SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5b5x'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EKJ_A_ACTA3001_0
(BETA-CARBONIC
ANHYDRASE)		 5b5x LIMITING
CO2-INDUCIBLE
PROTEIN LCIC
(Chlamydomonas
reinhardtii) 		5 / 8 CYH A 119
ASP A 121
HIS A 179
CYH A 203
GLY A 204
 ZN  A 500 (-2.2A)
ZN  A 500 ( 4.9A)
ZN  A 500 (-3.2A)
ZN  A 500 (-2.5A)
None
 0.36A 1ekjA-5b5xA:
9.9
1ekjB-5b5xA:
10.3		 1ekjA-5b5xA:
21.59
1ekjB-5b5xA:
21.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EKJ_A_ACTA3001_0
(BETA-CARBONIC
ANHYDRASE)		 5b5x LIMITING
CO2-INDUCIBLE
PROTEIN LCIC
(Chlamydomonas
reinhardtii) 		5 / 8 CYH A 119
ASP A 121
HIS A 179
CYH A 203
GLY A 204
 ZN  A 500 (-2.2A)
ZN  A 500 ( 4.9A)
ZN  A 500 (-3.2A)
ZN  A 500 (-2.5A)
None
 1.10A 1ekjA-5b5xA:
9.9
1ekjB-5b5xA:
10.3		 1ekjA-5b5xA:
21.59
1ekjB-5b5xA:
21.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EKJ_A_ACTA3003_0
(BETA-CARBONIC
ANHYDRASE)		 5b5x LIMITING
CO2-INDUCIBLE
PROTEIN LCIC
(Chlamydomonas
reinhardtii) 		5 / 8 CYH A 119
ASP A 121
HIS A 179
CYH A 203
GLY A 204
 ZN  A 500 (-2.2A)
ZN  A 500 ( 4.9A)
ZN  A 500 (-3.2A)
ZN  A 500 (-2.5A)
None
 0.40A 1ekjA-5b5xA:
10.0
1ekjB-5b5xA:
10.3		 1ekjA-5b5xA:
21.59
1ekjB-5b5xA:
21.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EKJ_E_ACTE3005_0
(BETA-CARBONIC
ANHYDRASE)		 5b5x LIMITING
CO2-INDUCIBLE
PROTEIN LCIC
(Chlamydomonas
reinhardtii) 		4 / 7 CYH A 119
ASP A 121
HIS A 179
GLY A 204
 ZN  A 500 (-2.2A)
ZN  A 500 ( 4.9A)
ZN  A 500 (-3.2A)
None
 0.34A 1ekjE-5b5xA:
10.9
1ekjF-5b5xA:
10.8		 1ekjE-5b5xA:
21.59
1ekjF-5b5xA:
21.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EKJ_E_ACTE3005_0
(BETA-CARBONIC
ANHYDRASE)		 5b5x LIMITING
CO2-INDUCIBLE
PROTEIN LCIC
(Chlamydomonas
reinhardtii) 		4 / 7 CYH A 119
ASP A 121
HIS A 179
GLY A 204
 ZN  A 500 (-2.2A)
ZN  A 500 ( 4.9A)
ZN  A 500 (-3.2A)
None
 0.99A 1ekjE-5b5xA:
10.9
1ekjF-5b5xA:
10.8		 1ekjE-5b5xA:
21.59
1ekjF-5b5xA:
21.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EKJ_G_ACTG3002_0
(BETA-CARBONIC
ANHYDRASE)		 5b5x LIMITING
CO2-INDUCIBLE
PROTEIN LCIC
(Chlamydomonas
reinhardtii) 		5 / 8 CYH A 119
ASP A 121
HIS A 179
CYH A 203
GLY A 204
 ZN  A 500 (-2.2A)
ZN  A 500 ( 4.9A)
ZN  A 500 (-3.2A)
ZN  A 500 (-2.5A)
None
 0.38A 1ekjG-5b5xA:
11.0
1ekjH-5b5xA:
9.9		 1ekjG-5b5xA:
21.59
1ekjH-5b5xA:
21.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EKJ_G_ACTG3002_0
(BETA-CARBONIC
ANHYDRASE)		 5b5x LIMITING
CO2-INDUCIBLE
PROTEIN LCIC
(Chlamydomonas
reinhardtii) 		5 / 8 CYH A 119
ASP A 121
HIS A 179
CYH A 203
GLY A 204
 ZN  A 500 (-2.2A)
ZN  A 500 ( 4.9A)
ZN  A 500 (-3.2A)
ZN  A 500 (-2.5A)
None
 1.08A 1ekjG-5b5xA:
11.0
1ekjH-5b5xA:
9.9		 1ekjG-5b5xA:
21.59
1ekjH-5b5xA:
21.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EKJ_H_ACTH3006_0
(BETA-CARBONIC
ANHYDRASE)		 5b5x LIMITING
CO2-INDUCIBLE
PROTEIN LCIC
(Chlamydomonas
reinhardtii) 		4 / 6 CYH A 119
ASP A 121
HIS A 179
CYH A 203
 ZN  A 500 (-2.2A)
ZN  A 500 ( 4.9A)
ZN  A 500 (-3.2A)
ZN  A 500 (-2.5A)
 0.37A 1ekjG-5b5xA:
11.0
1ekjH-5b5xA:
9.9		 1ekjG-5b5xA:
21.59
1ekjH-5b5xA:
21.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FM6_D_BRLD503_2
(PEROXISOME
PROLIFERATOR
ACTIVATED RECEPTOR
GAMMA)		 5b5x LIMITING
CO2-INDUCIBLE
PROTEIN LCIC
(Chlamydomonas
reinhardtii) 		4 / 4 ILE A 291
LEU A 118
VAL A 127
ILE A 314
 None
 0.92A 1fm6D-5b5xA:
undetectable		 1fm6D-5b5xA:
20.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1L2I_A_CCSA417_0
(ESTROGEN RECEPTOR)		 5b5x LIMITING
CO2-INDUCIBLE
PROTEIN LCIC
(Chlamydomonas
reinhardtii) 		3 / 3 GLU A 312
LYS A 128
VAL A 126
 None
 0.80A 1l2iA-5b5xA:
undetectable		 1l2iA-5b5xA:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DRD_A_MIYA2001_1
(ACRB)		 5b5x LIMITING
CO2-INDUCIBLE
PROTEIN LCIC
(Chlamydomonas
reinhardtii) 		5 / 9 GLY A 145
GLU A 234
ILE A 269
ALA A 265
PHE A 177
 ZN  A 500 ( 4.6A)
None
None
None
None
 1.12A 2drdA-5b5xA:
undetectable		 2drdA-5b5xA:
16.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q6O_A_SAMA500_0
(HYPOTHETICAL PROTEIN)		 5b5x LIMITING
CO2-INDUCIBLE
PROTEIN LCIC
(Chlamydomonas
reinhardtii) 		4 / 7 ALA A 146
PHE A  94
PRO A 316
THR A 317
 None
 1.02A 2q6oA-5b5xA:
undetectable		 2q6oA-5b5xA:
22.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RLC_A_CHDA332_0
(CHOLOYLGLYCINE
HYDROLASE)		 5b5x LIMITING
CO2-INDUCIBLE
PROTEIN LCIC
(Chlamydomonas
reinhardtii) 		5 / 12 ILE A 296
ALA A 202
ILE A 269
THR A 262
LEU A 258
 None
 1.08A 2rlcA-5b5xA:
undetectable		 2rlcA-5b5xA:
20.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_Q_TFPQ201_1
(PROTEIN S100-A4)		 5b5x LIMITING
CO2-INDUCIBLE
PROTEIN LCIC
(Chlamydomonas
reinhardtii) 		4 / 8 GLY A 109
PHE A 135
ILE A 100
PHE A 175
 None
 0.91A 3ko0O-5b5xA:
2.8
3ko0Q-5b5xA:
undetectable		 3ko0O-5b5xA:
15.46
3ko0Q-5b5xA:
15.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N8Y_B_SALB900_1
(PROSTAGLANDIN G/H
SYNTHASE 1)		 5b5x LIMITING
CO2-INDUCIBLE
PROTEIN LCIC
(Chlamydomonas
reinhardtii) 		4 / 5 VAL A 101
LEU A 102
ILE A 291
ALA A 319
 None
 0.83A 3n8yB-5b5xA:
undetectable		 3n8yB-5b5xA:
21.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UCJ_A_AZMA229_1
(CARBONIC ANHYDRASE)		 5b5x LIMITING
CO2-INDUCIBLE
PROTEIN LCIC
(Chlamydomonas
reinhardtii) 		6 / 10 CYH A 119
ASP A 121
HIS A 179
CYH A 203
GLY A 204
ALA A 205
 ZN  A 500 (-2.2A)
ZN  A 500 ( 4.9A)
ZN  A 500 (-3.2A)
ZN  A 500 (-2.5A)
None
None
 0.40A 3ucjA-5b5xA:
12.1		 3ucjA-5b5xA:
22.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UCJ_B_AZMB229_2
(CARBONIC ANHYDRASE)		 5b5x LIMITING
CO2-INDUCIBLE
PROTEIN LCIC
(Chlamydomonas
reinhardtii) 		6 / 10 CYH A 119
ASP A 121
HIS A 179
CYH A 203
GLY A 204
ALA A 205
 ZN  A 500 (-2.2A)
ZN  A 500 ( 4.9A)
ZN  A 500 (-3.2A)
ZN  A 500 (-2.5A)
None
None
 0.39A 3ucjB-5b5xA:
7.5		 3ucjB-5b5xA:
22.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FN9_A_STRA301_1
(STEROID RECEPTOR 2)		 5b5x LIMITING
CO2-INDUCIBLE
PROTEIN LCIC
(Chlamydomonas
reinhardtii) 		5 / 12 LEU A 258
LEU A 261
LEU A 264
ALA A 265
CYH A 203
 None
None
None
None
ZN  A 500 (-2.5A)
 0.94A 4fn9A-5b5xA:
undetectable		 4fn9A-5b5xA:
21.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IK7_A_IMNA201_1
(TRANSTHYRETIN)		 5b5x LIMITING
CO2-INDUCIBLE
PROTEIN LCIC
(Chlamydomonas
reinhardtii) 		4 / 7 MET A 115
ALA A 176
THR A 292
VAL A 290
 None
 0.82A 4ik7A-5b5xA:
undetectable		 4ik7A-5b5xA:
17.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FUK_A_SNPA1236_1
(MROUPO)		 5b5x LIMITING
CO2-INDUCIBLE
PROTEIN LCIC
(Chlamydomonas
reinhardtii) 		4 / 7 ILE A 180
ILE A 314
PHE A  85
LEU A 118
 None
 0.72A 5fukA-5b5xA:
undetectable
5fukB-5b5xA:
undetectable		 5fukA-5b5xA:
21.22
5fukB-5b5xA:
21.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DJZ_A_GMJA301_0
(SIGMA NON-OPIOID
INTRACELLULAR
RECEPTOR 1)		 5b5x LIMITING
CO2-INDUCIBLE
PROTEIN LCIC
(Chlamydomonas
reinhardtii) 		5 / 12 LEU A 343
HIS A 297
VAL A 127
LEU A  82
ALA A  88
 None
 1.15A 6djzA-5b5xA:
undetectable		 6djzA-5b5xA:
20.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DJZ_C_GMJC301_0
(SIGMA NON-OPIOID
INTRACELLULAR
RECEPTOR 1)		 5b5x LIMITING
CO2-INDUCIBLE
PROTEIN LCIC
(Chlamydomonas
reinhardtii) 		5 / 12 LEU A 343
HIS A 297
VAL A 127
LEU A  82
ALA A  88
 None
 1.14A 6djzC-5b5xA:
undetectable		 6djzC-5b5xA:
20.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F88_B_STRB502_1
(CYTOCHROME P450
CYP260A1)		 5b5x LIMITING
CO2-INDUCIBLE
PROTEIN LCIC
(Chlamydomonas
reinhardtii) 		4 / 6 LEU A 213
ALA A 221
LEU A 264
THR A 268
 None
 0.88A 6f88B-5b5xA:
undetectable		 6f88B-5b5xA:
13.61