SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5b8c'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1H8S_A_AICA1000_1
(MUTANT AL2 6E7P9G)		 5b8c PEMBROLIZUMAB HEAVY
CHAIN VARIABLE
REGION (PEMVH)
PEMBROLIZUMAB LIGHT
CHAIN VARIABLE
REGION (PEMVL)
(Homo
sapiens) 		7 / 12 TYR A  40
GLN A  93
LEU A 100
PHE A 102
VAL B  37
ALA B  97
TRP B 110
 None
 0.54A 1h8sA-5b8cA:
22.0		 1h8sA-5b8cA:
29.29
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1I7Z_C_COCC302_1
(CHIMERA OF IG KAPPA
CHAIN: HUMAN
CONSTANT REGION AND
MOUSE VARIABLE
REGION)		 5b8c PEMBROLIZUMAB LIGHT
CHAIN VARIABLE
REGION (PEMVL)
(Homo
sapiens) 		5 / 9 TYR A  34
HIS A  38
TYR A  40
TYR A  53
SER A  95
 None
 1.07A 1i7zC-5b8cA:
21.7		 1i7zC-5b8cA:
39.27
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1IBG_H_OBNH1_2
(IGG2B-KAPPA 40-50
FAB (HEAVY CHAIN)
IGG2B-KAPPA 40-50
FAB (LIGHT CHAIN))		 5b8c PEMBROLIZUMAB LIGHT
CHAIN VARIABLE
REGION (PEMVL)
(Homo
sapiens) 		5 / 7 THR A  31
SER A  32
SER A  95
ARG A  96
LEU A 100
 None
 0.66A 1ibgL-5b8cA:
22.9		 1ibgL-5b8cA:
42.72
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2OLD_B_IPHB2001_0
(BENCE JONES KWR
PROTEIN -
IMMUNOGLOBULIN LIGHT
CHAIN)		 5b8c PEMBROLIZUMAB LIGHT
CHAIN VARIABLE
REGION (PEMVL)
PEMBROLIZUMAB HEAVY
CHAIN VARIABLE
REGION (PEMVH)
(Homo
sapiens;
Homo
sapiens) 		4 / 7 TYR A  40
PRO A  48
TYR A  91
TYR B  95
 None
 0.67A 2oldA-5b8cA:
17.7
2oldB-5b8cA:
17.6		 2oldA-5b8cA:
32.29
2oldB-5b8cA:
32.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OLD_B_IPHB2001_0
(BENCE JONES KWR
PROTEIN -
IMMUNOGLOBULIN LIGHT
CHAIN)		 5b8c PEMBROLIZUMAB LIGHT
CHAIN VARIABLE
REGION (PEMVL)
PEMBROLIZUMAB HEAVY
CHAIN VARIABLE
REGION (PEMVH)
(Homo
sapiens;
Homo
sapiens) 		4 / 7 TYR B  95
TYR A  40
PRO A  48
TYR A  91
 None
 0.72A 2oldA-5b8cB:
14.8
2oldB-5b8cB:
14.8		 2oldA-5b8cB:
19.82
2oldB-5b8cB:
19.82
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3LS4_H_TCIH220_2
(HEAVY CHAIN OF
ANTIBODY FAB
FRAGMENT
LIGHT CHAIN OF
ANTIBODY FAB
FRAGMENT)		 5b8c PEMBROLIZUMAB LIGHT
CHAIN VARIABLE
REGION (PEMVL)
(Homo
sapiens) 		4 / 5 TYR A  40
GLN A  93
LEU A 100
PHE A 102
 None
 0.33A 3ls4L-5b8cA:
21.2		 3ls4L-5b8cA:
35.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JH7_B_6K9B503_0
(TUBULIN BETA-2B
CHAIN)		 5b8c PEMBROLIZUMAB LIGHT
CHAIN VARIABLE
REGION (PEMVL)
PEMBROLIZUMAB HEAVY
CHAIN VARIABLE
REGION (PEMVH)
(Homo
sapiens;
Homo
sapiens) 		5 / 11 ASN B  59
VAL B  37
TYR B  95
PRO A  48
LEU B  45
 None
 1.48A 5jh7B-5b8cB:
undetectable		 5jh7B-5b8cB:
13.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L4E_D_EDPD402_1
(PROTON-GATED ION
CHANNEL)		 5b8c PEMBROLIZUMAB LIGHT
CHAIN VARIABLE
REGION (PEMVL)
(Homo
sapiens) 		4 / 8 THR A  78
SER A  67
THR A  76
SER A  69
 None
 1.00A 5l4eA-5b8cA:
undetectable
5l4eB-5b8cA:
undetectable
5l4eC-5b8cA:
undetectable
5l4eD-5b8cA:
undetectable
5l4eE-5b8cA:
undetectable		 5l4eA-5b8cA:
18.33
5l4eB-5b8cA:
18.33
5l4eC-5b8cA:
18.33
5l4eD-5b8cA:
18.33
5l4eE-5b8cA:
18.33