SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5b6h'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)

Filter list by:

	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1RK3_A_VDXA500_2 (VITAMIN D3 RECEPTOR)	5b6h	ADENINE PHOSPHORIBOSYLTRANSF ERASE (Yersinia pseudotuberculos is)	4 / 4	LEU A 52 ILE A 19 ARG A 33 TYR A 45	None	1.47A	1rk3A-5b6hA: undetectable	1rk3A-5b6hA: 18.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2DG9_A_RAPA501_1 (FK506-BINDING PROTEIN 1A)	5b6h	ADENINE PHOSPHORIBOSYLTRANSF ERASE (Yersinia pseudotuberculos is)	5 / 11	ASP A 131 VAL A 78 ILE A 49 LEU A 52 TYR A 45	AMP A 501 ( 2.8A) None None None None	1.08A	2dg9A-5b6hA: undetectable	2dg9A-5b6hA: 25.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2W98_A_P1ZA1351_1 (PROSTAGLANDIN REDUCTASE 2)	5b6h	ADENINE PHOSPHORIBOSYLTRANSF ERASE (Yersinia pseudotuberculos is)	5 / 10	TYR A 45 ILE A 49 LEU A 39 VAL A 35 LEU A 38	None	1.04A	2w98A-5b6hA: 4.6	2w98A-5b6hA: 17.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3G2O_B_SAMB600_0 (PCZA361.24)	5b6h	ADENINE PHOSPHORIBOSYLTRANSF ERASE (Yersinia pseudotuberculos is)	5 / 12	ALA A 134 GLY A 166 LEU A 171 LEU A 162 GLY A 137	AMP A 501 (-3.4A) None None None AMP A 501 (-4.0A)	1.09A	3g2oB-5b6hA: 3.3	3g2oB-5b6hA: 21.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4F84_A_SAMA501_0 (GERANYL DIPHOSPHATE 2-C-METHYLTRANSFERAS E)	5b6h	ADENINE PHOSPHORIBOSYLTRANSF ERASE (Yersinia pseudotuberculos is)	5 / 12	GLY A 66 GLY A 71 VAL A 89 THR A 67 VAL A 126	None NA A 502 ( 4.7A) None None None	1.20A	4f84A-5b6hA: undetectable	4f84A-5b6hA: 19.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4RET_A_DGXA1107_1 (SODIUM/POTASSIUM-TRA NSPORTING ATPASE SUBUNIT ALPHA-1)	5b6h	ADENINE PHOSPHORIBOSYLTRANSF ERASE (Yersinia pseudotuberculos is)	5 / 12	LEU A 127 GLU A 68 PHE A 72 GLY A 75 ALA A 79	None	1.08A	4retA-5b6hA: undetectable	4retA-5b6hA: 12.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4RET_A_DGXA1107_1 (SODIUM/POTASSIUM-TRA NSPORTING ATPASE SUBUNIT ALPHA-1)	5b6h	ADENINE PHOSPHORIBOSYLTRANSF ERASE (Yersinia pseudotuberculos is)	5 / 12	LEU A 127 GLU A 68 PHE A 72 GLY A 75 PHE A 86	None	0.80A	4retA-5b6hA: undetectable	4retA-5b6hA: 12.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5KSN_A_NIZA809_1 (CATALASE-PEROXIDASE)	5b6h	ADENINE PHOSPHORIBOSYLTRANSF ERASE (Yersinia pseudotuberculos is)	5 / 9	GLU A 140 VAL A 143 GLY A 167 LEU A 133 THR A 135	None None None None AMP A 501 (-2.8A)	1.40A	5ksnA-5b6hA: undetectable	5ksnA-5b6hA: 13.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6CZM_C_HISC402_0 (ATP PHOSPHORIBOSYLTRANSF ERASE CATALYTIC SUBUNIT)	5b6h	ADENINE PHOSPHORIBOSYLTRANSF ERASE (Yersinia pseudotuberculos is)	5 / 9	VAL A 65 GLY A 150 LEU A 149 GLN A 121 VAL A 153	None None NA A 503 ( 4.2A) None None	1.31A	6czmB-5b6hA: undetectable 6czmC-5b6hA: undetectable	6czmB-5b6hA: 19.72 6czmC-5b6hA: 19.72

[["DrReposER ID","Desc.","Hit PDB","Hit molecule","Hit organism","Res. no.","Interface","HETATM","RMSD","Z-score","Seq ID"],["1RK3_A_VDXA500_2","VITAMIN D3 RECEPTOR","5b6h","ADENINE PHOSPHORIBOSYLTRANSFERASE","Yersinia pseudotuberculosis",4,"LEU A  52;ILE A  19;ARG A  33;TYR A  45","None","1.47A","1rk3A-5b6hA:undetectable","1rk3A-5b6hA:18.71"],["2DG9_A_RAPA501_1","FK506-BINDING PROTEIN 1A","5b6h","ADENINE PHOSPHORIBOSYLTRANSFERASE","Yersinia pseudotuberculosis",5,"ASP A 131;VAL A  78;ILE A  49;LEU A  52;TYR A  45","AMP A 501 ( 2.8A);None;None;None;None","1.08A","2dg9A-5b6hA:undetectable","2dg9A-5b6hA:25.85"],["2W98_A_P1ZA1351_1","PROSTAGLANDIN REDUCTASE 2","5b6h","ADENINE PHOSPHORIBOSYLTRANSFERASE","Yersinia pseudotuberculosis",5,"TYR A  45;ILE A  49;LEU A  39;VAL A  35;LEU A  38","None","1.04A","2w98A-5b6hA:4.6","2w98A-5b6hA:17.36"],["3G2O_B_SAMB600_0","PCZA361.24","5b6h","ADENINE PHOSPHORIBOSYLTRANSFERASE","Yersinia pseudotuberculosis",5,"ALA A 134;GLY A 166;LEU A 171;LEU A 162;GLY A 137","AMP A 501 (-3.4A);None;None;None;AMP A 501 (-4.0A)","1.09A","3g2oB-5b6hA:3.3","3g2oB-5b6hA:21.24"],["4F84_A_SAMA501_0","GERANYL DIPHOSPHATE 2-C-METHYLTRANSFERASE","5b6h","ADENINE PHOSPHORIBOSYLTRANSFERASE","Yersinia pseudotuberculosis",5,"GLY A  66;GLY A  71;VAL A  89;THR A  67;VAL A 126","None; NA A 502 ( 4.7A);None;None;None","1.20A","4f84A-5b6hA:undetectable","4f84A-5b6hA:19.14"],["4RET_A_DGXA1107_1","SODIUM\/POTASSIUM-TRANSPORTING ATPASE SUBUNIT ALPHA-1","5b6h","ADENINE PHOSPHORIBOSYLTRANSFERASE","Yersinia pseudotuberculosis",5,"LEU A 127;GLU A  68;PHE A  72;GLY A  75;ALA A  79","None","1.08A","4retA-5b6hA:undetectable","4retA-5b6hA:12.27"],["4RET_A_DGXA1107_1","SODIUM\/POTASSIUM-TRANSPORTING ATPASE SUBUNIT ALPHA-1","5b6h","ADENINE PHOSPHORIBOSYLTRANSFERASE","Yersinia pseudotuberculosis",5,"LEU A 127;GLU A  68;PHE A  72;GLY A  75;PHE A  86","None","0.80A","4retA-5b6hA:undetectable","4retA-5b6hA:12.27"],["5KSN_A_NIZA809_1","CATALASE-PEROXIDASE","5b6h","ADENINE PHOSPHORIBOSYLTRANSFERASE","Yersinia pseudotuberculosis",5,"GLU A 140;VAL A 143;GLY A 167;LEU A 133;THR A 135","None;None;None;None;AMP A 501 (-2.8A)","1.40A","5ksnA-5b6hA:undetectable","5ksnA-5b6hA:13.74"],["6CZM_C_HISC402_0","ATP PHOSPHORIBOSYLTRANSFERASE CATALYTIC SUBUNIT","5b6h","ADENINE PHOSPHORIBOSYLTRANSFERASE","Yersinia pseudotuberculosis",5,"VAL A  65;GLY A 150;LEU A 149;GLN A 121;VAL A 153","None;None; NA A 503 ( 4.2A);None;None","1.31A","6czmB-5b6hA:undetectable;6czmC-5b6hA:undetectable","6czmB-5b6hA:19.72;6czmC-5b6hA:19.72"]]