SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5b4c'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EI6_D_PPFD412_1
(PHOSPHONOACETATE
HYDROLASE)		 5b4c UDP-2,3-DIACYLGLUCOS
AMINE HYDROLASE
(Pseudomonas
aeruginosa) 		4 / 8 ASP A  41
HIS A 114
ILE A 171
HIS A 195
 MN  A 301 (-2.6A)
MN  A 301 (-3.5A)
GOL  A 302 (-4.7A)
MN  A 301 ( 3.4A)
 0.90A 1ei6D-5b4cA:
undetectable		 1ei6D-5b4cA:
19.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q8J_A_C2FA801_0
(5-METHYLTETRAHYDROFO
LATE S-HOMOCYSTEINE
METHYLTRANSFERASE)		 5b4c UDP-2,3-DIACYLGLUCOS
AMINE HYDROLASE
(Pseudomonas
aeruginosa) 		5 / 12 ARG A 213
ASP A 116
ASN A  79
ASP A  81
GLY A  40
 None
None
MN  A 301 (-2.7A)
None
None
 1.06A 1q8jA-5b4cA:
2.4		 1q8jA-5b4cA:
19.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RJD_A_SAMA801_1
(CARBOXY METHYL
TRANSFERASE FOR
PROTEIN PHOSPHATASE
2A CATALYTIC SUBUNIT)		 5b4c UDP-2,3-DIACYLGLUCOS
AMINE HYDROLASE
(Pseudomonas
aeruginosa) 		4 / 6 ARG A 181
ASP A 116
ASP A   8
GLU A 178
 None
None
MN  A 301 ( 4.9A)
None
 1.22A 1rjdA-5b4cA:
undetectable		 1rjdA-5b4cA:
23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RJD_B_SAMB802_1
(CARBOXY METHYL
TRANSFERASE FOR
PROTEIN PHOSPHATASE
2A CATALYTIC SUBUNIT)		 5b4c UDP-2,3-DIACYLGLUCOS
AMINE HYDROLASE
(Pseudomonas
aeruginosa) 		4 / 6 ARG A 181
ASP A 116
ASP A   8
GLU A 178
 None
None
MN  A 301 ( 4.9A)
None
 1.20A 1rjdB-5b4cA:
undetectable		 1rjdB-5b4cA:
23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RJD_C_SAMC803_1
(CARBOXY METHYL
TRANSFERASE FOR
PROTEIN PHOSPHATASE
2A CATALYTIC SUBUNIT)		 5b4c UDP-2,3-DIACYLGLUCOS
AMINE HYDROLASE
(Pseudomonas
aeruginosa) 		4 / 6 ARG A 181
ASP A 116
ASP A   8
GLU A 178
 None
None
MN  A 301 ( 4.9A)
None
 1.20A 1rjdC-5b4cA:
undetectable		 1rjdC-5b4cA:
23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CIZ_A_ACTA1321_0
(CHLOROPEROXIDASE)		 5b4c UDP-2,3-DIACYLGLUCOS
AMINE HYDROLASE
(Pseudomonas
aeruginosa) 		4 / 5 LEU A  36
PHE A  22
VAL A  66
ALA A  30
 None
 1.04A 2cizA-5b4cA:
undetectable		 2cizA-5b4cA:
20.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VCV_H_ASDH1224_1
(GLUTATHIONE
S-TRANSFERASE A3)		 5b4c UDP-2,3-DIACYLGLUCOS
AMINE HYDROLASE
(Pseudomonas
aeruginosa) 		5 / 9 LEU A  75
ALA A  67
LEU A  63
ALA A  60
PHE A  88
 None
 1.19A 2vcvH-5b4cA:
undetectable		 2vcvH-5b4cA:
22.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3C0Z_C_SHHC301_1
(HISTONE DEACETYLASE
7A)		 5b4c UDP-2,3-DIACYLGLUCOS
AMINE HYDROLASE
(Pseudomonas
aeruginosa) 		4 / 6 ASP A 122
HIS A 114
HIS A 195
ASP A  41
 GOL  A 302 (-3.9A)
MN  A 301 (-3.5A)
MN  A 301 ( 3.4A)
MN  A 301 (-2.6A)
 1.12A 3c0zC-5b4cA:
undetectable		 3c0zC-5b4cA:
21.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K13_C_THHC643_1
(5-METHYLTETRAHYDROFO
LATE-HOMOCYSTEINE
METHYLTRANSFERASE)		 5b4c UDP-2,3-DIACYLGLUCOS
AMINE HYDROLASE
(Pseudomonas
aeruginosa) 		3 / 3 ASN A  10
ASP A  81
ARG A 213
 None
 0.72A 3k13C-5b4cA:
undetectable		 3k13C-5b4cA:
23.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3Q1E_C_T44C128_1
(5-HYDROXYISOURATE
HYDROLASE)		 5b4c UDP-2,3-DIACYLGLUCOS
AMINE HYDROLASE
(Pseudomonas
aeruginosa) 		4 / 6 LEU A  96
LEU A  75
LEU A 112
LEU A  39
 None
 1.05A 3q1eA-5b4cA:
undetectable
3q1eC-5b4cA:
undetectable		 3q1eA-5b4cA:
18.10
3q1eC-5b4cA:
18.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3Q1E_C_T44C128_1
(5-HYDROXYISOURATE
HYDROLASE)		 5b4c UDP-2,3-DIACYLGLUCOS
AMINE HYDROLASE
(Pseudomonas
aeruginosa) 		4 / 6 LEU A 112
LEU A  39
LEU A  96
LEU A  75
 None
 1.04A 3q1eA-5b4cA:
undetectable
3q1eC-5b4cA:
undetectable		 3q1eA-5b4cA:
18.10
3q1eC-5b4cA:
18.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QEO_B_LLTB261_1
(DEOXYCYTIDINE KINASE)		 5b4c UDP-2,3-DIACYLGLUCOS
AMINE HYDROLASE
(Pseudomonas
aeruginosa) 		4 / 7 GLU A 108
VAL A 110
LEU A 112
TYR A  37
 None
 1.05A 3qeoB-5b4cA:
undetectable		 3qeoB-5b4cA:
18.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ZQ8_D_DVAD8_0
(VAL-GRAMICIDIN A)		 5b4c UDP-2,3-DIACYLGLUCOS
AMINE HYDROLASE
(Pseudomonas
aeruginosa) 		3 / 3 TRP A 219
VAL A 215
TRP A 224
 None
 1.27A 3zq8C-5b4cA:
undetectable
3zq8D-5b4cA:
undetectable		 3zq8C-5b4cA:
8.70
3zq8D-5b4cA:
8.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C5N_B_PXLB300_1
(PHOSPHOMETHYLPYRIMID
INE KINASE)		 5b4c UDP-2,3-DIACYLGLUCOS
AMINE HYDROLASE
(Pseudomonas
aeruginosa) 		5 / 10 GLY A 194
GLY A 115
VAL A 215
HIS A 202
CYH A 119
 None
None
None
None
GOL  A 302 (-3.6A)
 1.35A 4c5nB-5b4cA:
3.2		 4c5nB-5b4cA:
21.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IAA_A_RTZA401_1
(SERINE/THREONINE-PRO
TEIN KINASE PIM-1)		 5b4c UDP-2,3-DIACYLGLUCOS
AMINE HYDROLASE
(Pseudomonas
aeruginosa) 		6 / 11 VAL A   3
ALA A  35
GLU A 108
LEU A 112
ILE A 103
ASP A 104
 None
None
None
None
None
GOL  A 303 (-4.8A)
 1.33A 4iaaA-5b4cA:
undetectable		 4iaaA-5b4cA:
23.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XJ7_D_ADND303_1
(5'/3'-NUCLEOTIDASE
SURE)		 5b4c UDP-2,3-DIACYLGLUCOS
AMINE HYDROLASE
(Pseudomonas
aeruginosa) 		5 / 10 LEU A 105
GLY A 107
TYR A 106
ALA A  35
ILE A 103
 None
None
GOL  A 303 (-3.4A)
None
None
 0.91A 4xj7C-5b4cA:
undetectable
4xj7D-5b4cA:
undetectable		 4xj7C-5b4cA:
24.49
4xj7D-5b4cA:
24.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AWO_A_SREA701_1
(SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER)		 5b4c UDP-2,3-DIACYLGLUCOS
AMINE HYDROLASE
(Pseudomonas
aeruginosa) 		5 / 9 ASP A   8
ALA A  21
ILE A  18
PHE A  42
GLY A 223
 MN  A 301 ( 4.9A)
None
None
None
None
 1.33A 6awoA-5b4cA:
undetectable		 6awoA-5b4cA:
17.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AWQ_A_SREA701_1
(SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER)		 5b4c UDP-2,3-DIACYLGLUCOS
AMINE HYDROLASE
(Pseudomonas
aeruginosa) 		5 / 9 ASP A   8
ALA A  21
ILE A  18
PHE A  42
GLY A 223
 MN  A 301 ( 4.9A)
None
None
None
None
 1.33A 6awqA-5b4cA:
undetectable		 6awqA-5b4cA:
17.15