SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5b6a'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1B02_A_C2FA281_0
(PROTEIN (THYMIDYLATE
SYNTHASE))		 5b6a PYRIDOXAL KINASE
PDXY
(Pseudomonas
aeruginosa) 		5 / 11 THR A  40
ILE A  10
LEU A  75
ASP A  97
ALA A 100
 None
 1.13A 1b02A-5b6aA:
undetectable		 1b02A-5b6aA:
21.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GXS_A_BEZA601_0
(P-(S)-HYDROXYMANDELO
NITRILE LYASE CHAIN
A
P-(S)-HYDROXYMANDELO
NITRILE LYASE CHAIN
B)		 5b6a PYRIDOXAL KINASE
PDXY
(Pseudomonas
aeruginosa) 		4 / 7 GLY A  84
PRO A 115
SER A  83
ALA A 139
 None
 0.94A 1gxsA-5b6aA:
3.1
1gxsB-5b6aA:
0.9		 1gxsA-5b6aA:
19.46
1gxsB-5b6aA:
21.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SKX_A_RFPA1_2
(ORPHAN NUCLEAR
RECEPTOR PXR)		 5b6a PYRIDOXAL KINASE
PDXY
(Pseudomonas
aeruginosa) 		4 / 5 PHE A 283
LEU A 213
MET A 198
LEU A 230
 None
 1.45A 1skxA-5b6aA:
undetectable		 1skxA-5b6aA:
23.94
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1TD2_A_PXLA288_1
(PYRIDOXAMINE KINASE)		 5b6a PYRIDOXAL KINASE
PDXY
(Pseudomonas
aeruginosa) 		8 / 10 SER A  12
VAL A  14
ALA A  19
HIS A  46
THR A  47
GLN A  48
VAL A 221
ASP A 225
 TRS  A 301 (-3.1A)
None
TRS  A 301 ( 3.7A)
None
TRS  A 301 (-3.0A)
None
None
MG  A 302 (-3.0A)
 0.56A 1td2A-5b6aA:
43.8		 1td2A-5b6aA:
57.09
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1TD2_B_PXLB289_1
(PYRIDOXAMINE KINASE)		 5b6a PYRIDOXAL KINASE
PDXY
(Pseudomonas
aeruginosa) 		7 / 9 SER A  12
ALA A  19
HIS A  46
THR A  47
VAL A 116
VAL A 221
ASP A 225
 TRS  A 301 (-3.1A)
TRS  A 301 ( 3.7A)
None
TRS  A 301 (-3.0A)
MG  A 302 (-4.8A)
None
MG  A 302 (-3.0A)
 0.80A 1td2B-5b6aA:
43.7		 1td2B-5b6aA:
57.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AYL_A_FLPA1701_1
(PROSTAGLANDIN G/H
SYNTHASE 1)		 5b6a PYRIDOXAL KINASE
PDXY
(Pseudomonas
aeruginosa) 		5 / 12 ARG A 101
LEU A   8
GLY A  71
ALA A  70
LEU A  75
 None
 1.05A 2aylA-5b6aA:
undetectable		 2aylA-5b6aA:
19.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DTU_C_DXCC576_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 2)		 5b6a PYRIDOXAL KINASE
PDXY
(Pseudomonas
aeruginosa) 		4 / 8 ALA A  90
PRO A  59
ILE A  62
THR A  40
 None
 0.77A 3dtuC-5b6aA:
undetectable
3dtuD-5b6aA:
undetectable		 3dtuC-5b6aA:
19.79
3dtuD-5b6aA:
20.72
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3FHX_A_PXLA313_1
(PYRIDOXAL KINASE)		 5b6a PYRIDOXAL KINASE
PDXY
(Pseudomonas
aeruginosa) 		4 / 4 SER A  12
HIS A  46
THR A  47
VAL A 221
 TRS  A 301 (-3.1A)
None
TRS  A 301 (-3.0A)
None
 0.40A 3fhxA-5b6aA:
39.8		 3fhxA-5b6aA:
31.88
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3FHX_B_PXLB313_1
(PYRIDOXAL KINASE)		 5b6a PYRIDOXAL KINASE
PDXY
(Pseudomonas
aeruginosa) 		6 / 8 SER A  12
PHE A  43
HIS A  46
THR A  47
TYR A  85
VAL A 221
 TRS  A 301 (-3.1A)
TRS  A 301 ( 4.8A)
None
TRS  A 301 (-3.0A)
TRS  A 301 (-4.3A)
None
 0.46A 3fhxB-5b6aA:
39.5		 3fhxB-5b6aA:
31.88
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3FHX_B_PXLB313_1
(PYRIDOXAL KINASE)		 5b6a PYRIDOXAL KINASE
PDXY
(Pseudomonas
aeruginosa) 		6 / 8 SER A  12
VAL A  41
PHE A  43
HIS A  46
THR A  47
VAL A 221
 TRS  A 301 (-3.1A)
None
TRS  A 301 ( 4.8A)
None
TRS  A 301 (-3.0A)
None
 0.58A 3fhxB-5b6aA:
39.5		 3fhxB-5b6aA:
31.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MBH_A_PXLA400_1
(PUTATIVE
PHOSPHOMETHYLPYRIMID
INE KINASE)		 5b6a PYRIDOXAL KINASE
PDXY
(Pseudomonas
aeruginosa) 		5 / 11 HIS A  46
THR A  47
GLN A  48
VAL A 116
ASP A 225
 None
TRS  A 301 (-3.0A)
None
MG  A 302 (-4.8A)
MG  A 302 (-3.0A)
 0.75A 3mbhA-5b6aA:
34.7		 3mbhA-5b6aA:
26.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MBH_B_PXLB400_1
(PUTATIVE
PHOSPHOMETHYLPYRIMID
INE KINASE)		 5b6a PYRIDOXAL KINASE
PDXY
(Pseudomonas
aeruginosa) 		5 / 12 HIS A  46
THR A  47
GLN A  48
VAL A 116
ASP A 225
 None
TRS  A 301 (-3.0A)
None
MG  A 302 (-4.8A)
MG  A 302 (-3.0A)
 0.67A 3mbhB-5b6aA:
34.5		 3mbhB-5b6aA:
26.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MBH_C_PXLC400_1
(PUTATIVE
PHOSPHOMETHYLPYRIMID
INE KINASE)		 5b6a PYRIDOXAL KINASE
PDXY
(Pseudomonas
aeruginosa) 		5 / 12 HIS A  46
THR A  47
GLN A  48
VAL A 116
ASP A 225
 None
TRS  A 301 (-3.0A)
None
MG  A 302 (-4.8A)
MG  A 302 (-3.0A)
 0.66A 3mbhC-5b6aA:
34.8		 3mbhC-5b6aA:
26.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MBH_D_PXLD400_1
(PUTATIVE
PHOSPHOMETHYLPYRIMID
INE KINASE)		 5b6a PYRIDOXAL KINASE
PDXY
(Pseudomonas
aeruginosa) 		5 / 12 HIS A  46
THR A  47
GLN A  48
VAL A 116
ASP A 225
 None
TRS  A 301 (-3.0A)
None
MG  A 302 (-4.8A)
MG  A 302 (-3.0A)
 0.69A 3mbhD-5b6aA:
34.4		 3mbhD-5b6aA:
26.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MBH_E_PXLE400_1
(PUTATIVE
PHOSPHOMETHYLPYRIMID
INE KINASE)		 5b6a PYRIDOXAL KINASE
PDXY
(Pseudomonas
aeruginosa) 		5 / 12 HIS A  46
THR A  47
GLN A  48
VAL A 116
ASP A 225
 None
TRS  A 301 (-3.0A)
None
MG  A 302 (-4.8A)
MG  A 302 (-3.0A)
 0.66A 3mbhE-5b6aA:
34.6		 3mbhE-5b6aA:
26.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MBH_F_PXLF400_1
(PUTATIVE
PHOSPHOMETHYLPYRIMID
INE KINASE)		 5b6a PYRIDOXAL KINASE
PDXY
(Pseudomonas
aeruginosa) 		5 / 11 HIS A  46
THR A  47
GLN A  48
VAL A 116
ASP A 225
 None
TRS  A 301 (-3.0A)
None
MG  A 302 (-4.8A)
MG  A 302 (-3.0A)
 0.68A 3mbhF-5b6aA:
34.7		 3mbhF-5b6aA:
26.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N8Z_A_FLPA701_1
(PROSTAGLANDIN G/H
SYNTHASE 1)		 5b6a PYRIDOXAL KINASE
PDXY
(Pseudomonas
aeruginosa) 		5 / 12 ARG A 101
LEU A   8
GLY A  71
ALA A  70
LEU A  75
 None
 0.98A 3n8zA-5b6aA:
2.4		 3n8zA-5b6aA:
19.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RR3_A_FLRA700_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 5b6a PYRIDOXAL KINASE
PDXY
(Pseudomonas
aeruginosa) 		6 / 12 VAL A  98
ARG A 101
LEU A   8
GLY A  71
ALA A  70
LEU A  75
 None
 1.46A 3rr3A-5b6aA:
1.5		 3rr3A-5b6aA:
18.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RR3_B_FLRB700_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 5b6a PYRIDOXAL KINASE
PDXY
(Pseudomonas
aeruginosa) 		6 / 12 VAL A  98
ARG A 101
LEU A   8
GLY A  71
ALA A  70
LEU A  75
 None
 1.45A 3rr3B-5b6aA:
1.6		 3rr3B-5b6aA:
18.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BQF_B_QPSB951_1
(ALPHA-GLUCAN
PHOSPHORYLASE 2,
CYTOSOLIC)		 5b6a PYRIDOXAL KINASE
PDXY
(Pseudomonas
aeruginosa) 		4 / 8 ARG A 280
GLU A 254
GLU A 258
ARG A 271
 None
 0.99A 4bqfB-5b6aA:
3.0		 4bqfB-5b6aA:
15.74
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4EOH_A_TEPA402_1
(PYRIDOXAL KINASE)		 5b6a PYRIDOXAL KINASE
PDXY
(Pseudomonas
aeruginosa) 		5 / 5 SER A  12
GLY A  20
THR A  47
VAL A 221
ASP A 225
 TRS  A 301 (-3.1A)
TRS  A 301 ( 4.5A)
TRS  A 301 (-3.0A)
None
MG  A 302 (-3.0A)
 0.31A 4eohA-5b6aA:
39.0		 4eohA-5b6aA:
31.76
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4EOH_B_TEPB402_1
(PYRIDOXAL KINASE)		 5b6a PYRIDOXAL KINASE
PDXY
(Pseudomonas
aeruginosa) 		5 / 5 SER A  12
HIS A  46
TYR A  85
VAL A 221
ASP A 225
 TRS  A 301 (-3.1A)
None
TRS  A 301 (-4.3A)
None
MG  A 302 (-3.0A)
 0.40A 4eohB-5b6aA:
38.9		 4eohB-5b6aA:
31.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4F3T_A_IPHA902_0
(PROTEIN ARGONAUTE-2)		 5b6a PYRIDOXAL KINASE
PDXY
(Pseudomonas
aeruginosa) 		4 / 6 LEU A 110
TYR A 111
LEU A 232
TYR A 144
 None
 0.94A 4f3tA-5b6aA:
3.2		 4f3tA-5b6aA:
15.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MA3_L_ACTL301_0
(C2095 HEAVY CHAIN
C2095 LIGHT CHAIN)		 5b6a PYRIDOXAL KINASE
PDXY
(Pseudomonas
aeruginosa) 		3 / 3 PRO A  37
ASN A  39
HIS A  13
 None
 0.93A 4ma3H-5b6aA:
undetectable
4ma3L-5b6aA:
undetectable		 4ma3H-5b6aA:
23.51
4ma3L-5b6aA:
23.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PH9_A_IBPA601_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 5b6a PYRIDOXAL KINASE
PDXY
(Pseudomonas
aeruginosa) 		6 / 10 VAL A  98
ARG A 101
LEU A   8
GLY A  71
ALA A  70
LEU A  75
 None
 1.43A 4ph9A-5b6aA:
1.5		 4ph9A-5b6aA:
19.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PH9_B_IBPB601_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 5b6a PYRIDOXAL KINASE
PDXY
(Pseudomonas
aeruginosa) 		6 / 10 VAL A  98
ARG A 101
LEU A   8
GLY A  71
ALA A  70
LEU A  75
 None
 1.41A 4ph9B-5b6aA:
undetectable		 4ph9B-5b6aA:
19.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KT8_B_NIZB809_1
(CATALASE-PEROXIDASE)		 5b6a PYRIDOXAL KINASE
PDXY
(Pseudomonas
aeruginosa) 		5 / 9 VAL A 116
GLY A 229
SER A 228
GLN A  11
LEU A  82
 MG  A 302 (-4.8A)
None
None
None
None
 1.50A 5kt8B-5b6aA:
undetectable		 5kt8B-5b6aA:
18.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N5D_A_SAMA306_0
(METHYLTRANSFERASE)		 5b6a PYRIDOXAL KINASE
PDXY
(Pseudomonas
aeruginosa) 		5 / 12 ALA A 251
VAL A 252
GLY A 229
ALA A   9
ALA A  24
 None
 1.05A 5n5dA-5b6aA:
4.5		 5n5dA-5b6aA:
24.84