SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5b7s'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DIT_P_2PPP1_1
(ALPHA-THROMBIN
PEPTIDE INHIBITOR
CVS995)		 5b7s CYSTEINE DESULFURASE
(Thermococcus
onnurineus) 		4 / 6 LEU A 277
ILE A  68
GLU A 285
PRO A 218
 None
None
None
LLP  A 216 ( 4.0A)
 1.15A 1ditH-5b7sA:
undetectable
1ditP-5b7sA:
undetectable		 1ditH-5b7sA:
21.34
1ditP-5b7sA:
4.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UDU_B_CIAB2003_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		 5b7s CYSTEINE DESULFURASE
(Thermococcus
onnurineus) 		5 / 12 ALA A 148
ILE A 179
ILE A 135
VAL A 160
ALA A 159
 None
 1.09A 1uduB-5b7sA:
undetectable		 1uduB-5b7sA:
21.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_A_CTXA11_1
(CES1 PROTEIN)		 5b7s CYSTEINE DESULFURASE
(Thermococcus
onnurineus) 		4 / 8 PRO A 218
MET A 219
LEU A 277
GLY A 273
 LLP  A 216 ( 4.0A)
None
None
None
 0.86A 1ya4A-5b7sA:
undetectable		 1ya4A-5b7sA:
21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JAP_A_J01A1249_1
(CLAVALDEHYDE
DEHYDROGENASE)		 5b7s CYSTEINE DESULFURASE
(Thermococcus
onnurineus) 		5 / 12 ILE A 224
ALA A 274
VAL A  69
TYR A  62
THR A  83
 None
 0.86A 2japA-5b7sA:
3.0		 2japA-5b7sA:
22.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JAP_B_J01B1249_1
(CLAVALDEHYDE
DEHYDROGENASE)		 5b7s CYSTEINE DESULFURASE
(Thermococcus
onnurineus) 		5 / 12 ILE A 224
ALA A 274
VAL A  69
TYR A  62
THR A  83
 None
 0.86A 2japB-5b7sA:
3.1		 2japB-5b7sA:
22.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JAP_C_J01C1249_1
(CLAVALDEHYDE
DEHYDROGENASE)		 5b7s CYSTEINE DESULFURASE
(Thermococcus
onnurineus) 		5 / 12 ILE A 224
ALA A 274
VAL A  69
TYR A  62
THR A  83
 None
 0.86A 2japC-5b7sA:
undetectable		 2japC-5b7sA:
22.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JAP_D_J01D1249_1
(CLAVALDEHYDE
DEHYDROGENASE)		 5b7s CYSTEINE DESULFURASE
(Thermococcus
onnurineus) 		5 / 12 ILE A 224
ALA A 274
VAL A  69
TYR A  62
THR A  83
 None
 0.87A 2japD-5b7sA:
3.1		 2japD-5b7sA:
22.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GYQ_A_SAMA270_0
(RRNA
(ADENOSINE-2'-O-)-ME
THYLTRANSFERASE)		 5b7s CYSTEINE DESULFURASE
(Thermococcus
onnurineus) 		5 / 12 LEU A 277
ALA A 279
GLY A 272
ILE A  68
SER A  65
 None
 1.28A 3gyqA-5b7sA:
undetectable
3gyqB-5b7sA:
undetectable		 3gyqA-5b7sA:
18.90
3gyqB-5b7sA:
18.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T7V_A_SAMA992_0
(METHYLORNITHINE
SYNTHASE PYLB)		 5b7s CYSTEINE DESULFURASE
(Thermococcus
onnurineus) 		5 / 12 GLY A 353
GLY A 368
LEU A 393
MET A 390
VAL A 350
 None
 1.22A 3t7vA-5b7sA:
undetectable		 3t7vA-5b7sA:
22.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IAR_A_ERMA2001_1
(CHIMERA PROTEIN OF
HUMAN
5-HYDROXYTRYPTAMINE
RECEPTOR 1B AND E.
COLI SOLUBLE
CYTOCHROME B562)		 5b7s CYSTEINE DESULFURASE
(Thermococcus
onnurineus) 		5 / 12 ASP A 117
VAL A  93
ALA A 207
LEU A 130
THR A 109
 None
 1.47A 4iarA-5b7sA:
undetectable		 4iarA-5b7sA:
20.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J5J_B_478B401_2
(PROTEASE)		 5b7s CYSTEINE DESULFURASE
(Thermococcus
onnurineus) 		5 / 10 ALA A 191
ILE A  73
VAL A 226
GLY A 214
VAL A 200
 None
None
None
LLP  A 216 ( 4.4A)
None
 0.81A 4j5jB-5b7sA:
undetectable		 4j5jB-5b7sA:
11.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KSZ_A_CYSA620_0
(LACTOPEROXIDASE)		 5b7s CYSTEINE DESULFURASE
(Thermococcus
onnurineus) 		3 / 3 ARG A 230
GLU A 231
PHE A 234
 GOL  A 401 ( 4.6A)
None
None
 0.98A 4kszA-5b7sA:
undetectable		 4kszA-5b7sA:
21.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KYA_E_FOLE703_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 5b7s CYSTEINE DESULFURASE
(Thermococcus
onnurineus) 		5 / 11 ALA A 159
ASP A 117
SER A 164
VAL A 173
THR A 109
 None
 1.41A 4kyaE-5b7sA:
undetectable		 4kyaE-5b7sA:
22.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KYA_G_FOLG703_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 5b7s CYSTEINE DESULFURASE
(Thermococcus
onnurineus) 		5 / 11 ALA A 159
ASP A 117
SER A 164
VAL A 173
THR A 109
 None
 1.39A 4kyaG-5b7sA:
undetectable		 4kyaG-5b7sA:
22.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NKV_C_AERC601_1
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 5b7s CYSTEINE DESULFURASE
(Thermococcus
onnurineus) 		5 / 12 ALA A 191
ILE A 284
ILE A 281
GLY A 214
VAL A  69
 None
None
None
LLP  A 216 ( 4.4A)
None
 0.94A 4nkvC-5b7sA:
undetectable		 4nkvC-5b7sA:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NKV_D_AERD601_1
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 5b7s CYSTEINE DESULFURASE
(Thermococcus
onnurineus) 		5 / 12 ALA A 191
ILE A 284
ILE A 281
GLY A 214
VAL A  69
 None
None
None
LLP  A 216 ( 4.4A)
None
 0.93A 4nkvD-5b7sA:
undetectable		 4nkvD-5b7sA:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4U9U_A_ACTA1502_0
(NA(+)-TRANSLOCATING
NADH-QUINONE
REDUCTASE SUBUNIT F)		 5b7s CYSTEINE DESULFURASE
(Thermococcus
onnurineus) 		4 / 5 GLY A 276
ALA A 279
GLY A 220
PRO A 221
 None
 0.90A 4u9uA-5b7sA:
undetectable		 4u9uA-5b7sA:
22.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4U9U_B_ACTB1502_0
(NA(+)-TRANSLOCATING
NADH-QUINONE
REDUCTASE SUBUNIT F)		 5b7s CYSTEINE DESULFURASE
(Thermococcus
onnurineus) 		4 / 5 GLY A 276
ALA A 279
GLY A 220
PRO A 221
 None
 0.91A 4u9uB-5b7sA:
undetectable		 4u9uB-5b7sA:
22.95
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5DB5_A_CYSA503_0
(CYSTEINE DESULFURASE)		 5b7s CYSTEINE DESULFURASE
(Thermococcus
onnurineus) 		5 / 8 ALA A  24
HIS A 114
ASN A 165
ARG A 351
ARG A 371
 None
LLP  A 216 ( 3.4A)
LLP  A 216 ( 3.8A)
None
None
 0.58A 5db5A-5b7sA:
53.0
5db5B-5b7sA:
55.2		 5db5A-5b7sA:
40.81
5db5B-5b7sA:
40.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HNZ_B_TA1B902_1
(TUBULIN BETA-2B
CHAIN)		 5b7s CYSTEINE DESULFURASE
(Thermococcus
onnurineus) 		5 / 12 VAL A 200
ALA A 191
SER A 194
THR A  83
PRO A 218
 None
None
None
None
LLP  A 216 ( 4.0A)
 1.38A 5hnzB-5b7sA:
2.1		 5hnzB-5b7sA:
20.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KVA_A_SAMA301_1
(CAFFEOYL-COA
O-METHYLTRANSFERASE)		 5b7s CYSTEINE DESULFURASE
(Thermococcus
onnurineus) 		3 / 3 THR A 369
SER A 328
ASP A  21
 None
 0.75A 5kvaA-5b7sA:
undetectable		 5kvaA-5b7sA:
23.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KVA_B_SAMB301_1
(CAFFEOYL-COA
O-METHYLTRANSFERASE)		 5b7s CYSTEINE DESULFURASE
(Thermococcus
onnurineus) 		3 / 3 THR A 369
SER A 328
ASP A  21
 None
 0.78A 5kvaB-5b7sA:
undetectable		 5kvaB-5b7sA:
23.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OEX_D_CUD603_0
(THIOCYANATE
DEHYDROGENASE)		 5b7s CYSTEINE DESULFURASE
(Thermococcus
onnurineus) 		3 / 3 LYS A 217
HIS A 197
HIS A 375
 LLP  A 216 ( 2.8A)
None
None
 1.42A 5oexD-5b7sA:
undetectable		 5oexD-5b7sA:
21.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VCE_A_RITA602_1
(CYTOCHROME P450 3A4)		 5b7s CYSTEINE DESULFURASE
(Thermococcus
onnurineus) 		5 / 12 PHE A  82
ILE A  80
ILE A  73
ALA A 195
GLU A  88
 None
 1.03A 5vceA-5b7sA:
undetectable		 5vceA-5b7sA:
21.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EF6_A_ACTA405_0
(AMINOGLYCOSIDE
PHOSPHOTRANSFERASE)		 5b7s CYSTEINE DESULFURASE
(Thermococcus
onnurineus) 		4 / 6 THR A 109
PRO A 120
GLN A 122
ILE A 107
 None
 1.30A 6ef6A-5b7sA:
undetectable		 6ef6A-5b7sA:
23.98