SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5b8i'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1BKF_A_FK5A108_1
(FK506 BINDING
PROTEIN)		 5b8i PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
(Coccidioides
immitis) 		8 / 9 TYR C  36
ASP C  56
PHE C  64
VAL C  73
ILE C  74
TRP C  77
TYR C 100
PHE C 117
 FK5  C 201 (-4.1A)
FK5  C 201 ( 3.8A)
FK5  C 201 (-3.8A)
FK5  C 201 (-3.5A)
FK5  C 201 (-3.8A)
FK5  C 201 (-3.4A)
FK5  C 201 (-4.5A)
FK5  C 201 (-4.7A)
 0.31A 1bkfA-5b8iC:
19.7		 1bkfA-5b8iC:
42.75
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1C9H_A_RAPA108_1
(FKBP12.6)		 5b8i PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
(Coccidioides
immitis) 		8 / 12 TYR C  36
ASP C  56
PHE C  64
VAL C  73
ILE C  74
TYR C 100
ILE C 109
PHE C 117
 FK5  C 201 (-4.1A)
FK5  C 201 ( 3.8A)
FK5  C 201 (-3.8A)
FK5  C 201 (-3.5A)
FK5  C 201 (-3.8A)
FK5  C 201 (-4.5A)
None
FK5  C 201 (-4.7A)
 0.42A 1c9hA-5b8iC:
19.3		 1c9hA-5b8iC:
44.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DZM_A_BZMA600_0
(ODORANT-BINDING
PROTEIN)		 5b8i PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
(Coccidioides
immitis) 		4 / 8 ILE C 124
MET C  84
VAL C  73
GLY C 123
 None
None
FK5  C 201 (-3.5A)
None
 0.99A 1dzmA-5b8iC:
undetectable		 1dzmA-5b8iC:
23.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E06_B_IPBB600_0
(ODORANT-BINDING
PROTEIN)		 5b8i PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
(Coccidioides
immitis) 		4 / 4 ILE C 124
MET C  84
VAL C  73
GLY C 123
 None
None
FK5  C 201 (-3.5A)
None
 0.96A 1e06B-5b8iC:
undetectable		 1e06B-5b8iC:
23.75
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1FAP_A_RAPA108_1
(FK506-BINDING
PROTEIN)		 5b8i PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
(Coccidioides
immitis) 		9 / 12 TYR C  36
ASP C  56
PHE C  64
VAL C  73
ILE C  74
TRP C  77
TYR C 100
ILE C 109
PHE C 117
 FK5  C 201 (-4.1A)
FK5  C 201 ( 3.8A)
FK5  C 201 (-3.8A)
FK5  C 201 (-3.5A)
FK5  C 201 (-3.8A)
FK5  C 201 (-3.4A)
FK5  C 201 (-4.5A)
None
FK5  C 201 (-4.7A)
 0.36A 1fapA-5b8iC:
19.9		 1fapA-5b8iC:
43.51
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1FAP_A_RAPA108_1
(FK506-BINDING
PROTEIN)		 5b8i PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
(Coccidioides
immitis) 		6 / 12 TYR C  36
PHE C  64
VAL C  73
TRP C  77
ILE C 109
PHE C 117
 FK5  C 201 (-4.1A)
FK5  C 201 (-3.8A)
FK5  C 201 (-3.5A)
FK5  C 201 (-3.4A)
None
FK5  C 201 (-4.7A)
 1.13A 1fapA-5b8iC:
19.9		 1fapA-5b8iC:
43.51
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1FKB_A_RAPA108_1
(FK506 BINDING
PROTEIN)		 5b8i PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
(Coccidioides
immitis) 		8 / 12 TYR C  36
ASP C  56
PHE C  64
VAL C  73
ILE C  74
TRP C  77
TYR C 100
PHE C 117
 FK5  C 201 (-4.1A)
FK5  C 201 ( 3.8A)
FK5  C 201 (-3.8A)
FK5  C 201 (-3.5A)
FK5  C 201 (-3.8A)
FK5  C 201 (-3.4A)
FK5  C 201 (-4.5A)
FK5  C 201 (-4.7A)
 0.30A 1fkbA-5b8iC:
20.3		 1fkbA-5b8iC:
43.51
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1FKB_A_RAPA108_1
(FK506 BINDING
PROTEIN)		 5b8i PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
(Coccidioides
immitis) 		5 / 12 TYR C  36
PHE C  64
VAL C  73
TRP C  77
ILE C 109
 FK5  C 201 (-4.1A)
FK5  C 201 (-3.8A)
FK5  C 201 (-3.5A)
FK5  C 201 (-3.4A)
None
 1.04A 1fkbA-5b8iC:
20.3		 1fkbA-5b8iC:
43.51
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1FKF_A_FK5A108_1
(FK506 BINDING
PROTEIN)		 5b8i PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
(Coccidioides
immitis) 		10 / 11 TYR C  36
ASP C  56
ARG C  61
PHE C  64
VAL C  73
ILE C  74
TRP C  77
TYR C 100
ILE C 109
PHE C 117
 FK5  C 201 (-4.1A)
FK5  C 201 ( 3.8A)
FK5  C 201 (-3.8A)
FK5  C 201 (-3.8A)
FK5  C 201 (-3.5A)
FK5  C 201 (-3.8A)
FK5  C 201 (-3.4A)
FK5  C 201 (-4.5A)
None
FK5  C 201 (-4.7A)
 0.58A 1fkfA-5b8iC:
19.6		 1fkfA-5b8iC:
43.51
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1FKJ_A_FK5A108_1
(FK506 BINDING
PROTEIN)		 5b8i PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
(Coccidioides
immitis) 		10 / 11 TYR C  36
ASP C  56
ARG C  61
PHE C  64
VAL C  73
ILE C  74
TRP C  77
TYR C 100
ILE C 109
PHE C 117
 FK5  C 201 (-4.1A)
FK5  C 201 ( 3.8A)
FK5  C 201 (-3.8A)
FK5  C 201 (-3.8A)
FK5  C 201 (-3.5A)
FK5  C 201 (-3.8A)
FK5  C 201 (-3.4A)
FK5  C 201 (-4.5A)
None
FK5  C 201 (-4.7A)
 0.59A 1fkjA-5b8iC:
19.6		 1fkjA-5b8iC:
43.51
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1FKL_A_RAPA108_1
(FK506 BINDING
PROTEIN)		 5b8i PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
(Coccidioides
immitis) 		9 / 12 TYR C  36
ASP C  56
PHE C  64
VAL C  73
ILE C  74
TRP C  77
TYR C 100
ILE C 109
PHE C 117
 FK5  C 201 (-4.1A)
FK5  C 201 ( 3.8A)
FK5  C 201 (-3.8A)
FK5  C 201 (-3.5A)
FK5  C 201 (-3.8A)
FK5  C 201 (-3.4A)
FK5  C 201 (-4.5A)
None
FK5  C 201 (-4.7A)
 0.32A 1fklA-5b8iC:
20.1		 1fklA-5b8iC:
41.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTN_J_TRPJ81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 5b8i SERINE/THREONINE-PRO
TEIN PHOSPHATASE
(Coccidioides
immitis) 		4 / 8 ALA A 282
GLY A 219
ALA A 283
ILE A 295
 None
 0.71A 1gtnI-5b8iA:
undetectable
1gtnJ-5b8iA:
undetectable		 1gtnI-5b8iA:
12.43
1gtnJ-5b8iA:
12.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I9G_A_SAMA301_0
(HYPOTHETICAL PROTEIN
RV2118C)		 5b8i SERINE/THREONINE-PRO
TEIN PHOSPHATASE
(Coccidioides
immitis) 		5 / 12 ILE A 216
GLY A 167
ALA A 206
ASP A 139
LEU A 174
 None
 1.27A 1i9gA-5b8iA:
undetectable		 1i9gA-5b8iA:
19.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OE1_A_CUA502_0
(DISSIMILATORY
COPPER-CONTAINING
NITRITE REDUCTASE)		 5b8i SERINE/THREONINE-PRO
TEIN PHOSPHATASE
(Coccidioides
immitis) 		3 / 3 ASP A 136
HIS A 169
HIS A 110
 ZN  A 401 (-2.7A)
MES  A 403 (-3.8A)
FE  A 402 ( 3.3A)
 0.60A 1oe1A-5b8iA:
undetectable		 1oe1A-5b8iA:
20.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OE3_A_CUA502_0
(DISSIMILATORY
COPPER-CONTAINING
NITRITE REDUCTASE)		 5b8i SERINE/THREONINE-PRO
TEIN PHOSPHATASE
(Coccidioides
immitis) 		3 / 3 ASP A 136
HIS A 169
HIS A 110
 ZN  A 401 (-2.7A)
MES  A 403 (-3.8A)
FE  A 402 ( 3.3A)
 0.59A 1oe3A-5b8iA:
undetectable		 1oe3A-5b8iA:
20.63
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1PBK_A_RAPA225_1
(FKBP25)		 5b8i PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
(Coccidioides
immitis) 		5 / 12 TYR C  36
ASP C  56
GLY C  69
TRP C  77
PHE C 117
 FK5  C 201 (-4.1A)
FK5  C 201 ( 3.8A)
None
FK5  C 201 (-3.4A)
FK5  C 201 (-4.7A)
 0.99A 1pbkA-5b8iC:
18.9		 1pbkA-5b8iC:
41.98
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1PBK_A_RAPA225_1
(FKBP25)		 5b8i PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
(Coccidioides
immitis) 		9 / 12 TYR C  36
ASP C  56
GLY C  71
VAL C  73
ILE C  74
TRP C  77
TYR C 100
ILE C 109
PHE C 117
 FK5  C 201 (-4.1A)
FK5  C 201 ( 3.8A)
None
FK5  C 201 (-3.5A)
FK5  C 201 (-3.8A)
FK5  C 201 (-3.4A)
FK5  C 201 (-4.5A)
None
FK5  C 201 (-4.7A)
 0.36A 1pbkA-5b8iC:
18.9		 1pbkA-5b8iC:
41.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q6I_A_FK5A301_1
(FKBP-TYPE
PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
FKPA)		 5b8i PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
(Coccidioides
immitis) 		8 / 9 TYR C  36
ASP C  56
VAL C  73
ILE C  74
TRP C  77
TYR C 100
ILE C 109
PHE C 117
 FK5  C 201 (-4.1A)
FK5  C 201 ( 3.8A)
FK5  C 201 (-3.5A)
FK5  C 201 (-3.8A)
FK5  C 201 (-3.4A)
FK5  C 201 (-4.5A)
None
FK5  C 201 (-4.7A)
 0.39A 1q6iA-5b8iC:
15.5		 1q6iA-5b8iC:
24.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q6I_B_FK5B401_1
(FKBP-TYPE
PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
FKPA)		 5b8i PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
(Coccidioides
immitis) 		9 / 10 TYR C  36
ASP C  56
ARG C  61
VAL C  73
ILE C  74
TRP C  77
TYR C 100
ILE C 109
PHE C 117
 FK5  C 201 (-4.1A)
FK5  C 201 ( 3.8A)
FK5  C 201 (-3.8A)
FK5  C 201 (-3.5A)
FK5  C 201 (-3.8A)
FK5  C 201 (-3.4A)
FK5  C 201 (-4.5A)
None
FK5  C 201 (-4.7A)
 0.51A 1q6iB-5b8iC:
15.1		 1q6iB-5b8iC:
24.47
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1TCO_C_FK5C509_2
(FK506-BINDING
PROTEIN)		 5b8i PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
(Coccidioides
immitis) 		10 / 11 TYR C  36
ASP C  56
ARG C  61
PHE C  64
VAL C  73
ILE C  74
TRP C  77
TYR C 100
ILE C 109
PHE C 117
 FK5  C 201 (-4.1A)
FK5  C 201 ( 3.8A)
FK5  C 201 (-3.8A)
FK5  C 201 (-3.8A)
FK5  C 201 (-3.5A)
FK5  C 201 (-3.8A)
FK5  C 201 (-3.4A)
FK5  C 201 (-4.5A)
None
FK5  C 201 (-4.7A)
 0.47A 1tcoC-5b8iC:
19.5		 1tcoC-5b8iC:
43.51
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1YAT_A_FK5A108_1
(FK506 BINDING
PROTEIN)		 5b8i PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
(Coccidioides
immitis) 		11 / 11 TYR C  36
ASP C  56
ARG C  61
PHE C  64
VAL C  73
ILE C  74
TRP C  77
TYR C 100
LEU C 108
ILE C 109
PHE C 117
 FK5  C 201 (-4.1A)
FK5  C 201 ( 3.8A)
FK5  C 201 (-3.8A)
FK5  C 201 (-3.8A)
FK5  C 201 (-3.5A)
FK5  C 201 (-3.8A)
FK5  C 201 (-3.4A)
FK5  C 201 (-4.5A)
None
None
FK5  C 201 (-4.7A)
 0.51A 1yatA-5b8iC:
19.7		 1yatA-5b8iC:
45.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZZ1_B_SHHB2552_1
(HISTONE
DEACETYLASE-LIKE
AMIDOHYDROLASE)		 5b8i CALCINEURIN SUBUNIT
B, VARIANT
SERINE/THREONINE-PRO
TEIN PHOSPHATASE
(Coccidioides
immitis) 		5 / 12 LEU B  30
ILE A 386
PHE B  62
ASP B  71
PHE B  43
 None
 1.14A 1zz1B-5b8iB:
undetectable
1zz1C-5b8iB:
undetectable		 1zz1B-5b8iB:
18.45
1zz1C-5b8iB:
18.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A1M_A_CAMA1422_0
(CYTOCHROME P450-CAM)		 5b8i SERINE/THREONINE-PRO
TEIN PHOSPHATASE
CALCINEURIN SUBUNIT
B, VARIANT
(Coccidioides
immitis;
Coccidioides
immitis) 		4 / 7 PHE B 153
THR B 160
VAL A 375
GLY A 376
 None
 0.95A 2a1mA-5b8iB:
undetectable		 2a1mA-5b8iB:
17.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A1O_A_CAMA1422_0
(CYTOCHROME P450-CAM)		 5b8i SERINE/THREONINE-PRO
TEIN PHOSPHATASE
CALCINEURIN SUBUNIT
B, VARIANT
(Coccidioides
immitis;
Coccidioides
immitis) 		4 / 8 PHE B 153
THR B 160
VAL A 375
GLY A 376
 None
 0.91A 2a1oA-5b8iB:
undetectable		 2a1oA-5b8iB:
17.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A3C_A_PNXA1435_1
(CHITINASE)		 5b8i SERINE/THREONINE-PRO
TEIN PHOSPHATASE
(Coccidioides
immitis) 		4 / 6 TYR A 309
GLY A 107
PHE A 324
SER A 325
 None
 1.32A 2a3cA-5b8iA:
undetectable		 2a3cA-5b8iA:
21.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A3C_B_PNXB2434_1
(CHITINASE)		 5b8i SERINE/THREONINE-PRO
TEIN PHOSPHATASE
(Coccidioides
immitis) 		4 / 6 TYR A 309
GLY A 107
PHE A 324
SER A 325
 None
 1.35A 2a3cB-5b8iA:
undetectable		 2a3cB-5b8iA:
21.27
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2DG3_A_RAPA501_1
(FK506-BINDING
PROTEIN 1A)		 5b8i PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
(Coccidioides
immitis) 		8 / 11 TYR C  36
ASP C  56
PHE C  64
VAL C  73
ILE C  74
TRP C  77
TYR C 100
PHE C 117
 FK5  C 201 (-4.1A)
FK5  C 201 ( 3.8A)
FK5  C 201 (-3.8A)
FK5  C 201 (-3.5A)
FK5  C 201 (-3.8A)
FK5  C 201 (-3.4A)
FK5  C 201 (-4.5A)
FK5  C 201 (-4.7A)
 0.38A 2dg3A-5b8iC:
20.0		 2dg3A-5b8iC:
43.51
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2DG3_A_RAPA501_1
(FK506-BINDING
PROTEIN 1A)		 5b8i PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
(Coccidioides
immitis) 		5 / 11 TYR C  36
PHE C  64
VAL C  73
TRP C  77
ILE C 109
 FK5  C 201 (-4.1A)
FK5  C 201 (-3.8A)
FK5  C 201 (-3.5A)
FK5  C 201 (-3.4A)
None
 1.11A 2dg3A-5b8iC:
20.0		 2dg3A-5b8iC:
43.51
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2DG4_A_RAPA501_1
(FK506-BINDING
PROTEIN 1A)		 5b8i PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
(Coccidioides
immitis) 		7 / 11 TYR C  36
ASP C  56
PHE C  64
VAL C  73
ILE C  74
TYR C 100
PHE C 117
 FK5  C 201 (-4.1A)
FK5  C 201 ( 3.8A)
FK5  C 201 (-3.8A)
FK5  C 201 (-3.5A)
FK5  C 201 (-3.8A)
FK5  C 201 (-4.5A)
FK5  C 201 (-4.7A)
 0.39A 2dg4A-5b8iC:
19.4		 2dg4A-5b8iC:
42.75
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2DG9_A_RAPA501_1
(FK506-BINDING
PROTEIN 1A)		 5b8i PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
(Coccidioides
immitis) 		7 / 11 TYR C  36
ASP C  56
PHE C  64
VAL C  73
ILE C  74
TYR C 100
PHE C 117
 FK5  C 201 (-4.1A)
FK5  C 201 ( 3.8A)
FK5  C 201 (-3.8A)
FK5  C 201 (-3.5A)
FK5  C 201 (-3.8A)
FK5  C 201 (-4.5A)
FK5  C 201 (-4.7A)
 0.46A 2dg9A-5b8iC:
19.6		 2dg9A-5b8iC:
42.75
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2FKE_A_FK5A108_1
(FK506 BINDING
PROTEIN)		 5b8i PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
(Coccidioides
immitis) 		10 / 11 TYR C  36
ASP C  56
ARG C  61
PHE C  64
VAL C  73
ILE C  74
TRP C  77
TYR C 100
ILE C 109
PHE C 117
 FK5  C 201 (-4.1A)
FK5  C 201 ( 3.8A)
FK5  C 201 (-3.8A)
FK5  C 201 (-3.8A)
FK5  C 201 (-3.5A)
FK5  C 201 (-3.8A)
FK5  C 201 (-3.4A)
FK5  C 201 (-4.5A)
None
FK5  C 201 (-4.7A)
 0.53A 2fkeA-5b8iC:
19.8		 2fkeA-5b8iC:
43.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PNJ_A_CHDA501_0
(FERROCHELATASE,
MITOCHONDRIAL)		 5b8i SERINE/THREONINE-PRO
TEIN PHOSPHATASE
PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
(Coccidioides
immitis;
Coccidioides
immitis) 		5 / 12 LEU C 115
PHE C 117
ILE C 109
LEU A 330
VAL A 332
 None
FK5  C 201 (-4.7A)
None
None
None
 0.84A 2pnjA-5b8iC:
undetectable		 2pnjA-5b8iC:
17.60
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2VCD_A_RAPA138_1
(OUTER MEMBRANE
PROTEIN MIP)		 5b8i PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
(Coccidioides
immitis) 		5 / 11 PHE C  55
ASP C  56
VAL C  73
ILE C  74
TRP C  77
 FK5  C 201 ( 4.8A)
FK5  C 201 ( 3.8A)
FK5  C 201 (-3.5A)
FK5  C 201 (-3.8A)
FK5  C 201 (-3.4A)
 0.73A 2vcdA-5b8iC:
12.8		 2vcdA-5b8iC:
30.20
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2VCD_A_RAPA138_1
(OUTER MEMBRANE
PROTEIN MIP)		 5b8i PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
(Coccidioides
immitis) 		5 / 11 PHE C  55
VAL C  73
ILE C  74
TRP C  77
TYR C 100
 FK5  C 201 ( 4.8A)
FK5  C 201 (-3.5A)
FK5  C 201 (-3.8A)
FK5  C 201 (-3.4A)
FK5  C 201 (-4.5A)
 0.92A 2vcdA-5b8iC:
12.8		 2vcdA-5b8iC:
30.20
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2VCD_A_RAPA138_1
(OUTER MEMBRANE
PROTEIN MIP)		 5b8i PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
(Coccidioides
immitis) 		5 / 11 TYR C  36
ASP C  56
VAL C  73
ILE C  74
TRP C  77
 FK5  C 201 (-4.1A)
FK5  C 201 ( 3.8A)
FK5  C 201 (-3.5A)
FK5  C 201 (-3.8A)
FK5  C 201 (-3.4A)
 0.86A 2vcdA-5b8iC:
12.8		 2vcdA-5b8iC:
30.20
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2VCD_A_RAPA138_1
(OUTER MEMBRANE
PROTEIN MIP)		 5b8i PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
(Coccidioides
immitis) 		5 / 11 TYR C  36
VAL C  73
ILE C  74
TRP C  77
TYR C 100
 FK5  C 201 (-4.1A)
FK5  C 201 (-3.5A)
FK5  C 201 (-3.8A)
FK5  C 201 (-3.4A)
FK5  C 201 (-4.5A)
 0.68A 2vcdA-5b8iC:
12.8		 2vcdA-5b8iC:
30.20
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2VN1_A_FK5A501_1
(70 KDA
PEPTIDYLPROLYL
ISOMERASE)		 5b8i PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
(Coccidioides
immitis) 		10 / 11 TYR C  36
PHE C  55
ASP C  56
ARG C  61
PHE C  64
VAL C  73
TRP C  77
TYR C 100
ILE C 109
PHE C 117
 FK5  C 201 (-4.1A)
FK5  C 201 ( 4.8A)
FK5  C 201 ( 3.8A)
FK5  C 201 (-3.8A)
FK5  C 201 (-3.8A)
FK5  C 201 (-3.5A)
FK5  C 201 (-3.4A)
FK5  C 201 (-4.5A)
None
FK5  C 201 (-4.7A)
 0.51A 2vn1A-5b8iC:
18.4		 2vn1A-5b8iC:
36.23
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2VN1_B_FK5B501_1
(70 KDA
PEPTIDYLPROLYL
ISOMERASE)		 5b8i PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
(Coccidioides
immitis) 		9 / 10 TYR C  36
ASP C  56
ARG C  61
PHE C  64
VAL C  73
ILE C  74
TRP C  77
TYR C 100
PHE C 117
 FK5  C 201 (-4.1A)
FK5  C 201 ( 3.8A)
FK5  C 201 (-3.8A)
FK5  C 201 (-3.8A)
FK5  C 201 (-3.5A)
FK5  C 201 (-3.8A)
FK5  C 201 (-3.4A)
FK5  C 201 (-4.5A)
FK5  C 201 (-4.7A)
 0.47A 2vn1B-5b8iC:
18.4		 2vn1B-5b8iC:
36.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XXG_A_CUA1338_0
(DISSIMILATORY
COPPER-CONTAINING
NITRITE REDUCTASE)		 5b8i SERINE/THREONINE-PRO
TEIN PHOSPHATASE
(Coccidioides
immitis) 		3 / 3 ASP A 136
HIS A 169
HIS A 110
 ZN  A 401 (-2.7A)
MES  A 403 (-3.8A)
FE  A 402 ( 3.3A)
 0.62A 2xxgA-5b8iA:
undetectable		 2xxgA-5b8iA:
21.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XXG_C_CUC1339_0
(DISSIMILATORY
COPPER-CONTAINING
NITRITE REDUCTASE)		 5b8i SERINE/THREONINE-PRO
TEIN PHOSPHATASE
(Coccidioides
immitis) 		3 / 3 ASP A 136
HIS A 169
HIS A 110
 ZN  A 401 (-2.7A)
MES  A 403 (-3.8A)
FE  A 402 ( 3.3A)
 0.63A 2xxgC-5b8iA:
undetectable		 2xxgC-5b8iA:
21.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A2Q_A_ACAA601_1
(6-AMINOHEXANOATE-CYC
LIC-DIMER HYDROLASE)		 5b8i CALCINEURIN SUBUNIT
B, VARIANT
SERINE/THREONINE-PRO
TEIN PHOSPHATASE
(Coccidioides
immitis) 		4 / 7 GLY B 110
ASN B 109
VAL A 367
ILE B 137
 None
 0.79A 3a2qA-5b8iB:
undetectable		 3a2qA-5b8iB:
17.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A51_A_VDYA6178_1
(VITAMIN D
HYDROXYLASE)		 5b8i SERINE/THREONINE-PRO
TEIN PHOSPHATASE
(Coccidioides
immitis) 		5 / 11 ILE A 216
LEU A 214
ILE A 208
VAL A 105
LEU A 132
 None
 1.21A 3a51A-5b8iA:
undetectable		 3a51A-5b8iA:
23.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A51_D_VDYD6178_1
(VITAMIN D
HYDROXYLASE)		 5b8i SERINE/THREONINE-PRO
TEIN PHOSPHATASE
(Coccidioides
immitis) 		5 / 12 ILE A 216
LEU A 214
ILE A 208
VAL A 105
LEU A 132
 None
 1.24A 3a51D-5b8iA:
undetectable		 3a51D-5b8iA:
23.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AF3_A_PAUA314_0
(PANTOTHENATE KINASE)		 5b8i CALCINEURIN SUBUNIT
B, VARIANT
(Coccidioides
immitis) 		4 / 6 PHE B  43
MET B  58
PHE B  62
PHE B  75
 None
 1.12A 3af3A-5b8iB:
undetectable		 3af3A-5b8iB:
21.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EM0_B_CHDB151_0
(ILEAL BILE
ACID-BINDING PROTEIN)		 5b8i SERINE/THREONINE-PRO
TEIN PHOSPHATASE
(Coccidioides
immitis) 		5 / 12 TYR A 131
CYH A 106
ILE A 323
VAL A 122
GLY A 124
 None
 1.11A 3em0B-5b8iA:
undetectable		 3em0B-5b8iA:
16.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IA4_D_MTXD164_2
(DIHYDROFOLATE
REDUCTASE)		 5b8i PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
SERINE/THREONINE-PRO
TEIN PHOSPHATASE
(Coccidioides
immitis) 		3 / 3 ARG C  53
ILE C 109
THR A 369
 MES  A 404 (-2.9A)
None
None
 0.75A 3ia4D-5b8iC:
undetectable		 3ia4D-5b8iC:
19.50
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3IHZ_A_FK5A501_1
(70 KDA
PEPTIDYLPROLYL
ISOMERASE, PUTATIVE)		 5b8i PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
(Coccidioides
immitis) 		10 / 10 TYR C  36
ASP C  56
ARG C  61
PHE C  64
VAL C  73
ILE C  74
TRP C  77
TYR C 100
ILE C 109
PHE C 117
 FK5  C 201 (-4.1A)
FK5  C 201 ( 3.8A)
FK5  C 201 (-3.8A)
FK5  C 201 (-3.8A)
FK5  C 201 (-3.5A)
FK5  C 201 (-3.8A)
FK5  C 201 (-3.4A)
FK5  C 201 (-4.5A)
None
FK5  C 201 (-4.7A)
 0.56A 3ihzA-5b8iC:
18.1		 3ihzA-5b8iC:
38.41
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3IHZ_A_FK5A501_2
(70 KDA
PEPTIDYLPROLYL
ISOMERASE, PUTATIVE)		 5b8i PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
(Coccidioides
immitis) 		4 / 8 TYR C  36
ASP C  56
PHE C  64
GLY C 107
 FK5  C 201 (-4.1A)
FK5  C 201 ( 3.8A)
FK5  C 201 (-3.8A)
EDO  C 204 (-3.6A)
 0.59A 3ihzB-5b8iC:
18.3		 3ihzB-5b8iC:
38.41
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3IHZ_A_FK5A501_2
(70 KDA
PEPTIDYLPROLYL
ISOMERASE, PUTATIVE)		 5b8i PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
(Coccidioides
immitis) 		5 / 8 TYR C  36
PHE C  64
TRP C  77
TYR C 100
ILE C 109
 FK5  C 201 (-4.1A)
FK5  C 201 (-3.8A)
FK5  C 201 (-3.4A)
FK5  C 201 (-4.5A)
None
 0.48A 3ihzB-5b8iC:
18.3		 3ihzB-5b8iC:
38.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_A_TFPA202_1
(PROTEIN S100-A4)		 5b8i CALCINEURIN SUBUNIT
B, VARIANT
SERINE/THREONINE-PRO
TEIN PHOSPHATASE
(Coccidioides
immitis) 		5 / 12 LEU B 168
SER B  83
PHE B  82
LEU A 387
ASP B  16
 None
None
None
None
EDO  B 205 (-3.6A)
 1.13A 3ko0A-5b8iB:
5.9
3ko0B-5b8iB:
6.3
3ko0C-5b8iB:
6.1
3ko0D-5b8iB:
6.2		 3ko0A-5b8iB:
19.54
3ko0B-5b8iB:
19.54
3ko0C-5b8iB:
19.54
3ko0D-5b8iB:
19.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_J_TFPJ202_1
(PROTEIN S100-A4)		 5b8i CALCINEURIN SUBUNIT
B, VARIANT
SERINE/THREONINE-PRO
TEIN PHOSPHATASE
(Coccidioides
immitis) 		5 / 11 ASP B  16
LEU A 387
LEU B 168
SER B  83
PHE B  82
 EDO  B 205 (-3.6A)
None
None
None
None
 1.09A 3ko0A-5b8iB:
5.9
3ko0B-5b8iB:
6.3
3ko0I-5b8iB:
6.3
3ko0J-5b8iB:
6.2		 3ko0A-5b8iB:
19.54
3ko0B-5b8iB:
19.54
3ko0I-5b8iB:
19.54
3ko0J-5b8iB:
19.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_K_TFPK202_1
(PROTEIN S100-A4)		 5b8i CALCINEURIN SUBUNIT
B, VARIANT
SERINE/THREONINE-PRO
TEIN PHOSPHATASE
(Coccidioides
immitis) 		5 / 12 LEU B 168
SER B  83
PHE B  82
LEU A 387
ASP B  16
 None
None
None
None
EDO  B 205 (-3.6A)
 1.16A 3ko0K-5b8iB:
6.2
3ko0L-5b8iB:
6.3
3ko0S-5b8iB:
6.2
3ko0T-5b8iB:
6.2		 3ko0K-5b8iB:
19.54
3ko0L-5b8iB:
19.54
3ko0S-5b8iB:
19.54
3ko0T-5b8iB:
19.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_L_TFPL202_1
(PROTEIN S100-A4)		 5b8i CALCINEURIN SUBUNIT
B, VARIANT
SERINE/THREONINE-PRO
TEIN PHOSPHATASE
(Coccidioides
immitis) 		5 / 12 LEU A 387
LEU B 168
SER B  83
PHE B  82
ASP B  16
 None
None
None
None
EDO  B 205 (-3.6A)
 1.17A 3ko0K-5b8iA:
undetectable
3ko0L-5b8iA:
undetectable
3ko0M-5b8iA:
undetectable
3ko0N-5b8iA:
undetectable		 3ko0K-5b8iA:
13.49
3ko0L-5b8iA:
13.49
3ko0M-5b8iA:
13.49
3ko0N-5b8iA:
13.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_M_TFPM202_1
(PROTEIN S100-A4)		 5b8i CALCINEURIN SUBUNIT
B, VARIANT
SERINE/THREONINE-PRO
TEIN PHOSPHATASE
(Coccidioides
immitis) 		5 / 12 LEU B 168
SER B  83
PHE B  82
LEU A 387
ASP B  16
 None
None
None
None
EDO  B 205 (-3.6A)
 1.12A 3ko0M-5b8iB:
6.2
3ko0N-5b8iB:
6.2
3ko0O-5b8iB:
6.2
3ko0P-5b8iB:
6.3		 3ko0M-5b8iB:
19.54
3ko0N-5b8iB:
19.54
3ko0O-5b8iB:
19.54
3ko0P-5b8iB:
19.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_P_TFPP202_1
(PROTEIN S100-A4)		 5b8i CALCINEURIN SUBUNIT
B, VARIANT
SERINE/THREONINE-PRO
TEIN PHOSPHATASE
(Coccidioides
immitis) 		5 / 12 ASP B  16
LEU A 387
LEU B 168
SER B  83
PHE B  82
 EDO  B 205 (-3.6A)
None
None
None
None
 1.12A 3ko0M-5b8iB:
6.2
3ko0N-5b8iB:
6.2
3ko0O-5b8iB:
6.2
3ko0P-5b8iB:
6.3		 3ko0M-5b8iB:
19.54
3ko0N-5b8iB:
19.54
3ko0O-5b8iB:
19.54
3ko0P-5b8iB:
19.54
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3KZ7_A_RAPA225_1
(FK506-BINDING
PROTEIN 3)		 5b8i PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
(Coccidioides
immitis) 		8 / 10 TYR C  36
ASP C  56
VAL C  73
ILE C  74
TRP C  77
TYR C 100
ILE C 109
PHE C 117
 FK5  C 201 (-4.1A)
FK5  C 201 ( 3.8A)
FK5  C 201 (-3.5A)
FK5  C 201 (-3.8A)
FK5  C 201 (-3.4A)
FK5  C 201 (-4.5A)
None
FK5  C 201 (-4.7A)
 0.30A 3kz7A-5b8iC:
18.8		 3kz7A-5b8iC:
42.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LB3_B_4CHB192_0
(DEHALOPEROXIDASE A)		 5b8i SERINE/THREONINE-PRO
TEIN PHOSPHATASE
(Coccidioides
immitis) 		4 / 6 PHE A 133
PHE A 120
TYR A 131
VAL A 109
 None
 1.33A 3lb3B-5b8iA:
undetectable		 3lb3B-5b8iA:
15.49
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3O5R_A_FK5A1001_1
(PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
FKBP5)		 5b8i PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
(Coccidioides
immitis) 		10 / 11 TYR C  36
ASP C  56
ARG C  61
PHE C  64
VAL C  73
ILE C  74
TRP C  77
TYR C 100
ILE C 109
PHE C 117
 FK5  C 201 (-4.1A)
FK5  C 201 ( 3.8A)
FK5  C 201 (-3.8A)
FK5  C 201 (-3.8A)
FK5  C 201 (-3.5A)
FK5  C 201 (-3.8A)
FK5  C 201 (-3.4A)
FK5  C 201 (-4.5A)
None
FK5  C 201 (-4.7A)
 0.55A 3o5rA-5b8iC:
17.8		 3o5rA-5b8iC:
36.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OHT_A_1N1A2000_1
(P38A)		 5b8i CALCINEURIN SUBUNIT
B, VARIANT
SERINE/THREONINE-PRO
TEIN PHOSPHATASE
(Coccidioides
immitis) 		5 / 12 ASP B 100
ILE B 101
VAL A 367
ILE B 132
ILE B 114
 CA  B 203 (-3.2A)
None
None
None
None
 1.22A 3ohtA-5b8iB:
undetectable
3ohtB-5b8iB:
undetectable		 3ohtA-5b8iB:
21.23
3ohtB-5b8iB:
21.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P6G_A_IZPA133_1
(FATTY ACID-BINDING
PROTEIN, ADIPOCYTE)		 5b8i SERINE/THREONINE-PRO
TEIN PHOSPHATASE
(Coccidioides
immitis) 		5 / 12 PHE A 180
ILE A  83
VAL A 192
CYH A 196
TYR A 188
 None
None
None
None
EDO  A 408 (-4.3A)
 1.30A 3p6gA-5b8iA:
undetectable		 3p6gA-5b8iA:
16.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PS9_A_SAMA670_0
(TRNA
5-METHYLAMINOMETHYL-
2-THIOURIDINE
BIOSYNTHESIS
BIFUNCTIONAL PROTEIN
MNMC)		 5b8i PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
(Coccidioides
immitis) 		5 / 12 ASN C  35
LYS C 127
ILE C 124
GLY C  87
ASN C  21
 None
 1.22A 3ps9A-5b8iC:
undetectable		 3ps9A-5b8iC:
10.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UF8_A_FK5A114_1
(UBIQUITIN-LIKE
PROTEIN SMT3,
PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE)		 5b8i PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
(Coccidioides
immitis) 		10 / 10 TYR C  36
ASP C  56
ARG C  61
PHE C  64
VAL C  73
ILE C  74
TRP C  77
TYR C 100
ILE C 109
PHE C 117
 FK5  C 201 (-4.1A)
FK5  C 201 ( 3.8A)
FK5  C 201 (-3.8A)
FK5  C 201 (-3.8A)
FK5  C 201 (-3.5A)
FK5  C 201 (-3.8A)
FK5  C 201 (-3.4A)
FK5  C 201 (-4.5A)
None
FK5  C 201 (-4.7A)
 0.42A 3uf8A-5b8iC:
18.1		 3uf8A-5b8iC:
28.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UQA_A_FK5A114_1
(UBIQUITIN-LIKE
PROTEIN SMT3,
PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE)		 5b8i PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
(Coccidioides
immitis) 		10 / 10 TYR C  36
ASP C  56
ARG C  61
PHE C  64
VAL C  73
ILE C  74
TRP C  77
TYR C 100
ILE C 109
PHE C 117
 FK5  C 201 (-4.1A)
FK5  C 201 ( 3.8A)
FK5  C 201 (-3.8A)
FK5  C 201 (-3.8A)
FK5  C 201 (-3.5A)
FK5  C 201 (-3.8A)
FK5  C 201 (-3.4A)
FK5  C 201 (-4.5A)
None
FK5  C 201 (-4.7A)
 0.33A 3uqaA-5b8iC:
18.1		 3uqaA-5b8iC:
28.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UQB_A_FK5A114_1
(UBIQUITIN-LIKE
PROTEIN SMT3,
PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE)		 5b8i PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
(Coccidioides
immitis) 		8 / 8 TYR C  36
PHE C  64
VAL C  73
ILE C  74
TRP C  77
TYR C 100
ILE C 109
PHE C 117
 FK5  C 201 (-4.1A)
FK5  C 201 (-3.8A)
FK5  C 201 (-3.5A)
FK5  C 201 (-3.8A)
FK5  C 201 (-3.4A)
FK5  C 201 (-4.5A)
None
FK5  C 201 (-4.7A)
 0.25A 3uqbA-5b8iC:
18.0		 3uqbA-5b8iC:
28.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VAW_A_FK5A114_1
(UBIQUITIN-LIKE
PROTEIN
SMT3,PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE)		 5b8i PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
(Coccidioides
immitis) 		10 / 11 TYR C  36
ASP C  56
ARG C  61
PHE C  64
VAL C  73
ILE C  74
TRP C  77
TYR C 100
ILE C 109
PHE C 117
 FK5  C 201 (-4.1A)
FK5  C 201 ( 3.8A)
FK5  C 201 (-3.8A)
FK5  C 201 (-3.8A)
FK5  C 201 (-3.5A)
FK5  C 201 (-3.8A)
FK5  C 201 (-3.4A)
FK5  C 201 (-4.5A)
None
FK5  C 201 (-4.7A)
 0.45A 3vawA-5b8iC:
17.0		 3vawA-5b8iC:
28.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VN2_A_TLSA501_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 5b8i SERINE/THREONINE-PRO
TEIN PHOSPHATASE
(Coccidioides
immitis) 		5 / 12 CYH A 106
SER A 325
HIS A 110
LEU A 116
LEU A 162
 None
None
FE  A 402 ( 3.3A)
None
None
 1.28A 3vn2A-5b8iA:
undetectable		 3vn2A-5b8iA:
22.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_D_W9TD507_1
(HEMOLYTIC LECTIN
CEL-III)		 5b8i PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
(Coccidioides
immitis) 		4 / 5 GLU C  63
GLY C  62
TYR C  36
ASP C  56
 None
None
FK5  C 201 (-4.1A)
FK5  C 201 ( 3.8A)
 1.16A 3w9tD-5b8iC:
undetectable		 3w9tD-5b8iC:
13.98
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4DRH_A_RAPA201_1
(PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
FKBP5)		 5b8i PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
(Coccidioides
immitis) 		9 / 12 TYR C  36
ASP C  56
PHE C  64
VAL C  73
ILE C  74
TRP C  77
TYR C 100
ILE C 109
PHE C 117
 FK5  C 201 (-4.1A)
FK5  C 201 ( 3.8A)
FK5  C 201 (-3.8A)
FK5  C 201 (-3.5A)
FK5  C 201 (-3.8A)
FK5  C 201 (-3.4A)
FK5  C 201 (-4.5A)
None
FK5  C 201 (-4.7A)
 0.48A 4drhA-5b8iC:
17.0		 4drhA-5b8iC:
33.99
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4DRH_D_RAPD201_1
(PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
FKBP5)		 5b8i PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
(Coccidioides
immitis) 		9 / 12 TYR C  36
ASP C  56
PHE C  64
VAL C  73
ILE C  74
TRP C  77
TYR C 100
ILE C 109
PHE C 117
 FK5  C 201 (-4.1A)
FK5  C 201 ( 3.8A)
FK5  C 201 (-3.8A)
FK5  C 201 (-3.5A)
FK5  C 201 (-3.8A)
FK5  C 201 (-3.4A)
FK5  C 201 (-4.5A)
None
FK5  C 201 (-4.7A)
 0.53A 4drhD-5b8iC:
17.1		 4drhD-5b8iC:
33.99
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4DRI_A_RAPA201_1
(PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
FKBP5)		 5b8i PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
(Coccidioides
immitis) 		9 / 11 TYR C  36
ASP C  56
ARG C  61
VAL C  73
ILE C  74
TRP C  77
TYR C 100
ILE C 109
PHE C 117
 FK5  C 201 (-4.1A)
FK5  C 201 ( 3.8A)
FK5  C 201 (-3.8A)
FK5  C 201 (-3.5A)
FK5  C 201 (-3.8A)
FK5  C 201 (-3.4A)
FK5  C 201 (-4.5A)
None
FK5  C 201 (-4.7A)
 0.57A 4driA-5b8iC:
18.6		 4driA-5b8iC:
33.99
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4DRI_A_RAPA201_1
(PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
FKBP5)		 5b8i PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
(Coccidioides
immitis) 		9 / 11 TYR C  36
ASP C  56
PHE C  64
VAL C  73
ILE C  74
TRP C  77
TYR C 100
ILE C 109
PHE C 117
 FK5  C 201 (-4.1A)
FK5  C 201 ( 3.8A)
FK5  C 201 (-3.8A)
FK5  C 201 (-3.5A)
FK5  C 201 (-3.8A)
FK5  C 201 (-3.4A)
FK5  C 201 (-4.5A)
None
FK5  C 201 (-4.7A)
 0.40A 4driA-5b8iC:
18.6		 4driA-5b8iC:
33.99
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4DRJ_A_RAPA201_1
(PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
FKBP4)		 5b8i PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
(Coccidioides
immitis) 		9 / 11 TYR C  36
ASP C  56
PHE C  64
VAL C  73
ILE C  74
TRP C  77
TYR C 100
ILE C 109
PHE C 117
 FK5  C 201 (-4.1A)
FK5  C 201 ( 3.8A)
FK5  C 201 (-3.8A)
FK5  C 201 (-3.5A)
FK5  C 201 (-3.8A)
FK5  C 201 (-3.4A)
FK5  C 201 (-4.5A)
None
FK5  C 201 (-4.7A)
 0.32A 4drjA-5b8iC:
18.4		 4drjA-5b8iC:
36.60
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4DZ2_A_FK5A200_1
(PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE)		 5b8i PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
(Coccidioides
immitis) 		10 / 11 TYR C  36
ASP C  56
ARG C  61
PHE C  64
VAL C  73
ILE C  74
TRP C  77
TYR C 100
ILE C 109
PHE C 117
 FK5  C 201 (-4.1A)
FK5  C 201 ( 3.8A)
FK5  C 201 (-3.8A)
FK5  C 201 (-3.8A)
FK5  C 201 (-3.5A)
FK5  C 201 (-3.8A)
FK5  C 201 (-3.4A)
FK5  C 201 (-4.5A)
None
FK5  C 201 (-4.7A)
 0.72A 4dz2A-5b8iC:
17.8
4dz2B-5b8iC:
17.8		 4dz2A-5b8iC:
39.68
4dz2B-5b8iC:
39.68
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4DZ2_B_FK5B200_1
(PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE)		 5b8i PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
(Coccidioides
immitis) 		10 / 11 TYR C  36
ASP C  56
ARG C  61
PHE C  64
VAL C  73
ILE C  74
TRP C  77
TYR C 100
ILE C 109
PHE C 117
 FK5  C 201 (-4.1A)
FK5  C 201 ( 3.8A)
FK5  C 201 (-3.8A)
FK5  C 201 (-3.8A)
FK5  C 201 (-3.5A)
FK5  C 201 (-3.8A)
FK5  C 201 (-3.4A)
FK5  C 201 (-4.5A)
None
FK5  C 201 (-4.7A)
 0.72A 4dz2A-5b8iC:
17.8
4dz2B-5b8iC:
17.8		 4dz2A-5b8iC:
39.68
4dz2B-5b8iC:
39.68
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4DZ3_A_FK5A201_1
(PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE)		 5b8i PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
(Coccidioides
immitis) 		10 / 10 TYR C  36
ASP C  56
ARG C  61
PHE C  64
VAL C  73
ILE C  74
TRP C  77
TYR C 100
ILE C 109
PHE C 117
 FK5  C 201 (-4.1A)
FK5  C 201 ( 3.8A)
FK5  C 201 (-3.8A)
FK5  C 201 (-3.8A)
FK5  C 201 (-3.5A)
FK5  C 201 (-3.8A)
FK5  C 201 (-3.4A)
FK5  C 201 (-4.5A)
None
FK5  C 201 (-4.7A)
 0.60A 4dz3A-5b8iC:
18.0		 4dz3A-5b8iC:
41.13
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4DZ3_B_FK5B201_1
(PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE)		 5b8i PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
(Coccidioides
immitis) 		10 / 10 TYR C  36
ASP C  56
ARG C  61
PHE C  64
VAL C  73
ILE C  74
TRP C  77
TYR C 100
ILE C 109
PHE C 117
 FK5  C 201 (-4.1A)
FK5  C 201 ( 3.8A)
FK5  C 201 (-3.8A)
FK5  C 201 (-3.8A)
FK5  C 201 (-3.5A)
FK5  C 201 (-3.8A)
FK5  C 201 (-3.4A)
FK5  C 201 (-4.5A)
None
FK5  C 201 (-4.7A)
 0.50A 4dz3B-5b8iC:
17.9		 4dz3B-5b8iC:
41.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FEU_B_KANB301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 5b8i SERINE/THREONINE-PRO
TEIN PHOSPHATASE
(Coccidioides
immitis) 		4 / 7 ASP A 139
ASP A 136
ASN A 168
GLU A 170
 None
ZN  A 401 (-2.7A)
MES  A 403 ( 2.4A)
None
 1.18A 4feuB-5b8iA:
undetectable		 4feuB-5b8iA:
20.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FEV_D_KAND301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 5b8i SERINE/THREONINE-PRO
TEIN PHOSPHATASE
(Coccidioides
immitis) 		4 / 7 ASP A 139
ASP A 136
ASN A 168
GLU A 170
 None
ZN  A 401 (-2.7A)
MES  A 403 ( 2.4A)
None
 1.21A 4fevD-5b8iA:
undetectable		 4fevD-5b8iA:
20.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FEV_F_KANF301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 5b8i SERINE/THREONINE-PRO
TEIN PHOSPHATASE
(Coccidioides
immitis) 		4 / 7 ASP A 139
ASP A 136
ASN A 168
GLU A 170
 None
ZN  A 401 (-2.7A)
MES  A 403 ( 2.4A)
None
 1.20A 4fevF-5b8iA:
undetectable		 4fevF-5b8iA:
20.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FEW_D_KAND301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 5b8i SERINE/THREONINE-PRO
TEIN PHOSPHATASE
(Coccidioides
immitis) 		4 / 8 ASP A 139
ASP A 136
ASN A 168
GLU A 170
 None
ZN  A 401 (-2.7A)
MES  A 403 ( 2.4A)
None
 1.20A 4fewD-5b8iA:
undetectable		 4fewD-5b8iA:
20.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FEW_F_KANF301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 5b8i SERINE/THREONINE-PRO
TEIN PHOSPHATASE
(Coccidioides
immitis) 		4 / 8 ASP A 139
ASP A 136
ASN A 168
GLU A 170
 None
ZN  A 401 (-2.7A)
MES  A 403 ( 2.4A)
None
 1.19A 4fewF-5b8iA:
undetectable		 4fewF-5b8iA:
20.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FEX_B_KANB301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 5b8i SERINE/THREONINE-PRO
TEIN PHOSPHATASE
(Coccidioides
immitis) 		4 / 7 ASP A 139
ASP A 136
ASN A 168
GLU A 170
 None
ZN  A 401 (-2.7A)
MES  A 403 ( 2.4A)
None
 1.20A 4fexB-5b8iA:
undetectable		 4fexB-5b8iA:
20.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4GKH_B_KANB301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 5b8i SERINE/THREONINE-PRO
TEIN PHOSPHATASE
(Coccidioides
immitis) 		4 / 8 ASP A 139
ASP A 136
ASN A 168
GLU A 170
 None
ZN  A 401 (-2.7A)
MES  A 403 ( 2.4A)
None
 1.21A 4gkhB-5b8iA:
undetectable		 4gkhB-5b8iA:
20.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4GKH_G_KANG301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 5b8i SERINE/THREONINE-PRO
TEIN PHOSPHATASE
(Coccidioides
immitis) 		4 / 7 ASP A 139
ASP A 136
ASN A 168
GLU A 170
 None
ZN  A 401 (-2.7A)
MES  A 403 ( 2.4A)
None
 1.19A 4gkhG-5b8iA:
undetectable		 4gkhG-5b8iA:
20.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4GKI_A_KANA301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 5b8i SERINE/THREONINE-PRO
TEIN PHOSPHATASE
(Coccidioides
immitis) 		4 / 8 ASP A 139
ASP A 136
ASN A 168
GLU A 170
 None
ZN  A 401 (-2.7A)
MES  A 403 ( 2.4A)
None
 1.20A 4gkiA-5b8iA:
undetectable		 4gkiA-5b8iA:
20.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4GKI_C_KANC301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 5b8i SERINE/THREONINE-PRO
TEIN PHOSPHATASE
(Coccidioides
immitis) 		4 / 8 ASP A 139
ASP A 136
ASN A 168
GLU A 170
 None
ZN  A 401 (-2.7A)
MES  A 403 ( 2.4A)
None
 1.18A 4gkiC-5b8iA:
undetectable		 4gkiC-5b8iA:
20.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KR3_A_GLYA701_0
(GLYCINE--TRNA LIGASE)		 5b8i PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
(Coccidioides
immitis) 		4 / 6 ARG C  53
GLU C  60
GLU C  59
SER C  57
 MES  A 404 (-2.9A)
EDO  C 202 ( 2.7A)
EDO  C 203 ( 4.4A)
EDO  C 202 ( 4.2A)
 1.43A 4kr3A-5b8iC:
undetectable		 4kr3A-5b8iC:
13.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LAX_A_FK5A301_1
(PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
FKBP4)		 5b8i PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
(Coccidioides
immitis) 		9 / 10 TYR C  36
ASP C  56
PHE C  64
VAL C  73
ILE C  74
TRP C  77
TYR C 100
ILE C 109
PHE C 117
 FK5  C 201 (-4.1A)
FK5  C 201 ( 3.8A)
FK5  C 201 (-3.8A)
FK5  C 201 (-3.5A)
FK5  C 201 (-3.8A)
FK5  C 201 (-3.4A)
FK5  C 201 (-4.5A)
None
FK5  C 201 (-4.7A)
 0.28A 4laxA-5b8iC:
18.9		 4laxA-5b8iC:
26.75
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4NNR_A_FK5A201_1
(PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
FKBP2)		 5b8i PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
(Coccidioides
immitis) 		9 / 12 TYR C  36
ASP C  56
PHE C  64
VAL C  73
ILE C  74
TRP C  77
TYR C 100
ILE C 109
PHE C 117
 FK5  C 201 (-4.1A)
FK5  C 201 ( 3.8A)
FK5  C 201 (-3.8A)
FK5  C 201 (-3.5A)
FK5  C 201 (-3.8A)
FK5  C 201 (-3.4A)
FK5  C 201 (-4.5A)
None
FK5  C 201 (-4.7A)
 0.34A 4nnrA-5b8iC:
15.6
4nnrB-5b8iC:
15.7		 4nnrA-5b8iC:
36.00
4nnrB-5b8iC:
36.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4NNR_B_FK5B201_1
(PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
FKBP2)		 5b8i PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
(Coccidioides
immitis) 		9 / 10 TYR C  36
ASP C  56
PHE C  64
VAL C  73
ILE C  74
TRP C  77
TYR C 100
ILE C 109
PHE C 117
 FK5  C 201 (-4.1A)
FK5  C 201 ( 3.8A)
FK5  C 201 (-3.8A)
FK5  C 201 (-3.5A)
FK5  C 201 (-3.8A)
FK5  C 201 (-3.4A)
FK5  C 201 (-4.5A)
None
FK5  C 201 (-4.7A)
 0.37A 4nnrB-5b8iC:
15.7		 4nnrB-5b8iC:
36.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OBW_B_SAMB601_0
(2-METHOXY-6-POLYPREN
YL-1,4-BENZOQUINOL
METHYLASE,
MITOCHONDRIAL)		 5b8i SERINE/THREONINE-PRO
TEIN PHOSPHATASE
(Coccidioides
immitis) 		5 / 12 ASN A 269
GLY A 218
GLY A 219
ASP A 247
GLY A 107
 None
 1.06A 4obwB-5b8iA:
undetectable		 4obwB-5b8iA:
22.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ODO_A_FK5A205_1
(PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
SLYD)		 5b8i PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
(Coccidioides
immitis) 		5 / 10 TYR C  36
ASP C  56
ILE C  74
TYR C 100
PHE C 117
 FK5  C 201 (-4.1A)
FK5  C 201 ( 3.8A)
FK5  C 201 (-3.8A)
FK5  C 201 (-4.5A)
FK5  C 201 (-4.7A)
 0.41A 4odoA-5b8iC:
11.4		 4odoA-5b8iC:
16.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ODO_B_FK5B203_1
(PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
SLYD)		 5b8i PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
(Coccidioides
immitis) 		5 / 10 TYR C  36
ASP C  56
ILE C  74
TYR C 100
PHE C 117
 FK5  C 201 (-4.1A)
FK5  C 201 ( 3.8A)
FK5  C 201 (-3.8A)
FK5  C 201 (-4.5A)
FK5  C 201 (-4.7A)
 0.40A 4odoB-5b8iC:
11.0		 4odoB-5b8iC:
16.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ODO_C_FK5C204_1
(PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
SLYD)		 5b8i PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
(Coccidioides
immitis) 		5 / 10 TYR C  36
ASP C  56
ILE C  74
TYR C 100
PHE C 117
 FK5  C 201 (-4.1A)
FK5  C 201 ( 3.8A)
FK5  C 201 (-3.8A)
FK5  C 201 (-4.5A)
FK5  C 201 (-4.7A)
 0.45A 4odoC-5b8iC:
11.0		 4odoC-5b8iC:
16.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ODR_A_FK5A201_1
(PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
SLYD,
PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
FKBP1A CHIMERA)		 5b8i PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
SERINE/THREONINE-PRO
TEIN PHOSPHATASE
(Coccidioides
immitis) 		7 / 12 TYR C  36
ASP C  56
ILE C  74
TYR C 100
ILE C 109
PHE C 117
PRO A 362
 FK5  C 201 (-4.1A)
FK5  C 201 ( 3.8A)
FK5  C 201 (-3.8A)
FK5  C 201 (-4.5A)
None
FK5  C 201 (-4.7A)
EDO  C 202 ( 4.0A)
 0.55A 4odrA-5b8iC:
13.1
4odrB-5b8iC:
13.2		 4odrA-5b8iC:
29.17
4odrB-5b8iC:
29.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ODR_B_FK5B201_1
(PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
SLYD,
PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
FKBP1A CHIMERA)		 5b8i PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
SERINE/THREONINE-PRO
TEIN PHOSPHATASE
(Coccidioides
immitis) 		6 / 11 PRO A 362
TYR C  36
ASP C  56
ILE C  74
TYR C 100
PHE C 117
 EDO  C 202 ( 4.0A)
FK5  C 201 (-4.1A)
FK5  C 201 ( 3.8A)
FK5  C 201 (-3.8A)
FK5  C 201 (-4.5A)
FK5  C 201 (-4.7A)
 0.63A 4odrA-5b8iA:
undetectable
4odrB-5b8iA:
undetectable		 4odrA-5b8iA:
14.57
4odrB-5b8iA:
14.57
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4QT2_A_RAPA202_1
(FK506-BINDING
PROTEIN (FKBP)-TYPE
PEPTIDYL-PROPYL
ISOMERASE)		 5b8i PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
(Coccidioides
immitis) 		9 / 10 TYR C  36
ASP C  56
PHE C  64
VAL C  73
ILE C  74
TRP C  77
TYR C 100
ILE C 109
PHE C 117
 FK5  C 201 (-4.1A)
FK5  C 201 ( 3.8A)
FK5  C 201 (-3.8A)
FK5  C 201 (-3.5A)
FK5  C 201 (-3.8A)
FK5  C 201 (-3.4A)
FK5  C 201 (-4.5A)
None
FK5  C 201 (-4.7A)
 0.37A 4qt2A-5b8iC:
18.7		 4qt2A-5b8iC:
37.12
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4QT3_A_RAPA202_1
(FK506-BINDING
PROTEIN (FKBP)-TYPE
PEPTIDYL-PROPYL
ISOMERASE)		 5b8i PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
(Coccidioides
immitis) 		9 / 10 TYR C  36
ASP C  56
PHE C  64
VAL C  73
ILE C  74
TRP C  77
TYR C 100
ILE C 109
PHE C 117
 FK5  C 201 (-4.1A)
FK5  C 201 ( 3.8A)
FK5  C 201 (-3.8A)
FK5  C 201 (-3.5A)
FK5  C 201 (-3.8A)
FK5  C 201 (-3.4A)
FK5  C 201 (-4.5A)
None
FK5  C 201 (-4.7A)
 0.40A 4qt3A-5b8iC:
17.4		 4qt3A-5b8iC:
35.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RTR_A_SAMA301_0
(DNA ADENINE
METHYLASE)		 5b8i SERINE/THREONINE-PRO
TEIN PHOSPHATASE
(Coccidioides
immitis) 		5 / 11 GLY A 263
PHE A 257
ASP A 256
TYR A 309
TYR A 265
 None
 1.50A 4rtrA-5b8iA:
undetectable		 4rtrA-5b8iA:
24.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TWD_C_377C401_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 5b8i SERINE/THREONINE-PRO
TEIN PHOSPHATASE
(Coccidioides
immitis) 		4 / 6 TYR A 158
TYR A 150
LEU A 151
PHE A 120
 None
 1.06A 4twdB-5b8iA:
undetectable
4twdC-5b8iA:
undetectable		 4twdB-5b8iA:
22.66
4twdC-5b8iA:
22.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TWD_E_377E401_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 5b8i SERINE/THREONINE-PRO
TEIN PHOSPHATASE
(Coccidioides
immitis) 		4 / 6 TYR A 158
TYR A 150
LEU A 151
PHE A 120
 None
 1.01A 4twdD-5b8iA:
undetectable
4twdE-5b8iA:
undetectable		 4twdD-5b8iA:
22.66
4twdE-5b8iA:
22.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TWD_F_377F401_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 5b8i SERINE/THREONINE-PRO
TEIN PHOSPHATASE
(Coccidioides
immitis) 		4 / 7 TYR A 150
LEU A 151
PHE A 120
TYR A 158
 None
 1.12A 4twdF-5b8iA:
undetectable
4twdJ-5b8iA:
undetectable		 4twdF-5b8iA:
22.66
4twdJ-5b8iA:
22.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TWD_G_377G401_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 5b8i SERINE/THREONINE-PRO
TEIN PHOSPHATASE
(Coccidioides
immitis) 		4 / 6 TYR A 158
TYR A 150
LEU A 151
PHE A 120
 None
 1.06A 4twdF-5b8iA:
undetectable
4twdG-5b8iA:
undetectable		 4twdF-5b8iA:
22.66
4twdG-5b8iA:
22.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TWD_J_377J401_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 5b8i SERINE/THREONINE-PRO
TEIN PHOSPHATASE
(Coccidioides
immitis) 		4 / 6 TYR A 158
TYR A 150
LEU A 151
PHE A 120
 None
 1.10A 4twdI-5b8iA:
undetectable
4twdJ-5b8iA:
undetectable		 4twdI-5b8iA:
22.66
4twdJ-5b8iA:
22.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z2E_F_TR6F101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
SYMMETRIZED E-SITE
DNA)		 5b8i PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
(Coccidioides
immitis) 		4 / 5 GLY C  11
ARG C  75
GLY C  76
GLU C  79
 None
 1.28A 4z2eB-5b8iC:
undetectable
4z2eC-5b8iC:
undetectable		 4z2eB-5b8iC:
15.79
4z2eC-5b8iC:
19.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CAD_A_ACTA402_0
(SM80.1 VICILIN)		 5b8i SERINE/THREONINE-PRO
TEIN PHOSPHATASE
CALCINEURIN SUBUNIT
B, VARIANT
(Coccidioides
immitis;
Coccidioides
immitis) 		4 / 6 PHE A  42
ALA A  39
ASN B 109
ARG A  32
 None
 1.37A 5cadA-5b8iA:
0.0		 5cadA-5b8iA:
18.16
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5D75_A_FK5A301_1
(PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
FKBP3)		 5b8i PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
(Coccidioides
immitis) 		8 / 11 TYR C  36
ASP C  56
VAL C  73
ILE C  74
TRP C  77
TYR C 100
ILE C 109
PHE C 117
 FK5  C 201 (-4.1A)
FK5  C 201 ( 3.8A)
FK5  C 201 (-3.5A)
FK5  C 201 (-3.8A)
FK5  C 201 (-3.4A)
FK5  C 201 (-4.5A)
None
FK5  C 201 (-4.7A)
 0.41A 5d75A-5b8iC:
19.1		 5d75A-5b8iC:
40.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_2_BEZ2801_0
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 1
BEZ-LEU-LEU)		 5b8i CALCINEURIN SUBUNIT
B, VARIANT
(Coccidioides
immitis) 		4 / 4 LEU B 112
ARG B  57
ILE B 114
ILE B 101
 None
 1.36A 5dzk2-5b8iB:
undetectable
5dzkM-5b8iB:
undetectable
5dzkN-5b8iB:
undetectable		 5dzk2-5b8iB:
4.35
5dzkM-5b8iB:
24.40
5dzkN-5b8iB:
24.40
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5GPG_A_RAPA301_1
(PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
FKBP3)		 5b8i PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
(Coccidioides
immitis) 		8 / 11 TYR C  36
ASP C  56
VAL C  73
ILE C  74
TRP C  77
TYR C 100
ILE C 109
PHE C 117
 FK5  C 201 (-4.1A)
FK5  C 201 ( 3.8A)
FK5  C 201 (-3.5A)
FK5  C 201 (-3.8A)
FK5  C 201 (-3.4A)
FK5  C 201 (-4.5A)
None
FK5  C 201 (-4.7A)
 0.32A 5gpgA-5b8iC:
19.9		 5gpgA-5b8iC:
42.11
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5HKG_A_RAPA201_1
(PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
FKBP1B)		 5b8i PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
(Coccidioides
immitis) 		8 / 12 TYR C  36
ASP C  56
PHE C  64
VAL C  73
ILE C  74
TYR C 100
ILE C 109
PHE C 117
 FK5  C 201 (-4.1A)
FK5  C 201 ( 3.8A)
FK5  C 201 (-3.8A)
FK5  C 201 (-3.5A)
FK5  C 201 (-3.8A)
FK5  C 201 (-4.5A)
None
FK5  C 201 (-4.7A)
 0.36A 5hkgA-5b8iC:
19.4		 5hkgA-5b8iC:
44.07
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5HUA_A_FK5A201_1
(FK506-BINDING
PROTEIN 1)		 5b8i PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
(Coccidioides
immitis) 		11 / 11 TYR C  36
ASP C  56
ARG C  61
PHE C  64
VAL C  73
ILE C  74
TRP C  77
TYR C 100
PHE C 105
LEU C 108
PHE C 117
 FK5  C 201 (-4.1A)
FK5  C 201 ( 3.8A)
FK5  C 201 (-3.8A)
FK5  C 201 (-3.8A)
FK5  C 201 (-3.5A)
FK5  C 201 (-3.8A)
FK5  C 201 (-3.4A)
FK5  C 201 (-4.5A)
FK5  C 201 (-4.3A)
None
FK5  C 201 (-4.7A)
 0.48A 5huaA-5b8iC:
19.9		 5huaA-5b8iC:
46.46
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5HW8_A_FK5A201_1
(FK506-BINDING
PROTEIN 1)		 5b8i PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
(Coccidioides
immitis) 		9 / 11 TYR C  36
ASP C  56
ARG C  61
PHE C  64
VAL C  73
ILE C  74
TRP C  77
TYR C 100
ILE C 109
 FK5  C 201 (-4.1A)
FK5  C 201 ( 3.8A)
FK5  C 201 (-3.8A)
FK5  C 201 (-3.8A)
FK5  C 201 (-3.5A)
FK5  C 201 (-3.8A)
FK5  C 201 (-3.4A)
FK5  C 201 (-4.5A)
None
 0.73A 5hw8A-5b8iC:
19.2
5hw8D-5b8iC:
19.1		 5hw8A-5b8iC:
37.86
5hw8D-5b8iC:
37.86
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5HW8_B_FK5B201_1
(FK506-BINDING
PROTEIN 1)		 5b8i PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
(Coccidioides
immitis) 		9 / 11 TYR C  36
ASP C  56
ARG C  61
PHE C  64
VAL C  73
TRP C  77
TYR C 100
ILE C 109
PHE C 117
 FK5  C 201 (-4.1A)
FK5  C 201 ( 3.8A)
FK5  C 201 (-3.8A)
FK5  C 201 (-3.8A)
FK5  C 201 (-3.5A)
FK5  C 201 (-3.4A)
FK5  C 201 (-4.5A)
None
FK5  C 201 (-4.7A)
 0.62A 5hw8B-5b8iC:
19.1		 5hw8B-5b8iC:
37.86
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5HW8_C_FK5C201_1
(FK506-BINDING
PROTEIN 1)		 5b8i PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
(Coccidioides
immitis) 		9 / 10 TYR C  36
ASP C  56
ARG C  61
VAL C  73
ILE C  74
TRP C  77
TYR C 100
LEU C 115
PHE C 117
 FK5  C 201 (-4.1A)
FK5  C 201 ( 3.8A)
FK5  C 201 (-3.8A)
FK5  C 201 (-3.5A)
FK5  C 201 (-3.8A)
FK5  C 201 (-3.4A)
FK5  C 201 (-4.5A)
None
FK5  C 201 (-4.7A)
 0.68A 5hw8C-5b8iC:
19.0
5hw8H-5b8iC:
15.2		 5hw8C-5b8iC:
37.86
5hw8H-5b8iC:
37.86
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5HW8_D_FK5D201_1
(FK506-BINDING
PROTEIN 1)		 5b8i PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
(Coccidioides
immitis) 		10 / 11 TYR C  36
ASP C  56
ARG C  61
PHE C  64
VAL C  73
ILE C  74
TRP C  77
TYR C 100
ILE C 109
PHE C 117
 FK5  C 201 (-4.1A)
FK5  C 201 ( 3.8A)
FK5  C 201 (-3.8A)
FK5  C 201 (-3.8A)
FK5  C 201 (-3.5A)
FK5  C 201 (-3.8A)
FK5  C 201 (-3.4A)
FK5  C 201 (-4.5A)
None
FK5  C 201 (-4.7A)
 0.40A 5hw8D-5b8iC:
19.1		 5hw8D-5b8iC:
37.86
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5HW8_E_FK5E201_1
(FK506-BINDING
PROTEIN 1)		 5b8i PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
(Coccidioides
immitis) 		9 / 11 TYR C  36
ASP C  56
ARG C  61
PHE C  64
VAL C  73
ILE C  74
TRP C  77
TYR C 100
PHE C 117
 FK5  C 201 (-4.1A)
FK5  C 201 ( 3.8A)
FK5  C 201 (-3.8A)
FK5  C 201 (-3.8A)
FK5  C 201 (-3.5A)
FK5  C 201 (-3.8A)
FK5  C 201 (-3.4A)
FK5  C 201 (-4.5A)
FK5  C 201 (-4.7A)
 0.63A 5hw8E-5b8iC:
18.5		 5hw8E-5b8iC:
37.86
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5HW8_F_FK5F201_1
(FK506-BINDING
PROTEIN 1)		 5b8i PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
(Coccidioides
immitis) 		8 / 12 TYR C  36
ASP C  56
PHE C  64
VAL C  73
ILE C  74
TRP C  77
TYR C 100
PHE C 117
 FK5  C 201 (-4.1A)
FK5  C 201 ( 3.8A)
FK5  C 201 (-3.8A)
FK5  C 201 (-3.5A)
FK5  C 201 (-3.8A)
FK5  C 201 (-3.4A)
FK5  C 201 (-4.5A)
FK5  C 201 (-4.7A)
 0.44A 5hw8B-5b8iC:
19.1
5hw8F-5b8iC:
15.2
5hw8G-5b8iC:
18.1		 5hw8B-5b8iC:
37.86
5hw8F-5b8iC:
37.86
5hw8G-5b8iC:
37.86
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5HW8_G_FK5G201_2
(FK506-BINDING
PROTEIN 1)		 5b8i PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
(Coccidioides
immitis) 		9 / 11 TYR C  36
ASP C  56
PHE C  64
VAL C  73
ILE C  74
TRP C  77
TYR C 100
ILE C 109
PHE C 117
 FK5  C 201 (-4.1A)
FK5  C 201 ( 3.8A)
FK5  C 201 (-3.8A)
FK5  C 201 (-3.5A)
FK5  C 201 (-3.8A)
FK5  C 201 (-3.4A)
FK5  C 201 (-4.5A)
None
FK5  C 201 (-4.7A)
 0.32A 5hw8G-5b8iC:
18.1		 5hw8G-5b8iC:
37.86
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5HW8_H_FK5H201_1
(FK506-BINDING
PROTEIN 1)		 5b8i PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
(Coccidioides
immitis) 		7 / 8 TYR C  36
ASP C  56
PHE C  64
VAL C  73
ILE C  74
TRP C  77
PHE C 117
 FK5  C 201 (-4.1A)
FK5  C 201 ( 3.8A)
FK5  C 201 (-3.8A)
FK5  C 201 (-3.5A)
FK5  C 201 (-3.8A)
FK5  C 201 (-3.4A)
FK5  C 201 (-4.7A)
 0.56A 5hw8H-5b8iC:
15.2		 5hw8H-5b8iC:
37.86
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5HWC_A_FK5A201_1
(FK506-BINDING
PROTEIN 1A)		 5b8i PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
(Coccidioides
immitis) 		11 / 11 TYR C  36
ASP C  56
ARG C  61
PHE C  64
VAL C  73
ILE C  74
TRP C  77
TYR C 100
PHE C 105
ILE C 109
PHE C 117
 FK5  C 201 (-4.1A)
FK5  C 201 ( 3.8A)
FK5  C 201 (-3.8A)
FK5  C 201 (-3.8A)
FK5  C 201 (-3.5A)
FK5  C 201 (-3.8A)
FK5  C 201 (-3.4A)
FK5  C 201 (-4.5A)
FK5  C 201 (-4.3A)
None
FK5  C 201 (-4.7A)
 0.58A 5hwcA-5b8iC:
21.7		 5hwcA-5b8iC:
56.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IEN_A_VDYA201_1
(CDL2.2)		 5b8i CALCINEURIN SUBUNIT
B, VARIANT
SERINE/THREONINE-PRO
TEIN PHOSPHATASE
(Coccidioides
immitis) 		5 / 12 PHE B 153
LEU B 116
ILE B 132
THR B 160
LEU A 361
 None
FK5  C 201 ( 4.7A)
None
None
None
 1.16A 5ienA-5b8iB:
undetectable		 5ienA-5b8iB:
21.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IEN_A_VDYA201_2
(CDL2.2)		 5b8i SERINE/THREONINE-PRO
TEIN PHOSPHATASE
(Coccidioides
immitis) 		5 / 12 ILE A 295
ILE A 230
LEU A 244
GLY A 243
LEU A 292
 None
 1.09A 5ienA-5b8iA:
undetectable		 5ienA-5b8iA:
15.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MLM_A_STRA401_1
(-)		 5b8i SERINE/THREONINE-PRO
TEIN PHOSPHATASE
(Coccidioides
immitis) 		5 / 12 ILE A 233
ALA A 251
SER A 275
ILE A 248
CYH A 246
 None
 1.27A 5mlmA-5b8iA:
undetectable		 5mlmA-5b8iA:
22.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NCD_D_ACTD301_0
(PEPTIDOGLYCAN
N-ACETYLGLUCOSAMINE
DEACETYLASE)		 5b8i SERINE/THREONINE-PRO
TEIN PHOSPHATASE
(Coccidioides
immitis) 		4 / 4 ASP A 136
HIS A 217
HIS A 299
HIS A 169
 ZN  A 401 (-2.7A)
ZN  A 401 (-3.5A)
ZN  A 401 ( 3.4A)
MES  A 403 (-3.8A)
 1.50A 5ncdD-5b8iA:
undetectable		 5ncdD-5b8iA:
21.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BEC_C_RBTC601_1
(SCAFFOLD PROTEIN D13)		 5b8i PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
SERINE/THREONINE-PRO
TEIN PHOSPHATASE
(Coccidioides
immitis) 		5 / 12 VAL C  81
PRO A 373
PHE A 374
PHE C 105
ILE C 109
 None
None
FK5  C 201 (-3.6A)
FK5  C 201 (-4.3A)
None
 1.25A 6becA-5b8iC:
undetectable
6becB-5b8iC:
undetectable
6becC-5b8iC:
undetectable		 6becA-5b8iC:
15.93
6becB-5b8iC:
15.93
6becC-5b8iC:
15.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DEB_B_MTXB302_1
(BIFUNCTIONAL PROTEIN
FOLD)		 5b8i SERINE/THREONINE-PRO
TEIN PHOSPHATASE
(Coccidioides
immitis) 		5 / 12 LEU A 154
LEU A 116
PHE A 133
THR A 104
VAL A 339
 None
None
None
EDO  A 406 (-4.0A)
None
 1.21A 6debB-5b8iA:
undetectable		 6debB-5b8iA:
12.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F88_B_STRB502_1
(CYTOCHROME P450
CYP260A1)		 5b8i CALCINEURIN SUBUNIT
B, VARIANT
SERINE/THREONINE-PRO
TEIN PHOSPHATASE
(Coccidioides
immitis) 		4 / 6 LEU A 361
LEU B 129
SER A 371
ASN B 109
 None
None
FK5  C 201 (-4.6A)
None
 0.93A 6f88B-5b8iA:
undetectable		 6f88B-5b8iA:
15.28
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6MKE_A_FK5A201_0
(PEPTIDYLPROLYL
ISOMERASE)		 5b8i PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
(Coccidioides
immitis) 		10 / 12 TYR C  36
ASP C  56
ARG C  61
PHE C  64
VAL C  73
ILE C  74
TRP C  77
TYR C 100
ILE C 109
PHE C 117
 FK5  C 201 (-4.1A)
FK5  C 201 ( 3.8A)
FK5  C 201 (-3.8A)
FK5  C 201 (-3.8A)
FK5  C 201 (-3.5A)
FK5  C 201 (-3.8A)
FK5  C 201 (-3.4A)
FK5  C 201 (-4.5A)
None
FK5  C 201 (-4.7A)
 0.35A 6mkeA-5b8iC:
18.3
6mkeD-5b8iC:
18.1		 6mkeA-5b8iC:
32.98
6mkeD-5b8iC:
32.98
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6MKE_B_FK5B201_0
(PEPTIDYLPROLYL
ISOMERASE)		 5b8i PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
(Coccidioides
immitis) 		10 / 12 TYR C  36
ASP C  56
ARG C  61
PHE C  64
VAL C  73
ILE C  74
TRP C  77
TYR C 100
ILE C 109
PHE C 117
 FK5  C 201 (-4.1A)
FK5  C 201 ( 3.8A)
FK5  C 201 (-3.8A)
FK5  C 201 (-3.8A)
FK5  C 201 (-3.5A)
FK5  C 201 (-3.8A)
FK5  C 201 (-3.4A)
FK5  C 201 (-4.5A)
None
FK5  C 201 (-4.7A)
 0.47A 6mkeB-5b8iC:
18.3
6mkeC-5b8iC:
18.2		 6mkeB-5b8iC:
32.98
6mkeC-5b8iC:
32.98
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6MKE_C_FK5C201_1
(PEPTIDYLPROLYL
ISOMERASE)		 5b8i PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
(Coccidioides
immitis) 		10 / 10 TYR C  36
ASP C  56
ARG C  61
PHE C  64
VAL C  73
ILE C  74
TRP C  77
TYR C 100
ILE C 109
PHE C 117
 FK5  C 201 (-4.1A)
FK5  C 201 ( 3.8A)
FK5  C 201 (-3.8A)
FK5  C 201 (-3.8A)
FK5  C 201 (-3.5A)
FK5  C 201 (-3.8A)
FK5  C 201 (-3.4A)
FK5  C 201 (-4.5A)
None
FK5  C 201 (-4.7A)
 0.51A 6mkeC-5b8iC:
18.2		 6mkeC-5b8iC:
32.98
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6MKE_D_FK5D201_1
(PEPTIDYLPROLYL
ISOMERASE)		 5b8i PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
(Coccidioides
immitis) 		10 / 10 TYR C  36
ASP C  56
ARG C  61
PHE C  64
VAL C  73
ILE C  74
TRP C  77
TYR C 100
ILE C 109
PHE C 117
 FK5  C 201 (-4.1A)
FK5  C 201 ( 3.8A)
FK5  C 201 (-3.8A)
FK5  C 201 (-3.8A)
FK5  C 201 (-3.5A)
FK5  C 201 (-3.8A)
FK5  C 201 (-3.4A)
FK5  C 201 (-4.5A)
None
FK5  C 201 (-4.7A)
 0.48A 6mkeD-5b8iC:
18.1		 6mkeD-5b8iC:
32.98