A 4bqfB-5b47A:
undetectable		 4bqfB-5b47A:
21.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4GH8_B_MTXB201_1
(DIHYDROFOLATE
REDUCTASE)		 5b47 2-OXOACID--FERREDOXI
N OXIDOREDUCTASE
ALPHA SUBUNIT
(Sulfurisphaera
tokodaii) 		5 / 12 ILE A 384
ALA A 411
SER A 263
ILE A 266
ASN A 269
 None
 1.26A 4gh8B-5b47A:
undetectable		 4gh8B-5b47A:
14.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K4Y_A_ACTA502_0
(RNA-DEPENDENT RNA
POLYMERASE)		 5b47 2-OXOACID--FERREDOXI
N OXIDOREDUCTASE
ALPHA SUBUNIT
(Sulfurisphaera
tokodaii) 		4 / 5 LYS A 536
LEU A 534
GLU A 533
LYS A 612
 None
 1.34A 4k4yA-5b47A:
undetectable		 4k4yA-5b47A:
21.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K4Y_I_ACTI503_0
(RNA-DEPENDENT RNA
POLYMERASE)		 5b47 2-OXOACID--FERREDOXI
N OXIDOREDUCTASE
ALPHA SUBUNIT
(Sulfurisphaera
tokodaii) 		4 / 5 LYS A 536
LEU A 534
GLU A 533
LYS A 612
 None
 1.32A 4k4yI-5b47A:
undetectable		 4k4yI-5b47A:
21.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K87_A_ADNA602_1
(PROLINE--TRNA LIGASE)		 5b47 2-OXOACID--FERREDOXI
N OXIDOREDUCTASE
ALPHA SUBUNIT
(Sulfurisphaera
tokodaii) 		4 / 8 ARG A  47
GLY A 350
THR A 349
THR A 353
 None
None
TPP  B 402 ( 4.5A)
None
 0.88A 4k87A-5b47A:
2.7		 4k87A-5b47A:
23.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MI4_B_SPMB201_1
(SPERMIDINE
N1-ACETYLTRANSFERASE)		 5b47 2-OXOACID--FERREDOXI
N OXIDOREDUCTASE
ALPHA SUBUNIT
(Sulfurisphaera
tokodaii) 		4 / 7 GLU A 606
GLU A 605
GLU A  52
ARG A   3
 None
 1.12A 4mi4B-5b47A:
undetectable
4mi4C-5b47A:
undetectable		 4mi4B-5b47A:
16.26
4mi4C-5b47A:
16.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MJ8_B_SPMB201_1
(SPERMIDINE
N1-ACETYLTRANSFERASE)		 5b47 2-OXOACID--FERREDOXI
N OXIDOREDUCTASE
ALPHA SUBUNIT
(Sulfurisphaera
tokodaii) 		4 / 8 GLU A 606
GLU A 605
GLU A  52
ARG A   3
 None
 1.12A 4mj8B-5b47A:
undetectable
4mj8C-5b47A:
undetectable		 4mj8B-5b47A:
15.81
4mj8C-5b47A:
15.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QN9_B_DXCB610_0
(N-ACYL-PHOSPHATIDYLE
THANOLAMINE-HYDROLYZ
ING PHOSPHOLIPASE D)		 5b47 2-OXOACID--FERREDOXI
N OXIDOREDUCTASE
ALPHA SUBUNIT
(Sulfurisphaera
tokodaii) 		3 / 3 GLY A 319
PRO A 318
ALA A 346
 TPP  B 402 ( 4.6A)
TPP  B 402 (-4.6A)
None
 0.47A 4qn9B-5b47A:
undetectable		 4qn9B-5b47A:
19.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QOI_B_ML1B303_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 5b47 2-OXOACID--FERREDOXI
N OXIDOREDUCTASE
ALPHA SUBUNIT
(Sulfurisphaera
tokodaii) 		5 / 11 GLY A 317
GLY A 319
MET A 323
ILE A 256
GLY A 356
 None
TPP  B 402 ( 4.6A)
None
TPP  B 402 (-3.9A)
None
 1.19A 4qoiA-5b47A:
4.4
4qoiB-5b47A:
4.8		 4qoiA-5b47A:
16.72
4qoiB-5b47A:
16.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RYA_A_ACTA502_0
(ABC TRANSPORTER
SUBSTRATE BINDING
PROTEIN (SORBITOL))		 5b47 2-OXOACID--FERREDOXI
N OXIDOREDUCTASE
ALPHA SUBUNIT
(Sulfurisphaera
tokodaii) 		4 / 4 LYS A 283
ARG A 282
GLY A 284
ASP A 273
 None
 1.34A 4ryaA-5b47A:
undetectable		 4ryaA-5b47A:
22.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UW0_A_SAMA1506_0
(WBDD)		 5b47 2-OXOACID--FERREDOXI
N OXIDOREDUCTASE
ALPHA SUBUNIT
(Sulfurisphaera
tokodaii) 		5 / 12 ARG A 455
ALA A 304
ILE A 298
VAL A 337
ILE A 339
 None
 0.94A 4uw0A-5b47A:
undetectable		 4uw0A-5b47A:
20.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YMG_A_SAMA1001_0
(PUTATIVE
SAM-DEPENDENT
O-METHYLTRANFERASE)		 5b47 2-OXOACID--FERREDOXI
N OXIDOREDUCTASE
ALPHA SUBUNIT
(Sulfurisphaera
tokodaii) 		5 / 12 LYS A 361
GLY A 578
ALA A 590
ALA A 576
TYR A 593
 None
 1.14A 4ymgA-5b47A:
undetectable		 4ymgA-5b47A:
16.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YOA_A_017A100_1
(HIV-1 PROTEASE)		 5b47 2-OXOACID--FERREDOXI
N OXIDOREDUCTASE
ALPHA SUBUNIT
(Sulfurisphaera
tokodaii) 		4 / 6 ASP A 387
PRO A 336
THR A 400
VAL A 402
 None
 1.07A 4yoaA-5b47A:
undetectable		 4yoaA-5b47A:
10.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZJO_D_ERYD1101_0
(MULTIDRUG EFFLUX
PUMP SUBUNIT ACRB)		 5b47 2-OXOACID--FERREDOXI
N OXIDOREDUCTASE
ALPHA SUBUNIT
(Sulfurisphaera
tokodaii) 		5 / 11 TYR A 265
ALA A  28
GLU A 419
ASP A 234
THR A 237
 None
 1.46A 4zjoD-5b47A:
2.8		 4zjoD-5b47A:
21.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ECN_A_LEUA602_0
(JASMONIC ACID-AMIDO
SYNTHETASE JAR1)		 5b47 2-OXOACID--FERREDOXI
N OXIDOREDUCTASE
BETA SUBUNIT
(Sulfurisphaera
tokodaii) 		4 / 7 ALA B  70
THR B  73
VAL B  86
HIS B 100
 None
 1.11A 5ecnA-5b47B:
1.1		 5ecnA-5b47B:
21.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FLC_C_RAPC999_1
(SERINE/THREONINE-PRO
TEIN KINASE MTOR
FKBP)		 5b47 2-OXOACID--FERREDOXI
N OXIDOREDUCTASE
ALPHA SUBUNIT
2-OXOACID--FERREDOXI
N OXIDOREDUCTASE
BETA SUBUNIT
(Sulfurisphaera
tokodaii) 		4 / 8 GLU A 292
GLY B  91
THR A 257
TYR A 253
 None
TPP  B 402 (-3.4A)
PYR  A 701 (-3.0A)
None
 0.96A 5flcB-5b47A:
undetectable		 5flcB-5b47A:
19.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FLC_G_RAPG999_1
(SERINE/THREONINE-PRO
TEIN KINASE MTOR
FKBP)		 5b47 2-OXOACID--FERREDOXI
N OXIDOREDUCTASE
ALPHA SUBUNIT
2-OXOACID--FERREDOXI
N OXIDOREDUCTASE
BETA SUBUNIT
(Sulfurisphaera
tokodaii) 		4 / 8 GLU A 292
GLY B  91
THR A 257
TYR A 253
 None
TPP  B 402 (-3.4A)
PYR  A 701 (-3.0A)
None
 0.96A 5flcF-5b47A:
undetectable		 5flcF-5b47A:
19.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HIK_A_SAMA301_0
(GLYCINE SARCOSINE
N-METHYLTRANSFERASE)		 5b47 2-OXOACID--FERREDOXI
N OXIDOREDUCTASE
BETA SUBUNIT
(Sulfurisphaera
tokodaii) 		5 / 12 GLY B  89
ASN B 117
GLY B  97
GLY B 119
SER B 129
 MG  B 403 (-3.6A)
None
None
None
None
 1.14A 5hikA-5b47B:
2.2		 5hikA-5b47B:
23.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5K50_A_ACTA1403_0
(L-THREONINE
3-DEHYDROGENASE)		 5b47 2-OXOACID--FERREDOXI
N OXIDOREDUCTASE
ALPHA SUBUNIT
(Sulfurisphaera
tokodaii) 		4 / 5 SER A 214
VAL A 215
GLY A 178
ALA A 175
 None
 0.92A 5k50A-5b47A:
undetectable		 5k50A-5b47A:
18.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UXD_A_ZITA501_1
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E MPHH)		 5b47 2-OXOACID--FERREDOXI
N OXIDOREDUCTASE
ALPHA SUBUNIT
(Sulfurisphaera
tokodaii) 		4 / 7 PHE A 195
ALA A 208
GLY A 174
TYR A 177
 None
 1.02A 5uxdA-5b47A:
undetectable		 5uxdA-5b47A:
20.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X7P_A_ACRA1481_1
(GLYCOSIDE HYDROLASE
FAMILY 31
ALPHA-GLUCOSIDASE)		 5b47 2-OXOACID--FERREDOXI
N OXIDOREDUCTASE
ALPHA SUBUNIT
(Sulfurisphaera
tokodaii) 		4 / 6 SER A 415
HIS A 381
ARG A  38
TYR A 414
 None
 1.37A 5x7pA-5b47A:
undetectable		 5x7pA-5b47A:
17.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X7P_A_ACRA1481_1
(GLYCOSIDE HYDROLASE
FAMILY 31
ALPHA-GLUCOSIDASE)		 5b47 2-OXOACID--FERREDOXI
N OXIDOREDUCTASE
ALPHA SUBUNIT
(Sulfurisphaera
tokodaii) 		4 / 6 TRP A 329
HIS A 470
ARG A 444
TYR A 465
 None
 1.18A 5x7pA-5b47A:
undetectable		 5x7pA-5b47A:
17.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X7P_B_ACRB1481_1
(GLYCOSIDE HYDROLASE
FAMILY 31
ALPHA-GLUCOSIDASE)		 5b47 2-OXOACID--FERREDOXI
N OXIDOREDUCTASE
ALPHA SUBUNIT
(Sulfurisphaera
tokodaii) 		4 / 6 SER A 415
HIS A 381
ARG A  38
TYR A 414
 None
 1.36A 5x7pB-5b47A:
undetectable		 5x7pB-5b47A:
17.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X7P_B_ACRB1481_1
(GLYCOSIDE HYDROLASE
FAMILY 31
ALPHA-GLUCOSIDASE)		 5b47 2-OXOACID--FERREDOXI
N OXIDOREDUCTASE
ALPHA SUBUNIT
(Sulfurisphaera
tokodaii) 		4 / 6 TRP A 329
HIS A 470
ARG A 444
TYR A 465
 None
 1.22A 5x7pB-5b47A:
undetectable		 5x7pB-5b47A:
17.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X7Q_A_ACRA1481_1
(GLYCOSIDE HYDROLASE
FAMILY 31
ALPHA-GLUCOSIDASE)		 5b47 2-OXOACID--FERREDOXI
N OXIDOREDUCTASE
ALPHA SUBUNIT
(Sulfurisphaera
tokodaii) 		4 / 6 SER A 415
HIS A 381
ARG A  38
TYR A 414
 None
 1.39A 5x7qA-5b47A:
undetectable		 5x7qA-5b47A:
17.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X7Q_A_ACRA1481_1
(GLYCOSIDE HYDROLASE
FAMILY 31
ALPHA-GLUCOSIDASE)		 5b47 2-OXOACID--FERREDOXI
N OXIDOREDUCTASE
ALPHA SUBUNIT
(Sulfurisphaera
tokodaii) 		4 / 6 TRP A 329
HIS A 470
ARG A 444
TYR A 465
 None
 1.18A 5x7qA-5b47A:
undetectable		 5x7qA-5b47A:
17.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X7Q_B_ACRB1481_1
(GLYCOSIDE HYDROLASE
FAMILY 31
ALPHA-GLUCOSIDASE)		 5b47 2-OXOACID--FERREDOXI
N OXIDOREDUCTASE
ALPHA SUBUNIT
(Sulfurisphaera
tokodaii) 		4 / 6 SER A 415
HIS A 381
ARG A  38
TYR A 414
 None
 1.37A 5x7qB-5b47A:
undetectable		 5x7qB-5b47A:
17.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X7Q_B_ACRB1481_1
(GLYCOSIDE HYDROLASE
FAMILY 31
ALPHA-GLUCOSIDASE)		 5b47 2-OXOACID--FERREDOXI
N OXIDOREDUCTASE
ALPHA SUBUNIT
(Sulfurisphaera
tokodaii) 		4 / 6 TRP A 329
HIS A 470
ARG A 444
TYR A 465
 None
 1.22A 5x7qB-5b47A:
undetectable		 5x7qB-5b47A:
17.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X7R_A_ACRA1481_1
(GLYCOSIDE HYDROLASE
FAMILY 31
ALPHA-GLUCOSIDASE)		 5b47 2-OXOACID--FERREDOXI
N OXIDOREDUCTASE
ALPHA SUBUNIT
(Sulfurisphaera
tokodaii) 		4 / 6 SER A 415
HIS A 381
ARG A  38
TYR A 414
 None
 1.39A 5x7rA-5b47A:
undetectable		 5x7rA-5b47A:
17.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X7R_A_ACRA1481_1
(GLYCOSIDE HYDROLASE
FAMILY 31
ALPHA-GLUCOSIDASE)		 5b47 2-OXOACID--FERREDOXI
N OXIDOREDUCTASE
ALPHA SUBUNIT
(Sulfurisphaera
tokodaii) 		4 / 6 TRP A 329
HIS A 470
ARG A 444
TYR A 465
 None
 1.18A 5x7rA-5b47A:
undetectable		 5x7rA-5b47A:
17.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X7R_B_ACRB1481_1
(GLYCOSIDE HYDROLASE
FAMILY 31
ALPHA-GLUCOSIDASE)		 5b47 2-OXOACID--FERREDOXI
N OXIDOREDUCTASE
ALPHA SUBUNIT
(Sulfurisphaera
tokodaii) 		4 / 6 SER A 415
HIS A 381
ARG A  38
TYR A 414
 None
 1.38A 5x7rB-5b47A:
undetectable		 5x7rB-5b47A:
17.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X7R_B_ACRB1481_1
(GLYCOSIDE HYDROLASE
FAMILY 31
ALPHA-GLUCOSIDASE)		 5b47 2-OXOACID--FERREDOXI
N OXIDOREDUCTASE
ALPHA SUBUNIT
(Sulfurisphaera
tokodaii) 		4 / 6 TRP A 329
HIS A 470
ARG A 444
TYR A 465
 None
 1.20A 5x7rB-5b47A:
undetectable		 5x7rB-5b47A:
17.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B94_B_W9TB201_0
(GALECTIN-1)		 5b47 2-OXOACID--FERREDOXI
N OXIDOREDUCTASE
ALPHA SUBUNIT
(Sulfurisphaera
tokodaii) 		5 / 10 THR A 353
HIS A  48
ASN A  37
GLU A  39
ARG A 600
 None
 1.39A 6b94A-5b47A:
undetectable
6b94B-5b47A:
undetectable		 6b94A-5b47A:
8.56
6b94B-5b47A:
8.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6C2M_B_SUEB1202_0
(NS3 PROTEASE)		 5b47 2-OXOACID--FERREDOXI
N OXIDOREDUCTASE
ALPHA SUBUNIT
(Sulfurisphaera
tokodaii) 		5 / 12 GLY A 356
ILE A 339
GLY A 317
PHE A 362
ALA A 363
 None
 1.18A 6c2mB-5b47A:
undetectable		 6c2mB-5b47A:
9.77