SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5b5u'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HRK_A_CHDA1502_0
(FERROCHELATASE)		 5b5u L-ASPARAGINASE
(Pyrococcus
furiosus) 		4 / 8 LEU B 280
VAL B 268
GLY B 288
MET B 290
 None
 0.81A 1hrkA-5b5uB:
undetectable		 1hrkA-5b5uB:
19.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HRK_B_CHDB2502_0
(FERROCHELATASE)		 5b5u L-ASPARAGINASE
(Pyrococcus
furiosus) 		4 / 8 LEU B 280
VAL B 268
GLY B 288
MET B 290
 None
 0.83A 1hrkB-5b5uB:
undetectable		 1hrkB-5b5uB:
19.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RB3_A_MTXA161_1
(DIHYDROFOLATE
REDUCTASE)		 5b5u L-ASPARAGINASE
(Pyrococcus
furiosus) 		5 / 10 ILE B 255
ALA B 201
LEU B 222
ILE B 215
ILE B 227
 None
CL  B 401 ( 4.3A)
None
None
None
 1.23A 1rb3A-5b5uB:
undetectable		 1rb3A-5b5uB:
22.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OIQ_A_STIA1001_2
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 5b5u L-ASPARAGINASE
(Pyrococcus
furiosus) 		4 / 5 LEU A   5
VAL A 150
LEU A 148
ARG A  98
 None
 1.04A 2oiqA-5b5uA:
undetectable		 2oiqA-5b5uA:
19.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PO5_A_CHDA502_0
(FERROCHELATASE,
MITOCHONDRIAL)		 5b5u L-ASPARAGINASE
(Pyrococcus
furiosus) 		4 / 8 LEU B 280
VAL B 268
GLY B 288
MET B 290
 None
 0.90A 2po5A-5b5uB:
undetectable		 2po5A-5b5uB:
19.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VN0_A_TDZA501_1
(CYTOCHROME P450 2C8)		 5b5u L-ASPARAGINASE
(Pyrococcus
furiosus) 		5 / 12 ILE A  93
THR A  89
ASN A  70
VAL A 138
VAL A  79
 None
 1.13A 2vn0A-5b5uA:
undetectable		 2vn0A-5b5uA:
18.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XKW_A_P1BA1478_2
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 5b5u L-ASPARAGINASE
(Pyrococcus
furiosus) 		4 / 7 GLU A 116
ILE A  33
ALA A 127
ILE A  78
 None
 0.71A 2xkwA-5b5uA:
undetectable		 2xkwA-5b5uA:
20.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YGP_A_PCFA1213_0
(WNT INHIBITORY
FACTOR 1)		 5b5u L-ASPARAGINASE
(Pyrococcus
furiosus) 		6 / 12 LEU B 324
ILE B 302
MET B 290
VAL B 228
VAL B 202
PRO B 256
 None
 1.29A 2ygpA-5b5uB:
undetectable		 2ygpA-5b5uB:
19.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BF1_B_PAUB248_0
(TYPE III
PANTOTHENATE KINASE)		 5b5u L-ASPARAGINASE
L-ASPARAGINASE
(Pyrococcus
furiosus;
Pyrococcus
furiosus) 		5 / 12 THR B 291
VAL A 140
VAL A 150
GLY A 149
ILE A 166
 None
 1.23A 3bf1A-5b5uB:
undetectable
3bf1B-5b5uB:
undetectable		 3bf1A-5b5uB:
20.48
3bf1B-5b5uB:
20.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CV9_A_VDXA501_1
(CYTOCHROME P450-SU1)		 5b5u L-ASPARAGINASE
(Pyrococcus
furiosus) 		5 / 9 THR A  80
VAL A 140
SER A 165
ILE A  12
GLY A  82
 None
None
GOL  A 207 (-4.6A)
None
ASP  A 201 (-3.1A)
 1.17A 3cv9A-5b5uA:
undetectable		 3cv9A-5b5uA:
16.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JX1_B_CAMB502_0
(CAMPHOR
5-MONOOXYGENASE)		 5b5u L-ASPARAGINASE
(Pyrococcus
furiosus) 		6 / 10 PHE B 216
GLY B 231
THR B 260
VAL B 204
ILE B 227
VAL B 228
 None
 1.43A 4jx1B-5b5uB:
undetectable		 4jx1B-5b5uB:
14.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RN6_A_15UA301_1
(THROMBIN HEAVY CHAIN)		 5b5u L-ASPARAGINASE
(Pyrococcus
furiosus) 		5 / 10 LEU B 244
LEU B 270
ALA B 234
ALA B 279
GLY B 231
 None
 1.47A 4rn6A-5b5uB:
undetectable		 4rn6A-5b5uB:
16.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YPM_A_BO2A801_1
(LON PROTEASE)		 5b5u L-ASPARAGINASE
(Pyrococcus
furiosus) 		5 / 12 ALA B 294
THR B 295
GLY A 149
SER A  90
ALA A  87
 None
 1.11A 4ypmA-5b5uB:
undetectable		 4ypmA-5b5uB:
23.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HS6_A_J3ZA302_1
(17-BETA-HYDROXYSTERO
ID DEHYDROGENASE 14)		 5b5u L-ASPARAGINASE
(Pyrococcus
furiosus) 		4 / 8 HIS A  81
LEU A  63
TRP A  60
THR B 297
 None
 1.16A 5hs6A-5b5uA:
3.9		 5hs6A-5b5uA:
21.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KQR_A_SAMA301_0
(METHYLTRANSFERASE)		 5b5u L-ASPARAGINASE
(Pyrococcus
furiosus) 		5 / 12 GLY B 288
GLY B 231
GLY B 235
GLY B 267
ILE B 229
 None
 0.96A 5kqrA-5b5uB:
undetectable		 5kqrA-5b5uB:
18.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5W4Z_A_RBFA502_2
(RIBOFLAVIN LYASE)		 5b5u L-ASPARAGINASE
(Pyrococcus
furiosus) 		4 / 5 ASN A 143
ASP A 161
SER A 159
ARG A 156
 None
 1.36A 5w4zA-5b5uA:
undetectable		 5w4zA-5b5uA:
18.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6IEY_A_CLMA401_0
(ESTERASE)		 5b5u L-ASPARAGINASE
(Pyrococcus
furiosus) 		5 / 11 ASP A  84
HIS A  81
GLY A  82
PHE A 163
ALA A 162
 ASP  A 201 (-3.4A)
None
ASP  A 201 (-3.1A)
None
None
 1.32A 6ieyA-5b5uA:
3.7
6ieyB-5b5uA:
3.8		 6ieyA-5b5uA:
23.40
6ieyB-5b5uA:
23.40