SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5b4p'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DHJ_B_MTXB361_1
(DIHYDROFOLATE
REDUCTASE)		 5b4p REPEBODY
(synthetic
construct) 		5 / 12 ILE A   9
ILE A  59
LEU A  62
PRO A  63
ILE A  22
 None
 1.03A 1dhjB-5b4pA:
undetectable		 1dhjB-5b4pA:
19.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HK2_A_T44A3002_1
(SERUM ALBUMIN)		 5b4p REPEBODY
(synthetic
construct) 		4 / 8 GLN A  60
LEU A  84
LEU A  68
LEU A  75
 SO4  A 302 ( 4.9A)
None
None
None
 1.12A 1hk2A-5b4pA:
undetectable		 1hk2A-5b4pA:
19.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HRC_A_CHDA701_0
(FERROCHELATASE)		 5b4p REPEBODY
(synthetic
construct) 		5 / 12 LEU A  70
LEU A  92
ILE A  22
LEU A 107
VAL A  65
 None
 1.14A 2hrcA-5b4pA:
undetectable		 2hrcA-5b4pA:
22.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HRC_B_CHDB1605_0
(FERROCHELATASE)		 5b4p REPEBODY
(synthetic
construct) 		5 / 12 LEU A  70
LEU A  92
ILE A  22
LEU A 107
VAL A  65
 None
 1.06A 2hrcB-5b4pA:
undetectable		 2hrcB-5b4pA:
22.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5GS4_A_ESTA603_2
(ESTROGEN RECEPTOR)		 5b4p REPEBODY
(synthetic
construct) 		4 / 6 LEU A 161
LEU A 113
PHE A 152
LEU A 123
 None
 0.97A 5gs4A-5b4pA:
undetectable		 5gs4A-5b4pA:
24.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5GTR_A_ESTA601_2
(ESTROGEN RECEPTOR)		 5b4p REPEBODY
(synthetic
construct) 		4 / 5 LEU A 161
LEU A 113
PHE A 152
LEU A 123
 None
 1.03A 5gtrA-5b4pA:
undetectable		 5gtrA-5b4pA:
24.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EW0_F_TA1F502_1
(TUBULIN BETA CHAIN)		 5b4p REPEBODY
(synthetic
construct) 		5 / 12 ASP A  77
LEU A 131
ASP A 105
LEU A 110
LEU A  92
 SO4  A 302 (-4.4A)
None
None
None
None
 1.18A 6ew0F-5b4pA:
undetectable		 6ew0F-5b4pA:
15.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HLP_A_GAWA1501_0
(SUBSTANCE-P
RECEPTOR,SUBSTANCE-P
RECEPTOR)		 5b4p REPEBODY
(synthetic
construct) 		5 / 12 PRO A  14
ILE A  12
VAL A  31
THR A  32
ILE A   9
 None
 1.14A 6hlpA-5b4pA:
undetectable		 6hlpA-5b4pA:
16.92