SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5b7z'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MAA_B_DMEB996_1
(ACETYLCHOLINESTERASE)		 5b7z UNCHARACTERIZED
PROTEIN TM_0416
(Thermotoga
maritima) 		4 / 6 TYR A 236
GLU A  39
ILE A 162
GLY A 201
 None
 1.14A 1maaB-5b7zA:
2.3
1maaD-5b7zA:
undetectable		 1maaB-5b7zA:
19.27
1maaD-5b7zA:
19.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TUV_A_VK3A4558_1
(PROTEIN YGIN)		 5b7z UNCHARACTERIZED
PROTEIN TM_0416
(Thermotoga
maritima) 		4 / 7 GLU A 243
HIS A 185
LEU A 151
ILE A 110
 NI  A 305 (-2.5A)
None
None
None
 1.15A 1tuvA-5b7zA:
undetectable		 1tuvA-5b7zA:
17.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BNN_B_FCNB1199_1
(EPOXIDASE)		 5b7z UNCHARACTERIZED
PROTEIN TM_0416
(Thermotoga
maritima) 		4 / 8 LEU A 108
HIS A 208
GLU A  39
ALA A  66
 1PG  A 306 (-4.8A)
NI  A 305 (-3.0A)
None
None
 0.94A 2bnnA-5b7zA:
undetectable
2bnnB-5b7zA:
undetectable		 2bnnA-5b7zA:
25.00
2bnnB-5b7zA:
25.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PO5_A_CHDA502_0
(FERROCHELATASE,
MITOCHONDRIAL)		 5b7z UNCHARACTERIZED
PROTEIN TM_0416
(Thermotoga
maritima) 		4 / 8 LEU A 137
ARG A 115
PRO A  45
GLY A  68
 None
None
MPD  A 302 ( 4.8A)
None
 0.81A 2po5A-5b7zA:
undetectable		 2po5A-5b7zA:
23.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q83_B_ADNB2_1
(YTAA PROTEIN)		 5b7z UNCHARACTERIZED
PROTEIN TM_0416
(Thermotoga
maritima) 		4 / 6 ILE A 234
PRO A 150
LEU A 166
ILE A 179
 None
 0.97A 2q83B-5b7zA:
undetectable		 2q83B-5b7zA:
22.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HCR_B_CHDB924_0
(FERROCHELATASE,
MITOCHONDRIAL)		 5b7z UNCHARACTERIZED
PROTEIN TM_0416
(Thermotoga
maritima) 		4 / 7 LEU A 137
ARG A 115
PRO A  45
GLY A  68
 None
None
MPD  A 302 ( 4.8A)
None
 1.06A 3hcrB-5b7zA:
undetectable		 3hcrB-5b7zA:
23.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LCV_B_SAMB301_0
(SISOMICIN-GENTAMICIN
RESISTANCE METHYLASE
SGM)		 5b7z UNCHARACTERIZED
PROTEIN TM_0416
(Thermotoga
maritima) 		5 / 12 HIS A 206
ALA A  37
ILE A  64
LEU A  62
LEU A   3
 None
None
None
None
1PG  A 307 ( 4.6A)
 1.19A 3lcvB-5b7zA:
undetectable		 3lcvB-5b7zA:
23.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NNE_G_ACTG601_0
(CHOLINE OXIDASE)		 5b7z UNCHARACTERIZED
PROTEIN TM_0416
(Thermotoga
maritima) 		4 / 6 ALA A  66
ILE A 110
HIS A 208
VAL A   6
 None
None
NI  A 305 (-3.0A)
None
 0.84A 3nneG-5b7zA:
undetectable		 3nneG-5b7zA:
18.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NVK_I_SAMI228_0
(FIBRILLARIN-LIKE
RRNA/TRNA
2'-O-METHYLTRANSFERA
SE)		 5b7z UNCHARACTERIZED
PROTEIN TM_0416
(Thermotoga
maritima) 		5 / 12 GLY A 112
THR A 156
ILE A 110
VAL A 114
GLU A 119
 None
None
None
None
MPD  A 301 ( 4.3A)
 1.15A 3nvkI-5b7zA:
undetectable		 3nvkI-5b7zA:
22.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K50_B_ACTB701_0
(RNA (33-MER)
RNA POLYMERASE
3D-POL)		 5b7z UNCHARACTERIZED
PROTEIN TM_0416
(Thermotoga
maritima) 		3 / 3 HIS A 208
GLY A  68
ILE A 110
 NI  A 305 (-3.0A)
None
None
 0.54A 4k50A-5b7zA:
undetectable		 4k50A-5b7zA:
19.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K50_J_ACTJ701_0
(RNA (33-MER)
RNA POLYMERASE
3D-POL)		 5b7z UNCHARACTERIZED
PROTEIN TM_0416
(Thermotoga
maritima) 		3 / 3 HIS A 208
GLY A  68
ILE A 110
 NI  A 305 (-3.0A)
None
None
 0.53A 4k50I-5b7zA:
undetectable		 4k50I-5b7zA:
19.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MJW_A_ACTA603_0
(CHOLINE OXIDASE)		 5b7z UNCHARACTERIZED
PROTEIN TM_0416
(Thermotoga
maritima) 		3 / 3 ARG A  94
HIS A  98
SER A  46
 None
 0.93A 4mjwA-5b7zA:
undetectable
4mjwB-5b7zA:
undetectable		 4mjwA-5b7zA:
18.81
4mjwB-5b7zA:
18.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MJW_B_ACTB603_0
(CHOLINE OXIDASE)		 5b7z UNCHARACTERIZED
PROTEIN TM_0416
(Thermotoga
maritima) 		3 / 3 SER A  46
ARG A  94
HIS A  98
 None
 0.98A 4mjwA-5b7zA:
undetectable
4mjwB-5b7zA:
undetectable		 4mjwA-5b7zA:
18.81
4mjwB-5b7zA:
18.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_2_BEZ2801_0
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 1
BEZ-LEU-LEU)		 5b7z UNCHARACTERIZED
PROTEIN TM_0416
(Thermotoga
maritima) 		4 / 4 LEU A 180
ARG A 115
ILE A 148
ILE A 159
 None
 1.06A 5dzk2-5b7zA:
undetectable
5dzkM-5b7zA:
undetectable
5dzkN-5b7zA:
undetectable		 5dzk2-5b7zA:
1.27
5dzkM-5b7zA:
21.40
5dzkN-5b7zA:
21.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M45_A_ACTA803_0
(ACETONE CARBOXYLASE
ALPHA SUBUNIT)		 5b7z UNCHARACTERIZED
PROTEIN TM_0416
(Thermotoga
maritima) 		4 / 4 GLU A 149
PRO A 150
ILE A 148
LEU A 180
 NI  A 305 (-2.4A)
None
None
None
 1.30A 5m45A-5b7zA:
undetectable		 5m45A-5b7zA:
16.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M45_D_ACTD803_0
(ACETONE CARBOXYLASE
ALPHA SUBUNIT)		 5b7z UNCHARACTERIZED
PROTEIN TM_0416
(Thermotoga
maritima) 		4 / 4 GLU A 149
PRO A 150
ILE A 148
LEU A 180
 NI  A 305 (-2.4A)
None
None
None
 1.27A 5m45D-5b7zA:
undetectable		 5m45D-5b7zA:
16.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M45_G_ACTG803_0
(ACETONE CARBOXYLASE
ALPHA SUBUNIT)		 5b7z UNCHARACTERIZED
PROTEIN TM_0416
(Thermotoga
maritima) 		4 / 4 GLU A 149
PRO A 150
ILE A 148
LEU A 180
 NI  A 305 (-2.4A)
None
None
None
 1.27A 5m45G-5b7zA:
0.0		 5m45G-5b7zA:
16.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M45_J_ACTJ803_0
(ACETONE CARBOXYLASE
ALPHA SUBUNIT)		 5b7z UNCHARACTERIZED
PROTEIN TM_0416
(Thermotoga
maritima) 		4 / 4 GLU A 149
PRO A 150
ILE A 148
LEU A 180
 NI  A 305 (-2.4A)
None
None
None
 1.30A 5m45J-5b7zA:
undetectable		 5m45J-5b7zA:
16.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DK1_C_GM4C301_0
(SIGMA NON-OPIOID
INTRACELLULAR
RECEPTOR 1)		 5b7z UNCHARACTERIZED
PROTEIN TM_0416
(Thermotoga
maritima) 		5 / 11 VAL A   6
LEU A 180
GLU A 149
THR A  69
ALA A  41
 None
None
NI  A 305 (-2.4A)
None
None
 1.17A 6dk1C-5b7zA:
undetectable		 6dk1C-5b7zA:
21.14