SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5b86'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1J8U_A_H4BA429_1
(PHENYLALANINE-4-HYDR
OXYLASE)		 5b86 TUMOR NECROSIS
FACTOR ALPHA-INDUCED
PROTEIN 2
(Mus
musculus) 		4 / 7 VAL A 432
LEU A 361
LEU A 356
ALA A 331
 None
 0.88A 1j8uA-5b86A:
undetectable		 1j8uA-5b86A:
21.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QZR_B_CDXB901_1
(DNA TOPOISOMERASE II)		 5b86 TUMOR NECROSIS
FACTOR ALPHA-INDUCED
PROTEIN 2
(Mus
musculus) 		4 / 7 THR A 244
TYR A 245
TYR A 249
LEU A 224
 None
 1.06A 1qzrA-5b86A:
undetectable		 1qzrA-5b86A:
18.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QZR_B_CDXB901_2
(DNA TOPOISOMERASE II)		 5b86 TUMOR NECROSIS
FACTOR ALPHA-INDUCED
PROTEIN 2
(Mus
musculus) 		4 / 7 THR A 244
TYR A 245
TYR A 249
LEU A 224
 None
 1.07A 1qzrB-5b86A:
1.8		 1qzrB-5b86A:
18.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BNN_B_FCNB1199_1
(EPOXIDASE)		 5b86 TUMOR NECROSIS
FACTOR ALPHA-INDUCED
PROTEIN 2
(Mus
musculus) 		4 / 8 LEU A 332
ASN A 424
HIS A 353
ALA A 331
 None
 1.03A 2bnnA-5b86A:
undetectable
2bnnB-5b86A:
undetectable		 2bnnA-5b86A:
16.48
2bnnB-5b86A:
16.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DG3_A_RAPA501_1
(FK506-BINDING
PROTEIN 1A)		 5b86 TUMOR NECROSIS
FACTOR ALPHA-INDUCED
PROTEIN 2
(Mus
musculus) 		5 / 11 TYR A 600
VAL A 522
ILE A 526
ILE A 580
PHE A 644
 None
 1.24A 2dg3A-5b86A:
undetectable		 2dg3A-5b86A:
10.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DG4_A_RAPA501_1
(FK506-BINDING
PROTEIN 1A)		 5b86 TUMOR NECROSIS
FACTOR ALPHA-INDUCED
PROTEIN 2
(Mus
musculus) 		5 / 11 TYR A 600
VAL A 522
ILE A 526
ILE A 580
PHE A 644
 None
 1.24A 2dg4A-5b86A:
undetectable		 2dg4A-5b86A:
10.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DG9_A_RAPA501_1
(FK506-BINDING
PROTEIN 1A)		 5b86 TUMOR NECROSIS
FACTOR ALPHA-INDUCED
PROTEIN 2
(Mus
musculus) 		5 / 11 TYR A 600
VAL A 522
ILE A 526
ILE A 580
PHE A 644
 None
 1.17A 2dg9A-5b86A:
undetectable		 2dg9A-5b86A:
10.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2R2V_D_ACTD36_0
(GCN4 LEUCINE ZIPPER)		 5b86 TUMOR NECROSIS
FACTOR ALPHA-INDUCED
PROTEIN 2
(Mus
musculus) 		3 / 3 SER A 248
TYR A 251
HIS A 252
 None
 0.53A 2r2vD-5b86A:
undetectable		 2r2vD-5b86A:
6.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U5J_A_08HA1_1
(BROMODOMAIN-CONTAINI
NG PROTEIN 4)		 5b86 TUMOR NECROSIS
FACTOR ALPHA-INDUCED
PROTEIN 2
(Mus
musculus) 		4 / 7 PRO A 289
LEU A 295
LEU A 300
ILE A 285
 None
 1.03A 3u5jA-5b86A:
undetectable		 3u5jA-5b86A:
12.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DRH_A_RAPA201_1
(PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
FKBP5)		 5b86 TUMOR NECROSIS
FACTOR ALPHA-INDUCED
PROTEIN 2
(Mus
musculus) 		5 / 12 TYR A 600
VAL A 522
ILE A 526
ILE A 611
PHE A 644
 None
 1.27A 4drhA-5b86A:
undetectable		 4drhA-5b86A:
13.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DRH_D_RAPD201_1
(PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
FKBP5)		 5b86 TUMOR NECROSIS
FACTOR ALPHA-INDUCED
PROTEIN 2
(Mus
musculus) 		5 / 12 TYR A 600
VAL A 522
ILE A 526
ILE A 611
PHE A 644
 None
 1.28A 4drhD-5b86A:
undetectable		 4drhD-5b86A:
13.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DRI_A_RAPA201_1
(PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
FKBP5)		 5b86 TUMOR NECROSIS
FACTOR ALPHA-INDUCED
PROTEIN 2
(Mus
musculus) 		5 / 11 TYR A 600
VAL A 522
ILE A 526
ILE A 611
PHE A 644
 None
 1.26A 4driA-5b86A:
undetectable		 4driA-5b86A:
13.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4F8Y_B_VK3B202_1
(NADPH QUINONE
OXIDOREDUCTASE)		 5b86 TUMOR NECROSIS
FACTOR ALPHA-INDUCED
PROTEIN 2
(Mus
musculus) 		4 / 6 TRP A 339
ASN A 423
TYR A 397
LEU A 453
 None
 1.28A 4f8yA-5b86A:
undetectable
4f8yB-5b86A:
undetectable		 4f8yA-5b86A:
14.83
4f8yB-5b86A:
14.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4F8Y_C_VK3C202_1
(NADPH QUINONE
OXIDOREDUCTASE)		 5b86 TUMOR NECROSIS
FACTOR ALPHA-INDUCED
PROTEIN 2
(Mus
musculus) 		4 / 7 TYR A 397
LEU A 453
TRP A 339
ASN A 423
 None
 1.29A 4f8yC-5b86A:
undetectable
4f8yD-5b86A:
undetectable		 4f8yC-5b86A:
14.83
4f8yD-5b86A:
14.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RTB_A_SAMA501_1
(HYDG PROTEIN)		 5b86 TUMOR NECROSIS
FACTOR ALPHA-INDUCED
PROTEIN 2
(Mus
musculus) 		3 / 3 GLU A 355
ARG A 338
GLN A 362
 None
 0.88A 4rtbA-5b86A:
undetectable		 4rtbA-5b86A:
22.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UHX_A_LZUA3008_1
(ALDEHYDE OXIDASE)		 5b86 TUMOR NECROSIS
FACTOR ALPHA-INDUCED
PROTEIN 2
(Mus
musculus) 		4 / 8 GLU A 158
ASP A 159
ARG A  96
TRP A 179
 None
 1.12A 4uhxA-5b86A:
undetectable		 4uhxA-5b86A:
18.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UHX_A_RTZA3009_1
(ALDEHYDE OXIDASE)		 5b86 TUMOR NECROSIS
FACTOR ALPHA-INDUCED
PROTEIN 2
(Mus
musculus) 		4 / 8 GLU A 158
ASP A 159
ARG A  96
TRP A 179
 None
 1.12A 4uhxA-5b86A:
undetectable		 4uhxA-5b86A:
18.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HW4_C_SAMC801_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE I)		 5b86 TUMOR NECROSIS
FACTOR ALPHA-INDUCED
PROTEIN 2
(Mus
musculus) 		5 / 12 ILE A 422
GLY A 457
THR A 460
ASP A 459
GLU A 512
 None
 1.23A 5hw4C-5b86A:
undetectable		 5hw4C-5b86A:
19.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KC4_E_RBFE201_1
(RIBOFLAVIN
TRANSPORTER RIBU)		 5b86 TUMOR NECROSIS
FACTOR ALPHA-INDUCED
PROTEIN 2
(Mus
musculus) 		5 / 12 LEU A 286
GLY A 217
MET A 220
LEU A 224
ALA A 246
 None
 0.59A 5kc4E-5b86A:
2.4		 5kc4E-5b86A:
14.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DCH_A_ACTA401_0
(SCOE PROTEIN)		 5b86 TUMOR NECROSIS
FACTOR ALPHA-INDUCED
PROTEIN 2
(Mus
musculus) 		4 / 5 THR A 219
ASP A 196
HIS A 252
ARG A 212
 None
 1.40A 6dchA-5b86A:
undetectable		 6dchA-5b86A:
19.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FBV_D_FI8D1904_0
(DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA
DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA')		 5b86 TUMOR NECROSIS
FACTOR ALPHA-INDUCED
PROTEIN 2
(Mus
musculus) 		4 / 8 GLN A 326
THR A 322
VAL A 321
GLU A 389
 None
 1.17A 6fbvC-5b86A:
undetectable		 6fbvC-5b86A:
19.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HU9_S_PCFS603_0
(CYTOCHROME B-C1
COMPLEX SUBUNIT 8
CYTOCHROME C OXIDASE
POLYPEPTIDE 5A,
MITOCHONDRIAL)		 5b86 TUMOR NECROSIS
FACTOR ALPHA-INDUCED
PROTEIN 2
(Mus
musculus) 		4 / 7 GLN A 557
GLY A 558
PHE A 559
SER A 565
 None
 1.06A 6hu9S-5b86A:
undetectable
6hu9q-5b86A:
2.9		 6hu9S-5b86A:
9.76
6hu9q-5b86A:
10.88