SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5b8f'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)

Filter list by:

	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1DYR_A_TOPA407_1 (DIHYDROFOLATE REDUCTASE)	5b8f	2-C-METHYL-D-ERYTHRI TOL 2,4-CYCLODIPHOSPHATE SYNTHASE (Pseudomonas aeruginosa)	5 / 11	ILE A 146 ALA A 102 ILE A 25 ILE A 109 ILE A 98	None	1.07A	1dyrA-5b8fA: undetectable	1dyrA-5b8fA: 16.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1ETB_1_T441128_1 (TRANSTHYRETIN)	5b8f	2-C-METHYL-D-ERYTHRI TOL 2,4-CYCLODIPHOSPHATE SYNTHASE (Pseudomonas aeruginosa)	4 / 6	MET A 1 LEU A 48 ALA A 51 LEU A 49	None	1.17A	1etb1-5b8fA: undetectable	1etb1-5b8fA: 20.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4KS8_A_B49A701_1 (SERINE/THREONINE-PRO TEIN KINASE PAK 6)	5b8f	2-C-METHYL-D-ERYTHRI TOL 2,4-CYCLODIPHOSPHATE SYNTHASE (Pseudomonas aeruginosa)	6 / 10	ILE A 109 ALA A 131 VAL A 148 LEU A 20 GLY A 21 LEU A 40	None C5P A 202 (-3.8A) None None None None	1.43A	4ks8A-5b8fA: undetectable	4ks8A-5b8fA: 18.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5G48_A_1FLA1375_1 (DNA POLYMERASE III SUBUNIT BETA)	5b8f	2-C-METHYL-D-ERYTHRI TOL 2,4-CYCLODIPHOSPHATE SYNTHASE (Pseudomonas aeruginosa)	4 / 8	LEU A 20 PRO A 103 ILE A 98 LEU A 40	None	0.88A	5g48A-5b8fA: undetectable	5g48A-5b8fA: 17.65

[["DrReposER ID","Desc.","Hit PDB","Hit molecule","Hit organism","Res. no.","Interface","HETATM","RMSD","Z-score","Seq ID"],["1DYR_A_TOPA407_1","DIHYDROFOLATE REDUCTASE","5b8f","2-C-METHYL-D-ERYTHRITOL 2,4-CYCLODIPHOSPHATE SYNTHASE","Pseudomonas aeruginosa",5,"ILE A 146;ALA A 102;ILE A  25;ILE A 109;ILE A  98","None","1.07A","1dyrA-5b8fA:undetectable","1dyrA-5b8fA:16.02"],["1ETB_1_T441128_1","TRANSTHYRETIN","5b8f","2-C-METHYL-D-ERYTHRITOL 2,4-CYCLODIPHOSPHATE SYNTHASE","Pseudomonas aeruginosa",4,"MET A   1;LEU A  48;ALA A  51;LEU A  49","None","1.17A","1etb1-5b8fA:undetectable","1etb1-5b8fA:20.81"],["4KS8_A_B49A701_1","SERINE\/THREONINE-PROTEIN KINASE PAK 6","5b8f","2-C-METHYL-D-ERYTHRITOL 2,4-CYCLODIPHOSPHATE SYNTHASE","Pseudomonas aeruginosa",6,"ILE A 109;ALA A 131;VAL A 148;LEU A  20;GLY A  21;LEU A  40","None;C5P A 202 (-3.8A);None;None;None;None","1.43A","4ks8A-5b8fA:undetectable","4ks8A-5b8fA:18.24"],["5G48_A_1FLA1375_1","DNA POLYMERASE III SUBUNIT BETA","5b8f","2-C-METHYL-D-ERYTHRITOL 2,4-CYCLODIPHOSPHATE SYNTHASE","Pseudomonas aeruginosa",4,"LEU A  20;PRO A 103;ILE A  98;LEU A  40","None","0.88A","5g48A-5b8fA:undetectable","5g48A-5b8fA:17.65"]]