SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5b7i'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A4L_B_DCFB853_1
(ADENOSINE DEAMINASE)		 5b7i CRISPR-ASSOCIATED
NUCLEASE/HELICASE
CAS3 SUBTYPE
I-F/YPEST
(Pseudomonas
aeruginosa) 		5 / 12 HIS A 149
ASP A 145
LEU A 136
HIS A 352
ASP A 124
 CA  A1101 (-3.8A)
None
None
CA  A1102 (-3.6A)
CA  A1102 ( 2.6A)
 1.45A 1a4lB-5b7iA:
undetectable		 1a4lB-5b7iA:
15.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EI6_D_PPFD412_1
(PHOSPHONOACETATE
HYDROLASE)		 5b7i CRISPR-ASSOCIATED
NUCLEASE/HELICASE
CAS3 SUBTYPE
I-F/YPEST
(Pseudomonas
aeruginosa) 		4 / 8 ASP A 124
HIS A 123
HIS A 220
HIS A 352
 CA  A1102 ( 2.6A)
CA  A1102 (-3.9A)
CA  A1101 (-3.7A)
CA  A1102 (-3.6A)
 0.72A 1ei6D-5b7iA:
undetectable		 1ei6D-5b7iA:
17.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FWE_C_HAEC989_1
(UREASE)		 5b7i CRISPR-ASSOCIATED
NUCLEASE/HELICASE
CAS3 SUBTYPE
I-F/YPEST
(Pseudomonas
aeruginosa) 		5 / 6 HIS A 123
HIS A 352
HIS A 149
HIS A 220
ASP A 315
 CA  A1102 (-3.9A)
CA  A1102 (-3.6A)
CA  A1101 (-3.8A)
CA  A1101 (-3.7A)
CA  A1102 (-2.6A)
 1.17A 1fweC-5b7iA:
undetectable		 1fweC-5b7iA:
20.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I9G_A_SAMA301_1
(HYPOTHETICAL PROTEIN
RV2118C)		 5b7i CRISPR-ASSOCIATED
NUCLEASE/HELICASE
CAS3 SUBTYPE
I-F/YPEST
(Pseudomonas
aeruginosa) 		3 / 3 GLU A 150
HIS A 221
ASP A 145
 None
CA  A1101 (-3.5A)
None
 0.75A 1i9gA-5b7iA:
undetectable		 1i9gA-5b7iA:
14.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JG3_A_ADNA500_1
(PROTEIN-L-ISOASPARTA
TE
O-METHYLTRANSFERASE)		 5b7i CRISPR-ASSOCIATED
NUCLEASE/HELICASE
CAS3 SUBTYPE
I-F/YPEST
(Pseudomonas
aeruginosa) 		5 / 11 GLY A 468
ILE A 541
LEU A 474
GLY A 382
LEU A 428
 None
None
None
None
ADP  A1103 (-4.0A)
 0.94A 1jg3A-5b7iA:
undetectable		 1jg3A-5b7iA:
12.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JG3_B_ADNB550_1
(PROTEIN-L-ISOASPARTA
TE
O-METHYLTRANSFERASE)		 5b7i CRISPR-ASSOCIATED
NUCLEASE/HELICASE
CAS3 SUBTYPE
I-F/YPEST
(Pseudomonas
aeruginosa) 		5 / 11 GLY A 468
ILE A 541
LEU A 474
GLY A 382
LEU A 428
 None
None
None
None
ADP  A1103 (-4.0A)
 0.94A 1jg3B-5b7iA:
undetectable		 1jg3B-5b7iA:
12.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MX1_B_THAB2_1
(LIVER
CARBOXYLESTERASE I)		 5b7i CRISPR-ASSOCIATED
NUCLEASE/HELICASE
CAS3 SUBTYPE
I-F/YPEST
(Pseudomonas
aeruginosa) 		5 / 11 VAL A 671
LEU A 419
LEU A 937
LEU A 614
HIS A 934
 None
 0.85A 1mx1B-5b7iA:
undetectable		 1mx1B-5b7iA:
19.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PBC_A_BHAA396_0
(P-HYDROXYBENZOATE
HYDROXYLASE)		 5b7i CRISPR-ASSOCIATED
NUCLEASE/HELICASE
CAS3 SUBTYPE
I-F/YPEST
(Pseudomonas
aeruginosa) 		5 / 10 GLY A 827
VAL A 826
LEU A 452
LEU A 455
ARG A 828
 None
 1.29A 1pbcA-5b7iA:
undetectable		 1pbcA-5b7iA:
17.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1VPT_A_SAMA400_1
(VP39)		 5b7i CRISPR-ASSOCIATED
NUCLEASE/HELICASE
CAS3 SUBTYPE
I-F/YPEST
(Pseudomonas
aeruginosa) 		3 / 3 ASP A 473
ARG A  46
ASP A 471
 None
 0.93A 1vptA-5b7iA:
undetectable		 1vptA-5b7iA:
13.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WRL_A_TFPA204_1
(TROPONIN C, SLOW
SKELETAL AND CARDIAC
MUSCLES)		 5b7i CRISPR-ASSOCIATED
NUCLEASE/HELICASE
CAS3 SUBTYPE
I-F/YPEST
(Pseudomonas
aeruginosa) 		4 / 7 PHE A 160
PHE A 122
MET A 118
VAL A 117
 None
 0.95A 1wrlA-5b7iA:
undetectable
1wrlB-5b7iA:
undetectable		 1wrlA-5b7iA:
6.85
1wrlB-5b7iA:
6.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AVD_B_SAMB601_1
(CATECHOL-O-METHYLTRA
NSFERASE)		 5b7i CRISPR-ASSOCIATED
NUCLEASE/HELICASE
CAS3 SUBTYPE
I-F/YPEST
(Pseudomonas
aeruginosa) 		3 / 3 SER A 776
GLU A1041
ASP A 471
 None
 0.60A 2avdB-5b7iA:
3.2		 2avdB-5b7iA:
13.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F6D_A_ACRA996_1
(GLUCOAMYLASE GLU1)		 5b7i CRISPR-ASSOCIATED
NUCLEASE/HELICASE
CAS3 SUBTYPE
I-F/YPEST
(Pseudomonas
aeruginosa) 		4 / 7 ARG A 466
ASP A 783
THR A 422
GLY A 423
 ADP  A1103 (-4.1A)
None
ADP  A1103 (-4.0A)
ADP  A1103 (-3.1A)
 0.85A 2f6dA-5b7iA:
undetectable		 2f6dA-5b7iA:
18.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HRE_B_CHDB701_0
(FERROCHELATASE)		 5b7i CRISPR-ASSOCIATED
NUCLEASE/HELICASE
CAS3 SUBTYPE
I-F/YPEST
(Pseudomonas
aeruginosa) 		3 / 3 LYS A  11
GLY A 521
PRO A 522
 None
 1.00A 2hreB-5b7iA:
undetectable		 2hreB-5b7iA:
15.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OAX_D_SNLD4001_2
(MINERALOCORTICOID
RECEPTOR)		 5b7i CRISPR-ASSOCIATED
NUCLEASE/HELICASE
CAS3 SUBTYPE
I-F/YPEST
(Pseudomonas
aeruginosa) 		4 / 5 LEU A 506
LEU A 537
CYH A 544
THR A 545
 None
 1.23A 2oaxD-5b7iA:
undetectable		 2oaxD-5b7iA:
11.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RHM_B_BEZB194_0
(PUTATIVE KINASE)		 5b7i CRISPR-ASSOCIATED
NUCLEASE/HELICASE
CAS3 SUBTYPE
I-F/YPEST
(Pseudomonas
aeruginosa) 		4 / 5 PRO A 915
ILE A 911
ARG A 910
ASP A 912
 None
 1.48A 2rhmB-5b7iA:
2.6		 2rhmB-5b7iA:
11.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RLF_B_RIMB299_1
(MATRIX PROTEIN 2)		 5b7i CRISPR-ASSOCIATED
NUCLEASE/HELICASE
CAS3 SUBTYPE
I-F/YPEST
(Pseudomonas
aeruginosa) 		4 / 6 LEU A 929
LEU A 932
ILE A 845
ARG A 916
 None
 1.17A 2rlfB-5b7iA:
undetectable
2rlfC-5b7iA:
undetectable		 2rlfB-5b7iA:
4.77
2rlfC-5b7iA:
4.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VCV_P_ASDP1224_1
(GLUTATHIONE
S-TRANSFERASE A3)		 5b7i CRISPR-ASSOCIATED
NUCLEASE/HELICASE
CAS3 SUBTYPE
I-F/YPEST
(Pseudomonas
aeruginosa) 		4 / 8 PHE A 415
LEU A 589
LEU A 586
ALA A 621
 None
 0.78A 2vcvP-5b7iA:
undetectable		 2vcvP-5b7iA:
12.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VPP_A_GEOA1210_1
(DEOXYNUCLEOSIDE
KINASE)		 5b7i CRISPR-ASSOCIATED
NUCLEASE/HELICASE
CAS3 SUBTYPE
I-F/YPEST
(Pseudomonas
aeruginosa) 		5 / 12 VAL A 478
GLN A 458
ARG A 464
ALA A 462
GLU A1041
 None
 1.13A 2vppA-5b7iA:
1.7		 2vppA-5b7iA:
12.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VPP_B_GEOB1207_1
(DEOXYNUCLEOSIDE
KINASE)		 5b7i CRISPR-ASSOCIATED
NUCLEASE/HELICASE
CAS3 SUBTYPE
I-F/YPEST
(Pseudomonas
aeruginosa) 		5 / 12 VAL A 478
GLN A 458
ARG A 464
ALA A 462
GLU A1041
 None
 1.14A 2vppB-5b7iA:
2.0		 2vppB-5b7iA:
12.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JZJ_A_ACRA405_1
(ACARBOSE/MALTOSE
BINDING PROTEIN GACH)		 5b7i CRISPR-ASSOCIATED
NUCLEASE/HELICASE
CAS3 SUBTYPE
I-F/YPEST
(Pseudomonas
aeruginosa) 		5 / 12 GLY A 850
ARG A 843
ALA A 420
ASP A 576
ASP A 829
 None
None
None
None
ADP  A1103 (-3.8A)
 1.11A 3jzjA-5b7iA:
undetectable		 3jzjA-5b7iA:
17.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K2H_A_LYAA514_1
(DIHYDROFOLATE
REDUCTASE/THYMIDYLAT
E SYNTHASE)		 5b7i CRISPR-ASSOCIATED
NUCLEASE/HELICASE
CAS3 SUBTYPE
I-F/YPEST
(Pseudomonas
aeruginosa) 		5 / 12 ALA A 552
LEU A 309
THR A 570
LEU A 367
LEU A 566
 None
 1.14A 3k2hA-5b7iA:
undetectable		 3k2hA-5b7iA:
18.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K5V_B_STIB2_2
(TYROSINE-PROTEIN
KINASE ABL1)		 5b7i CRISPR-ASSOCIATED
NUCLEASE/HELICASE
CAS3 SUBTYPE
I-F/YPEST
(Pseudomonas
aeruginosa) 		4 / 6 LEU A1014
VAL A 823
VAL A 765
ILE A 740
 None
 0.90A 3k5vB-5b7iA:
undetectable		 3k5vB-5b7iA:
13.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LN1_D_CELD682_2
(PROSTAGLANDIN G/H
SYNTHASE 2)		 5b7i CRISPR-ASSOCIATED
NUCLEASE/HELICASE
CAS3 SUBTYPE
I-F/YPEST
(Pseudomonas
aeruginosa) 		4 / 5 ARG A 736
LEU A 929
ILE A 583
PHE A 887
 None
 1.26A 3ln1D-5b7iA:
0.0		 3ln1D-5b7iA:
19.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NDV_B_AICB376_1
(BETA-PEPTIDYL
AMINOPEPTIDASE)		 5b7i CRISPR-ASSOCIATED
NUCLEASE/HELICASE
CAS3 SUBTYPE
I-F/YPEST
(Pseudomonas
aeruginosa) 		5 / 11 LEU A 867
LEU A 865
ARG A 685
ASN A 864
LEU A 734
 None
 1.36A 3ndvA-5b7iA:
undetectable
3ndvB-5b7iA:
undetectable		 3ndvA-5b7iA:
16.16
3ndvB-5b7iA:
16.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NDV_C_AICC375_1
(BETA-PEPTIDYL
AMINOPEPTIDASE)		 5b7i CRISPR-ASSOCIATED
NUCLEASE/HELICASE
CAS3 SUBTYPE
I-F/YPEST
(Pseudomonas
aeruginosa) 		5 / 11 LEU A 865
ARG A 685
ASN A 864
LEU A 734
LEU A 867
 None
 1.34A 3ndvC-5b7iA:
undetectable
3ndvD-5b7iA:
undetectable		 3ndvC-5b7iA:
16.16
3ndvD-5b7iA:
16.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OU6_C_SAMC300_0
(SAM-DEPENDENT
METHYLTRANSFERASE)		 5b7i CRISPR-ASSOCIATED
NUCLEASE/HELICASE
CAS3 SUBTYPE
I-F/YPEST
(Pseudomonas
aeruginosa) 		5 / 12 LEU A 154
ALA A 119
GLY A 214
LEU A 216
ALA A 357
 None
 1.20A 3ou6C-5b7iA:
undetectable		 3ou6C-5b7iA:
12.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OU7_C_SAMC300_0
(SAM-DEPENDENT
METHYLTRANSFERASE)		 5b7i CRISPR-ASSOCIATED
NUCLEASE/HELICASE
CAS3 SUBTYPE
I-F/YPEST
(Pseudomonas
aeruginosa) 		5 / 12 LEU A 154
ALA A 119
GLY A 214
LEU A 216
ALA A 357
 None
 1.20A 3ou7C-5b7iA:
undetectable		 3ou7C-5b7iA:
12.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OZW_B_KKKB413_1
(FLAVOHEMOGLOBIN)		 5b7i CRISPR-ASSOCIATED
NUCLEASE/HELICASE
CAS3 SUBTYPE
I-F/YPEST
(Pseudomonas
aeruginosa) 		5 / 12 ALA A 738
LEU A 737
LEU A 706
GLY A 886
PRO A 885
 None
 1.11A 3ozwB-5b7iA:
undetectable		 3ozwB-5b7iA:
17.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PYY_A_STIA3_2
(V-ABL ABELSON MURINE
LEUKEMIA VIRAL
ONCOGENE HOMOLOG 1
ISOFORM B VARIANT)		 5b7i CRISPR-ASSOCIATED
NUCLEASE/HELICASE
CAS3 SUBTYPE
I-F/YPEST
(Pseudomonas
aeruginosa) 		4 / 6 TYR A1066
VAL A 823
VAL A 765
ILE A 740
 None
 1.10A 3pyyA-5b7iA:
undetectable		 3pyyA-5b7iA:
12.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QX3_D_EVPD1_1
(DNA TOPOISOMERASE
2-BETA)		 5b7i CRISPR-ASSOCIATED
NUCLEASE/HELICASE
CAS3 SUBTYPE
I-F/YPEST
(Pseudomonas
aeruginosa) 		4 / 5 GLY A 976
ARG A 974
GLN A 971
MET A 941
 None
 1.24A 3qx3B-5b7iA:
undetectable		 3qx3B-5b7iA:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S39_A_CUA803_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 5b7i CRISPR-ASSOCIATED
NUCLEASE/HELICASE
CAS3 SUBTYPE
I-F/YPEST
(Pseudomonas
aeruginosa) 		3 / 3 HIS A 760
HIS A 762
HIS A 814
 None
 0.77A 3s39A-5b7iA:
undetectable		 3s39A-5b7iA:
20.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S3C_A_CUA803_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 5b7i CRISPR-ASSOCIATED
NUCLEASE/HELICASE
CAS3 SUBTYPE
I-F/YPEST
(Pseudomonas
aeruginosa) 		3 / 3 HIS A 760
HIS A 762
HIS A 814
 None
 0.80A 3s3cA-5b7iA:
undetectable		 3s3cA-5b7iA:
20.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UQ6_A_ADNA401_1
(ADENOSINE KINASE,
PUTATIVE)		 5b7i CRISPR-ASSOCIATED
NUCLEASE/HELICASE
CAS3 SUBTYPE
I-F/YPEST
(Pseudomonas
aeruginosa) 		5 / 12 LEU A 353
GLY A 265
LEU A 349
GLY A 181
ASP A 182
 None
 0.90A 3uq6A-5b7iA:
undetectable		 3uq6A-5b7iA:
14.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UQ6_B_ADNB401_1
(ADENOSINE KINASE,
PUTATIVE)		 5b7i CRISPR-ASSOCIATED
NUCLEASE/HELICASE
CAS3 SUBTYPE
I-F/YPEST
(Pseudomonas
aeruginosa) 		5 / 12 LEU A 353
GLY A 265
LEU A 349
GLY A 181
ASP A 182
 None
 0.94A 3uq6B-5b7iA:
undetectable		 3uq6B-5b7iA:
14.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VAQ_A_ADNA401_1
(PUTATIVE ADENOSINE
KINASE)		 5b7i CRISPR-ASSOCIATED
NUCLEASE/HELICASE
CAS3 SUBTYPE
I-F/YPEST
(Pseudomonas
aeruginosa) 		5 / 12 LEU A 353
GLY A 265
LEU A 349
GLY A 181
ASP A 182
 None
 0.90A 3vaqA-5b7iA:
undetectable		 3vaqA-5b7iA:
14.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VAQ_B_ADNB401_1
(PUTATIVE ADENOSINE
KINASE)		 5b7i CRISPR-ASSOCIATED
NUCLEASE/HELICASE
CAS3 SUBTYPE
I-F/YPEST
(Pseudomonas
aeruginosa) 		5 / 12 LEU A 353
GLY A 265
LEU A 349
GLY A 181
ASP A 182
 None
 0.93A 3vaqB-5b7iA:
undetectable		 3vaqB-5b7iA:
14.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VAS_A_ADNA401_1
(PUTATIVE ADENOSINE
KINASE)		 5b7i CRISPR-ASSOCIATED
NUCLEASE/HELICASE
CAS3 SUBTYPE
I-F/YPEST
(Pseudomonas
aeruginosa) 		5 / 12 LEU A 353
GLY A 265
LEU A 349
GLY A 181
ASP A 182
 None
 0.91A 3vasA-5b7iA:
undetectable		 3vasA-5b7iA:
14.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VAS_B_ADNB401_1
(PUTATIVE ADENOSINE
KINASE)		 5b7i CRISPR-ASSOCIATED
NUCLEASE/HELICASE
CAS3 SUBTYPE
I-F/YPEST
(Pseudomonas
aeruginosa) 		5 / 12 LEU A 353
GLY A 265
LEU A 349
GLY A 181
ASP A 182
 None
 0.95A 3vasB-5b7iA:
undetectable		 3vasB-5b7iA:
14.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VM4_A_IZPA1_1
(FATTY ACID
ALPHA-HYDROXYLASE)		 5b7i CRISPR-ASSOCIATED
NUCLEASE/HELICASE
CAS3 SUBTYPE
I-F/YPEST
(Pseudomonas
aeruginosa) 		4 / 5 LEU A 848
ARG A 736
PRO A 822
ALA A 820
 None
 1.28A 3vm4A-5b7iA:
undetectable		 3vm4A-5b7iA:
18.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4APJ_A_ACTA1635_0
(ANGIOTENSIN-CONVERTI
NG ENZYME
BRADYKININ-POTENTIAT
ING PEPTIDE B)		 5b7i CRISPR-ASSOCIATED
NUCLEASE/HELICASE
CAS3 SUBTYPE
I-F/YPEST
(Pseudomonas
aeruginosa) 		4 / 6 HIS A 123
HIS A 149
ASP A 315
SER A 319
 CA  A1102 (-3.9A)
CA  A1101 (-3.8A)
CA  A1102 (-2.6A)
CA  A1102 ( 4.2A)
 1.39A 4apjA-5b7iA:
undetectable
4apjP-5b7iA:
undetectable		 4apjA-5b7iA:
18.92
4apjP-5b7iA:
3.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4B7Q_A_ZMRA601_2
(NEURAMINIDASE)		 5b7i CRISPR-ASSOCIATED
NUCLEASE/HELICASE
CAS3 SUBTYPE
I-F/YPEST
(Pseudomonas
aeruginosa) 		3 / 3 ARG A 936
ARG A 935
ILE A 583
 None
 0.78A 4b7qA-5b7iA:
undetectable		 4b7qA-5b7iA:
17.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4B7Q_C_ZMRC601_2
(NEURAMINIDASE)		 5b7i CRISPR-ASSOCIATED
NUCLEASE/HELICASE
CAS3 SUBTYPE
I-F/YPEST
(Pseudomonas
aeruginosa) 		3 / 3 ARG A 936
ARG A 935
ILE A 583
 None
 0.85A 4b7qC-5b7iA:
undetectable		 4b7qC-5b7iA:
17.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C1D_B_X8ZB350_1
(BETA-LACTAMASE CLASS
B VIM-2)		 5b7i CRISPR-ASSOCIATED
NUCLEASE/HELICASE
CAS3 SUBTYPE
I-F/YPEST
(Pseudomonas
aeruginosa) 		5 / 10 HIS A 221
HIS A 220
ASP A 315
HIS A 149
HIS A 352
 CA  A1101 (-3.5A)
CA  A1101 (-3.7A)
CA  A1102 (-2.6A)
CA  A1101 (-3.8A)
CA  A1102 (-3.6A)
 1.17A 4c1dB-5b7iA:
undetectable		 4c1dB-5b7iA:
14.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C1F_A_X8ZA300_1
(BETA-LACTAMASE IMP-1)		 5b7i CRISPR-ASSOCIATED
NUCLEASE/HELICASE
CAS3 SUBTYPE
I-F/YPEST
(Pseudomonas
aeruginosa) 		5 / 11 HIS A 221
HIS A 220
ASP A 315
HIS A 149
HIS A 352
 CA  A1101 (-3.5A)
CA  A1101 (-3.7A)
CA  A1102 (-2.6A)
CA  A1101 (-3.8A)
CA  A1102 (-3.6A)
 1.24A 4c1fA-5b7iA:
undetectable
4c1fB-5b7iA:
undetectable		 4c1fA-5b7iA:
11.94
4c1fB-5b7iA:
11.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C1H_A_X8ZA305_1
(BETA-LACTAMASE 2)		 5b7i CRISPR-ASSOCIATED
NUCLEASE/HELICASE
CAS3 SUBTYPE
I-F/YPEST
(Pseudomonas
aeruginosa) 		5 / 9 HIS A 221
HIS A 220
ASP A 315
HIS A 149
HIS A 352
 CA  A1101 (-3.5A)
CA  A1101 (-3.7A)
CA  A1102 (-2.6A)
CA  A1101 (-3.8A)
CA  A1102 (-3.6A)
 1.15A 4c1hA-5b7iA:
undetectable		 4c1hA-5b7iA:
11.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CP3_B_RBTB1129_1
(B-CELL LYMPHOMA 6
PROTEIN)		 5b7i CRISPR-ASSOCIATED
NUCLEASE/HELICASE
CAS3 SUBTYPE
I-F/YPEST
(Pseudomonas
aeruginosa) 		4 / 7 ARG A 155
LEU A 188
GLY A 126
SER A 129
 None
 1.00A 4cp3A-5b7iA:
undetectable
4cp3B-5b7iA:
undetectable		 4cp3A-5b7iA:
6.85
4cp3B-5b7iA:
6.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FE1_A_PQNA846_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A1
PHOTOSYSTEM I
REACTION CENTER
SUBUNIT IX)		 5b7i CRISPR-ASSOCIATED
NUCLEASE/HELICASE
CAS3 SUBTYPE
I-F/YPEST
(Pseudomonas
aeruginosa) 		5 / 10 SER A 809
ARG A1021
ALA A 755
LEU A 759
ALA A 863
 None
 1.27A 4fe1A-5b7iA:
undetectable
4fe1J-5b7iA:
undetectable		 4fe1A-5b7iA:
21.39
4fe1J-5b7iA:
3.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FFW_A_715A801_1
(DIPEPTIDYL PEPTIDASE
4)		 5b7i CRISPR-ASSOCIATED
NUCLEASE/HELICASE
CAS3 SUBTYPE
I-F/YPEST
(Pseudomonas
aeruginosa) 		5 / 12 GLU A 779
GLY A 827
ARG A 854
VAL A1028
VAL A 774
 None
None
ADP  A1103 (-3.0A)
None
None
 1.44A 4ffwA-5b7iA:
undetectable		 4ffwA-5b7iA:
20.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G0U_B_ASWB1301_1
(DNA TOPOISOMERASE
2-BETA)		 5b7i CRISPR-ASSOCIATED
NUCLEASE/HELICASE
CAS3 SUBTYPE
I-F/YPEST
(Pseudomonas
aeruginosa) 		4 / 7 ILE A 541
PRO A 540
GLY A  77
ALA A 444
 None
 0.94A 4g0uB-5b7iA:
undetectable		 4g0uB-5b7iA:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KMM_B_CHDB503_0
(FERROCHELATASE,
MITOCHONDRIAL)		 5b7i CRISPR-ASSOCIATED
NUCLEASE/HELICASE
CAS3 SUBTYPE
I-F/YPEST
(Pseudomonas
aeruginosa) 		4 / 5 LEU A 743
ARG A 775
PRO A 885
SER A 840
 None
 1.49A 4kmmB-5b7iA:
2.4		 4kmmB-5b7iA:
15.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MWZ_A_SAMA301_1
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE,
PUTATIVE)		 5b7i CRISPR-ASSOCIATED
NUCLEASE/HELICASE
CAS3 SUBTYPE
I-F/YPEST
(Pseudomonas
aeruginosa) 		3 / 3 SER A 821
ASP A 580
ASP A 576
 None
 0.86A 4mwzA-5b7iA:
3.1		 4mwzA-5b7iA:
11.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4N09_C_ADNC401_1
(ADENOSINE KINASE)		 5b7i CRISPR-ASSOCIATED
NUCLEASE/HELICASE
CAS3 SUBTYPE
I-F/YPEST
(Pseudomonas
aeruginosa) 		5 / 12 LEU A 353
GLY A 265
LEU A 349
GLY A 181
ASP A 182
 None
 0.89A 4n09C-5b7iA:
2.9		 4n09C-5b7iA:
14.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PST_A_FOLA201_1
(DIHYDROFOLATE
REDUCTASE)		 5b7i CRISPR-ASSOCIATED
NUCLEASE/HELICASE
CAS3 SUBTYPE
I-F/YPEST
(Pseudomonas
aeruginosa) 		3 / 3 ILE A 730
ASP A 833
ARG A 799
 None
 0.80A 4pstA-5b7iA:
undetectable		 4pstA-5b7iA:
8.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UAC_A_ACRA501_2
(CARBOHYDRATE ABC
TRANSPORTER
SUBSTRATE-BINDING
PROTEIN, CUT1 FAMILY
(TC 3.A.1.1.-))		 5b7i CRISPR-ASSOCIATED
NUCLEASE/HELICASE
CAS3 SUBTYPE
I-F/YPEST
(Pseudomonas
aeruginosa) 		4 / 7 PRO A 742
GLU A 741
SER A 821
THR A 456
 None
 1.09A 4uacA-5b7iA:
undetectable		 4uacA-5b7iA:
16.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4URO_A_NOVA2000_1
(DNA GYRASE SUBUNIT B)		 5b7i CRISPR-ASSOCIATED
NUCLEASE/HELICASE
CAS3 SUBTYPE
I-F/YPEST
(Pseudomonas
aeruginosa) 		5 / 12 SER A 421
ARG A 843
ILE A 917
PRO A 611
ARG A 916
 None
 1.24A 4uroA-5b7iA:
undetectable		 4uroA-5b7iA:
11.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4URO_B_NOVB2000_1
(DNA GYRASE SUBUNIT B)		 5b7i CRISPR-ASSOCIATED
NUCLEASE/HELICASE
CAS3 SUBTYPE
I-F/YPEST
(Pseudomonas
aeruginosa) 		5 / 12 SER A 421
ARG A 843
ILE A 917
PRO A 611
ARG A 916
 None
 1.27A 4uroB-5b7iA:
undetectable		 4uroB-5b7iA:
11.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4URO_D_NOVD2000_1
(DNA GYRASE SUBUNIT B)		 5b7i CRISPR-ASSOCIATED
NUCLEASE/HELICASE
CAS3 SUBTYPE
I-F/YPEST
(Pseudomonas
aeruginosa) 		5 / 12 SER A 421
ARG A 843
ILE A 917
PRO A 611
ARG A 916
 None
 1.24A 4uroD-5b7iA:
undetectable		 4uroD-5b7iA:
11.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WAN_C_ACTC303_0
(BRANCHPOINT-BRIDGING
PROTEIN)		 5b7i CRISPR-ASSOCIATED
NUCLEASE/HELICASE
CAS3 SUBTYPE
I-F/YPEST
(Pseudomonas
aeruginosa) 		3 / 3 ASP A 580
ARG A 736
PRO A 822
 None
 0.74A 4wanC-5b7iA:
undetectable		 4wanC-5b7iA:
7.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X1F_A_3WFA501_1
(NUCLEAR RECEPTOR
SUBFAMILY 1 GROUP I
MEMBER 2)		 5b7i CRISPR-ASSOCIATED
NUCLEASE/HELICASE
CAS3 SUBTYPE
I-F/YPEST
(Pseudomonas
aeruginosa) 		5 / 12 LEU A 589
LEU A 575
SER A 601
LEU A 549
ILE A 546
 None
 0.97A 4x1fA-5b7iA:
undetectable		 4x1fA-5b7iA:
15.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X1G_A_3WFA501_1
(NUCLEAR RECEPTOR
SUBFAMILY 1 GROUP I
MEMBER 2)		 5b7i CRISPR-ASSOCIATED
NUCLEASE/HELICASE
CAS3 SUBTYPE
I-F/YPEST
(Pseudomonas
aeruginosa) 		5 / 12 LEU A 589
LEU A 575
SER A 601
LEU A 549
ILE A 546
 None
 0.94A 4x1gA-5b7iA:
undetectable		 4x1gA-5b7iA:
15.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z69_A_DIFA1008_1
(SERUM ALBUMIN)		 5b7i CRISPR-ASSOCIATED
NUCLEASE/HELICASE
CAS3 SUBTYPE
I-F/YPEST
(Pseudomonas
aeruginosa) 		5 / 9 ALA A 119
PHE A 122
TRP A 273
SER A 360
VAL A 356
 None
 1.48A 4z69A-5b7iA:
undetectable		 4z69A-5b7iA:
19.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZJL_A_ERYA1101_0
(MULTIDRUG EFFLUX
PUMP SUBUNIT ACRB)		 5b7i CRISPR-ASSOCIATED
NUCLEASE/HELICASE
CAS3 SUBTYPE
I-F/YPEST
(Pseudomonas
aeruginosa) 		5 / 12 PHE A 973
GLU A 779
LEU A 772
THR A 459
GLY A 460
 None
 1.16A 4zjlA-5b7iA:
undetectable		 4zjlA-5b7iA:
22.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5C0O_G_SAMG301_1
(TRNA
(ADENINE(58)-N(1))-M
ETHYLTRANSFERASE
TRMI)		 5b7i CRISPR-ASSOCIATED
NUCLEASE/HELICASE
CAS3 SUBTYPE
I-F/YPEST
(Pseudomonas
aeruginosa) 		3 / 3 GLU A 150
HIS A 221
ASP A 145
 None
CA  A1101 (-3.5A)
None
 0.80A 5c0oG-5b7iA:
2.4		 5c0oG-5b7iA:
12.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IEO_A_VDYA206_1
(CDL2.3A)		 5b7i CRISPR-ASSOCIATED
NUCLEASE/HELICASE
CAS3 SUBTYPE
I-F/YPEST
(Pseudomonas
aeruginosa) 		5 / 12 PHE A 157
LEU A 171
TRP A 170
LEU A 209
THR A 277
 None
 1.33A 5ieoA-5b7iA:
undetectable		 5ieoA-5b7iA:
8.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L6E_A_SAMA601_1
(N6-ADENOSINE-METHYLT
RANSFERASE 70 KDA
SUBUNIT)		 5b7i CRISPR-ASSOCIATED
NUCLEASE/HELICASE
CAS3 SUBTYPE
I-F/YPEST
(Pseudomonas
aeruginosa) 		4 / 6 ASP A 648
ASP A 400
ARG A 432
GLN A 395
 None
None
None
ADP  A1103 (-3.4A)
 1.17A 5l6eA-5b7iA:
undetectable		 5l6eA-5b7iA:
12.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NEL_A_ACTA302_0
(PEPTIDOGLYCAN
N-ACETYLGLUCOSAMINE
DEACETYLASE)		 5b7i CRISPR-ASSOCIATED
NUCLEASE/HELICASE
CAS3 SUBTYPE
I-F/YPEST
(Pseudomonas
aeruginosa) 		5 / 6 ASP A 124
HIS A 352
HIS A 123
HIS A 149
HIS A 221
 CA  A1102 ( 2.6A)
CA  A1102 (-3.6A)
CA  A1102 (-3.9A)
CA  A1101 (-3.8A)
CA  A1101 (-3.5A)
 1.35A 5nelA-5b7iA:
undetectable
5nelD-5b7iA:
undetectable		 5nelA-5b7iA:
11.59
5nelD-5b7iA:
11.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TE8_B_08JB602_1
(CYTOCHROME P450 3A4)		 5b7i CRISPR-ASSOCIATED
NUCLEASE/HELICASE
CAS3 SUBTYPE
I-F/YPEST
(Pseudomonas
aeruginosa) 		4 / 8 ALA A 687
ILE A 836
ALA A 835
LEU A 717
 None
 0.81A 5te8B-5b7iA:
undetectable		 5te8B-5b7iA:
17.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TE8_B_08JB602_1
(CYTOCHROME P450 3A4)		 5b7i CRISPR-ASSOCIATED
NUCLEASE/HELICASE
CAS3 SUBTYPE
I-F/YPEST
(Pseudomonas
aeruginosa) 		4 / 8 SER A 571
ILE A 476
ALA A 475
LEU A 474
 None
 0.77A 5te8B-5b7iA:
undetectable		 5te8B-5b7iA:
17.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TIW_A_OAQA302_0
(SULFOTRANSFERASE)		 5b7i CRISPR-ASSOCIATED
NUCLEASE/HELICASE
CAS3 SUBTYPE
I-F/YPEST
(Pseudomonas
aeruginosa) 		5 / 12 ILE A 546
LEU A 542
LEU A 589
LEU A 605
LEU A 618
 None
 1.28A 5tiwA-5b7iA:
undetectable		 5tiwA-5b7iA:
11.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UL4_A_SAMA803_0
(OXSB PROTEIN)		 5b7i CRISPR-ASSOCIATED
NUCLEASE/HELICASE
CAS3 SUBTYPE
I-F/YPEST
(Pseudomonas
aeruginosa) 		5 / 12 ALA A 507
GLU A1054
GLY A 479
GLU A1041
LEU A1043
 None
 0.79A 5ul4A-5b7iA:
2.2		 5ul4A-5b7iA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VEU_H_RITH602_2
(CYTOCHROME P450 3A5)		 5b7i CRISPR-ASSOCIATED
NUCLEASE/HELICASE
CAS3 SUBTYPE
I-F/YPEST
(Pseudomonas
aeruginosa) 		4 / 5 ARG A 916
PHE A 892
PHE A 887
LEU A 932
 None
 1.33A 5veuH-5b7iA:
undetectable		 5veuH-5b7iA:
18.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YVN_A_ACTA305_0
(GLUTATHIONE
S-TRANSFERASE
OMEGA-1)		 5b7i CRISPR-ASSOCIATED
NUCLEASE/HELICASE
CAS3 SUBTYPE
I-F/YPEST
(Pseudomonas
aeruginosa) 		4 / 6 LEU A 374
GLN A 538
LEU A 527
LEU A 523
 None
 1.05A 5yvnA-5b7iA:
undetectable		 5yvnA-5b7iA:
12.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZRD_A_CUA607_0
(TYROSINASE)		 5b7i CRISPR-ASSOCIATED
NUCLEASE/HELICASE
CAS3 SUBTYPE
I-F/YPEST
(Pseudomonas
aeruginosa) 		3 / 3 HIS A 221
HIS A 220
HIS A 149
 CA  A1101 (-3.5A)
CA  A1101 (-3.7A)
CA  A1101 (-3.8A)
 0.42A 5zrdA-5b7iA:
undetectable		 5zrdA-5b7iA:
19.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B58_A_ACTA609_0
(FUMARATE REDUCTASE
FLAVOPROTEIN SUBUNIT)		 5b7i CRISPR-ASSOCIATED
NUCLEASE/HELICASE
CAS3 SUBTYPE
I-F/YPEST
(Pseudomonas
aeruginosa) 		3 / 3 HIS A 513
HIS A 511
ARG A 535
 None
 1.02A 6b58A-5b7iA:
undetectable		 6b58A-5b7iA:
19.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6D8P_B_ACTB804_0
(UNCHARACTERIZED
PROTEIN)		 5b7i CRISPR-ASSOCIATED
NUCLEASE/HELICASE
CAS3 SUBTYPE
I-F/YPEST
(Pseudomonas
aeruginosa) 		4 / 4 HIS A 830
VAL A 818
LEU A 782
ALA A 824
 None
 1.44A 6d8pB-5b7iA:
2.5		 6d8pB-5b7iA:
22.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EW0_F_TA1F502_2
(TUBULIN BETA CHAIN)		 5b7i CRISPR-ASSOCIATED
NUCLEASE/HELICASE
CAS3 SUBTYPE
I-F/YPEST
(Pseudomonas
aeruginosa) 		4 / 5 LEU A 717
LEU A 735
THR A 712
ARG A 870
 None
 1.10A 6ew0F-5b7iA:
undetectable		 6ew0F-5b7iA:
5.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNG_A_QPSA601_1
(-)		 5b7i CRISPR-ASSOCIATED
NUCLEASE/HELICASE
CAS3 SUBTYPE
I-F/YPEST
(Pseudomonas
aeruginosa) 		5 / 12 GLY A 451
VAL A 574
GLY A 886
ASN A 430
GLN A 847
 None
None
None
None
ADP  A1103 (-3.7A)
 1.11A 6gngA-5b7iA:
undetectable		 6gngA-5b7iA:
20.55