SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5b4s'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID
Hit
Macromolecule
Res.
Matches
Interface HETATM RMSD Dali
Z-score
Seq.
Identity (%)
View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIJ_B_NOVB444_2
(DNA GYRASE SUBUNIT B)
5b4s CHITOSANASE
(Mitsuaria
chitosanitabida)
3 / 3 ASP A 163
PHE A 158
VAL A   6
None
0.66A 1kijB-5b4sA:
1.0
1kijB-5b4sA:
20.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DRD_A_MIYA2001_1
(ACRB)
5b4s CHITOSANASE
(Mitsuaria
chitosanitabida)
5 / 9 GLN A 204
GLY A 200
ILE A 269
ALA A  32
VAL A 282
None
1.27A 2drdA-5b4sA:
undetectable
2drdA-5b4sA:
15.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IJ7_A_TPFA2472_1
(CYTOCHROME P450 121)
5b4s CHITOSANASE
(Mitsuaria
chitosanitabida)
5 / 11 ASN A 283
THR A  45
ALA A  38
PHE A 203
GLN A 204
None
1.46A 2ij7A-5b4sA:
undetectable
2ij7A-5b4sA:
21.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X2I_A_QPSA1050_2
(ALPHA-1,4-GLUCAN
LYASE ISOZYME 1)
5b4s CHITOSANASE
(Mitsuaria
chitosanitabida)
4 / 6 VAL A 205
TRP A 247
MET A 308
THR A 299
None
1.44A 2x2iA-5b4sA:
undetectable
2x2iA-5b4sA:
14.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X7H_A_PFNA1372_1
(ZINC-BINDING ALCOHOL
DEHYDROGENASE
DOMAIN-CONTAINING
PROTEIN 2)
5b4s CHITOSANASE
(Mitsuaria
chitosanitabida)
5 / 11 LEU A 201
LEU A 267
LEU A 240
MET A 308
THR A 299
None
1.43A 2x7hA-5b4sA:
undetectable
2x7hB-5b4sA:
undetectable
2x7hA-5b4sA:
25.06
2x7hB-5b4sA:
25.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y69_C_CHDC1265_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 3)
5b4s CHITOSANASE
(Mitsuaria
chitosanitabida)
4 / 5 PHE A  93
PHE A  85
LEU A 130
PHE A 123
None
0.81A 2y69C-5b4sA:
undetectable
2y69J-5b4sA:
undetectable
2y69C-5b4sA:
22.65
2y69J-5b4sA:
14.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y69_P_CHDP1265_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 3)
5b4s CHITOSANASE
(Mitsuaria
chitosanitabida)
4 / 5 PHE A  93
PHE A  85
LEU A 130
PHE A 123
None
0.76A 2y69P-5b4sA:
undetectable
2y69W-5b4sA:
undetectable
2y69P-5b4sA:
22.65
2y69W-5b4sA:
14.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ABK_P_CHDP1271_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 3)
5b4s CHITOSANASE
(Mitsuaria
chitosanitabida)
4 / 6 PHE A  93
PHE A  85
LEU A 130
PHE A 123
None
0.95A 3abkP-5b4sA:
undetectable
3abkW-5b4sA:
undetectable
3abkP-5b4sA:
22.65
3abkW-5b4sA:
12.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ABL_P_CHDP1271_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 3)
5b4s CHITOSANASE
(Mitsuaria
chitosanitabida)
4 / 6 PHE A  93
PHE A  85
LEU A 130
PHE A 123
None
0.98A 3ablP-5b4sA:
undetectable
3ablW-5b4sA:
undetectable
3ablP-5b4sA:
22.65
3ablW-5b4sA:
12.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ABM_C_CHDC271_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 3)
5b4s CHITOSANASE
(Mitsuaria
chitosanitabida)
4 / 5 PHE A  93
PHE A  85
LEU A 130
PHE A 123
None
0.86A 3abmC-5b4sA:
undetectable
3abmJ-5b4sA:
undetectable
3abmC-5b4sA:
22.65
3abmJ-5b4sA:
12.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ABM_P_CHDP1271_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 3)
5b4s CHITOSANASE
(Mitsuaria
chitosanitabida)
4 / 5 PHE A  93
PHE A  85
LEU A 130
PHE A 123
None
0.74A 3abmP-5b4sA:
undetectable
3abmW-5b4sA:
undetectable
3abmP-5b4sA:
22.65
3abmW-5b4sA:
12.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AG3_C_CHDC271_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 3)
5b4s CHITOSANASE
(Mitsuaria
chitosanitabida)
4 / 5 PHE A  93
PHE A  85
LEU A 130
PHE A 123
None
0.88A 3ag3C-5b4sA:
undetectable
3ag3J-5b4sA:
undetectable
3ag3C-5b4sA:
22.65
3ag3J-5b4sA:
12.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GWX_B_EPAB3_1
(PROTEIN (PEROXISOME
PROLIFERATOR
ACTIVATED RECEPTOR
(PPAR-DELTA)))
5b4s CHITOSANASE
(Mitsuaria
chitosanitabida)
5 / 12 THR A  73
THR A  80
HIS A 169
LEU A 154
TYR A 165
None
1.43A 3gwxB-5b4sA:
undetectable
3gwxB-5b4sA:
21.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MBG_A_ACTA207_0
(FAD-LINKED
SULFHYDRYL OXIDASE
ALR)
5b4s CHITOSANASE
(Mitsuaria
chitosanitabida)
4 / 7 LEU A 267
LYS A 271
THR A 234
ALA A 237
None
1.33A 3mbgA-5b4sA:
undetectable
3mbgB-5b4sA:
undetectable
3mbgA-5b4sA:
18.50
3mbgB-5b4sA:
18.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ROD_D_NCAD302_0
(NICOTINAMIDE
N-METHYLTRANSFERASE)
5b4s CHITOSANASE
(Mitsuaria
chitosanitabida)
4 / 7 LEU A  34
ASP A  37
ALA A  38
TYR A 170
None
1.21A 3rodD-5b4sA:
undetectable
3rodD-5b4sA:
24.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WG7_P_CHDP306_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)
5b4s CHITOSANASE
(Mitsuaria
chitosanitabida)
4 / 6 PHE A  93
PHE A  85
LEU A 130
PHE A 123
None
0.99A 3wg7P-5b4sA:
undetectable
3wg7W-5b4sA:
undetectable
3wg7P-5b4sA:
22.65
3wg7W-5b4sA:
12.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IB4_A_ERMA2001_1
(CHIMERA PROTEIN OF
HUMAN
5-HYDROXYTRYPTAMINE
RECEPTOR 2B AND E.
COLI SOLUBLE
CYTOCHROME B562)
5b4s CHITOSANASE
(Mitsuaria
chitosanitabida)
5 / 12 SER A 168
ALA A 157
PHE A  74
LEU A 147
VAL A  79
None
1.20A 4ib4A-5b4sA:
undetectable
4ib4A-5b4sA:
22.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KFB_A_T27A607_1
(REVERSE
TRANSCRIPTASE/RIBONU
CLEASE H,
EXORIBONUCLEA P66 RT)
5b4s CHITOSANASE
(Mitsuaria
chitosanitabida)
5 / 12 LEU A  34
VAL A  14
TYR A  15
PRO A   8
TYR A  47
None
1.34A 4kfbA-5b4sA:
undetectable
4kfbA-5b4sA:
21.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NC3_A_ERMA1202_1
(CHIMERA PROTEIN OF
HUMAN
5-HYDROXYTRYPTAMINE
RECEPTOR 2B AND E.
COLI SOLUBLE
CYTOCHROME B562)
5b4s CHITOSANASE
(Mitsuaria
chitosanitabida)
5 / 12 SER A 168
ALA A 157
PHE A  74
LEU A 147
VAL A  79
None
1.18A 4nc3A-5b4sA:
undetectable
4nc3A-5b4sA:
22.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QWP_B_GCSB307_1
(CHITOSANASE)
5b4s CHITOSANASE
(Mitsuaria
chitosanitabida)
4 / 7 ARG A  70
THR A  73
GLY A  78
THR A  80
None
0.28A 4qwpB-5b4sA:
15.2
4qwpB-5b4sA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TZC_D_EF2D505_1
(PROTEIN CEREBLON)
5b4s CHITOSANASE
(Mitsuaria
chitosanitabida)
4 / 8 TYR A 165
THR A 160
TRP A 111
PHE A  85
None
1.32A 4tzcB-5b4sA:
undetectable
4tzcD-5b4sA:
undetectable
4tzcB-5b4sA:
17.52
4tzcD-5b4sA:
17.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XP6_A_B40A601_1
(TRANSPORTER)
5b4s CHITOSANASE
(Mitsuaria
chitosanitabida)
4 / 5 ASP A  20
VAL A 181
PHE A 193
GLY A 200
None
1.24A 4xp6A-5b4sA:
0.0
4xp6A-5b4sA:
18.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B1B_C_CHDC306_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)
5b4s CHITOSANASE
(Mitsuaria
chitosanitabida)
4 / 6 PHE A  93
PHE A  85
LEU A 130
PHE A 123
None
1.06A 5b1bC-5b4sA:
undetectable
5b1bJ-5b4sA:
undetectable
5b1bC-5b4sA:
22.65
5b1bJ-5b4sA:
12.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LW1_H_ADNH401_1
(MITOGEN-ACTIVATED
PROTEIN KINASE 8)
5b4s CHITOSANASE
(Mitsuaria
chitosanitabida)
5 / 9 GLY A 112
VAL A 115
ALA A 153
LEU A 154
LEU A  98
None
1.08A 5lw1H-5b4sA:
undetectable
5lw1H-5b4sA:
15.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TUD_A_ERMA2001_1
(5-HYDROXYTRYPTAMINE
RECEPTOR 2B,SOLUBLE
CYTOCHROME B562
CHIMERA)
5b4s CHITOSANASE
(Mitsuaria
chitosanitabida)
5 / 12 SER A 168
ALA A 157
PHE A  74
LEU A 147
VAL A  79
None
1.17A 5tudA-5b4sA:
undetectable
5tudA-5b4sA:
21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WAU_C_CHDC306_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)
5b4s CHITOSANASE
(Mitsuaria
chitosanitabida)
4 / 5 PHE A  93
PHE A  85
LEU A 130
PHE A 123
None
0.82A 5wauC-5b4sA:
undetectable
5wauJ-5b4sA:
undetectable
5wauC-5b4sA:
22.65
5wauJ-5b4sA:
12.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WAU_C_CHDC308_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)
5b4s CHITOSANASE
(Mitsuaria
chitosanitabida)
4 / 5 PHE A  93
PHE A  85
LEU A 130
PHE A 123
None
0.80A 5wauc-5b4sA:
undetectable
5wauj-5b4sA:
undetectable
5wauc-5b4sA:
22.65
5wauj-5b4sA:
12.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XDQ_C_CHDC308_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)
5b4s CHITOSANASE
(Mitsuaria
chitosanitabida)
4 / 5 PHE A  93
PHE A  85
LEU A 130
PHE A 123
None
0.76A 5xdqC-5b4sA:
undetectable
5xdqJ-5b4sA:
undetectable
5xdqC-5b4sA:
22.65
5xdqJ-5b4sA:
12.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XDQ_P_CHDP306_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)
5b4s CHITOSANASE
(Mitsuaria
chitosanitabida)
4 / 5 PHE A  93
PHE A  85
LEU A 130
PHE A 123
None
0.78A 5xdqP-5b4sA:
undetectable
5xdqW-5b4sA:
undetectable
5xdqP-5b4sA:
22.65
5xdqW-5b4sA:
12.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z84_P_CHDP305_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)
5b4s CHITOSANASE
(Mitsuaria
chitosanitabida)
4 / 6 PHE A  93
PHE A  85
LEU A 130
PHE A 123
None
0.78A 5z84P-5b4sA:
undetectable
5z84W-5b4sA:
undetectable
5z84P-5b4sA:
22.65
5z84W-5b4sA:
12.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z85_P_CHDP307_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)
5b4s CHITOSANASE
(Mitsuaria
chitosanitabida)
4 / 6 PHE A  93
PHE A  85
LEU A 130
PHE A 123
None
0.82A 5z85P-5b4sA:
undetectable
5z85W-5b4sA:
undetectable
5z85P-5b4sA:
22.65
5z85W-5b4sA:
12.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z86_C_CHDC306_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)
5b4s CHITOSANASE
(Mitsuaria
chitosanitabida)
4 / 6 PHE A  93
PHE A  85
LEU A 130
PHE A 123
None
0.80A 5z86C-5b4sA:
undetectable
5z86J-5b4sA:
undetectable
5z86C-5b4sA:
22.65
5z86J-5b4sA:
12.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z86_P_CHDP307_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)
5b4s CHITOSANASE
(Mitsuaria
chitosanitabida)
4 / 6 PHE A  93
PHE A  85
LEU A 130
PHE A 123
None
0.81A 5z86P-5b4sA:
undetectable
5z86W-5b4sA:
undetectable
5z86P-5b4sA:
22.65
5z86W-5b4sA:
12.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZCO_P_CHDP305_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)
5b4s CHITOSANASE
(Mitsuaria
chitosanitabida)
4 / 6 PHE A  93
PHE A  85
LEU A 130
PHE A 123
None
0.77A 5zcoP-5b4sA:
undetectable
5zcoW-5b4sA:
undetectable
5zcoP-5b4sA:
22.65
5zcoW-5b4sA:
12.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZCP_C_CHDC306_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)
5b4s CHITOSANASE
(Mitsuaria
chitosanitabida)
4 / 6 PHE A  93
PHE A  85
LEU A 130
PHE A 123
None
0.76A 5zcpC-5b4sA:
undetectable
5zcpJ-5b4sA:
undetectable
5zcpC-5b4sA:
22.65
5zcpJ-5b4sA:
12.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZCP_P_CHDP306_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)
5b4s CHITOSANASE
(Mitsuaria
chitosanitabida)
4 / 6 PHE A  93
PHE A  85
LEU A 130
PHE A 123
None
0.77A 5zcpP-5b4sA:
undetectable
5zcpW-5b4sA:
undetectable
5zcpP-5b4sA:
22.65
5zcpW-5b4sA:
12.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HCO_A_FY5A1003_0
(ATP-BINDING CASSETTE
SUB-FAMILY G MEMBER
2)
5b4s CHITOSANASE
(Mitsuaria
chitosanitabida)
5 / 11 THR A 209
VAL A 181
THR A 241
ILE A 245
MET A 308
None
1.44A 6hcoA-5b4sA:
undetectable
6hcoB-5b4sA:
undetectable
6hcoA-5b4sA:
18.93
6hcoB-5b4sA:
18.93