SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5b7c'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GSF_C_EAAC223_1
(GLUTATHIONE
TRANSFERASE A1-1)		 5b7c S-CRYSTALLIN OCTVUS4
(Octopus
vulgaris) 		4 / 8 TYR A   8
GLY A  13
ARG A  14
LEU A 100
 None
None
GSH  A 301 (-4.1A)
None
 0.75A 1gsfC-5b7cA:
21.4		 1gsfC-5b7cA:
25.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZXW_W_CHDW1060_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 1)		 5b7c S-CRYSTALLIN OCTVUS4
(Octopus
vulgaris) 		4 / 7 ILE A  92
PHE A  91
ARG A 145
MET A 149
 None
 1.15A 2zxwN-5b7cA:
undetectable
2zxwW-5b7cA:
undetectable		 2zxwN-5b7cA:
16.73
2zxwW-5b7cA:
17.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NDI_A_SAMA601_0
(METHYLTRANSFERASE)		 5b7c S-CRYSTALLIN OCTVUS4
(Octopus
vulgaris) 		5 / 12 PHE A  76
GLU A  16
ILE A  17
PHE A  78
ALA A  15
 None
 1.27A 3ndiA-5b7cA:
undetectable		 3ndiA-5b7cA:
18.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U5J_A_08HA1_1
(BROMODOMAIN-CONTAINI
NG PROTEIN 4)		 5b7c S-CRYSTALLIN OCTVUS4
(Octopus
vulgaris) 		4 / 7 PRO A 176
LEU A 184
LEU A 190
ILE A  99
 None
 1.03A 3u5jA-5b7cA:
undetectable		 3u5jA-5b7cA:
17.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P6X_I_HCYI900_2
(GLUCOCORTICOID
RECEPTOR)		 5b7c S-CRYSTALLIN OCTVUS4
(Octopus
vulgaris) 		3 / 3 MET A 162
MET A 143
TYR A 170
 None
 1.18A 4p6xI-5b7cA:
undetectable		 4p6xI-5b7cA:
18.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WQ4_B_ACTB403_0
(TRNA N6-ADENOSINE
THREONYLCARBAMOYLTRA
NSFERASE)		 5b7c S-CRYSTALLIN OCTVUS4
(Octopus
vulgaris) 		3 / 3 ARG A  32
ASP A  31
ARG A  33
 None
 0.51A 4wq4B-5b7cA:
undetectable		 4wq4B-5b7cA:
18.80