SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5b4x'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GXS_A_BEZA601_0
(P-(S)-HYDROXYMANDELO
NITRILE LYASE CHAIN
A
P-(S)-HYDROXYMANDELO
NITRILE LYASE CHAIN
B)		 5b4x REELIN
(Mus
musculus) 		5 / 7 GLY A2504
PRO A2511
ASP A2567
HIS A2489
ALA A2636
 None
NAG  A4006 (-4.4A)
None
None
None
 1.45A 1gxsA-5b4xA:
undetectable
1gxsB-5b4xA:
undetectable		 1gxsA-5b4xA:
16.58
1gxsB-5b4xA:
14.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JNO_A_DVAA6_0
(GRAMICIDIN A)		 5b4x LOW DENSITY
LIPOPROTEIN
RECEPTOR-RELATED
PROTEIN 8,
APOLIPOPROTEIN E
RECEPTOR, ISOFORM
CRA_E
(Homo
sapiens) 		3 / 3 ALA B 433
VAL B 449
TRP B 470
 None
 0.80A 1jnoA-5b4xB:
undetectable		 1jnoA-5b4xB:
2.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JNO_B_DVAB6_0
(GRAMICIDIN A)		 5b4x LOW DENSITY
LIPOPROTEIN
RECEPTOR-RELATED
PROTEIN 8,
APOLIPOPROTEIN E
RECEPTOR, ISOFORM
CRA_E
(Homo
sapiens) 		3 / 3 ALA B 433
VAL B 449
TRP B 470
 None
 0.80A 1jnoB-5b4xB:
undetectable		 1jnoB-5b4xB:
2.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1K2R_A_H4BA1760_1
(NITRIC-OXIDE
SYNTHASE)		 5b4x REELIN
(Mus
musculus) 		4 / 7 VAL A2595
TRP A2641
TRP A2654
PHE A2555
 None
 1.47A 1k2rA-5b4xA:
undetectable
1k2rB-5b4xA:
undetectable		 1k2rA-5b4xA:
19.94
1k2rB-5b4xA:
19.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1K2T_A_H4BA1760_1
(NITRIC-OXIDE
SYNTHASE)		 5b4x REELIN
(Mus
musculus) 		4 / 7 VAL A2595
TRP A2641
TRP A2654
PHE A2555
 None
 1.47A 1k2tA-5b4xA:
undetectable
1k2tB-5b4xA:
undetectable		 1k2tA-5b4xA:
19.94
1k2tB-5b4xA:
19.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LZX_A_H4BA760_1
(NITRIC-OXIDE
SYNTHASE)		 5b4x REELIN
(Mus
musculus) 		4 / 7 VAL A2595
TRP A2641
TRP A2654
PHE A2555
 None
 1.48A 1lzxA-5b4xA:
undetectable
1lzxB-5b4xA:
undetectable		 1lzxA-5b4xA:
19.94
1lzxB-5b4xA:
19.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LZZ_A_H4BA760_1
(NITRIC-OXIDE
SYNTHASE)		 5b4x REELIN
(Mus
musculus) 		4 / 7 VAL A2595
TRP A2641
TRP A2654
PHE A2555
 None
 1.48A 1lzzA-5b4xA:
undetectable
1lzzB-5b4xA:
undetectable		 1lzzA-5b4xA:
19.94
1lzzB-5b4xA:
19.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1M00_A_H4BA760_1
(NITRIC-OXIDE
SYNTHASE)		 5b4x REELIN
(Mus
musculus) 		4 / 7 VAL A2595
TRP A2641
TRP A2654
PHE A2555
 None
 1.48A 1m00A-5b4xA:
undetectable
1m00B-5b4xA:
undetectable		 1m00A-5b4xA:
19.94
1m00B-5b4xA:
19.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1M00_B_H4BB1760_1
(NITRIC-OXIDE
SYNTHASE)		 5b4x REELIN
(Mus
musculus) 		4 / 7 TRP A2654
PHE A2555
VAL A2595
TRP A2641
 None
 1.45A 1m00A-5b4xA:
undetectable
1m00B-5b4xA:
undetectable		 1m00A-5b4xA:
19.94
1m00B-5b4xA:
19.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MAG_A_DVAA6_0
(GRAMICIDIN A)		 5b4x LOW DENSITY
LIPOPROTEIN
RECEPTOR-RELATED
PROTEIN 8,
APOLIPOPROTEIN E
RECEPTOR, ISOFORM
CRA_E
(Homo
sapiens) 		3 / 3 ALA B 433
VAL B 449
TRP B 470
 None
 0.80A 1magA-5b4xB:
undetectable		 1magA-5b4xB:
2.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MAG_B_DVAB6_0
(GRAMICIDIN A)		 5b4x LOW DENSITY
LIPOPROTEIN
RECEPTOR-RELATED
PROTEIN 8,
APOLIPOPROTEIN E
RECEPTOR, ISOFORM
CRA_E
(Homo
sapiens) 		3 / 3 ALA B 433
VAL B 449
TRP B 470
 None
 0.80A 1magB-5b4xB:
undetectable		 1magB-5b4xB:
2.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MMV_A_H4BA1760_1
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 5b4x REELIN
(Mus
musculus) 		4 / 7 VAL A2595
TRP A2641
TRP A2654
PHE A2555
 None
 1.50A 1mmvA-5b4xA:
undetectable
1mmvB-5b4xA:
undetectable		 1mmvA-5b4xA:
19.94
1mmvB-5b4xA:
19.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MMW_A_H4BA1760_1
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 5b4x REELIN
(Mus
musculus) 		4 / 7 VAL A2595
TRP A2641
TRP A2654
PHE A2555
 None
 1.50A 1mmwA-5b4xA:
undetectable
1mmwB-5b4xA:
undetectable		 1mmwA-5b4xA:
19.94
1mmwB-5b4xA:
19.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NG8_A_DVAA6_0
(GRAMICIDIN A)		 5b4x LOW DENSITY
LIPOPROTEIN
RECEPTOR-RELATED
PROTEIN 8,
APOLIPOPROTEIN E
RECEPTOR, ISOFORM
CRA_E
(Homo
sapiens) 		3 / 3 ALA B 433
VAL B 449
TRP B 470
 None
 0.84A 1ng8A-5b4xB:
undetectable		 1ng8A-5b4xB:
2.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NG8_B_DVAB6_0
(GRAMICIDIN A)		 5b4x LOW DENSITY
LIPOPROTEIN
RECEPTOR-RELATED
PROTEIN 8,
APOLIPOPROTEIN E
RECEPTOR, ISOFORM
CRA_E
(Homo
sapiens) 		3 / 3 ALA B 433
VAL B 449
TRP B 470
 None
 0.83A 1ng8B-5b4xB:
undetectable		 1ng8B-5b4xB:
2.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NRM_A_DVAA6_0
(GRAMICIDIN A)		 5b4x LOW DENSITY
LIPOPROTEIN
RECEPTOR-RELATED
PROTEIN 8,
APOLIPOPROTEIN E
RECEPTOR, ISOFORM
CRA_E
(Homo
sapiens) 		3 / 3 ALA B 433
VAL B 449
TRP B 470
 None
 0.94A 1nrmA-5b4xB:
undetectable		 1nrmA-5b4xB:
2.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NRM_B_DVAB6_0
(GRAMICIDIN A)		 5b4x LOW DENSITY
LIPOPROTEIN
RECEPTOR-RELATED
PROTEIN 8,
APOLIPOPROTEIN E
RECEPTOR, ISOFORM
CRA_E
(Homo
sapiens) 		3 / 3 ALA B 433
VAL B 449
TRP B 470
 None
 0.94A 1nrmB-5b4xB:
undetectable		 1nrmB-5b4xB:
2.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NRU_A_DVAA6_0
(GRAMICIDIN A)		 5b4x LOW DENSITY
LIPOPROTEIN
RECEPTOR-RELATED
PROTEIN 8,
APOLIPOPROTEIN E
RECEPTOR, ISOFORM
CRA_E
(Homo
sapiens) 		3 / 3 ALA B 433
VAL B 449
TRP B 470
 None
 0.90A 1nruA-5b4xB:
undetectable		 1nruA-5b4xB:
2.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NRU_B_DVAB6_0
(GRAMICIDIN A)		 5b4x LOW DENSITY
LIPOPROTEIN
RECEPTOR-RELATED
PROTEIN 8,
APOLIPOPROTEIN E
RECEPTOR, ISOFORM
CRA_E
(Homo
sapiens) 		3 / 3 ALA B 433
VAL B 449
TRP B 470
 None
 0.89A 1nruB-5b4xB:
undetectable		 1nruB-5b4xB:
2.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NSI_B_H4BB601_1
(PROTEIN (NITRIC
OXIDE SYNTHASE))		 5b4x REELIN
(Mus
musculus) 		4 / 6 TRP A2471
PHE A2357
ILE A2396
TRP A2459
 None
 1.26A 1nsiA-5b4xA:
undetectable
1nsiB-5b4xA:
undetectable		 1nsiA-5b4xA:
19.75
1nsiB-5b4xA:
19.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NSI_C_H4BC602_1
(PROTEIN (NITRIC
OXIDE SYNTHASE))		 5b4x REELIN
(Mus
musculus) 		4 / 6 ILE A2396
TRP A2459
TRP A2471
PHE A2357
 None
 1.30A 1nsiC-5b4xA:
undetectable
1nsiD-5b4xA:
undetectable		 1nsiC-5b4xA:
19.75
1nsiD-5b4xA:
19.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NSI_D_H4BD603_1
(PROTEIN (NITRIC
OXIDE SYNTHASE))		 5b4x REELIN
(Mus
musculus) 		4 / 6 TRP A2471
PHE A2357
ILE A2396
TRP A2459
 None
 1.32A 1nsiC-5b4xA:
undetectable
1nsiD-5b4xA:
undetectable		 1nsiC-5b4xA:
19.75
1nsiD-5b4xA:
19.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OM4_A_H4BA760_1
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 5b4x REELIN
(Mus
musculus) 		4 / 7 VAL A2595
TRP A2641
TRP A2654
PHE A2555
 None
 1.47A 1om4A-5b4xA:
undetectable
1om4B-5b4xA:
undetectable		 1om4A-5b4xA:
19.36
1om4B-5b4xA:
19.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OM4_B_H4BB761_1
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 5b4x REELIN
(Mus
musculus) 		4 / 7 TRP A2654
PHE A2555
VAL A2595
TRP A2641
 None
 1.46A 1om4A-5b4xA:
undetectable
1om4B-5b4xA:
undetectable		 1om4A-5b4xA:
19.36
1om4B-5b4xA:
19.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P6I_A_H4BA760_1
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 5b4x REELIN
(Mus
musculus) 		4 / 7 VAL A2595
TRP A2641
TRP A2654
PHE A2555
 None
 1.46A 1p6iA-5b4xA:
undetectable
1p6iB-5b4xA:
undetectable		 1p6iA-5b4xA:
19.39
1p6iB-5b4xA:
19.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P6K_A_H4BA760_1
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 5b4x REELIN
(Mus
musculus) 		4 / 7 VAL A2595
TRP A2641
TRP A2654
PHE A2555
 None
 1.46A 1p6kA-5b4xA:
undetectable
1p6kB-5b4xA:
undetectable		 1p6kA-5b4xA:
19.39
1p6kB-5b4xA:
19.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QW6_A_H4BA901_1
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 5b4x LOW DENSITY
LIPOPROTEIN
RECEPTOR-RELATED
PROTEIN 8,
APOLIPOPROTEIN E
RECEPTOR, ISOFORM
CRA_E
REELIN
(Homo
sapiens;
Mus
musculus) 		3 / 3 ARG A2364
VAL B  62
TRP B  63
 None
 1.16A 1qw6A-5b4xA:
undetectable		 1qw6A-5b4xA:
18.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QWC_A_H4BA901_1
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 5b4x LOW DENSITY
LIPOPROTEIN
RECEPTOR-RELATED
PROTEIN 8,
APOLIPOPROTEIN E
RECEPTOR, ISOFORM
CRA_E
REELIN
(Homo
sapiens;
Mus
musculus) 		3 / 3 ARG A2364
VAL B  62
TRP B  63
 None
 1.27A 1qwcA-5b4xA:
undetectable		 1qwcA-5b4xA:
18.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RS6_A_H4BA760_1
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 5b4x REELIN
(Mus
musculus) 		4 / 6 VAL A2595
TRP A2641
TRP A2654
PHE A2555
 None
 1.48A 1rs6A-5b4xA:
undetectable
1rs6B-5b4xA:
undetectable		 1rs6A-5b4xA:
19.39
1rs6B-5b4xA:
19.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1VAG_A_H4BA901_1
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 5b4x LOW DENSITY
LIPOPROTEIN
RECEPTOR-RELATED
PROTEIN 8,
APOLIPOPROTEIN E
RECEPTOR, ISOFORM
CRA_E
REELIN
(Homo
sapiens;
Mus
musculus) 		3 / 3 ARG A2364
VAL B  62
TRP B  63
 None
 1.20A 1vagA-5b4xA:
undetectable		 1vagA-5b4xA:
18.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZVI_A_H4BA901_1
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 5b4x LOW DENSITY
LIPOPROTEIN
RECEPTOR-RELATED
PROTEIN 8,
APOLIPOPROTEIN E
RECEPTOR, ISOFORM
CRA_E
REELIN
(Homo
sapiens;
Mus
musculus) 		3 / 3 ARG A2364
VAL B  62
TRP B  63
 None
 1.21A 1zviA-5b4xA:
undetectable		 1zviA-5b4xA:
18.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZVL_A_H4BA900_1
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 5b4x REELIN
(Mus
musculus) 		4 / 7 VAL A2595
TRP A2641
TRP A2654
PHE A2555
 None
 1.44A 1zvlA-5b4xA:
undetectable
1zvlB-5b4xA:
undetectable		 1zvlA-5b4xA:
18.75
1zvlB-5b4xA:
18.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZZQ_A_H4BA760_1
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 5b4x REELIN
(Mus
musculus) 		4 / 7 VAL A2595
TRP A2641
TRP A2654
PHE A2555
 None
 1.47A 1zzqA-5b4xA:
undetectable
1zzqB-5b4xA:
undetectable		 1zzqA-5b4xA:
19.91
1zzqB-5b4xA:
19.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2B0Q_A_NMYA305_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E)		 5b4x LOW DENSITY
LIPOPROTEIN
RECEPTOR-RELATED
PROTEIN 8,
APOLIPOPROTEIN E
RECEPTOR, ISOFORM
CRA_E
REELIN
(Homo
sapiens;
Mus
musculus) 		5 / 12 GLU B 519
GLU B 537
ASP A2474
SER A2350
ASP A2327
 None
None
CA  A4003 (-2.0A)
None
None
 1.48A 2b0qA-5b4xB:
0.0		 2b0qA-5b4xB:
19.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HA6_A_SCKA902_1
(ACETYLCHOLINESTERASE)		 5b4x REELIN
(Mus
musculus) 		5 / 10 GLU A2091
GLU A2025
ASN A2126
LEU A2055
LEU A2056
 None
 1.48A 2ha6A-5b4xA:
undetectable		 2ha6A-5b4xA:
22.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HA6_B_SCKB952_1
(ACETYLCHOLINESTERASE)		 5b4x REELIN
(Mus
musculus) 		5 / 10 GLU A2091
GLU A2025
ASN A2126
LEU A2055
LEU A2056
 None
 1.42A 2ha6B-5b4xA:
undetectable		 2ha6B-5b4xA:
22.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JST_A_HLTA101_1
(FOUR-ALPHA-HELIX
BUNDLE)		 5b4x LOW DENSITY
LIPOPROTEIN
RECEPTOR-RELATED
PROTEIN 8,
APOLIPOPROTEIN E
RECEPTOR, ISOFORM
CRA_E
(Homo
sapiens) 		4 / 5 TRP B 336
ALA B 352
LEU B 325
ALA B 347
 None
 1.29A 2jstA-5b4xB:
undetectable
2jstB-5b4xB:
undetectable		 2jstA-5b4xB:
8.76
2jstB-5b4xB:
8.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XDC_D_DVAD8_0
(GRAMICIDIN A)		 5b4x LOW DENSITY
LIPOPROTEIN
RECEPTOR-RELATED
PROTEIN 8,
APOLIPOPROTEIN E
RECEPTOR, ISOFORM
CRA_E
(Homo
sapiens) 		3 / 3 TRP B 429
VAL B 471
TRP B 455
 None
 1.31A 2xdcC-5b4xB:
undetectable
2xdcD-5b4xB:
undetectable		 2xdcC-5b4xB:
2.23
2xdcD-5b4xB:
2.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XDC_F_DVAF8_0
(GRAMICIDIN A)		 5b4x LOW DENSITY
LIPOPROTEIN
RECEPTOR-RELATED
PROTEIN 8,
APOLIPOPROTEIN E
RECEPTOR, ISOFORM
CRA_E
(Homo
sapiens) 		3 / 3 TRP B 429
VAL B 471
TRP B 455
 None
 1.27A 2xdcE-5b4xB:
undetectable
2xdcF-5b4xB:
undetectable		 2xdcE-5b4xB:
2.23
2xdcF-5b4xB:
2.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y6N_D_DVAD8_0
(VAL-GRAMICIDIN A)		 5b4x LOW DENSITY
LIPOPROTEIN
RECEPTOR-RELATED
PROTEIN 8,
APOLIPOPROTEIN E
RECEPTOR, ISOFORM
CRA_E
(Homo
sapiens) 		3 / 3 TRP B 429
VAL B 471
TRP B 455
 None
 1.34A 2y6nC-5b4xB:
undetectable
2y6nD-5b4xB:
undetectable		 2y6nC-5b4xB:
2.23
2y6nD-5b4xB:
2.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y6N_F_DVAF8_0
(VAL-GRAMICIDIN A)		 5b4x LOW DENSITY
LIPOPROTEIN
RECEPTOR-RELATED
PROTEIN 8,
APOLIPOPROTEIN E
RECEPTOR, ISOFORM
CRA_E
(Homo
sapiens) 		3 / 3 TRP B 429
VAL B 471
TRP B 455
 None
 1.34A 2y6nE-5b4xB:
undetectable
2y6nF-5b4xB:
undetectable		 2y6nE-5b4xB:
2.23
2y6nF-5b4xB:
2.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZW9_B_SAMB801_1
(LEUCINE CARBOXYL
METHYLTRANSFERASE 2)		 5b4x REELIN
(Mus
musculus) 		4 / 8 ASN A2317
SER A2319
ASP A2168
SER A2222
 NAG  A4005 (-1.9A)
NAG  A4005 (-3.2A)
NAG  A4005 (-4.0A)
None
 1.15A 2zw9B-5b4xA:
undetectable		 2zw9B-5b4xA:
20.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AQI_B_CHDB6_0
(FERROCHELATASE)		 5b4x REELIN
(Mus
musculus) 		5 / 12 PHE A2265
LEU A2261
ILE A2309
PRO A2282
VAL A2227
 None
 1.31A 3aqiB-5b4xA:
undetectable		 3aqiB-5b4xA:
19.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B3N_A_H4BA760_1
(NITRIC-OXIDE
SYNTHASE)		 5b4x REELIN
(Mus
musculus) 		4 / 7 VAL A2595
TRP A2641
TRP A2654
PHE A2555
 None
 1.47A 3b3nA-5b4xA:
undetectable
3b3nB-5b4xA:
undetectable		 3b3nA-5b4xA:
19.36
3b3nB-5b4xA:
19.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CYX_A_ROCA201_4
(HIV-1 PROTEASE)		 5b4x REELIN
(Mus
musculus) 		4 / 4 LEU A2379
ASP A2376
VAL A2373
THR A2450
 None
 1.27A 3cyxB-5b4xA:
undetectable		 3cyxB-5b4xA:
9.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3E7G_A_H4BA902_1
(NITRIC OXIDE
SYNTHASE, INDUCIBLE)		 5b4x REELIN
(Mus
musculus) 		4 / 7 ILE A2396
TRP A2459
TRP A2471
PHE A2357
 None
 1.37A 3e7gA-5b4xA:
undetectable
3e7gB-5b4xA:
undetectable		 3e7gA-5b4xA:
19.78
3e7gB-5b4xA:
19.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3E7G_B_H4BB1902_1
(NITRIC OXIDE
SYNTHASE, INDUCIBLE)		 5b4x REELIN
(Mus
musculus) 		4 / 7 TRP A2471
PHE A2357
ILE A2396
TRP A2459
 None
 1.37A 3e7gA-5b4xA:
undetectable
3e7gB-5b4xA:
undetectable		 3e7gA-5b4xA:
19.78
3e7gB-5b4xA:
19.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3E7G_C_H4BC2902_1
(NITRIC OXIDE
SYNTHASE, INDUCIBLE)		 5b4x REELIN
(Mus
musculus) 		4 / 7 ILE A2396
TRP A2459
TRP A2471
PHE A2357
 None
 1.38A 3e7gC-5b4xA:
undetectable
3e7gD-5b4xA:
undetectable		 3e7gC-5b4xA:
19.78
3e7gD-5b4xA:
19.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3E7G_D_H4BD3902_1
(NITRIC OXIDE
SYNTHASE, INDUCIBLE)		 5b4x REELIN
(Mus
musculus) 		4 / 8 TRP A2471
PHE A2357
ILE A2396
TRP A2459
 None
 1.38A 3e7gC-5b4xA:
undetectable
3e7gD-5b4xA:
undetectable		 3e7gC-5b4xA:
19.78
3e7gD-5b4xA:
19.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EJ8_B_H4BB2902_1
(NITRIC OXIDE
SYNTHASE, INDUCIBLE)		 5b4x REELIN
(Mus
musculus) 		4 / 7 TRP A2471
PHE A2357
ILE A2396
TRP A2459
 None
 1.30A 3ej8A-5b4xA:
undetectable
3ej8B-5b4xA:
undetectable		 3ej8A-5b4xA:
20.19
3ej8B-5b4xA:
20.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EJ8_C_H4BC3902_1
(NITRIC OXIDE
SYNTHASE, INDUCIBLE)		 5b4x REELIN
(Mus
musculus) 		4 / 7 ILE A2396
TRP A2459
TRP A2471
PHE A2357
 None
 1.29A 3ej8C-5b4xA:
undetectable
3ej8D-5b4xA:
undetectable		 3ej8C-5b4xA:
20.19
3ej8D-5b4xA:
20.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EJ8_D_H4BD4902_1
(NITRIC OXIDE
SYNTHASE, INDUCIBLE)		 5b4x REELIN
(Mus
musculus) 		4 / 7 TRP A2471
PHE A2357
ILE A2396
TRP A2459
 None
 1.36A 3ej8C-5b4xA:
undetectable
3ej8D-5b4xA:
undetectable		 3ej8C-5b4xA:
20.19
3ej8D-5b4xA:
20.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FL9_A_TOPA200_1
(DIHYDROFOLATE
REDUCTASE (DHFR))		 5b4x LOW DENSITY
LIPOPROTEIN
RECEPTOR-RELATED
PROTEIN 8,
APOLIPOPROTEIN E
RECEPTOR, ISOFORM
CRA_E
(Homo
sapiens) 		5 / 10 ALA B 433
VAL B 449
ALA B 414
ILE B 459
LEU B 468
 None
 1.24A 3fl9A-5b4xB:
undetectable		 3fl9A-5b4xB:
13.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FL9_F_TOPF200_1
(DIHYDROFOLATE
REDUCTASE (DHFR))		 5b4x LOW DENSITY
LIPOPROTEIN
RECEPTOR-RELATED
PROTEIN 8,
APOLIPOPROTEIN E
RECEPTOR, ISOFORM
CRA_E
(Homo
sapiens) 		5 / 10 ALA B 433
VAL B 449
ALA B 414
ILE B 459
LEU B 468
 None
 1.16A 3fl9F-5b4xB:
undetectable		 3fl9F-5b4xB:
13.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HSN_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5b4x REELIN
(Mus
musculus) 		4 / 7 VAL A2595
TRP A2641
TRP A2654
PHE A2555
 None
 1.50A 3hsnA-5b4xA:
undetectable
3hsnB-5b4xA:
undetectable		 3hsnA-5b4xA:
19.36
3hsnB-5b4xA:
19.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HSN_B_H4BB1760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5b4x REELIN
(Mus
musculus) 		4 / 7 TRP A2654
PHE A2555
VAL A2595
TRP A2641
 None
 1.47A 3hsnA-5b4xA:
undetectable
3hsnB-5b4xA:
undetectable		 3hsnA-5b4xA:
19.36
3hsnB-5b4xA:
19.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HSO_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5b4x REELIN
(Mus
musculus) 		4 / 7 VAL A2595
TRP A2641
TRP A2654
PHE A2555
 None
 1.46A 3hsoA-5b4xA:
undetectable
3hsoB-5b4xA:
undetectable		 3hsoA-5b4xA:
19.36
3hsoB-5b4xA:
19.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JT4_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5b4x REELIN
(Mus
musculus) 		4 / 7 VAL A2595
TRP A2641
TRP A2654
PHE A2555
 None
 1.47A 3jt4A-5b4xA:
undetectable
3jt4B-5b4xA:
undetectable		 3jt4A-5b4xA:
19.36
3jt4B-5b4xA:
19.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JT8_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5b4x REELIN
(Mus
musculus) 		4 / 7 VAL A2595
TRP A2641
TRP A2654
PHE A2555
 None
 1.45A 3jt8A-5b4xA:
undetectable
3jt8B-5b4xA:
undetectable		 3jt8A-5b4xA:
19.36
3jt8B-5b4xA:
19.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JT8_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5b4x REELIN
(Mus
musculus) 		4 / 7 TRP A2654
PHE A2555
VAL A2595
TRP A2641
 None
 1.48A 3jt8A-5b4xA:
undetectable
3jt8B-5b4xA:
undetectable		 3jt8A-5b4xA:
19.36
3jt8B-5b4xA:
19.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JT9_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5b4x REELIN
(Mus
musculus) 		4 / 7 VAL A2595
TRP A2641
TRP A2654
PHE A2555
 None
 1.50A 3jt9A-5b4xA:
undetectable
3jt9B-5b4xA:
undetectable		 3jt9A-5b4xA:
19.36
3jt9B-5b4xA:
19.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LM8_B_VIBB223_1
(THIAMINE
PYROPHOSPHOKINASE)		 5b4x REELIN
(Mus
musculus) 		4 / 7 LEU A2098
LEU A2055
SER A2045
THR A2010
 None
 1.01A 3lm8B-5b4xA:
3.0
3lm8D-5b4xA:
2.7		 3lm8B-5b4xA:
14.76
3lm8D-5b4xA:
14.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N2R_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE)		 5b4x REELIN
(Mus
musculus) 		4 / 7 VAL A2595
TRP A2641
TRP A2654
PHE A2555
 None
 1.47A 3n2rA-5b4xA:
undetectable
3n2rB-5b4xA:
undetectable		 3n2rA-5b4xA:
19.36
3n2rB-5b4xA:
19.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N2R_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE)		 5b4x REELIN
(Mus
musculus) 		4 / 7 TRP A2654
PHE A2555
VAL A2595
TRP A2641
 None
 1.47A 3n2rA-5b4xA:
undetectable
3n2rB-5b4xA:
undetectable		 3n2rA-5b4xA:
19.36
3n2rB-5b4xA:
19.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3Q99_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5b4x REELIN
(Mus
musculus) 		4 / 7 VAL A2595
TRP A2641
TRP A2654
PHE A2555
 None
 1.47A 3q99A-5b4xA:
undetectable
3q99B-5b4xA:
undetectable		 3q99A-5b4xA:
19.36
3q99B-5b4xA:
19.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S8P_A_SAMA500_1
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SUV420H1)		 5b4x LOW DENSITY
LIPOPROTEIN
RECEPTOR-RELATED
PROTEIN 8,
APOLIPOPROTEIN E
RECEPTOR, ISOFORM
CRA_E
(Homo
sapiens) 		3 / 3 HIS B 543
SER B 368
GLU B 370
 None
 0.74A 3s8pA-5b4xB:
undetectable		 3s8pA-5b4xB:
18.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3THR_C_C2FC1410_0
(GLYCINE
N-METHYLTRANSFERASE)		 5b4x LOW DENSITY
LIPOPROTEIN
RECEPTOR-RELATED
PROTEIN 8,
APOLIPOPROTEIN E
RECEPTOR, ISOFORM
CRA_E
(Homo
sapiens) 		3 / 3 ARG B 526
PRO B 292
PHE B 512
 None
 1.04A 3thrC-5b4xB:
undetectable		 3thrC-5b4xB:
19.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ZQ8_B_DVAB8_0
(VAL-GRAMICIDIN A)		 5b4x LOW DENSITY
LIPOPROTEIN
RECEPTOR-RELATED
PROTEIN 8,
APOLIPOPROTEIN E
RECEPTOR, ISOFORM
CRA_E
(Homo
sapiens) 		3 / 3 TRP B 429
VAL B 471
TRP B 455
 None
 1.06A 3zq8A-5b4xB:
undetectable
3zq8B-5b4xB:
undetectable		 3zq8A-5b4xB:
2.23
3zq8B-5b4xB:
2.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A7A_B_RGZB601_1
(AMINE OXIDASE
[FLAVIN-CONTAINING]
B)		 5b4x REELIN
(Mus
musculus) 		5 / 12 LEU A2431
LEU A2398
ILE A2442
PHE A2457
TYR A2449
 None
 1.06A 4a7aB-5b4xA:
undetectable		 4a7aB-5b4xA:
19.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AT0_A_ACTA1490_0
(3-KETOSTEROID-DELTA4
-5ALPHA-DEHYDROGENAS
E)		 5b4x REELIN
(Mus
musculus) 		3 / 3 GLU A2091
TYR A2080
SER A2078
 None
 0.91A 4at0A-5b4xA:
undetectable		 4at0A-5b4xA:
20.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C8B_B_0LIB1000_2
(RECEPTOR-INTERACTING
SERINE/THREONINE-PRO
TEIN KINASE 2)		 5b4x LOW DENSITY
LIPOPROTEIN
RECEPTOR-RELATED
PROTEIN 8,
APOLIPOPROTEIN E
RECEPTOR, ISOFORM
CRA_E
(Homo
sapiens) 		3 / 3 TYR B 425
MET B 424
ILE B 381
 None
 0.66A 4c8bB-5b4xB:
undetectable		 4c8bB-5b4xB:
19.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CX7_B_H4BB600_1
(NITRIC OXIDE
SYNTHASE, INDUCIBLE)		 5b4x REELIN
(Mus
musculus) 		4 / 8 TRP A2471
PHE A2357
ILE A2396
TRP A2459
 None
 1.35A 4cx7A-5b4xA:
undetectable
4cx7B-5b4xA:
undetectable		 4cx7A-5b4xA:
19.75
4cx7B-5b4xA:
19.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CX7_D_H4BD600_1
(NITRIC OXIDE
SYNTHASE, INDUCIBLE)		 5b4x REELIN
(Mus
musculus) 		4 / 7 TRP A2471
PHE A2357
ILE A2396
TRP A2459
 None
 1.32A 4cx7C-5b4xA:
undetectable
4cx7D-5b4xA:
undetectable		 4cx7C-5b4xA:
19.75
4cx7D-5b4xA:
19.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D1N_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5b4x REELIN
(Mus
musculus) 		4 / 7 VAL A2595
TRP A2641
TRP A2654
PHE A2555
 None
 1.48A 4d1nA-5b4xA:
undetectable
4d1nB-5b4xA:
undetectable		 4d1nA-5b4xA:
19.94
4d1nB-5b4xA:
19.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EQ4_A_SALA601_1
(4-SUBSTITUTED
BENZOATES-GLUTAMATE
LIGASE GH3.12)		 5b4x REELIN
(Mus
musculus) 		4 / 7 LEU A2014
ILE A2022
THR A2020
GLY A2130
 None
 0.77A 4eq4A-5b4xA:
undetectable		 4eq4A-5b4xA:
21.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EQL_A_SALA602_1
(4-SUBSTITUTED
BENZOATES-GLUTAMATE
LIGASE GH3.12)		 5b4x REELIN
(Mus
musculus) 		4 / 7 LEU A2014
ILE A2022
THR A2020
GLY A2130
 None
 0.82A 4eqlA-5b4xA:
undetectable		 4eqlA-5b4xA:
21.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EQL_B_SALB602_1
(4-SUBSTITUTED
BENZOATES-GLUTAMATE
LIGASE GH3.12)		 5b4x REELIN
(Mus
musculus) 		4 / 7 LEU A2014
ILE A2022
THR A2020
GLY A2130
 None
 0.83A 4eqlB-5b4xA:
undetectable		 4eqlB-5b4xA:
21.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FVW_A_H4BA802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5b4x REELIN
(Mus
musculus) 		4 / 7 VAL A2595
TRP A2641
TRP A2654
PHE A2555
 None
 1.46A 4fvwA-5b4xA:
undetectable
4fvwB-5b4xA:
undetectable		 4fvwA-5b4xA:
19.36
4fvwB-5b4xA:
19.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FVW_B_H4BB802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5b4x REELIN
(Mus
musculus) 		4 / 7 TRP A2654
PHE A2555
VAL A2595
TRP A2641
 None
 1.45A 4fvwA-5b4xA:
undetectable
4fvwB-5b4xA:
undetectable		 4fvwA-5b4xA:
19.36
4fvwB-5b4xA:
19.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FVZ_A_H4BA802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5b4x REELIN
(Mus
musculus) 		4 / 7 VAL A2595
TRP A2641
TRP A2654
PHE A2555
 None
 1.49A 4fvzA-5b4xA:
undetectable
4fvzB-5b4xA:
undetectable		 4fvzA-5b4xA:
19.36
4fvzB-5b4xA:
19.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FW0_A_H4BA802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5b4x REELIN
(Mus
musculus) 		4 / 7 VAL A2595
TRP A2641
TRP A2654
PHE A2555
 None
 1.47A 4fw0A-5b4xA:
undetectable
4fw0B-5b4xA:
undetectable		 4fw0A-5b4xA:
19.36
4fw0B-5b4xA:
19.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FW0_B_H4BB802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5b4x REELIN
(Mus
musculus) 		4 / 7 TRP A2654
PHE A2555
VAL A2595
TRP A2641
 None
 1.48A 4fw0A-5b4xA:
undetectable
4fw0B-5b4xA:
undetectable		 4fw0A-5b4xA:
19.36
4fw0B-5b4xA:
19.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G0U_B_ASWB1301_1
(DNA TOPOISOMERASE
2-BETA)		 5b4x REELIN
(Mus
musculus) 		4 / 7 ILE A2371
GLY A2405
ALA A2454
GLN A2311
 None
 0.97A 4g0uB-5b4xA:
undetectable		 4g0uB-5b4xA:
20.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4GKI_A_KANA301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 5b4x REELIN
(Mus
musculus) 		4 / 8 ASP A2484
CSS A2497
ASP A2509
GLU A2510
 None
 1.04A 4gkiA-5b4xA:
undetectable		 4gkiA-5b4xA:
17.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4H2G_A_ADNA603_1
(5'-NUCLEOTIDASE)		 5b4x REELIN
(Mus
musculus) 		5 / 9 ASN A2602
GLY A2603
GLY A2604
ARG A2638
GLY A2488
 None
 1.47A 4h2gA-5b4xA:
undetectable		 4h2gA-5b4xA:
20.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JSJ_B_H4BB802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5b4x REELIN
(Mus
musculus) 		4 / 7 TRP A2654
PHE A2555
VAL A2595
TRP A2641
 None
 1.47A 4jsjA-5b4xA:
undetectable
4jsjB-5b4xA:
undetectable		 4jsjA-5b4xA:
19.36
4jsjB-5b4xA:
19.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L39_A_SALA602_1
(4-SUBSTITUTED
BENZOATES-GLUTAMATE
LIGASE GH3.12)		 5b4x REELIN
(Mus
musculus) 		4 / 6 LEU A2014
ILE A2022
THR A2020
GLY A2130
 None
 0.82A 4l39A-5b4xA:
undetectable		 4l39A-5b4xA:
21.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L39_B_SALB601_1
(4-SUBSTITUTED
BENZOATES-GLUTAMATE
LIGASE GH3.12)		 5b4x REELIN
(Mus
musculus) 		4 / 7 LEU A2014
ILE A2022
THR A2020
GLY A2130
 None
 0.82A 4l39B-5b4xA:
undetectable		 4l39B-5b4xA:
21.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QZU_D_ACTD201_0
(RETINOL-BINDING
PROTEIN 2)		 5b4x LOW DENSITY
LIPOPROTEIN
RECEPTOR-RELATED
PROTEIN 8,
APOLIPOPROTEIN E
RECEPTOR, ISOFORM
CRA_E
(Homo
sapiens) 		3 / 3 ASP B 375
HIS B 378
LYS B 379
 None
 0.75A 4qzuD-5b4xB:
undetectable		 4qzuD-5b4xB:
10.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UBE_A_2FAA401_1
(ADENOSINE KINASE)		 5b4x LOW DENSITY
LIPOPROTEIN
RECEPTOR-RELATED
PROTEIN 8,
APOLIPOPROTEIN E
RECEPTOR, ISOFORM
CRA_E
(Homo
sapiens) 		5 / 12 SER B 563
GLY B 569
GLY B 568
ASN B 567
ALA B 559
 None
 1.18A 4ubeA-5b4xB:
undetectable		 4ubeA-5b4xB:
22.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UH4_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5b4x REELIN
(Mus
musculus) 		4 / 7 TRP A2654
PHE A2555
VAL A2595
TRP A2641
 None
 1.46A 4uh4A-5b4xA:
undetectable
4uh4B-5b4xA:
undetectable		 4uh4A-5b4xA:
19.36
4uh4B-5b4xA:
19.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UH5_A_H4BA760_1
(NEURONAL NITRIC
OXIDE SYNTHASE)		 5b4x REELIN
(Mus
musculus) 		4 / 7 VAL A2595
TRP A2641
TRP A2654
PHE A2555
 None
 1.49A 4uh5A-5b4xA:
undetectable
4uh5B-5b4xA:
undetectable		 4uh5A-5b4xA:
20.31
4uh5B-5b4xA:
20.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UH5_B_H4BB760_1
(NEURONAL NITRIC
OXIDE SYNTHASE)		 5b4x REELIN
(Mus
musculus) 		4 / 7 TRP A2654
PHE A2555
VAL A2595
TRP A2641
 None
 1.49A 4uh5A-5b4xA:
undetectable
4uh5B-5b4xA:
undetectable		 4uh5A-5b4xA:
20.31
4uh5B-5b4xA:
20.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UH6_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5b4x REELIN
(Mus
musculus) 		4 / 7 VAL A2595
TRP A2641
TRP A2654
PHE A2555
 None
 1.44A 4uh6A-5b4xA:
undetectable
4uh6B-5b4xA:
undetectable		 4uh6A-5b4xA:
20.31
4uh6B-5b4xA:
20.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4V3U_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5b4x REELIN
(Mus
musculus) 		4 / 7 VAL A2595
TRP A2641
TRP A2654
PHE A2555
 None
 1.50A 4v3uA-5b4xA:
undetectable
4v3uB-5b4xA:
undetectable		 4v3uA-5b4xA:
19.94
4v3uB-5b4xA:
19.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XYZ_A_ACTA103_0
(POLYUBIQUITIN-C)		 5b4x REELIN
(Mus
musculus) 		4 / 4 LEU A2257
ILE A2021
HIS A2094
VAL A2092
 None
 0.85A 4xyzA-5b4xA:
undetectable		 4xyzA-5b4xA:
8.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AGM_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5b4x REELIN
(Mus
musculus) 		4 / 7 VAL A2595
TRP A2641
TRP A2654
PHE A2555
 None
 1.47A 5agmA-5b4xA:
undetectable
5agmB-5b4xA:
undetectable		 5agmA-5b4xA:
19.36
5agmB-5b4xA:
19.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AGM_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5b4x REELIN
(Mus
musculus) 		4 / 7 TRP A2654
PHE A2555
VAL A2595
TRP A2641
 None
 1.50A 5agmA-5b4xA:
undetectable
5agmB-5b4xA:
undetectable		 5agmA-5b4xA:
19.36
5agmB-5b4xA:
19.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AGN_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5b4x REELIN
(Mus
musculus) 		4 / 6 VAL A2595
TRP A2641
TRP A2654
PHE A2555
 None
 1.49A 5agnA-5b4xA:
undetectable
5agnB-5b4xA:
undetectable		 5agnA-5b4xA:
19.36
5agnB-5b4xA:
19.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FVQ_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5b4x REELIN
(Mus
musculus) 		4 / 6 VAL A2595
TRP A2641
TRP A2654
PHE A2555
 None
 1.45A 5fvqA-5b4xA:
undetectable
5fvqB-5b4xA:
undetectable		 5fvqA-5b4xA:
19.36
5fvqB-5b4xA:
19.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FVQ_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5b4x REELIN
(Mus
musculus) 		4 / 7 TRP A2654
PHE A2555
VAL A2595
TRP A2641
 None
 1.45A 5fvqA-5b4xA:
undetectable
5fvqB-5b4xA:
undetectable		 5fvqA-5b4xA:
19.36
5fvqB-5b4xA:
19.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FVR_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5b4x REELIN
(Mus
musculus) 		4 / 6 VAL A2595
TRP A2641
TRP A2654
PHE A2555
 None
 1.46A 5fvrA-5b4xA:
undetectable
5fvrB-5b4xA:
undetectable		 5fvrA-5b4xA:
19.36
5fvrB-5b4xA:
19.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FVR_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5b4x REELIN
(Mus
musculus) 		4 / 6 TRP A2654
PHE A2555
VAL A2595
TRP A2641
 None
 1.46A 5fvrA-5b4xA:
undetectable
5fvrB-5b4xA:
undetectable		 5fvrA-5b4xA:
19.36
5fvrB-5b4xA:
19.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FVT_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5b4x REELIN
(Mus
musculus) 		4 / 7 VAL A2595
TRP A2641
TRP A2654
PHE A2555
 None
 1.46A 5fvtA-5b4xA:
undetectable
5fvtB-5b4xA:
undetectable		 5fvtA-5b4xA:
19.36
5fvtB-5b4xA:
19.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FVT_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5b4x REELIN
(Mus
musculus) 		4 / 7 TRP A2654
PHE A2555
VAL A2595
TRP A2641
 None
 1.46A 5fvtA-5b4xA:
undetectable
5fvtB-5b4xA:
undetectable		 5fvtA-5b4xA:
19.36
5fvtB-5b4xA:
19.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FVU_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5b4x REELIN
(Mus
musculus) 		4 / 6 VAL A2595
TRP A2641
TRP A2654
PHE A2555
 None
 1.46A 5fvuA-5b4xA:
undetectable
5fvuB-5b4xA:
undetectable		 5fvuA-5b4xA:
20.31
5fvuB-5b4xA:
20.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FVU_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5b4x REELIN
(Mus
musculus) 		4 / 7 TRP A2654
PHE A2555
VAL A2595
TRP A2641
 None
 1.48A 5fvuA-5b4xA:
undetectable
5fvuB-5b4xA:
undetectable		 5fvuA-5b4xA:
20.31
5fvuB-5b4xA:
20.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FVW_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5b4x REELIN
(Mus
musculus) 		4 / 7 VAL A2595
TRP A2641
TRP A2654
PHE A2555
 None
 1.49A 5fvwA-5b4xA:
undetectable
5fvwB-5b4xA:
undetectable		 5fvwA-5b4xA:
20.31
5fvwB-5b4xA:
20.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FVW_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5b4x REELIN
(Mus
musculus) 		4 / 7 TRP A2654
PHE A2555
VAL A2595
TRP A2641
 None
 1.46A 5fvwA-5b4xA:
undetectable
5fvwB-5b4xA:
undetectable		 5fvwA-5b4xA:
20.31
5fvwB-5b4xA:
20.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FVX_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5b4x REELIN
(Mus
musculus) 		4 / 7 VAL A2595
TRP A2641
TRP A2654
PHE A2555
 None
 1.47A 5fvxA-5b4xA:
undetectable
5fvxB-5b4xA:
undetectable		 5fvxA-5b4xA:
20.31
5fvxB-5b4xA:
20.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IEN_B_VDYB201_1
(CDL2.2)		 5b4x REELIN
(Mus
musculus) 		5 / 10 ILE A2656
LEU A2563
VAL A2566
ILE A2661
LEU A2568
 None
 1.17A 5ienB-5b4xA:
undetectable		 5ienB-5b4xA:
10.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MUG_A_VIVA301_0
(ALPHA-TOCOPHEROL
TRANSFER PROTEIN)		 5b4x REELIN
(Mus
musculus) 		5 / 12 LEU A2563
ILE A2661
VAL A2659
VAL A2624
ILE A2626
 None
 1.09A 5mugA-5b4xA:
undetectable		 5mugA-5b4xA:
16.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5O96_B_SAMB501_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE E)		 5b4x LOW DENSITY
LIPOPROTEIN
RECEPTOR-RELATED
PROTEIN 8,
APOLIPOPROTEIN E
RECEPTOR, ISOFORM
CRA_E
(Homo
sapiens) 		5 / 9 ILE B 459
GLY B 458
GLY B 503
LEU B 461
ALA B 416
 None
 0.95A 5o96A-5b4xB:
undetectable
5o96B-5b4xB:
undetectable		 5o96A-5b4xB:
18.02
5o96B-5b4xB:
18.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TUD_A_ERMA2001_2
(5-HYDROXYTRYPTAMINE
RECEPTOR 2B,SOLUBLE
CYTOCHROME B562
CHIMERA)		 5b4x LOW DENSITY
LIPOPROTEIN
RECEPTOR-RELATED
PROTEIN 8,
APOLIPOPROTEIN E
RECEPTOR, ISOFORM
CRA_E
(Homo
sapiens) 		4 / 7 THR B 460
LEU B 498
ASN B 457
GLU B 454
 None
 1.12A 5tudA-5b4xB:
undetectable		 5tudA-5b4xB:
19.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UMD_A_YMZA3801_1
(60S RIBOSOMAL
PROTEIN L28
28S RIBOSOMAL RNA
60S RIBOSOMAL
PROTEIN L4)		 5b4x LOW DENSITY
LIPOPROTEIN
RECEPTOR-RELATED
PROTEIN 8,
APOLIPOPROTEIN E
RECEPTOR, ISOFORM
CRA_E
(Homo
sapiens) 		4 / 6 ASN B 262
VAL B 261
ASP B 246
TYR B 266
 CA  B5004 (-3.1A)
None
CA  B5004 (-2.5A)
None
 1.23A 5umd2-5b4xB:
undetectable
5umdF-5b4xB:
undetectable		 5umd2-5b4xB:
8.33
5umdF-5b4xB:
7.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VUW_A_H4BA802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5b4x REELIN
(Mus
musculus) 		4 / 7 VAL A2595
TRP A2641
TRP A2654
PHE A2555
 None
 1.50A 5vuwA-5b4xA:
undetectable
5vuwB-5b4xA:
undetectable		 5vuwA-5b4xA:
20.31
5vuwB-5b4xA:
20.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VUX_A_H4BA802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5b4x REELIN
(Mus
musculus) 		4 / 7 VAL A2595
TRP A2641
TRP A2654
PHE A2555
 None
 1.47A 5vuxA-5b4xA:
undetectable
5vuxB-5b4xA:
undetectable		 5vuxA-5b4xA:
20.31
5vuxB-5b4xA:
20.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AUR_B_H4BB802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5b4x REELIN
(Mus
musculus) 		4 / 7 TRP A2654
PHE A2555
VAL A2595
TRP A2641
 None
 1.46A 6aurA-5b4xA:
undetectable
6aurB-5b4xA:
undetectable		 6aurA-5b4xA:
7.58
6aurB-5b4xA:
7.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AUV_A_H4BA802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5b4x REELIN
(Mus
musculus) 		4 / 7 VAL A2595
TRP A2641
TRP A2654
PHE A2555
 None
 1.44A 6auvA-5b4xA:
undetectable
6auvB-5b4xA:
undetectable		 6auvA-5b4xA:
7.58
6auvB-5b4xA:
7.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AUV_B_H4BB802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5b4x REELIN
(Mus
musculus) 		4 / 7 TRP A2654
PHE A2555
VAL A2595
TRP A2641
 None
 1.46A 6auvA-5b4xA:
undetectable
6auvB-5b4xA:
undetectable		 6auvA-5b4xA:
7.58
6auvB-5b4xA:
7.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AUY_A_H4BA802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5b4x REELIN
(Mus
musculus) 		4 / 7 VAL A2595
TRP A2641
TRP A2654
PHE A2555
 None
 1.45A 6auyA-5b4xA:
undetectable
6auyB-5b4xA:
undetectable		 6auyA-5b4xA:
7.56
6auyB-5b4xA:
7.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AV0_A_H4BA802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5b4x REELIN
(Mus
musculus) 		4 / 7 VAL A2595
TRP A2641
TRP A2654
PHE A2555
 None
 1.44A 6av0A-5b4xA:
undetectable
6av0B-5b4xA:
undetectable		 6av0A-5b4xA:
7.56
6av0B-5b4xA:
7.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AV1_A_H4BA802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5b4x REELIN
(Mus
musculus) 		4 / 7 VAL A2595
TRP A2641
TRP A2654
PHE A2555
 None
 1.43A 6av1A-5b4xA:
undetectable
6av1B-5b4xA:
undetectable		 6av1A-5b4xA:
7.56
6av1B-5b4xA:
7.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AV3_A_H4BA802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5b4x REELIN
(Mus
musculus) 		4 / 7 VAL A2595
TRP A2641
TRP A2654
PHE A2555
 None
 1.48A 6av3A-5b4xA:
undetectable
6av3B-5b4xA:
undetectable		 6av3A-5b4xA:
7.56
6av3B-5b4xA:
7.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AV4_A_H4BA802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5b4x REELIN
(Mus
musculus) 		4 / 7 VAL A2595
TRP A2641
TRP A2654
PHE A2555
 None
 1.45A 6av4A-5b4xA:
undetectable
6av4B-5b4xA:
undetectable		 6av4A-5b4xA:
7.56
6av4B-5b4xA:
7.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AV4_B_H4BB802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5b4x REELIN
(Mus
musculus) 		4 / 7 TRP A2654
PHE A2555
VAL A2595
TRP A2641
 None
 1.47A 6av4A-5b4xA:
undetectable
6av4B-5b4xA:
undetectable		 6av4A-5b4xA:
7.56
6av4B-5b4xA:
7.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AV5_A_H4BA802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5b4x REELIN
(Mus
musculus) 		4 / 7 VAL A2595
TRP A2641
TRP A2654
PHE A2555
 None
 1.45A 6av5A-5b4xA:
undetectable
6av5B-5b4xA:
undetectable		 6av5A-5b4xA:
7.56
6av5B-5b4xA:
7.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BXM_A_SAMA402_0
(DIPHTHAMIDE
BIOSYNTHESIS ENZYME
DPH2)		 5b4x REELIN
(Mus
musculus) 		5 / 12 PHE A2457
GLY A2405
LEU A2446
ARG A2456
ASP A2370
 None
 1.09A 6bxmA-5b4xA:
undetectable		 6bxmA-5b4xA:
17.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BXM_A_SAMA402_0
(DIPHTHAMIDE
BIOSYNTHESIS ENZYME
DPH2)		 5b4x REELIN
(Mus
musculus) 		5 / 12 PHE A2639
GLY A2604
LEU A2628
ARG A2638
ASP A2567
 None
 1.16A 6bxmA-5b4xA:
undetectable		 6bxmA-5b4xA:
17.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CIC_A_H4BA802_0
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5b4x REELIN
(Mus
musculus) 		4 / 7 VAL A2595
TRP A2641
TRP A2654
PHE A2555
 None
 1.46A 6cicA-5b4xA:
undetectable
6cicB-5b4xA:
undetectable		 6cicA-5b4xA:
7.56
6cicB-5b4xA:
7.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CIC_B_H4BB802_0
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5b4x REELIN
(Mus
musculus) 		4 / 7 TRP A2654
PHE A2555
VAL A2595
TRP A2641
 None
 1.43A 6cicA-5b4xA:
undetectable
6cicB-5b4xA:
undetectable		 6cicA-5b4xA:
7.56
6cicB-5b4xA:
7.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DLZ_A_CYZA1302_0
(GLUTAMATE RECEPTOR
2,VOLTAGE-DEPENDENT
CALCIUM CHANNEL
GAMMA-2 SUBUNIT)		 5b4x REELIN
(Mus
musculus) 		5 / 10 PRO A2039
SER A2036
LEU A2054
SER A2077
SER A2298
 None
 1.47A 6dlzA-5b4xA:
undetectable
6dlzD-5b4xA:
undetectable		 6dlzA-5b4xA:
7.63
6dlzD-5b4xA:
7.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DLZ_C_CYZC1302_0
(GLUTAMATE RECEPTOR
2,VOLTAGE-DEPENDENT
CALCIUM CHANNEL
GAMMA-2 SUBUNIT)		 5b4x REELIN
(Mus
musculus) 		5 / 10 SER A2298
PRO A2039
SER A2036
LEU A2054
SER A2077
 None
 1.47A 6dlzB-5b4xA:
undetectable
6dlzC-5b4xA:
undetectable		 6dlzB-5b4xA:
7.63
6dlzC-5b4xA:
7.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DM0_A_CYZA1302_0
(GLUTAMATE RECEPTOR
2,VOLTAGE-DEPENDENT
CALCIUM CHANNEL
GAMMA-2 SUBUNIT)		 5b4x REELIN
(Mus
musculus) 		5 / 9 PRO A2039
SER A2036
LEU A2054
SER A2077
SER A2298
 None
 1.50A 6dm0A-5b4xA:
undetectable
6dm0D-5b4xA:
undetectable		 6dm0A-5b4xA:
7.63
6dm0D-5b4xA:
7.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DM0_C_CYZC1302_0
(GLUTAMATE RECEPTOR
2,VOLTAGE-DEPENDENT
CALCIUM CHANNEL
GAMMA-2 SUBUNIT)		 5b4x REELIN
(Mus
musculus) 		5 / 9 SER A2298
PRO A2039
SER A2036
LEU A2054
SER A2077
 None
 1.49A 6dm0B-5b4xA:
undetectable
6dm0C-5b4xA:
undetectable		 6dm0B-5b4xA:
7.63
6dm0C-5b4xA:
7.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DM1_A_CYZA1302_0
(GLUTAMATE RECEPTOR
2,VOLTAGE-DEPENDENT
CALCIUM CHANNEL
GAMMA-2 SUBUNIT)		 5b4x REELIN
(Mus
musculus) 		5 / 10 PRO A2039
SER A2036
LEU A2054
SER A2077
SER A2298
 None
 1.48A 6dm1A-5b4xA:
undetectable
6dm1D-5b4xA:
undetectable		 6dm1A-5b4xA:
7.63
6dm1D-5b4xA:
7.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DM1_C_CYZC1302_0
(GLUTAMATE RECEPTOR
2,VOLTAGE-DEPENDENT
CALCIUM CHANNEL
GAMMA-2 SUBUNIT)		 5b4x REELIN
(Mus
musculus) 		5 / 10 SER A2298
PRO A2039
SER A2036
LEU A2054
SER A2077
 None
 1.47A 6dm1B-5b4xA:
undetectable
6dm1C-5b4xA:
undetectable		 6dm1B-5b4xA:
7.63
6dm1C-5b4xA:
7.63