SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5b5s'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3C6G_B_VD3B700_1
(CYTOCHROME P450 2R1)		 5b5s ACETIC ACID
(Talaromyces
cellulolyticus) 		5 / 12 LEU A 176
ASN A 173
ALA A 169
GLY A 187
THR A  91
 None
 1.14A 3c6gB-5b5sA:
undetectable		 3c6gB-5b5sA:
18.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CL9_A_MTXA602_2
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE (DHFR-TS))		 5b5s ACETIC ACID
(Talaromyces
cellulolyticus) 		4 / 4 VAL A  34
ARG A  18
ILE A 125
THR A  26
 None
 1.32A 3cl9A-5b5sA:
undetectable		 3cl9A-5b5sA:
16.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E7C_D_ACTD504_0
(UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE)		 5b5s ACETIC ACID
(Talaromyces
cellulolyticus) 		3 / 3 GLY A 180
SER A 133
TRP A 134
 None
 0.93A 4e7cD-5b5sA:
undetectable		 4e7cD-5b5sA:
18.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J7U_D_YTZD802_1
(SEPIAPTERIN
REDUCTASE)		 5b5s ACETIC ACID
(Talaromyces
cellulolyticus) 		4 / 8 CYH A 165
PHE A 190
PRO A 197
GLN A  24
 None
 1.01A 4j7uD-5b5sA:
2.4		 4j7uD-5b5sA:
20.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QGI_A_ROCA101_1
(PROTEASE)		 5b5s ACETIC ACID
(Talaromyces
cellulolyticus) 		6 / 11 ASP A  93
GLY A  90
ALA A  65
ILE A 110
THR A 109
GLY A 106
 None
 1.46A 4qgiA-5b5sA:
undetectable		 4qgiA-5b5sA:
20.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E4D_A_BEZA201_0
(HYDROXYNITRILE LYASE)		 5b5s ACETIC ACID
(Talaromyces
cellulolyticus) 		5 / 9 VAL A 124
VAL A  85
ILE A  73
TRP A 149
LEU A 112
 None
 1.26A 5e4dA-5b5sA:
undetectable		 5e4dA-5b5sA:
18.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JGL_A_SAMA301_1
(UBIE/COQ5 FAMILY
METHYLTRANSFERASE,
PUTATIVE)		 5b5s ACETIC ACID
(Talaromyces
cellulolyticus) 		3 / 3 GLY A   8
ASP A   9
ASN A  95
 None
 0.56A 5jglA-5b5sA:
5.2		 5jglA-5b5sA:
20.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M24_A_9CRA501_1
(RETINOIC ACID
RECEPTOR GAMMA)		 5b5s ACETIC ACID
(Talaromyces
cellulolyticus) 		5 / 12 ALA A 163
ILE A 130
GLY A   8
LEU A   6
ILE A 125
 None
 1.05A 5m24A-5b5sA:
undetectable		 5m24A-5b5sA:
19.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X2T_I_PEMI202_1
(HEMOGLOBIN SUBUNIT
ALPHA
HEMOGLOBIN SUBUNIT
BETA)		 5b5s ACETIC ACID
(Talaromyces
cellulolyticus) 		4 / 8 PRO A 183
THR A  12
THR A  15
ALA A 192
 None
 0.90A 5x2tI-5b5sA:
undetectable
5x2tJ-5b5sA:
undetectable
5x2tK-5b5sA:
undetectable
5x2tL-5b5sA:
undetectable		 5x2tI-5b5sA:
23.46
5x2tJ-5b5sA:
18.45
5x2tK-5b5sA:
23.46
5x2tL-5b5sA:
18.45