SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5b5r'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A8U_A_BEZA295_0
(CHLOROPEROXIDASE T)		 5b5r GASDERMIN-A3
(Mus
musculus) 		5 / 10 GLY A 415
SER A 417
LEU A 441
THR A 353
LEU A 352
 None
 1.25A 1a8uA-5b5rA:
undetectable		 1a8uA-5b5rA:
20.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A8U_A_BEZA295_0
(CHLOROPEROXIDASE T)		 5b5r GASDERMIN-A3
(Mus
musculus) 		5 / 10 GLY A 418
SER A 417
LEU A 441
THR A 353
LEU A 352
 None
 1.24A 1a8uA-5b5rA:
undetectable		 1a8uA-5b5rA:
20.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A8U_B_BEZB294_0
(CHLOROPEROXIDASE T)		 5b5r GASDERMIN-A3
(Mus
musculus) 		5 / 10 GLY A 415
SER A 417
LEU A 441
THR A 353
LEU A 352
 None
 1.31A 1a8uB-5b5rA:
undetectable		 1a8uB-5b5rA:
20.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A8U_B_BEZB294_0
(CHLOROPEROXIDASE T)		 5b5r GASDERMIN-A3
(Mus
musculus) 		5 / 10 GLY A 418
SER A 417
LEU A 441
THR A 353
LEU A 352
 None
 1.25A 1a8uB-5b5rA:
undetectable		 1a8uB-5b5rA:
20.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1CMC_B_SAMB105_0
(MET REPRESSOR)		 5b5r GASDERMIN-A3
(Mus
musculus) 		5 / 10 GLU A 404
ARG A 423
GLU A 406
LEU A 409
GLY A 185
 None
 1.38A 1cmcA-5b5rA:
undetectable
1cmcB-5b5rA:
undetectable		 1cmcA-5b5rA:
12.50
1cmcB-5b5rA:
12.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E7A_B_PFLB4002_1
(SERUM ALBUMIN)		 5b5r GASDERMIN-A3
(Mus
musculus) 		4 / 6 LEU A  15
VAL A  93
VAL A  89
GLN A 116
 None
 1.12A 1e7aB-5b5rA:
0.7		 1e7aB-5b5rA:
21.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E7C_A_HLTA4007_1
(SERUM ALBUMIN)		 5b5r GASDERMIN-A3
(Mus
musculus) 		4 / 8 LEU A 141
HIS A 138
LEU A  64
LEU A  63
 None
 1.08A 1e7cA-5b5rA:
2.1		 1e7cA-5b5rA:
21.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ETA_1_T441128_1
(TRANSTHYRETIN)		 5b5r GASDERMIN-A3
(Mus
musculus) 		4 / 5 LEU A 447
GLU A 277
ALA A 443
LEU A 448
 None
 1.05A 1eta1-5b5rA:
undetectable		 1eta1-5b5rA:
13.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ETA_2_T442129_1
(TRANSTHYRETIN)		 5b5r GASDERMIN-A3
(Mus
musculus) 		4 / 5 LEU A 447
GLU A 277
ALA A 443
LEU A 448
 None
 1.08A 1eta2-5b5rA:
undetectable		 1eta2-5b5rA:
13.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ETB_1_T441128_1
(TRANSTHYRETIN)		 5b5r GASDERMIN-A3
(Mus
musculus) 		4 / 6 LEU A 447
GLU A 277
ALA A 443
LEU A 448
 None
 1.05A 1etb1-5b5rA:
undetectable		 1etb1-5b5rA:
12.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PBF_A_BHAA396_0
(P-HYDROXYBENZOATE
HYDROXYLASE)		 5b5r GASDERMIN-A3
(Mus
musculus) 		5 / 9 VAL A 120
TRP A 219
LEU A  60
ARG A 209
ALA A 124
 None
 1.48A 1pbfA-5b5rA:
undetectable		 1pbfA-5b5rA:
21.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V8B_C_ADNC2502_2
(ADENOSYLHOMOCYSTEINA
SE)		 5b5r GASDERMIN-A3
(Mus
musculus) 		3 / 3 GLU A 354
THR A 353
LEU A 181
 None
 0.57A 1v8bC-5b5rA:
undetectable		 1v8bC-5b5rA:
22.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AB2_A_SNLA502_2
(MINERALOCORTICOID
RECEPTOR)		 5b5r GASDERMIN-A3
(Mus
musculus) 		4 / 6 LEU A 352
LEU A 349
LEU A 445
LEU A 438
 None
 1.01A 2ab2A-5b5rA:
undetectable		 2ab2A-5b5rA:
22.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AB2_B_SNLB503_2
(MINERALOCORTICOID
RECEPTOR)		 5b5r GASDERMIN-A3
(Mus
musculus) 		4 / 5 LEU A 438
LEU A 441
LEU A 373
LEU A 375
 None
 0.97A 2ab2B-5b5rA:
2.7		 2ab2B-5b5rA:
22.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VCV_E_ASDE1224_1
(GLUTATHIONE
S-TRANSFERASE A3)		 5b5r GASDERMIN-A3
(Mus
musculus) 		5 / 9 LEU A 296
PRO A 329
LEU A 328
LEU A 334
ALA A 338
 None
 1.26A 2vcvE-5b5rA:
undetectable		 2vcvE-5b5rA:
18.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VCV_I_ASDI1224_1
(GLUTATHIONE
S-TRANSFERASE A3)		 5b5r GASDERMIN-A3
(Mus
musculus) 		5 / 9 LEU A 296
PRO A 329
LEU A 328
LEU A 334
ALA A 338
 None
 1.19A 2vcvI-5b5rA:
undetectable		 2vcvI-5b5rA:
18.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XN3_A_ID8A1356_1
(THYROXINE-BINDING
GLOBULIN)		 5b5r GASDERMIN-A3
(Mus
musculus) 		4 / 8 GLN A 356
LEU A 352
LEU A 448
LEU A 413
 None
 1.01A 2xn3A-5b5rA:
undetectable
2xn3B-5b5rA:
undetectable		 2xn3A-5b5rA:
21.77
2xn3B-5b5rA:
7.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZUL_A_SAMA376_1
(PROBABLE RIBOSOMAL
RNA SMALL SUBUNIT
METHYLTRANSFERASE)		 5b5r GASDERMIN-A3
(Mus
musculus) 		3 / 3 SER A 110
GLU A  14
ASP A 387
 None
 0.79A 2zulA-5b5rA:
undetectable		 2zulA-5b5rA:
25.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DMH_A_SAMA384_1
(PROBABLE RIBOSOMAL
RNA SMALL SUBUNIT
METHYLTRANSFERASE)		 5b5r GASDERMIN-A3
(Mus
musculus) 		3 / 3 SER A 110
GLU A  14
ASP A 387
 None
 0.81A 3dmhA-5b5rA:
undetectable		 3dmhA-5b5rA:
24.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NXU_B_RITB600_2
(CYTOCHROME P450 3A4)		 5b5r GASDERMIN-A3
(Mus
musculus) 		5 / 9 LEU A  61
PHE A  36
THR A  56
ARG A 209
LEU A 210
 None
 1.48A 3nxuB-5b5rA:
undetectable		 3nxuB-5b5rA:
22.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RD0_A_EDPA175_1
(FERRITIN LIGHT CHAIN)		 5b5r GASDERMIN-A3
(Mus
musculus) 		4 / 6 LEU A 438
TYR A 442
ALA A 348
LEU A 380
 None
 1.10A 3rd0A-5b5rA:
undetectable		 3rd0A-5b5rA:
18.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PBH_A_BEZA401_0
(TRAP DICARBOXYLATE
TRANSPORTER, DCTP
SUBUNIT, PUTATIVE)		 5b5r GASDERMIN-A3
(Mus
musculus) 		5 / 12 THR A 231
ARG A 145
LEU A  63
LEU A 134
PHE A 232
 None
 1.43A 4pbhA-5b5rA:
undetectable		 4pbhA-5b5rA:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WG0_B_CHDB102_0
(NUCLEAR RECEPTOR
COACTIVATOR 2)		 5b5r GASDERMIN-A3
(Mus
musculus) 		5 / 11 LEU A 352
LEU A 441
LEU A 360
ALA A 412
LEU A 413
 None
 1.12A 4wg0B-5b5rA:
undetectable
4wg0C-5b5rA:
undetectable
4wg0D-5b5rA:
undetectable		 4wg0B-5b5rA:
3.51
4wg0C-5b5rA:
3.51
4wg0D-5b5rA:
3.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WG0_D_CHDD102_0
(NUCLEAR RECEPTOR
COACTIVATOR 2)		 5b5r GASDERMIN-A3
(Mus
musculus) 		5 / 11 LEU A 352
LEU A 441
LEU A 360
ALA A 412
LEU A 413
 None
 1.12A 4wg0D-5b5rA:
undetectable
4wg0E-5b5rA:
undetectable
4wg0F-5b5rA:
undetectable		 4wg0D-5b5rA:
3.51
4wg0E-5b5rA:
3.51
4wg0F-5b5rA:
3.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WG0_F_CHDF103_0
(NUCLEAR RECEPTOR
COACTIVATOR 2)		 5b5r GASDERMIN-A3
(Mus
musculus) 		5 / 11 LEU A 352
LEU A 441
LEU A 360
ALA A 412
LEU A 413
 None
 1.13A 4wg0F-5b5rA:
undetectable
4wg0G-5b5rA:
undetectable
4wg0H-5b5rA:
undetectable		 4wg0F-5b5rA:
3.51
4wg0G-5b5rA:
3.51
4wg0H-5b5rA:
3.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WG0_H_CHDH103_0
(NUCLEAR RECEPTOR
COACTIVATOR 2)		 5b5r GASDERMIN-A3
(Mus
musculus) 		5 / 11 LEU A 352
LEU A 441
LEU A 360
ALA A 412
LEU A 413
 None
 1.15A 4wg0H-5b5rA:
undetectable
4wg0I-5b5rA:
undetectable
4wg0J-5b5rA:
undetectable		 4wg0H-5b5rA:
3.51
4wg0I-5b5rA:
3.51
4wg0J-5b5rA:
3.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WG0_I_CHDI103_0
(NUCLEAR RECEPTOR
COACTIVATOR 2)		 5b5r GASDERMIN-A3
(Mus
musculus) 		5 / 11 ALA A 412
LEU A 413
LEU A 360
LEU A 352
LEU A 441
 None
 1.13A 4wg0G-5b5rA:
undetectable
4wg0H-5b5rA:
undetectable
4wg0I-5b5rA:
undetectable		 4wg0G-5b5rA:
3.51
4wg0H-5b5rA:
3.51
4wg0I-5b5rA:
3.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WG0_J_CHDJ103_0
(NUCLEAR RECEPTOR
COACTIVATOR 2)		 5b5r GASDERMIN-A3
(Mus
musculus) 		5 / 11 LEU A 352
LEU A 441
LEU A 360
ALA A 412
LEU A 413
 None
 1.15A 4wg0J-5b5rA:
undetectable
4wg0K-5b5rA:
undetectable
4wg0L-5b5rA:
undetectable		 4wg0J-5b5rA:
3.51
4wg0K-5b5rA:
3.51
4wg0L-5b5rA:
3.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WG0_K_CHDK103_0
(NUCLEAR RECEPTOR
COACTIVATOR 2)		 5b5r GASDERMIN-A3
(Mus
musculus) 		5 / 11 ALA A 412
LEU A 413
LEU A 360
LEU A 352
LEU A 441
 None
 1.14A 4wg0I-5b5rA:
undetectable
4wg0J-5b5rA:
undetectable
4wg0K-5b5rA:
undetectable		 4wg0I-5b5rA:
3.51
4wg0J-5b5rA:
3.51
4wg0K-5b5rA:
3.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WG0_M_CHDM103_0
(NUCLEAR RECEPTOR
COACTIVATOR 2)		 5b5r GASDERMIN-A3
(Mus
musculus) 		5 / 11 ALA A 412
LEU A 413
LEU A 360
LEU A 352
LEU A 441
 None
 1.13A 4wg0K-5b5rA:
undetectable
4wg0L-5b5rA:
undetectable
4wg0M-5b5rA:
undetectable		 4wg0K-5b5rA:
3.51
4wg0L-5b5rA:
3.51
4wg0M-5b5rA:
3.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z4I_A_IPHA903_0
(PROTEIN ARGONAUTE-2)		 5b5r GASDERMIN-A3
(Mus
musculus) 		3 / 3 VAL A  54
ALA A  51
PHE A  33
 None
 0.75A 4z4iA-5b5rA:
undetectable		 4z4iA-5b5rA:
21.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JH7_B_6K9B503_0
(TUBULIN BETA-2B
CHAIN)		 5b5r GASDERMIN-A3
(Mus
musculus) 		5 / 11 VAL A 120
SER A 119
THR A 117
GLU A 156
LEU A 125
 None
 1.35A 5jh7B-5b5rA:
undetectable		 5jh7B-5b5rA:
20.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JS1_A_IPHA902_0
(PROTEIN ARGONAUTE-2)		 5b5r GASDERMIN-A3
(Mus
musculus) 		3 / 3 VAL A  54
ALA A  51
PHE A  33
 None
 0.77A 5js1A-5b5rA:
undetectable		 5js1A-5b5rA:
20.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KGP_A_GCSA407_1
(PREDICTED
ACETYLTRANSFERASE)		 5b5r GASDERMIN-A3
(Mus
musculus) 		4 / 8 GLU A 310
PRO A   0
GLY A  50
ASP A  25
 None
 1.14A 5kgpA-5b5rA:
undetectable		 5kgpA-5b5rA:
20.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5O96_A_SAMA501_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE E)		 5b5r GASDERMIN-A3
(Mus
musculus) 		5 / 11 LEU A 399
GLU A 405
GLY A 403
LEU A 375
THR A 408
 None
 1.04A 5o96A-5b5rA:
undetectable
5o96B-5b5rA:
undetectable		 5o96A-5b5rA:
20.74
5o96B-5b5rA:
20.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TE8_A_08JA602_1
(CYTOCHROME P450 3A4)		 5b5r GASDERMIN-A3
(Mus
musculus) 		4 / 7 SER A 378
LEU A 398
ILE A 368
LEU A 402
 None
 0.98A 5te8A-5b5rA:
undetectable		 5te8A-5b5rA:
22.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B89_A_NOVA403_1
(LIPOPOLYSACCHARIDE
EXPORT SYSTEM
ATP-BINDING PROTEIN
LPTB)		 5b5r GASDERMIN-A3
(Mus
musculus) 		5 / 10 LEU A 352
ALA A 440
GLU A 365
SER A 363
VAL A 376
 None
 1.46A 6b89A-5b5rA:
undetectable		 6b89A-5b5rA:
9.93