SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5b7o'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SQN_A_NDRA1001_0
(PROGESTERONE
RECEPTOR)		 5b7o PROLIFERATING CELL
NUCLEAR ANTIGEN
(Leishmania
donovani) 		5 / 12 LEU A  72
LEU A  70
ASN A  71
LEU A 118
LEU A  79
 None
 1.42A 1sqnA-5b7oA:
undetectable		 1sqnA-5b7oA:
20.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3D90_A_NOGA1001_1
(PROGESTERONE
RECEPTOR)		 5b7o PROLIFERATING CELL
NUCLEAR ANTIGEN
(Leishmania
donovani) 		5 / 12 LEU A  72
LEU A  70
ASN A  71
LEU A 118
LEU A  79
 None
 1.43A 3d90A-5b7oA:
undetectable		 3d90A-5b7oA:
20.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3I9J_B_NCAB302_0
(ADP-RIBOSYL CYCLASE)		 5b7o PROLIFERATING CELL
NUCLEAR ANTIGEN
(Leishmania
donovani) 		4 / 6 LEU A 119
GLU A  25
ASN A  24
PHE A  28
 None
 1.28A 3i9jB-5b7oA:
undetectable		 3i9jB-5b7oA:
22.83
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3VKX_A_T3A301_1
(PROLIFERATING CELL
NUCLEAR ANTIGEN)		 5b7o PROLIFERATING CELL
NUCLEAR ANTIGEN
(Leishmania
donovani) 		4 / 6 MET A  40
LEU A  47
PRO A 267
TYR A 283
 None
 0.65A 3vkxA-5b7oA:
34.6		 3vkxA-5b7oA:
40.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E7B_C_ACTC513_0
(UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE)		 5b7o PROLIFERATING CELL
NUCLEAR ANTIGEN
(Leishmania
donovani) 		3 / 3 TYR A 279
HIS A  49
ARG A 281
 None
 0.87A 4e7bC-5b7oA:
undetectable		 4e7bC-5b7oA:
23.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FFW_A_715A801_2
(DIPEPTIDYL PEPTIDASE
4)		 5b7o PROLIFERATING CELL
NUCLEAR ANTIGEN
(Leishmania
donovani) 		3 / 3 PHE A 144
TYR A 282
TYR A 272
 None
 0.92A 4ffwA-5b7oA:
undetectable		 4ffwA-5b7oA:
19.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YMG_B_SAMB1001_1
(PUTATIVE
SAM-DEPENDENT
O-METHYLTRANFERASE)		 5b7o PROLIFERATING CELL
NUCLEAR ANTIGEN
(Leishmania
donovani) 		3 / 3 SER A  96
GLU A   3
GLU A 104
 None
 0.84A 4ymgB-5b7oA:
undetectable		 4ymgB-5b7oA:
22.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5U63_A_ACTA406_0
(THIOREDOXIN
REDUCTASE)		 5b7o PROLIFERATING CELL
NUCLEAR ANTIGEN
(Leishmania
donovani) 		3 / 3 HIS A  49
SER A  36
ARG A  53
 None
 1.00A 5u63A-5b7oA:
undetectable		 5u63A-5b7oA:
22.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6J21_A_GBQA1201_0
(SUBSTANCE-P
RECEPTOR,ENDOLYSIN)		 5b7o PROLIFERATING CELL
NUCLEAR ANTIGEN
(Leishmania
donovani) 		5 / 12 ILE A  19
VAL A  23
ILE A 274
HIS A  49
VAL A  37
 None
 1.45A 6j21A-5b7oA:
undetectable		 6j21A-5b7oA:
21.62