SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5b4w'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PWY_E_AC2E290_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 5b4w PLEXIN-B1
(Homo
sapiens) 		5 / 10 GLY A 169
PHE A 230
VAL A 153
GLY A 154
THR A 185
 None
 1.11A 1pwyE-5b4wA:
undetectable		 1pwyE-5b4wA:
17.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1U1J_A_C2FA773_0
(5-METHYLTETRAHYDROPT
EROYLTRIGLUTAMATE--H
OMOCYSTEINE
METHYLTRANSFERASE)		 5b4w PLEXIN-B1
(Homo
sapiens) 		4 / 8 ARG A 210
HIS A 217
SER A 215
ARG A 234
 None
 1.05A 1u1jA-5b4wA:
undetectable		 1u1jA-5b4wA:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IGT_C_SAMC1003_0
(SAM DEPENDENT
METHYLTRANSFERASE)		 5b4w PLEXIN-B1
(Homo
sapiens) 		5 / 12 PHE A 324
ALA A 267
ALA A 394
GLY A 271
TYR A 229
 None
 1.30A 2igtC-5b4wA:
undetectable		 2igtC-5b4wA:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XCT_G_CPFG1020_1
(DNA GYRASE SUBUNIT
B, DNA GYRASE
SUBUNIT A)		 5b4w PLEXIN-B1
(Homo
sapiens) 		3 / 3 ARG A 272
GLY A 271
SER A 241
 None
 0.49A 2xctB-5b4wA:
undetectable		 2xctB-5b4wA:
22.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YVL_B_SAMB602_1
(HYPOTHETICAL PROTEIN)		 5b4w PLEXIN-B1
(Homo
sapiens) 		3 / 3 GLU A 291
ASP A 330
TYR A 229
 None
 0.85A 2yvlB-5b4wA:
undetectable		 2yvlB-5b4wA:
17.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZIA_B_CL9B401_1
(DEOXYCYTIDINE KINASE)		 5b4w PLEXIN-B1
(Homo
sapiens) 		5 / 12 VAL A 208
LEU A 206
TYR A 261
PHE A 218
GLU A 263
 None
 1.47A 2ziaB-5b4wA:
undetectable		 2ziaB-5b4wA:
20.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HCO_B_CHDB1_0
(FERROCHELATASE,
MITOCHONDRIAL)		 5b4w PLEXIN-B1
(Homo
sapiens) 		4 / 4 LEU A 264
PRO A 265
LEU A 392
ARG A 331
 None
 1.28A 3hcoB-5b4wA:
undetectable		 3hcoB-5b4wA:
21.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3I45_A_NIOA500_1
(TWIN-ARGININE
TRANSLOCATION
PATHWAY SIGNAL
PROTEIN)		 5b4w PLEXIN-B1
(Homo
sapiens) 		4 / 8 PHE A 297
LEU A 231
PHE A 324
LEU A 293
 None
 0.99A 3i45A-5b4wA:
undetectable		 3i45A-5b4wA:
24.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3R4X_A_PZAA597_0
(LACTOPEROXIDASE)		 5b4w PLEXIN-B1
(Homo
sapiens) 		4 / 5 GLN A 256
ASP A 255
HIS A 257
GLU A 201
 None
 1.47A 3r4xA-5b4wA:
undetectable		 3r4xA-5b4wA:
20.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RGL_A_GLYA301_0
(GLYCYL-TRNA
SYNTHETASE ALPHA
SUBUNIT)		 5b4w PLEXIN-B1
(Homo
sapiens) 		4 / 8 GLY A 125
GLN A  57
GLU A  65
THR A  46
 None
 0.93A 3rglA-5b4wA:
undetectable		 3rglA-5b4wA:
18.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TKG_C_ROCC901_3
(PROTEASE)		 5b4w PLEXIN-B1
(Homo
sapiens) 		3 / 3 ASP A 373
THR A 382
PRO A 383
 None
 0.65A 3tkgD-5b4wA:
undetectable		 3tkgD-5b4wA:
10.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DJE_B_C2FB302_0
(5-METHYLTETRAHYDROFO
LATE CORRINOID/IRON
SULFUR PROTEIN
METHYLTRANSFERASE)		 5b4w PLEXIN-B1
(Homo
sapiens) 		5 / 12 ASP A 147
ASN A 146
GLY A 171
SER A 215
ARG A 235
 None
 1.48A 4djeB-5b4wA:
undetectable		 4djeB-5b4wA:
18.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DJF_B_C2FB300_0
(5-METHYLTETRAHYDROFO
LATE CORRINOID/IRON
SULFUR PROTEIN
METHYLTRANSFERASE)		 5b4w PLEXIN-B1
(Homo
sapiens) 		5 / 12 ASP A 147
ASN A 146
GLY A 171
SER A 215
ARG A 235
 None
 1.44A 4djfB-5b4wA:
undetectable		 4djfB-5b4wA:
18.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J6C_A_STRA501_1
(CYTOCHROME P450
MONOOXYGENASE)		 5b4w PLEXIN-B1
(Homo
sapiens) 		5 / 11 PHE A 324
ALA A 320
ALA A 296
VAL A 219
LEU A 233
 None
 1.05A 4j6cA-5b4wA:
undetectable		 4j6cA-5b4wA:
22.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J6C_B_STRB503_1
(CYTOCHROME P450
MONOOXYGENASE)		 5b4w PLEXIN-B1
(Homo
sapiens) 		5 / 10 PHE A 324
ALA A 320
ALA A 296
VAL A 219
LEU A 233
 None
 1.05A 4j6cB-5b4wA:
undetectable		 4j6cB-5b4wA:
22.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L1A_A_AB1A101_2
(MDR769 HIV-1
PROTEASE)		 5b4w PLEXIN-B1
(Homo
sapiens) 		4 / 6 ASP A 456
GLY A  50
PRO A  30
THR A  29
 None
 0.95A 4l1aB-5b4wA:
undetectable		 4l1aB-5b4wA:
11.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MBS_A_MRVA1101_1
(CHIMERA PROTEIN OF
C-C CHEMOKINE
RECEPTOR TYPE 5 AND
RUBREDOXIN)		 5b4w PLEXIN-B1
(Homo
sapiens) 		5 / 12 PHE A 218
PHE A 230
ILE A 184
TYR A 261
GLU A 263
 None
 1.20A 4mbsA-5b4wA:
0.0		 4mbsA-5b4wA:
20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MBS_B_MRVB1101_1
(CHIMERA PROTEIN OF
C-C CHEMOKINE
RECEPTOR TYPE 5 AND
RUBREDOXIN)		 5b4w PLEXIN-B1
(Homo
sapiens) 		5 / 12 PHE A 218
PHE A 230
ILE A 184
TYR A 261
GLU A 263
 None
 1.23A 4mbsB-5b4wA:
0.0		 4mbsB-5b4wA:
20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ODO_A_FK5A205_2
(PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
SLYD)		 5b4w PLEXIN-B1
(Homo
sapiens) 		4 / 4 THR A  70
ARG A 122
GLU A 120
VAL A  68
 None
 1.43A 4odoC-5b4wA:
undetectable		 4odoC-5b4wA:
14.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5V4V_A_NCAA402_0
(NADPH DEHYDROGENASE
3)		 5b4w PLEXIN-B1
(Homo
sapiens) 		4 / 8 HIS A 216
TYR A 214
PRO A 385
TYR A 355
 None
 1.32A 5v4vA-5b4wA:
undetectable		 5v4vA-5b4wA:
21.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5V4V_B_NCAB402_0
(NADPH DEHYDROGENASE
3)		 5b4w PLEXIN-B1
(Homo
sapiens) 		4 / 8 HIS A 216
TYR A 214
PRO A 385
TYR A 355
 None
 1.30A 5v4vB-5b4wA:
undetectable		 5v4vB-5b4wA:
21.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B0C_D_TA1D502_1
(TUBULIN BETA CHAIN)		 5b4w PLEXIN-B1
(Homo
sapiens) 		5 / 12 LEU A 466
LEU A 428
SER A 451
LEU A 457
THR A 458
 None
 0.78A 6b0cD-5b4wA:
undetectable		 6b0cD-5b4wA:
8.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EF6_A_ACTA405_0
(AMINOGLYCOSIDE
PHOSPHOTRANSFERASE)		 5b4w PLEXIN-B1
(Homo
sapiens) 		4 / 6 THR A 173
ARG A 170
GLN A 116
ARG A  77
 None
 1.25A 6ef6A-5b4wA:
undetectable		 6ef6A-5b4wA:
20.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EXI_D_ADND502_1
(ADENOSYLHOMOCYSTEINA
SE)		 5b4w PLEXIN-B1
(Homo
sapiens) 		3 / 3 LEU A  58
ASN A  98
LEU A 108
 None
 0.74A 6exiD-5b4wA:
undetectable		 6exiD-5b4wA:
12.30