SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5b7d'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DLS_A_MTXA188_1
(DIHYDROFOLATE
REDUCTASE)		 5b7d LYSR FAMILY
TRANSCRIPTIONAL
REGULATOR
(Vibrio
vulnificus) 		5 / 12 ILE A 152
ALA A 294
SER A 284
PRO A 282
LEU A 143
 None
 1.21A 1dlsA-5b7dA:
undetectable		 1dlsA-5b7dA:
24.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FBM_B_RTLB951_1
(PROTEIN (CARTILAGE
OLIGOMERIC MATRIX
PROTEIN))		 5b7d LYSR FAMILY
TRANSCRIPTIONAL
REGULATOR
(Vibrio
vulnificus) 		4 / 4 THR A 289
LEU A 293
VAL A 296
LEU A 300
 None
 0.60A 1fbmB-5b7dA:
undetectable		 1fbmB-5b7dA:
17.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JOL_B_FFOB361_0
(DIHYDROFOLATE
REDUCTASE)		 5b7d LYSR FAMILY
TRANSCRIPTIONAL
REGULATOR
(Vibrio
vulnificus) 		5 / 12 ALA A 211
ILE A 188
LEU A 193
PRO A 194
THR A 208
 None
 1.09A 1jolB-5b7dA:
undetectable		 1jolB-5b7dA:
21.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MZ9_D_VDYD1001_4
(CARTILAGE OLIGOMERIC
MATRIX PROTEIN)		 5b7d LYSR FAMILY
TRANSCRIPTIONAL
REGULATOR
(Vibrio
vulnificus) 		4 / 4 THR A 289
LEU A 293
VAL A 296
LEU A 300
 None
 0.78A 1mz9D-5b7dA:
undetectable		 1mz9D-5b7dA:
14.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RX8_A_FOLA161_0
(DIHYDROFOLATE
REDUCTASE)		 5b7d LYSR FAMILY
TRANSCRIPTIONAL
REGULATOR
(Vibrio
vulnificus) 		5 / 12 ALA A 211
ILE A 188
LEU A 193
PRO A 194
THR A 208
 None
 1.09A 1rx8A-5b7dA:
undetectable		 1rx8A-5b7dA:
21.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A3A_A_TEPA1436_1
(CHITINASE)		 5b7d LYSR FAMILY
TRANSCRIPTIONAL
REGULATOR
(Vibrio
vulnificus) 		3 / 3 ASP A 149
PHE A 290
ARG A 286
 None
 0.80A 2a3aA-5b7dA:
undetectable		 2a3aA-5b7dA:
19.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GWX_A_EPAA1_2
(PROTEIN (PEROXISOME
PROLIFERATOR
ACTIVATED RECEPTOR
(PPAR-DELTA)))		 5b7d LYSR FAMILY
TRANSCRIPTIONAL
REGULATOR
(Vibrio
vulnificus) 		5 / 12 THR A 137
THR A 136
THR A 135
HIS A 210
LEU A 153
 None
 0.82A 3gwxA-5b7dA:
undetectable		 3gwxA-5b7dA:
21.58