SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5b5k'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HK3_A_T44A3004_1
(SERUM ALBUMIN)		 5b5k IZUMO SPERM-EGG
FUSION PROTEIN 1
(Mus
musculus) 		4 / 7 LEU A  41
VAL A  53
MET A  54
LEU A 112
 None
 0.90A 1hk3A-5b5kA:
1.4		 1hk3A-5b5kA:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AG2_W_CHDW1059_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 1)		 5b5k IZUMO SPERM-EGG
FUSION PROTEIN 1
(Mus
musculus) 		4 / 7 ILE A  97
LEU A 111
PHE A 107
THR A  39
 None
 1.05A 3ag2N-5b5kA:
2.3
3ag2W-5b5kA:
undetectable		 3ag2N-5b5kA:
17.82
3ag2W-5b5kA:
16.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AG4_W_CHDW1059_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 1)		 5b5k IZUMO SPERM-EGG
FUSION PROTEIN 1
(Mus
musculus) 		4 / 7 ILE A  97
LEU A 111
PHE A 107
THR A  35
 None
 1.06A 3ag4N-5b5kA:
2.4
3ag4W-5b5kA:
undetectable		 3ag4N-5b5kA:
17.82
3ag4W-5b5kA:
16.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AG4_W_CHDW1059_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 1)		 5b5k IZUMO SPERM-EGG
FUSION PROTEIN 1
(Mus
musculus) 		4 / 7 ILE A  97
LEU A 111
PHE A 107
THR A  39
 None
 1.05A 3ag4N-5b5kA:
2.4
3ag4W-5b5kA:
undetectable		 3ag4N-5b5kA:
17.82
3ag4W-5b5kA:
16.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AQL_A_TXCA1452_2
(GUANINE DEAMINASE)		 5b5k IZUMO SPERM-EGG
FUSION PROTEIN 1
(Mus
musculus) 		4 / 5 HIS A  44
LEU A  33
LEU A  91
ASP A  31
 None
None
EPE  A 302 ( 2.4A)
None
 1.08A 4aqlA-5b5kA:
undetectable		 4aqlA-5b5kA:
20.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JHD_J_EDTJ301_0
(TCRBETA CHAIN)		 5b5k IZUMO SPERM-EGG
FUSION PROTEIN 1
(Mus
musculus) 		4 / 5 LYS A 220
GLU A 226
GLY A 224
SER A 175
 None
 1.10A 5jhdJ-5b5kA:
7.7		 5jhdJ-5b5kA:
23.32