SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5b57'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ERR_B_RALB600_1
(ESTROGEN RECEPTOR)		 5b57 HEMIN IMPORT
ATP-BINDING PROTEIN
HMUV
(Burkholderia
cenocepacia) 		5 / 12 ALA C 223
LEU C 195
ILE C 249
LEU C  33
LEU C 179
 None
 1.19A 1errB-5b57C:
undetectable		 1errB-5b57C:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CIZ_A_ACTA1321_0
(CHLOROPEROXIDASE)		 5b57 HEMIN IMPORT
ATP-BINDING PROTEIN
HMUV
(Burkholderia
cenocepacia) 		4 / 5 LEU C 195
PHE C 156
VAL C 209
ALA C 211
 None
 0.95A 2cizA-5b57C:
undetectable		 2cizA-5b57C:
21.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DYR_W_CHDW1060_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART
CYTOCHROME C OXIDASE
SUBUNIT 1)		 5b57 HEMIN IMPORT
ATP-BINDING PROTEIN
HMUV
(Burkholderia
cenocepacia) 		4 / 7 ILE C  76
LEU C  81
THR C   3
LEU C   2
 None
 1.02A 2dyrN-5b57C:
undetectable
2dyrW-5b57C:
undetectable		 2dyrN-5b57C:
20.78
2dyrW-5b57C:
13.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JFA_B_RALB600_2
(ESTROGEN RECEPTOR)		 5b57 HEMIN IMPORT
ATP-BINDING PROTEIN
HMUV
(Burkholderia
cenocepacia) 		4 / 4 LEU C 229
THR C 233
ILE C 226
HIS C 237
 None
 1.38A 2jfaB-5b57C:
undetectable		 2jfaB-5b57C:
24.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OXT_B_SAMB300_1
(NUCLEOSIDE-2'-O-METH
YLTRANSFERASE)		 5b57 HEMIN IMPORT
ATP-BINDING PROTEIN
HMUV
(Burkholderia
cenocepacia) 		4 / 5 SER C 147
GLY C 148
ASP C 196
ASP C 187
 None
 1.08A 2oxtB-5b57C:
2.2		 2oxtB-5b57C:
21.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AQI_B_CHDB4_0
(FERROCHELATASE)		 5b57 HEMIN IMPORT
ATP-BINDING PROTEIN
HMUV
(Burkholderia
cenocepacia) 		4 / 6 ARG C 199
PRO C 174
GLY C 208
MET C   1
 None
 1.47A 3aqiB-5b57C:
undetectable		 3aqiB-5b57C:
21.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CKZ_A_ZMRA469_2
(NEURAMINIDASE)		 5b57 HEMIN IMPORT
ATP-BINDING PROTEIN
HMUV
(Burkholderia
cenocepacia) 		4 / 6 ASP C 166
ARG C 175
ILE C 125
SER C 119
 None
 1.37A 3ckzA-5b57C:
undetectable		 3ckzA-5b57C:
20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DTU_C_DXCC576_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 2)		 5b57 HEMIN IMPORT
ATP-BINDING PROTEIN
HMUV
(Burkholderia
cenocepacia) 		4 / 8 PRO C 216
ALA C 220
ALA C 223
PRO C 240
 None
 0.73A 3dtuC-5b57C:
undetectable
3dtuD-5b57C:
undetectable		 3dtuC-5b57C:
20.71
3dtuD-5b57C:
19.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WIP_G_ACTG306_0
(ACETYLCHOLINE-BINDIN
G PROTEIN)		 5b57 HEMIN IMPORT
ATP-BINDING PROTEIN
HMUV
(Burkholderia
cenocepacia) 		3 / 3 ARG C 203
ARG C 132
ASP C 196
 None
 1.00A 3wipG-5b57C:
undetectable
3wipH-5b57C:
undetectable		 3wipG-5b57C:
19.73
3wipH-5b57C:
19.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M11_D_MXMD606_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 5b57 HEMIN IMPORT
ATP-BINDING PROTEIN
HMUV
(Burkholderia
cenocepacia) 		5 / 12 VAL C 159
LEU C 160
TRP C 205
VAL C 198
LEU C 178
 None
 1.36A 4m11D-5b57C:
undetectable		 4m11D-5b57C:
19.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R82_A_ACTA207_0
(OXIDOREDUCTASE)		 5b57 HEMIN IMPORT
ATP-BINDING PROTEIN
HMUV
(Burkholderia
cenocepacia) 		4 / 4 GLU C 150
GLY C 148
HIS C 190
ARG C 153
 None
 1.28A 4r82A-5b57C:
undetectable
4r82B-5b57C:
undetectable		 4r82A-5b57C:
22.63
4r82B-5b57C:
22.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UHX_A_LZUA3008_1
(ALDEHYDE OXIDASE)		 5b57 HEMIN IMPORT
ATP-BINDING PROTEIN
HMUV
(Burkholderia
cenocepacia) 		4 / 8 GLU C  25
ASP C 224
ARG C 199
PRO C  26
 None
 1.22A 4uhxA-5b57C:
undetectable		 4uhxA-5b57C:
12.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UHX_A_RTZA3009_1
(ALDEHYDE OXIDASE)		 5b57 HEMIN IMPORT
ATP-BINDING PROTEIN
HMUV
(Burkholderia
cenocepacia) 		4 / 8 GLU C  25
ASP C 224
ARG C 199
PRO C  26
 None
 1.22A 4uhxA-5b57C:
undetectable		 4uhxA-5b57C:
12.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DB5_A_CYSA503_0
(CYSTEINE DESULFURASE)		 5b57 HEMIN IMPORT
ATP-BINDING PROTEIN
HMUV
(Burkholderia
cenocepacia) 		4 / 8 ALA C 219
HIS C 192
HIS C 214
THR C 183
 None
 1.21A 5db5A-5b57C:
undetectable
5db5B-5b57C:
undetectable		 5db5A-5b57C:
23.19
5db5B-5b57C:
23.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DWD_A_GLYA717_0
(DEOXYNUCLEOSIDE
TRIPHOSPHATE
TRIPHOSPHOHYDROLASE
SAMHD1)		 5b57 HEMIN IMPORT
ATP-BINDING PROTEIN
HMUV
(Burkholderia
cenocepacia) 		4 / 5 SER C 119
ARG C 121
ASP C 122
ARG C 108
 None
 1.49A 6dwdA-5b57C:
undetectable		 6dwdA-5b57C:
18.63