SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5b8h'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KYV_A_RBFA501_1
(6,7-DIMETHYL-8-RIBIT
YLLUMAZINE SYNTHASE)		 5b8h TYPE III
PANTOTHENATE KINASE
(Burkholderia
cenocepacia) 		5 / 12 GLY A 250
SER A 249
LEU A  26
ILE A  83
TRP A  54
 None
None
None
AMP  A 304 (-3.8A)
None
 1.23A 1kyvA-5b8hA:
undetectable
1kyvE-5b8hA:
undetectable		 1kyvA-5b8hA:
20.48
1kyvE-5b8hA:
20.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KYV_B_RBFB502_1
(6,7-DIMETHYL-8-RIBIT
YLLUMAZINE SYNTHASE)		 5b8h TYPE III
PANTOTHENATE KINASE
(Burkholderia
cenocepacia) 		5 / 11 ILE A  83
TRP A  54
GLY A 250
SER A 249
LEU A  26
 AMP  A 304 (-3.8A)
None
None
None
None
 1.23A 1kyvA-5b8hA:
undetectable
1kyvB-5b8hA:
undetectable		 1kyvA-5b8hA:
20.48
1kyvB-5b8hA:
20.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KYV_C_RBFC503_1
(6,7-DIMETHYL-8-RIBIT
YLLUMAZINE SYNTHASE)		 5b8h TYPE III
PANTOTHENATE KINASE
(Burkholderia
cenocepacia) 		5 / 12 ILE A  83
TRP A  54
GLY A 250
SER A 249
LEU A  26
 AMP  A 304 (-3.8A)
None
None
None
None
 1.23A 1kyvB-5b8hA:
undetectable
1kyvC-5b8hA:
undetectable		 1kyvB-5b8hA:
20.48
1kyvC-5b8hA:
20.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KYV_D_RBFD504_1
(6,7-DIMETHYL-8-RIBIT
YLLUMAZINE SYNTHASE)		 5b8h TYPE III
PANTOTHENATE KINASE
(Burkholderia
cenocepacia) 		5 / 12 ILE A  83
TRP A  54
GLY A 250
SER A 249
LEU A  26
 AMP  A 304 (-3.8A)
None
None
None
None
 1.23A 1kyvC-5b8hA:
undetectable
1kyvD-5b8hA:
undetectable		 1kyvC-5b8hA:
20.48
1kyvD-5b8hA:
20.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KYV_E_RBFE505_1
(6,7-DIMETHYL-8-RIBIT
YLLUMAZINE SYNTHASE)		 5b8h TYPE III
PANTOTHENATE KINASE
(Burkholderia
cenocepacia) 		5 / 12 ILE A  83
TRP A  54
GLY A 250
SER A 249
LEU A  26
 AMP  A 304 (-3.8A)
None
None
None
None
 1.25A 1kyvD-5b8hA:
undetectable
1kyvE-5b8hA:
undetectable		 1kyvD-5b8hA:
20.48
1kyvE-5b8hA:
20.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJ2_C_SAMC1200_0
(PROTEIN (METHIONINE
REPRESSOR))		 5b8h TYPE III
PANTOTHENATE KINASE
(Burkholderia
cenocepacia) 		5 / 9 GLU A 134
LEU A 110
ALA A 113
HIS A 243
LEU A 246
 None
 1.31A 1mj2C-5b8hA:
undetectable		 1mj2C-5b8hA:
14.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJL_A_SAMA200_0
(METHIONINE REPRESSOR
PROTEIN METJ)		 5b8h TYPE III
PANTOTHENATE KINASE
(Burkholderia
cenocepacia) 		5 / 11 GLU A 134
LEU A 110
ALA A 113
HIS A 243
LEU A 246
 None
 1.30A 1mjlA-5b8hA:
undetectable
1mjlB-5b8hA:
undetectable		 1mjlA-5b8hA:
14.83
1mjlB-5b8hA:
14.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJO_D_SAMD200_0
(METHIONINE REPRESSOR)		 5b8h TYPE III
PANTOTHENATE KINASE
(Burkholderia
cenocepacia) 		5 / 9 GLU A 134
LEU A 110
ALA A 113
HIS A 243
LEU A 246
 None
 1.32A 1mjoC-5b8hA:
undetectable		 1mjoC-5b8hA:
14.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SG9_B_SAMB302_1
(HEMK PROTEIN)		 5b8h TYPE III
PANTOTHENATE KINASE
(Burkholderia
cenocepacia) 		3 / 3 ASP A  37
PHE A  32
ASN A  12
 None
None
PAU  A 302 (-4.6A)
 0.76A 1sg9B-5b8hA:
undetectable		 1sg9B-5b8hA:
20.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A58_A_RBFA300_1
(6,7-DIMETHYL-8-RIBIT
YLLUMAZINE SYNTHASE)		 5b8h TYPE III
PANTOTHENATE KINASE
(Burkholderia
cenocepacia) 		5 / 11 GLY A 250
SER A 249
LEU A  26
ILE A  83
TRP A  54
 None
None
None
AMP  A 304 (-3.8A)
None
 1.25A 2a58A-5b8hA:
undetectable
2a58E-5b8hA:
undetectable		 2a58A-5b8hA:
20.48
2a58E-5b8hA:
20.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A58_B_RBFB301_1
(6,7-DIMETHYL-8-RIBIT
YLLUMAZINE SYNTHASE)		 5b8h TYPE III
PANTOTHENATE KINASE
(Burkholderia
cenocepacia) 		5 / 12 ILE A  83
TRP A  54
GLY A 250
SER A 249
LEU A  26
 AMP  A 304 (-3.8A)
None
None
None
None
 1.25A 2a58A-5b8hA:
undetectable
2a58B-5b8hA:
undetectable		 2a58A-5b8hA:
20.48
2a58B-5b8hA:
20.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A58_C_RBFC302_1
(6,7-DIMETHYL-8-RIBIT
YLLUMAZINE SYNTHASE)		 5b8h TYPE III
PANTOTHENATE KINASE
(Burkholderia
cenocepacia) 		5 / 12 ILE A  83
TRP A  54
GLY A 250
SER A 249
LEU A  26
 AMP  A 304 (-3.8A)
None
None
None
None
 1.25A 2a58B-5b8hA:
undetectable
2a58C-5b8hA:
undetectable		 2a58B-5b8hA:
20.48
2a58C-5b8hA:
20.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A58_D_RBFD303_1
(6,7-DIMETHYL-8-RIBIT
YLLUMAZINE SYNTHASE)		 5b8h TYPE III
PANTOTHENATE KINASE
(Burkholderia
cenocepacia) 		5 / 11 ILE A  83
TRP A  54
GLY A 250
SER A 249
LEU A  26
 AMP  A 304 (-3.8A)
None
None
None
None
 1.26A 2a58C-5b8hA:
undetectable
2a58D-5b8hA:
undetectable		 2a58C-5b8hA:
20.48
2a58D-5b8hA:
20.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A58_E_RBFE304_1
(6,7-DIMETHYL-8-RIBIT
YLLUMAZINE SYNTHASE)		 5b8h TYPE III
PANTOTHENATE KINASE
(Burkholderia
cenocepacia) 		5 / 12 ILE A  83
TRP A  54
GLY A 250
SER A 249
LEU A  26
 AMP  A 304 (-3.8A)
None
None
None
None
 1.25A 2a58D-5b8hA:
undetectable
2a58E-5b8hA:
undetectable		 2a58D-5b8hA:
20.48
2a58E-5b8hA:
20.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AOF_C_FRDC305_2
(POL POLYPROTEIN
PEPTIDE INHIBITOR)		 5b8h TYPE III
PANTOTHENATE KINASE
(Burkholderia
cenocepacia) 		4 / 5 LEU A 251
ASP A   9
ALA A 108
ILE A 247
 None
 1.00A 2aofB-5b8hA:
undetectable		 2aofB-5b8hA:
15.52
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2F9W_A_PAUA6001_0
(PANTOTHENATE KINASE)		 5b8h TYPE III
PANTOTHENATE KINASE
(Burkholderia
cenocepacia) 		8 / 11 ASN A  12
VAL A  58
TYR A  96
GLY A 103
ASP A 105
ARG A 106
THR A 132
ILE A 147
 PAU  A 302 (-4.6A)
PAU  A 302 ( 4.4A)
PAU  A 302 (-4.4A)
PAU  A 302 (-3.4A)
PAU  A 302 (-2.8A)
PAU  A 302 (-4.2A)
PAU  A 302 ( 4.4A)
PAU  A 302 ( 4.3A)
 0.66A 2f9wA-5b8hA:
26.6
2f9wB-5b8hA:
26.7		 2f9wA-5b8hA:
33.33
2f9wB-5b8hA:
33.33
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2F9W_A_PAUA6002_0
(PANTOTHENATE KINASE)		 5b8h TYPE III
PANTOTHENATE KINASE
(Burkholderia
cenocepacia) 		6 / 8 TYR A  96
GLY A 103
ASP A 105
ARG A 106
THR A 132
ILE A 147
 PAU  A 302 (-4.4A)
PAU  A 302 (-3.4A)
PAU  A 302 (-2.8A)
PAU  A 302 (-4.2A)
PAU  A 302 ( 4.4A)
PAU  A 302 ( 4.3A)
 0.48A 2f9wA-5b8hA:
26.6
2f9wB-5b8hA:
26.7		 2f9wA-5b8hA:
33.33
2f9wB-5b8hA:
33.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0M_A_KLNA1501_1
(CYTOCHROME P450 3A4)		 5b8h TYPE III
PANTOTHENATE KINASE
(Burkholderia
cenocepacia) 		5 / 10 ASP A 230
ARG A 242
ILE A 124
LEU A 198
GLY A 128
 None
None
None
None
2PN  A 301 (-3.3A)
 1.37A 2v0mA-5b8hA:
undetectable		 2v0mA-5b8hA:
18.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ARR_A_PNXA606_1
(CHITINASE A)		 5b8h TYPE III
PANTOTHENATE KINASE
(Burkholderia
cenocepacia) 		4 / 7 GLY A 196
ASP A 231
TYR A 199
ARG A 234
 None
 1.31A 3arrA-5b8hA:
undetectable		 3arrA-5b8hA:
21.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BEX_A_PAUA248_0
(TYPE III
PANTOTHENATE KINASE)		 5b8h TYPE III
PANTOTHENATE KINASE
(Burkholderia
cenocepacia) 		6 / 10 ASN A  12
VAL A  58
GLY A 103
ASP A 105
ARG A 106
THR A 132
 PAU  A 302 (-4.6A)
PAU  A 302 ( 4.4A)
PAU  A 302 (-3.4A)
PAU  A 302 (-2.8A)
PAU  A 302 (-4.2A)
PAU  A 302 ( 4.4A)
 0.36A 3bexA-5b8hA:
17.3
3bexB-5b8hA:
26.8		 3bexA-5b8hA:
25.08
3bexB-5b8hA:
25.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BEX_B_PAUB248_0
(TYPE III
PANTOTHENATE KINASE)		 5b8h TYPE III
PANTOTHENATE KINASE
(Burkholderia
cenocepacia) 		6 / 9 ASN A  12
VAL A  58
GLY A 103
ASP A 105
ARG A 106
THR A 132
 PAU  A 302 (-4.6A)
PAU  A 302 ( 4.4A)
PAU  A 302 (-3.4A)
PAU  A 302 (-2.8A)
PAU  A 302 (-4.2A)
PAU  A 302 ( 4.4A)
 0.36A 3bexA-5b8hA:
17.3
3bexB-5b8hA:
26.8		 3bexA-5b8hA:
25.08
3bexB-5b8hA:
25.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BEX_C_PAUC248_0
(TYPE III
PANTOTHENATE KINASE)		 5b8h TYPE III
PANTOTHENATE KINASE
(Burkholderia
cenocepacia) 		7 / 11 ASN A  12
VAL A  58
GLY A 103
ASP A 105
ARG A 106
THR A 132
ILE A 147
 PAU  A 302 (-4.6A)
PAU  A 302 ( 4.4A)
PAU  A 302 (-3.4A)
PAU  A 302 (-2.8A)
PAU  A 302 (-4.2A)
PAU  A 302 ( 4.4A)
PAU  A 302 ( 4.3A)
 0.37A 3bexC-5b8hA:
26.7
3bexD-5b8hA:
26.7		 3bexC-5b8hA:
25.08
3bexD-5b8hA:
25.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BEX_D_PAUD248_0
(TYPE III
PANTOTHENATE KINASE)		 5b8h TYPE III
PANTOTHENATE KINASE
(Burkholderia
cenocepacia) 		7 / 10 ASN A  12
VAL A  58
GLY A 103
ASP A 105
ARG A 106
THR A 132
ILE A 147
 PAU  A 302 (-4.6A)
PAU  A 302 ( 4.4A)
PAU  A 302 (-3.4A)
PAU  A 302 (-2.8A)
PAU  A 302 (-4.2A)
PAU  A 302 ( 4.4A)
PAU  A 302 ( 4.3A)
 0.35A 3bexC-5b8hA:
26.7
3bexD-5b8hA:
26.7		 3bexC-5b8hA:
25.08
3bexD-5b8hA:
25.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BEX_E_PAUE248_0
(TYPE III
PANTOTHENATE KINASE)		 5b8h TYPE III
PANTOTHENATE KINASE
(Burkholderia
cenocepacia) 		7 / 10 ASN A  12
VAL A  58
GLY A 103
ASP A 105
ARG A 106
THR A 132
ILE A 147
 PAU  A 302 (-4.6A)
PAU  A 302 ( 4.4A)
PAU  A 302 (-3.4A)
PAU  A 302 (-2.8A)
PAU  A 302 (-4.2A)
PAU  A 302 ( 4.4A)
PAU  A 302 ( 4.3A)
 0.35A 3bexE-5b8hA:
26.8
3bexF-5b8hA:
26.8		 3bexE-5b8hA:
25.08
3bexF-5b8hA:
25.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BEX_F_PAUF248_0
(TYPE III
PANTOTHENATE KINASE)		 5b8h TYPE III
PANTOTHENATE KINASE
(Burkholderia
cenocepacia) 		7 / 11 ASN A  12
VAL A  58
GLY A 103
ASP A 105
ARG A 106
THR A 132
ILE A 147
 PAU  A 302 (-4.6A)
PAU  A 302 ( 4.4A)
PAU  A 302 (-3.4A)
PAU  A 302 (-2.8A)
PAU  A 302 (-4.2A)
PAU  A 302 ( 4.4A)
PAU  A 302 ( 4.3A)
 0.36A 3bexE-5b8hA:
26.8
3bexF-5b8hA:
26.8		 3bexE-5b8hA:
25.08
3bexF-5b8hA:
25.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BF1_A_PAUA248_0
(TYPE III
PANTOTHENATE KINASE)		 5b8h TYPE III
PANTOTHENATE KINASE
(Burkholderia
cenocepacia) 		7 / 11 ASN A  12
VAL A  58
GLY A 103
ASP A 105
ARG A 106
THR A 132
ILE A 147
 PAU  A 302 (-4.6A)
PAU  A 302 ( 4.4A)
PAU  A 302 (-3.4A)
PAU  A 302 (-2.8A)
PAU  A 302 (-4.2A)
PAU  A 302 ( 4.4A)
PAU  A 302 ( 4.3A)
 0.43A 3bf1A-5b8hA:
26.7
3bf1B-5b8hA:
26.8		 3bf1A-5b8hA:
25.08
3bf1B-5b8hA:
25.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BF1_B_PAUB248_0
(TYPE III
PANTOTHENATE KINASE)		 5b8h TYPE III
PANTOTHENATE KINASE
(Burkholderia
cenocepacia) 		7 / 12 ASN A  12
VAL A  58
GLY A 103
ASP A 105
ARG A 106
THR A 132
ILE A 147
 PAU  A 302 (-4.6A)
PAU  A 302 ( 4.4A)
PAU  A 302 (-3.4A)
PAU  A 302 (-2.8A)
PAU  A 302 (-4.2A)
PAU  A 302 ( 4.4A)
PAU  A 302 ( 4.3A)
 0.48A 3bf1A-5b8hA:
26.7
3bf1B-5b8hA:
26.8		 3bf1A-5b8hA:
25.08
3bf1B-5b8hA:
25.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BF1_C_PAUC248_0
(TYPE III
PANTOTHENATE KINASE)		 5b8h TYPE III
PANTOTHENATE KINASE
(Burkholderia
cenocepacia) 		7 / 11 ASN A  12
VAL A  58
GLY A 103
ASP A 105
ARG A 106
THR A 132
ILE A 147
 PAU  A 302 (-4.6A)
PAU  A 302 ( 4.4A)
PAU  A 302 (-3.4A)
PAU  A 302 (-2.8A)
PAU  A 302 (-4.2A)
PAU  A 302 ( 4.4A)
PAU  A 302 ( 4.3A)
 0.35A 3bf1C-5b8hA:
26.7
3bf1D-5b8hA:
26.7		 3bf1C-5b8hA:
25.08
3bf1D-5b8hA:
25.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BF1_D_PAUD248_0
(TYPE III
PANTOTHENATE KINASE)		 5b8h TYPE III
PANTOTHENATE KINASE
(Burkholderia
cenocepacia) 		7 / 11 ASN A  12
VAL A  58
GLY A 103
ASP A 105
ARG A 106
THR A 132
ILE A 147
 PAU  A 302 (-4.6A)
PAU  A 302 ( 4.4A)
PAU  A 302 (-3.4A)
PAU  A 302 (-2.8A)
PAU  A 302 (-4.2A)
PAU  A 302 ( 4.4A)
PAU  A 302 ( 4.3A)
 0.38A 3bf1C-5b8hA:
26.7
3bf1D-5b8hA:
26.7		 3bf1C-5b8hA:
25.08
3bf1D-5b8hA:
25.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BF1_E_PAUE248_0
(TYPE III
PANTOTHENATE KINASE)		 5b8h TYPE III
PANTOTHENATE KINASE
(Burkholderia
cenocepacia) 		7 / 11 ASN A  12
VAL A  58
GLY A 103
ASP A 105
ARG A 106
THR A 132
ILE A 147
 PAU  A 302 (-4.6A)
PAU  A 302 ( 4.4A)
PAU  A 302 (-3.4A)
PAU  A 302 (-2.8A)
PAU  A 302 (-4.2A)
PAU  A 302 ( 4.4A)
PAU  A 302 ( 4.3A)
 0.33A 3bf1E-5b8hA:
26.9
3bf1F-5b8hA:
14.7		 3bf1E-5b8hA:
25.08
3bf1F-5b8hA:
25.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BF1_F_PAUF248_0
(TYPE III
PANTOTHENATE KINASE)		 5b8h TYPE III
PANTOTHENATE KINASE
(Burkholderia
cenocepacia) 		7 / 11 ASN A  12
VAL A  58
GLY A 103
ASP A 105
ARG A 106
THR A 132
ILE A 147
 PAU  A 302 (-4.6A)
PAU  A 302 ( 4.4A)
PAU  A 302 (-3.4A)
PAU  A 302 (-2.8A)
PAU  A 302 (-4.2A)
PAU  A 302 ( 4.4A)
PAU  A 302 ( 4.3A)
 0.36A 3bf1E-5b8hA:
26.9
3bf1F-5b8hA:
14.7		 3bf1E-5b8hA:
25.08
3bf1F-5b8hA:
25.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MBG_A_ACTA207_0
(FAD-LINKED
SULFHYDRYL OXIDASE
ALR)		 5b8h TYPE III
PANTOTHENATE KINASE
(Burkholderia
cenocepacia) 		4 / 7 LEU A 212
ARG A 137
THR A 143
ALA A 135
 None
 1.03A 3mbgA-5b8hA:
undetectable
3mbgB-5b8hA:
undetectable		 3mbgA-5b8hA:
19.80
3mbgB-5b8hA:
19.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TL9_A_ROCA401_4
(PROTEASE)		 5b8h TYPE III
PANTOTHENATE KINASE
(Burkholderia
cenocepacia) 		4 / 4 ASP A 230
ASP A 231
GLY A 226
THR A 131
 None
None
2PN  A 301 ( 4.9A)
None
 1.31A 3tl9B-5b8hA:
undetectable		 3tl9B-5b8hA:
16.25
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4O5F_A_PAUA301_0
(TYPE III
PANTOTHENATE KINASE)		 5b8h TYPE III
PANTOTHENATE KINASE
(Burkholderia
cenocepacia) 		9 / 12 ASN A  12
VAL A  58
TYR A  96
LEU A 102
GLY A 103
ASP A 105
ARG A 106
THR A 132
ILE A 147
 PAU  A 302 (-4.6A)
PAU  A 302 ( 4.4A)
PAU  A 302 (-4.4A)
PAU  A 302 (-4.6A)
PAU  A 302 (-3.4A)
PAU  A 302 (-2.8A)
PAU  A 302 (-4.2A)
PAU  A 302 ( 4.4A)
PAU  A 302 ( 4.3A)
 0.14A 4o5fA-5b8hA:
36.6
4o5fB-5b8hA:
36.8		 4o5fA-5b8hA:
71.33
4o5fB-5b8hA:
71.33
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4O5F_B_PAUB302_0
(TYPE III
PANTOTHENATE KINASE)		 5b8h TYPE III
PANTOTHENATE KINASE
(Burkholderia
cenocepacia) 		9 / 12 ASN A  12
VAL A  58
TYR A  96
LEU A 102
GLY A 103
ASP A 105
ARG A 106
THR A 132
ILE A 147
 PAU  A 302 (-4.6A)
PAU  A 302 ( 4.4A)
PAU  A 302 (-4.4A)
PAU  A 302 (-4.6A)
PAU  A 302 (-3.4A)
PAU  A 302 (-2.8A)
PAU  A 302 (-4.2A)
PAU  A 302 ( 4.4A)
PAU  A 302 ( 4.3A)
 0.11A 4o5fA-5b8hA:
36.6
4o5fB-5b8hA:
36.8		 4o5fA-5b8hA:
71.33
4o5fB-5b8hA:
71.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QW3_Y_BO2Y301_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)		 5b8h TYPE III
PANTOTHENATE KINASE
(Burkholderia
cenocepacia) 		5 / 10 ALA A 202
GLY A 226
GLY A 227
ALA A 228
ASP A 231
 None
2PN  A 301 ( 4.9A)
None
None
None
 1.05A 4qw3Y-5b8hA:
undetectable
4qw3Z-5b8hA:
undetectable		 4qw3Y-5b8hA:
18.86
4qw3Z-5b8hA:
20.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZBR_A_NPSA603_1
(SERUM ALBUMIN)		 5b8h TYPE III
PANTOTHENATE KINASE
(Burkholderia
cenocepacia) 		5 / 10 ALA A 135
LEU A 146
LEU A 212
ALA A 208
ALA A 215
 None
 0.95A 4zbrA-5b8hA:
undetectable		 4zbrA-5b8hA:
18.71
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5B8H_A_PAUA302_0
(TYPE III
PANTOTHENATE KINASE)		 5b8h TYPE III
PANTOTHENATE KINASE
(Burkholderia
cenocepacia) 		9 / 12 ASN A  12
VAL A  58
TYR A  96
LEU A 102
GLY A 103
ASP A 105
ARG A 106
THR A 132
ILE A 147
 PAU  A 302 (-4.6A)
PAU  A 302 ( 4.4A)
PAU  A 302 (-4.4A)
PAU  A 302 (-4.6A)
PAU  A 302 (-3.4A)
PAU  A 302 (-2.8A)
PAU  A 302 (-4.2A)
PAU  A 302 ( 4.4A)
PAU  A 302 ( 4.3A)
 0.01A 5b8hA-5b8hA:
44.3
5b8hB-5b8hA:
40.5		 5b8hA-5b8hA:
100.00
5b8hB-5b8hA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5B8H_B_PAUB302_0
(TYPE III
PANTOTHENATE KINASE)		 5b8h TYPE III
PANTOTHENATE KINASE
(Burkholderia
cenocepacia) 		9 / 12 ASN A  12
VAL A  58
TYR A  96
LEU A 102
GLY A 103
ASP A 105
ARG A 106
THR A 132
ILE A 147
 PAU  A 302 (-4.6A)
PAU  A 302 ( 4.4A)
PAU  A 302 (-4.4A)
PAU  A 302 (-4.6A)
PAU  A 302 (-3.4A)
PAU  A 302 (-2.8A)
PAU  A 302 (-4.2A)
PAU  A 302 ( 4.4A)
PAU  A 302 ( 4.3A)
 0.11A 5b8hA-5b8hA:
44.3
5b8hB-5b8hA:
40.5		 5b8hA-5b8hA:
100.00
5b8hB-5b8hA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E26_A_PAUA602_0
(PANTOTHENATE KINASE
2, MITOCHONDRIAL)		 5b8h TYPE III
PANTOTHENATE KINASE
(Burkholderia
cenocepacia) 		4 / 7 GLY A 128
SER A  13
GLY A  11
ALA A 130
 2PN  A 301 (-3.3A)
2PN  A 301 (-3.9A)
2PN  A 301 (-3.2A)
PAU  A 302 ( 4.4A)
 0.97A 5e26A-5b8hA:
11.7
5e26B-5b8hA:
10.9		 5e26A-5b8hA:
22.69
5e26B-5b8hA:
22.69