SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5b5h'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ONI_B_BEZB504_0
(14.5 KDA
TRANSLATIONAL
INHIBITOR PROTEIN)		 5b5h ANTIFREEZE PROTEIN
(Typhula
ishikariensis) 		4 / 7 LEU A 160
ILE A 134
ALA A 166
ILE A 189
 None
 0.97A 1oniB-5b5hA:
undetectable
1oniC-5b5hA:
undetectable		 1oniB-5b5hA:
23.70
1oniC-5b5hA:
23.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Z9H_D_IMND476_1
(MEMBRANE-ASSOCIATED
PROSTAGLANDIN E
SYNTHASE-2)		 5b5h ANTIFREEZE PROTEIN
(Typhula
ishikariensis) 		5 / 12 ILE A  16
VAL A 220
ILE A 189
VAL A 213
LEU A 197
 None
 1.12A 1z9hD-5b5hA:
undetectable		 1z9hD-5b5hA:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FT9_A_CHDA131_0
(FATTY ACID-BINDING
PROTEIN 2, LIVER)		 5b5h ANTIFREEZE PROTEIN
(Typhula
ishikariensis) 		5 / 11 TYR A  14
LEU A  17
ILE A  79
THR A  76
PRO A  75
 None
 1.33A 2ft9A-5b5hA:
undetectable		 2ft9A-5b5hA:
20.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HS1_B_017B203_1
(HIV-1 PROTEASE)		 5b5h ANTIFREEZE PROTEIN
(Typhula
ishikariensis) 		4 / 7 GLU A 186
TRP A 142
LYS A 167
GLY A 187
 None
 1.29A 2hs1B-5b5hA:
undetectable		 2hs1B-5b5hA:
20.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OGP_A_017A200_2
(FIV PROTEASE)		 5b5h ANTIFREEZE PROTEIN
(Typhula
ishikariensis) 		5 / 10 VAL A 177
GLY A 187
ILE A 169
VAL A 126
LEU A 150
 None
 1.33A 3ogpB-5b5hA:
undetectable		 3ogpB-5b5hA:
18.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WG7_G_CHDG103_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 2
CYTOCHROME C OXIDASE
SUBUNIT 6A2,
MITOCHONDRIAL)		 5b5h ANTIFREEZE PROTEIN
(Typhula
ishikariensis) 		5 / 10 ARG A  97
GLY A 118
TRP A 142
THR A 139
THR A 137
 None
 1.42A 3wg7G-5b5hA:
undetectable
3wg7N-5b5hA:
undetectable
3wg7O-5b5hA:
undetectable		 3wg7G-5b5hA:
12.56
3wg7N-5b5hA:
21.27
3wg7O-5b5hA:
23.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MMD_B_29EB603_1
(TRANSPORTER)		 5b5h ANTIFREEZE PROTEIN
(Typhula
ishikariensis) 		5 / 12 VAL A 173
ALA A 174
GLY A 127
SER A 124
GLY A 148
 None
 1.18A 4mmdB-5b5hA:
undetectable		 4mmdB-5b5hA:
20.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AMH_A_EF2A151_1
(CEREBLON ISOFORM 4)		 5b5h ANTIFREEZE PROTEIN
(Typhula
ishikariensis) 		4 / 7 ASN A 101
PRO A 100
TRP A 122
TYR A 106
 None
 1.36A 5amhA-5b5hA:
undetectable		 5amhA-5b5hA:
20.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5W97_B_CHDB301_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 2
CYTOCHROME C OXIDASE
SUBUNIT 6A2,
MITOCHONDRIAL)		 5b5h ANTIFREEZE PROTEIN
(Typhula
ishikariensis) 		5 / 11 ARG A  97
GLY A 118
TRP A 142
THR A 139
THR A 137
 None
 1.34A 5w97G-5b5hA:
undetectable
5w97a-5b5hA:
undetectable
5w97b-5b5hA:
undetectable		 5w97G-5b5hA:
12.56
5w97a-5b5hA:
21.27
5w97b-5b5hA:
23.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5W97_B_CHDB303_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 2
CYTOCHROME C OXIDASE
SUBUNIT 6A2,
MITOCHONDRIAL)		 5b5h ANTIFREEZE PROTEIN
(Typhula
ishikariensis) 		5 / 11 TRP A 142
THR A 139
THR A 137
ARG A  97
GLY A 118
 None
 1.32A 5w97A-5b5hA:
undetectable
5w97B-5b5hA:
undetectable
5w97g-5b5hA:
undetectable		 5w97A-5b5hA:
21.27
5w97B-5b5hA:
23.11
5w97g-5b5hA:
12.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WAU_G_CHDG103_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 2
CYTOCHROME C OXIDASE
SUBUNIT 6A2,
MITOCHONDRIAL)		 5b5h ANTIFREEZE PROTEIN
(Typhula
ishikariensis) 		5 / 10 ARG A  97
GLY A 118
TRP A 142
THR A 139
THR A 137
 None
 1.37A 5wauG-5b5hA:
undetectable
5waua-5b5hA:
undetectable
5waub-5b5hA:
undetectable		 5wauG-5b5hA:
12.56
5waua-5b5hA:
21.27
5waub-5b5hA:
23.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XDQ_G_CHDG102_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 2
CYTOCHROME C OXIDASE
SUBUNIT 6A2,
MITOCHONDRIAL)		 5b5h ANTIFREEZE PROTEIN
(Typhula
ishikariensis) 		5 / 10 ARG A  97
GLY A 118
TRP A 142
THR A 139
THR A 137
 None
 1.40A 5xdqG-5b5hA:
undetectable
5xdqN-5b5hA:
undetectable
5xdqO-5b5hA:
undetectable		 5xdqG-5b5hA:
12.56
5xdqN-5b5hA:
21.27
5xdqO-5b5hA:
23.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z86_B_CHDB302_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 2
CYTOCHROME C OXIDASE
SUBUNIT 6A2,
MITOCHONDRIAL)		 5b5h ANTIFREEZE PROTEIN
(Typhula
ishikariensis) 		5 / 11 TRP A 142
THR A 139
THR A 137
ARG A  97
GLY A 118
 None
 1.42A 5z86A-5b5hA:
undetectable
5z86B-5b5hA:
undetectable
5z86T-5b5hA:
undetectable		 5z86A-5b5hA:
21.27
5z86B-5b5hA:
23.11
5z86T-5b5hA:
12.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z86_G_CHDG103_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 2
CYTOCHROME C OXIDASE
SUBUNIT 6A2,
MITOCHONDRIAL)		 5b5h ANTIFREEZE PROTEIN
(Typhula
ishikariensis) 		5 / 10 ARG A  97
GLY A 118
TRP A 142
THR A 139
THR A 137
 None
 1.42A 5z86G-5b5hA:
undetectable
5z86N-5b5hA:
undetectable
5z86O-5b5hA:
undetectable		 5z86G-5b5hA:
12.56
5z86N-5b5hA:
21.27
5z86O-5b5hA:
23.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZCO_G_CHDG102_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 2
CYTOCHROME C OXIDASE
SUBUNIT 6A2,
MITOCHONDRIAL)		 5b5h ANTIFREEZE PROTEIN
(Typhula
ishikariensis) 		5 / 10 ARG A  97
GLY A 118
TRP A 142
THR A 139
THR A 137
 None
 1.42A 5zcoG-5b5hA:
undetectable
5zcoN-5b5hA:
undetectable
5zcoO-5b5hA:
undetectable		 5zcoG-5b5hA:
12.56
5zcoN-5b5hA:
21.27
5zcoO-5b5hA:
23.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZCP_B_CHDB301_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 2
CYTOCHROME C OXIDASE
SUBUNIT 6A2,
MITOCHONDRIAL)		 5b5h ANTIFREEZE PROTEIN
(Typhula
ishikariensis) 		5 / 11 TRP A 142
THR A 139
THR A 137
ARG A  97
GLY A 118
 None
 1.42A 5zcpA-5b5hA:
undetectable
5zcpB-5b5hA:
undetectable
5zcpT-5b5hA:
undetectable		 5zcpA-5b5hA:
21.27
5zcpB-5b5hA:
23.11
5zcpT-5b5hA:
12.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6C2M_C_SUEC1203_0
(NS3 PROTEASE)		 5b5h ANTIFREEZE PROTEIN
(Typhula
ishikariensis) 		5 / 12 GLY A 127
SER A 129
ALA A 154
ALA A 183
SER A 201
 None
NA  A1003 (-4.2A)
None
None
None
 0.97A 6c2mC-5b5hA:
undetectable		 6c2mC-5b5hA:
18.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NMF_B_CHDB303_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 2
CYTOCHROME C OXIDASE
SUBUNIT 6A2,
MITOCHONDRIAL)		 5b5h ANTIFREEZE PROTEIN
(Typhula
ishikariensis) 		5 / 9 TRP A 142
THR A 139
THR A 137
ARG A  97
GLY A 118
 None
 1.34A 6nmfA-5b5hA:
undetectable
6nmfB-5b5hA:
0.0
6nmfT-5b5hA:
0.0		 6nmfA-5b5hA:
21.27
6nmfB-5b5hA:
23.11
6nmfT-5b5hA:
12.56