SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5b69'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIJ_A_NOVA400_1
(DNA GYRASE SUBUNIT B)		 5b69 GERANYLGERANYLGLYCER
YL PHOSPHATE
SYNTHASE
(Thermoplasma
acidophilum) 		5 / 12 ASP A  23
ILE A  47
ASP A  90
ILE A  67
THR A  20
 None
 1.37A 1kijA-5b69A:
undetectable		 1kijA-5b69A:
21.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KXH_A_ACRA598_1
(ALPHA-AMYLASE)		 5b69 GERANYLGERANYLGLYCER
YL PHOSPHATE
SYNTHASE
(Thermoplasma
acidophilum) 		5 / 12 HIS A 181
ALA A 174
VAL A 200
GLY A 201
ALA A 212
 None
None
None
1GP  A 501 (-3.4A)
None
 1.02A 1kxhA-5b69A:
6.1		 1kxhA-5b69A:
20.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FK8_A_SAMA302_0
(METHOXY MYCOLIC ACID
SYNTHASE 4)		 5b69 GERANYLGERANYLGLYCER
YL PHOSPHATE
SYNTHASE
(Thermoplasma
acidophilum) 		5 / 12 ILE A 204
GLY A 203
GLY A 177
GLU A 184
ILE A 226
 None
1GP  A 501 (-3.7A)
1GP  A 501 (-3.7A)
None
None
 0.99A 2fk8A-5b69A:
undetectable		 2fk8A-5b69A:
21.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q9R_A_BEZA203_0
(PROTEIN OF UNKNOWN
FUNCTION)		 5b69 GERANYLGERANYLGLYCER
YL PHOSPHATE
SYNTHASE
(Thermoplasma
acidophilum) 		4 / 5 LEU A  83
PRO A  79
ILE A  92
ILE A  85
 None
 0.85A 2q9rA-5b69A:
undetectable		 2q9rA-5b69A:
22.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VE3_A_REAA1445_1
(PUTATIVE CYTOCHROME
P450 120)		 5b69 GERANYLGERANYLGLYCER
YL PHOSPHATE
SYNTHASE
(Thermoplasma
acidophilum) 		5 / 12 PHE A  78
ALA A 159
LEU A 194
VAL A 200
GLY A 201
 1GP  A 501 (-4.8A)
None
None
None
1GP  A 501 (-3.4A)
 0.96A 2ve3A-5b69A:
undetectable		 2ve3A-5b69A:
19.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YFB_A_ACTA501_0
(METHYL-ACCEPTING
CHEMOTAXIS
TRANSDUCER)		 5b69 GERANYLGERANYLGLYCER
YL PHOSPHATE
SYNTHASE
(Thermoplasma
acidophilum) 		4 / 7 MET A  60
ASP A  61
VAL A  49
ILE A  77
 None
 0.92A 2yfbA-5b69A:
undetectable		 2yfbA-5b69A:
21.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BOG_C_DVAC10_0
(6.5 KDA GLYCINE-RICH
ANTIFREEZE PROTEIN)		 5b69 GERANYLGERANYLGLYCER
YL PHOSPHATE
SYNTHASE
(Thermoplasma
acidophilum) 		3 / 3 GLY A 175
GLY A 139
GLY A 135
 None
 0.30A 3bogC-5b69A:
undetectable		 3bogC-5b69A:
18.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BOG_D_DVAD10_0
(6.5 KDA GLYCINE-RICH
ANTIFREEZE PROTEIN)		 5b69 GERANYLGERANYLGLYCER
YL PHOSPHATE
SYNTHASE
(Thermoplasma
acidophilum) 		3 / 3 GLY A 175
GLY A 139
GLY A 135
 None
 0.35A 3bogD-5b69A:
undetectable		 3bogD-5b69A:
18.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CE6_D_ADND500_2
(ADENOSYLHOMOCYSTEINA
SE)		 5b69 GERANYLGERANYLGLYCER
YL PHOSPHATE
SYNTHASE
(Thermoplasma
acidophilum) 		4 / 5 LEU A  73
THR A  71
HIS A  18
LEU A 237
 None
 1.04A 3ce6D-5b69A:
undetectable		 3ce6D-5b69A:
20.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EKW_B_DR7B100_2
(PROTEASE)		 5b69 GERANYLGERANYLGLYCER
YL PHOSPHATE
SYNTHASE
(Thermoplasma
acidophilum) 		5 / 12 GLY A 217
ALA A 218
ASP A 219
ILE A 199
VAL A 170
 None
 0.94A 3ekwB-5b69A:
undetectable		 3ekwB-5b69A:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUD_B_SUEB1201_1
(NS3 PROTEASE, NS4A
PROTEIN)		 5b69 GERANYLGERANYLGLYCER
YL PHOSPHATE
SYNTHASE
(Thermoplasma
acidophilum) 		5 / 12 ILE A 244
GLY A 217
ALA A 216
ALA A 212
SER A 243
 None
 1.04A 3sudB-5b69A:
undetectable		 3sudB-5b69A:
21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DT8_A_ADNA401_1
(APH(2'')-ID)		 5b69 GERANYLGERANYLGLYCER
YL PHOSPHATE
SYNTHASE
(Thermoplasma
acidophilum) 		5 / 11 GLY A 224
ALA A 227
ILE A  35
ILE A  67
ILE A  47
 1GP  A 501 (-3.4A)
None
None
None
None
 0.78A 4dt8A-5b69A:
undetectable		 4dt8A-5b69A:
20.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DT8_B_ADNB401_1
(APH(2'')-ID)		 5b69 GERANYLGERANYLGLYCER
YL PHOSPHATE
SYNTHASE
(Thermoplasma
acidophilum) 		5 / 10 GLY A 224
ALA A 227
ILE A  35
ILE A  67
ILE A  47
 1GP  A 501 (-3.4A)
None
None
None
None
 0.86A 4dt8B-5b69A:
undetectable		 4dt8B-5b69A:
20.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5H2U_A_1N1A501_2
(PROTEIN-TYROSINE
KINASE 6)		 5b69 GERANYLGERANYLGLYCER
YL PHOSPHATE
SYNTHASE
(Thermoplasma
acidophilum) 		3 / 3 ILE A  64
MET A  19
ASP A  90
 None
 0.68A 5h2uA-5b69A:
undetectable		 5h2uA-5b69A:
22.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OG9_A_TESA503_1
(-)		 5b69 GERANYLGERANYLGLYCER
YL PHOSPHATE
SYNTHASE
(Thermoplasma
acidophilum) 		5 / 9 LEU A   9
VAL A   4
LEU A   5
ILE A 199
MET A 127
 None
 1.23A 5og9A-5b69A:
undetectable		 5og9A-5b69A:
20.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EU9_B_REAB601_1
(RETINOIC ACID
RECEPTOR)		 5b69 GERANYLGERANYLGLYCER
YL PHOSPHATE
SYNTHASE
(Thermoplasma
acidophilum) 		5 / 10 VAL A 131
LEU A 130
GLY A 101
GLY A  80
VAL A 138
 None
 1.08A 6eu9B-5b69A:
undetectable		 6eu9B-5b69A:
16.74