SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5b6t'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DMI_A_BHSA1610_1
(NITRIC OXIDE
SYNTHASE)		 5b6t GLYCOSYL HYDROLASE
FAMILY 62 PROTEIN
(Coprinopsis
cinerea) 		4 / 8 SER A 137
VAL A 121
ALA A 147
PHE A 149
 GOL  A 504 (-2.8A)
None
GOL  A 504 ( 4.5A)
None
 1.04A 1dmiA-5b6tA:
undetectable
1dmiB-5b6tA:
undetectable		 1dmiA-5b6tA:
20.48
1dmiB-5b6tA:
20.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YNN_C_RFPC1120_1
(DNA-DIRECTED RNA
POLYMERASE BETA
CHAIN)		 5b6t GLYCOSYL HYDROLASE
FAMILY 62 PROTEIN
(Coprinopsis
cinerea) 		5 / 12 ASP A 268
ARG A 273
ARG A 305
SER A 306
LEU A 319
 None
 1.41A 1ynnC-5b6tA:
undetectable		 1ynnC-5b6tA:
15.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BM9_D_SAMD301_1
(CEPHALOSPORIN
HYDROXYLASE CMCI)		 5b6t GLYCOSYL HYDROLASE
FAMILY 62 PROTEIN
(Coprinopsis
cinerea) 		3 / 3 ASP A 268
ASP A 321
ASN A 272
 None
 0.74A 2bm9D-5b6tA:
undetectable		 2bm9D-5b6tA:
20.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BTE_A_LEUA1894_0
(AMINOACYL-TRNA
SYNTHETASE)		 5b6t GLYCOSYL HYDROLASE
FAMILY 62 PROTEIN
(Coprinopsis
cinerea) 		4 / 8 SER A 124
TYR A 131
TYR A 380
HIS A 346
 GOL  A 502 ( 4.4A)
GOL  A 502 (-4.2A)
PB  A 500 ( 4.5A)
CA  A 501 (-3.3A)
 1.19A 2bteA-5b6tA:
undetectable		 2bteA-5b6tA:
15.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2D55_C_DVAC2_0
(ACTINOMYCIN D)		 5b6t GLYCOSYL HYDROLASE
FAMILY 62 PROTEIN
(Coprinopsis
cinerea) 		3 / 3 THR A 200
PRO A 202
PRO A 156
 None
 0.74A 2d55C-5b6tA:
undetectable		 2d55C-5b6tA:
3.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2D55_C_DVAC8_0
(ACTINOMYCIN D)		 5b6t GLYCOSYL HYDROLASE
FAMILY 62 PROTEIN
(Coprinopsis
cinerea) 		3 / 3 PRO A 156
THR A 200
PRO A 202
 None
 0.50A 2d55C-5b6tA:
undetectable		 2d55C-5b6tA:
3.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FL5_F_RBFF204_1
(IMMUNOGLOBULIN IGG1
LAMBDA LIGHT CHAIN
IMMUNOGLOBULIN IGG1
HEAVY CHAIN)		 5b6t GLYCOSYL HYDROLASE
FAMILY 62 PROTEIN
(Coprinopsis
cinerea) 		4 / 8 TYR A 367
ARG A 302
GLU A 294
PHE A 304
 None
PB  A 500 ( 4.7A)
None
None
 1.17A 2fl5E-5b6tA:
undetectable
2fl5F-5b6tA:
undetectable		 2fl5E-5b6tA:
21.05
2fl5F-5b6tA:
21.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HRC_A_CHDA702_0
(FERROCHELATASE)		 5b6t GLYCOSYL HYDROLASE
FAMILY 62 PROTEIN
(Coprinopsis
cinerea) 		4 / 7 ARG A 366
LEU A 389
PRO A 165
VAL A 121
 None
 1.19A 2hrcA-5b6tA:
undetectable		 2hrcA-5b6tA:
22.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B0W_A_DGXA1_2
(NUCLEAR RECEPTOR
ROR-GAMMA)		 5b6t GLYCOSYL HYDROLASE
FAMILY 62 PROTEIN
(Coprinopsis
cinerea) 		3 / 3 TRP A 340
VAL A 121
ARG A 118
 None
 0.97A 3b0wA-5b6tA:
undetectable		 3b0wA-5b6tA:
21.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HJ3_A_MTXA605_1
(CHAIN A, CRYSTAL
STRUCTURE OF DHFR)		 5b6t GLYCOSYL HYDROLASE
FAMILY 62 PROTEIN
(Coprinopsis
cinerea) 		5 / 12 LEU A 292
LEU A 365
SER A 395
THR A 308
ILE A 283
 None
 1.12A 3hj3A-5b6tA:
undetectable		 3hj3A-5b6tA:
21.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HRD_E_NIOE5660_1
(NICOTINATE
DEHYDROGENASE LARGE
MOLYBDOPTERIN
SUBUNIT
NICOTINATE
DEHYDROGENASE MEDIUM
MOLYBDOPTERIN
SUBUNIT)		 5b6t GLYCOSYL HYDROLASE
FAMILY 62 PROTEIN
(Coprinopsis
cinerea) 		3 / 3 GLU A 276
GLU A 294
TRP A 385
 PB  A 500 (-2.4A)
None
None
 1.22A 3hrdA-5b6tA:
undetectable
3hrdE-5b6tA:
undetectable
3hrdF-5b6tA:
undetectable		 3hrdA-5b6tA:
21.43
3hrdE-5b6tA:
21.43
3hrdF-5b6tA:
20.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUD_A_SUEA1201_2
(NS3 PROTEASE, NS4A
PROTEIN)		 5b6t GLYCOSYL HYDROLASE
FAMILY 62 PROTEIN
(Coprinopsis
cinerea) 		4 / 4 PHE A 168
TYR A 180
ILE A 350
LEU A 349
 None
 1.24A 3sudA-5b6tA:
undetectable		 3sudA-5b6tA:
20.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VKX_A_T3A301_1
(PROLIFERATING CELL
NUCLEAR ANTIGEN)		 5b6t GLYCOSYL HYDROLASE
FAMILY 62 PROTEIN
(Coprinopsis
cinerea) 		4 / 6 LEU A 175
PRO A 172
GLN A 356
TYR A 177
 None
 1.42A 3vkxA-5b6tA:
undetectable		 3vkxA-5b6tA:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ACA_C_DXCC1475_0
(TRANSLATION
ELONGATION FACTOR
SELB)		 5b6t GLYCOSYL HYDROLASE
FAMILY 62 PROTEIN
(Coprinopsis
cinerea) 		4 / 8 ILE A 283
ASP A 284
ILE A 360
GLN A 392
 None
 0.77A 4acaC-5b6tA:
undetectable		 4acaC-5b6tA:
17.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E7C_A_ACTA504_0
(UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE)		 5b6t GLYCOSYL HYDROLASE
FAMILY 62 PROTEIN
(Coprinopsis
cinerea) 		3 / 3 ARG A 247
TRP A 316
GLY A 314
 None
 0.97A 4e7cA-5b6tA:
undetectable		 4e7cA-5b6tA:
20.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NED_A_PFNA709_1
(LACTOTRANSFERRIN)		 5b6t GLYCOSYL HYDROLASE
FAMILY 62 PROTEIN
(Coprinopsis
cinerea) 		4 / 6 VAL A 223
ASP A 224
SER A 124
PHE A 304
 GOL  A 502 (-4.0A)
GOL  A 502 (-3.0A)
GOL  A 502 ( 4.4A)
None
 1.14A 4nedA-5b6tA:
undetectable		 4nedA-5b6tA:
22.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OLT_A_GCSA302_1
(CHITOSANASE)		 5b6t GLYCOSYL HYDROLASE
FAMILY 62 PROTEIN
(Coprinopsis
cinerea) 		4 / 5 ARG A 203
THR A 189
THR A 200
TYR A 180
 None
 1.32A 4oltA-5b6tA:
undetectable		 4oltA-5b6tA:
24.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OLT_B_GCSB302_1
(CHITOSANASE)		 5b6t GLYCOSYL HYDROLASE
FAMILY 62 PROTEIN
(Coprinopsis
cinerea) 		4 / 5 ARG A 203
THR A 189
THR A 200
TYR A 180
 None
 1.27A 4oltB-5b6tA:
undetectable		 4oltB-5b6tA:
24.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QWP_A_GCSA302_1
(CHITOSANASE)		 5b6t GLYCOSYL HYDROLASE
FAMILY 62 PROTEIN
(Coprinopsis
cinerea) 		4 / 5 ARG A 203
THR A 189
THR A 200
TYR A 180
 None
 1.31A 4qwpA-5b6tA:
undetectable		 4qwpA-5b6tA:
24.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KGJ_A_X6XA402_1
(PREDICTED
ACETYLTRANSFERASE)		 5b6t GLYCOSYL HYDROLASE
FAMILY 62 PROTEIN
(Coprinopsis
cinerea) 		4 / 5 ARG A 302
GLU A 294
ASP A 109
TRP A 385
 PB  A 500 ( 4.7A)
None
GOL  A 502 (-2.8A)
None
 1.49A 5kgjA-5b6tA:
undetectable		 5kgjA-5b6tA:
20.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ODI_G_ACTG702_0
(HETERODISULFIDE
REDUCTASE, SUBUNIT A)		 5b6t GLYCOSYL HYDROLASE
FAMILY 62 PROTEIN
(Coprinopsis
cinerea) 		3 / 3 GLY A 198
THR A 200
ASN A 190
 None
 0.68A 5odiG-5b6tA:
undetectable		 5odiG-5b6tA:
18.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DH0_A_017A101_0
(PROTEASE)		 5b6t GLYCOSYL HYDROLASE
FAMILY 62 PROTEIN
(Coprinopsis
cinerea) 		5 / 12 GLY A 347
VAL A 121
ILE A  95
GLY A 388
VAL A 112
 None
 0.97A 6dh0A-5b6tA:
undetectable		 6dh0A-5b6tA:
15.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HU9_C_PCFC607_0
(CYTOCHROME B)		 5b6t GLYCOSYL HYDROLASE
FAMILY 62 PROTEIN
(Coprinopsis
cinerea) 		5 / 10 PHE A 237
TYR A 177
TYR A 187
THR A 189
PHE A 168
 None
 1.44A 6hu9C-5b6tA:
undetectable		 6hu9C-5b6tA:
22.22