SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5bn4'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1AGM_A_ACRA495_1
(GLUCOAMYLASE-471)		 5bn4 NEQ263
V-TYPE ATP SYNTHASE
ALPHA CHAIN
(Nanoarchaeum
equitans) 		5 / 12 ALA A 378
GLU A 327
ARG A 294
TYR B 256
GLU A 252
 None
None
None
None
MG  A 602 (-3.6A)
 1.27A 1agmA-5bn4A:
undetectable		 1agmA-5bn4A:
22.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1AGM_A_ACRA496_1
(GLUCOAMYLASE-471)		 5bn4 NEQ263
V-TYPE ATP SYNTHASE
ALPHA CHAIN
(Nanoarchaeum
equitans) 		5 / 12 ALA A 378
GLU A 327
ARG A 294
TYR B 256
GLU A 252
 None
None
None
None
MG  A 602 (-3.6A)
 1.27A 1agmA-5bn4A:
undetectable		 1agmA-5bn4A:
22.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1D8C_A_SORA4000_0
(MALATE SYNTHASE G)		 5bn4 V-TYPE ATP SYNTHASE
ALPHA CHAIN
(Nanoarchaeum
equitans) 		3 / 3 GLN A 490
HIS A 413
PRO A 415
 None
None
ANP  A 601 ( 4.4A)
 0.94A 1d8cA-5bn4A:
undetectable		 1d8cA-5bn4A:
23.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MXD_A_ACRA733_1
(ALPHA AMYLASE)		 5bn4 NEQ263
V-TYPE ATP SYNTHASE
ALPHA CHAIN
(Nanoarchaeum
equitans) 		4 / 6 SER A  96
THR A  94
ASN B 100
LEU A  87
 None
 0.99A 1mxdA-5bn4A:
undetectable		 1mxdA-5bn4A:
22.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MXG_A_ACRA443_1
(ALPHA AMYLASE)		 5bn4 NEQ263
V-TYPE ATP SYNTHASE
ALPHA CHAIN
(Nanoarchaeum
equitans) 		4 / 8 SER A  96
THR A  94
ASN B 100
LEU A  87
 None
 1.01A 1mxgA-5bn4A:
undetectable		 1mxgA-5bn4A:
22.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1N49_D_RITD401_2
(PROTEASE)		 5bn4 NEQ263
V-TYPE ATP SYNTHASE
ALPHA CHAIN
(Nanoarchaeum
equitans) 		4 / 6 GLY A  82
ILE A 283
PRO B 101
ILE A  90
 None
 0.94A 1n49D-5bn4A:
undetectable		 1n49D-5bn4A:
9.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OT7_B_IU5B1002_1
(BILE ACID RECEPTOR)		 5bn4 V-TYPE ATP SYNTHASE
ALPHA CHAIN
(Nanoarchaeum
equitans) 		5 / 12 HIS A 479
MET A 480
ARG A 482
ILE A 542
ILE A 512
 None
 1.47A 1ot7B-5bn4A:
undetectable		 1ot7B-5bn4A:
17.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PKV_A_RBFA100_1
(RIBOFLAVIN SYNTHASE
ALPHA CHAIN)		 5bn4 NEQ263
(Nanoarchaeum
equitans) 		5 / 11 LEU B 280
THR B 295
ILE B 298
THR B 299
ILE B 262
 None
 0.95A 1pkvA-5bn4B:
4.4
1pkvB-5bn4B:
4.5		 1pkvA-5bn4B:
12.68
1pkvB-5bn4B:
12.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PKV_B_RBFB101_1
(RIBOFLAVIN SYNTHASE
ALPHA CHAIN)		 5bn4 NEQ263
(Nanoarchaeum
equitans) 		5 / 11 ILE B 262
LEU B 280
THR B 295
ILE B 298
THR B 299
 None
 0.96A 1pkvA-5bn4B:
4.5
1pkvB-5bn4B:
4.5		 1pkvA-5bn4B:
12.68
1pkvB-5bn4B:
12.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RLB_F_REAF177_1
(RETINOL BINDING
PROTEIN)		 5bn4 NEQ263
(Nanoarchaeum
equitans) 		5 / 11 PHE B 383
LEU B 343
ALA B 328
LEU B 351
LEU B 321
 None
 1.19A 1rlbF-5bn4B:
undetectable		 1rlbF-5bn4B:
17.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YAT_A_FK5A108_1
(FK506 BINDING
PROTEIN)		 5bn4 NEQ263
V-TYPE ATP SYNTHASE
ALPHA CHAIN
(Nanoarchaeum
equitans) 		5 / 11 ARG A 335
VAL B  31
ILE B  30
LEU B 235
ILE B 200
 None
 1.00A 1yatA-5bn4A:
undetectable		 1yatA-5bn4A:
13.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F6D_A_ACRA995_1
(GLUCOAMYLASE GLU1)		 5bn4 NEQ263
V-TYPE ATP SYNTHASE
ALPHA CHAIN
(Nanoarchaeum
equitans) 		5 / 12 ALA A 378
GLU A 327
ARG A 294
TYR B 256
GLU A 252
 None
None
None
None
MG  A 602 (-3.6A)
 1.22A 2f6dA-5bn4A:
undetectable		 2f6dA-5bn4A:
21.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F8L_A_SAMA400_1
(HYPOTHETICAL PROTEIN
LMO1582)		 5bn4 V-TYPE ATP SYNTHASE
ALPHA CHAIN
NEQ263
(Nanoarchaeum
equitans;
Nanoarchaeum
equitans) 		4 / 4 THR B 229
THR B 295
ASP B 293
ASP A 385
 None
 1.21A 2f8lA-5bn4B:
3.5		 2f8lA-5bn4B:
22.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2GVC_B_MMZB501_1
(MONOOXYGENASE)		 5bn4 NEQ263
V-TYPE ATP SYNTHASE
ALPHA CHAIN
(Nanoarchaeum
equitans) 		3 / 3 ASN A   8
TYR B 254
SER A 334
 None
 0.81A 2gvcB-5bn4A:
undetectable		 2gvcB-5bn4A:
23.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2GVC_E_MMZE501_1
(MONOOXYGENASE)		 5bn4 NEQ263
V-TYPE ATP SYNTHASE
ALPHA CHAIN
(Nanoarchaeum
equitans) 		3 / 3 ASN A   8
TYR B 254
SER A 334
 None
 0.80A 2gvcE-5bn4A:
undetectable		 2gvcE-5bn4A:
23.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HC4_A_VDXA525_2
(VITAMIN D RECEPTOR)		 5bn4 NEQ263
(Nanoarchaeum
equitans) 		4 / 7 LEU B 241
LEU B  40
ILE B  22
ARG B  56
 None
 1.18A 2hc4A-5bn4B:
undetectable		 2hc4A-5bn4B:
21.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HDN_L_TACL6888_1
(ELONGATION FACTOR
EF-TU)		 5bn4 V-TYPE ATP SYNTHASE
ALPHA CHAIN
(Nanoarchaeum
equitans) 		4 / 6 VAL A 430
THR A 202
ASP A 208
PRO A 212
 None
 1.24A 2hdnJ-5bn4A:
undetectable
2hdnK-5bn4A:
undetectable
2hdnL-5bn4A:
3.9		 2hdnJ-5bn4A:
20.87
2hdnK-5bn4A:
9.18
2hdnL-5bn4A:
20.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NYR_B_SVRB401_1
(NAD-DEPENDENT
DEACETYLASE
SIRTUIN-5)		 5bn4 V-TYPE ATP SYNTHASE
ALPHA CHAIN
(Nanoarchaeum
equitans) 		5 / 12 ALA A 237
PHE A 356
TYR A 357
ILE A 376
LEU A 404
 None
 1.07A 2nyrA-5bn4A:
undetectable		 2nyrA-5bn4A:
17.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QD4_A_CHDA803_0
(FERROCHELATASE)		 5bn4 NEQ263
(Nanoarchaeum
equitans) 		4 / 5 LEU B   8
PRO B   7
LEU B  42
ILE B  32
 None
 0.84A 2qd4A-5bn4B:
2.6		 2qd4A-5bn4B:
24.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QD4_A_CHDA803_0
(FERROCHELATASE)		 5bn4 V-TYPE ATP SYNTHASE
ALPHA CHAIN
NEQ263
(Nanoarchaeum
equitans;
Nanoarchaeum
equitans) 		4 / 5 PRO B 101
LEU A  87
ILE A  90
ARG A  85
 None
 0.82A 2qd4A-5bn4B:
2.6		 2qd4A-5bn4B:
24.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2R5Q_B_1UNB900_1
(PROTEASE)		 5bn4 V-TYPE ATP SYNTHASE
ALPHA CHAIN
(Nanoarchaeum
equitans) 		5 / 9 ARG A 188
LEU A  71
ILE A 168
GLY A 133
ILE A 131
 None
 0.95A 2r5qA-5bn4A:
undetectable		 2r5qA-5bn4A:
11.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2R5Q_D_1UND900_1
(PROTEASE)		 5bn4 V-TYPE ATP SYNTHASE
ALPHA CHAIN
(Nanoarchaeum
equitans) 		5 / 9 ARG A 188
LEU A  71
ILE A 168
GLY A 133
ILE A 131
 None
 0.95A 2r5qC-5bn4A:
undetectable		 2r5qC-5bn4A:
11.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y7K_A_SALA1302_1
(LYSR-TYPE REGULATORY
PROTEIN)		 5bn4 NEQ263
(Nanoarchaeum
equitans) 		5 / 11 THR B 113
ILE B 115
GLY B 114
PHE B 383
PRO B 316
 None
 1.37A 2y7kA-5bn4B:
undetectable		 2y7kA-5bn4B:
17.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y7K_B_SALB1304_1
(LYSR-TYPE REGULATORY
PROTEIN)		 5bn4 NEQ263
(Nanoarchaeum
equitans) 		5 / 10 THR B 113
ILE B 115
GLY B 114
PHE B 383
PRO B 316
 None
 1.32A 2y7kB-5bn4B:
1.2		 2y7kB-5bn4B:
17.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y7K_C_SALC1302_1
(LYSR-TYPE REGULATORY
PROTEIN)		 5bn4 NEQ263
(Nanoarchaeum
equitans) 		5 / 12 THR B 113
ILE B 115
GLY B 114
PHE B 383
PRO B 316
 None
 1.25A 2y7kC-5bn4B:
1.3		 2y7kC-5bn4B:
17.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y7P_A_SALA1000_1
(LYSR-TYPE REGULATORY
PROTEIN)		 5bn4 NEQ263
(Nanoarchaeum
equitans) 		5 / 10 THR B 113
ILE B 115
GLY B 114
PHE B 383
PRO B 316
 None
 1.44A 2y7pA-5bn4B:
undetectable		 2y7pA-5bn4B:
17.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YVL_B_SAMB602_1
(HYPOTHETICAL PROTEIN)		 5bn4 V-TYPE ATP SYNTHASE
ALPHA CHAIN
NEQ263
(Nanoarchaeum
equitans;
Nanoarchaeum
equitans) 		3 / 3 GLU B 380
ASP B 319
TYR A 410
 None
 0.87A 2yvlB-5bn4B:
2.6		 2yvlB-5bn4B:
23.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3D9L_A_ACTA501_0
(CTD-PEPTIDE
RNA-BINDING PROTEIN
16)		 5bn4 V-TYPE ATP SYNTHASE
ALPHA CHAIN
NEQ263
(Nanoarchaeum
equitans;
Nanoarchaeum
equitans) 		4 / 5 PRO A  86
ILE A  90
TYR B 102
TYR A  91
 None
 1.13A 3d9lA-5bn4A:
undetectable
3d9lY-5bn4A:
undetectable		 3d9lA-5bn4A:
13.16
3d9lY-5bn4A:
2.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DGQ_A_EAAA211_1
(GLUTATHIONE
S-TRANSFERASE P)		 5bn4 NEQ263
(Nanoarchaeum
equitans) 		4 / 5 TYR B  69
ILE B  94
TYR B  61
THR B  60
 None
 1.40A 3dgqA-5bn4B:
undetectable		 3dgqA-5bn4B:
19.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EKY_A_DR7A100_2
(PROTEASE)		 5bn4 V-TYPE ATP SYNTHASE
ALPHA CHAIN
(Nanoarchaeum
equitans) 		5 / 9 ILE A 131
ILE A 168
PRO A 147
VAL A 150
ILE A 126
 None
 1.17A 3ekyB-5bn4A:
undetectable		 3ekyB-5bn4A:
10.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EM0_B_CHDB150_0
(ILEAL BILE
ACID-BINDING PROTEIN)		 5bn4 NEQ263
(Nanoarchaeum
equitans) 		5 / 12 PHE B 383
ILE B 400
GLN B 146
ASN B 150
LEU B 124
 None
 1.27A 3em0B-5bn4B:
undetectable		 3em0B-5bn4B:
14.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3F78_B_ICFB2_1
(INTEGRIN ALPHA-L)		 5bn4 V-TYPE ATP SYNTHASE
ALPHA CHAIN
(Nanoarchaeum
equitans) 		5 / 9 ILE A 304
TYR A 307
ILE A 244
LEU A  76
LEU A  75
 None
 1.10A 3f78B-5bn4A:
2.9		 3f78B-5bn4A:
15.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3I45_A_NIOA500_1
(TWIN-ARGININE
TRANSLOCATION
PATHWAY SIGNAL
PROTEIN)		 5bn4 V-TYPE ATP SYNTHASE
ALPHA CHAIN
(Nanoarchaeum
equitans) 		4 / 8 PHE A 211
LEU A 489
PHE A 449
LEU A 452
 None
 0.98A 3i45A-5bn4A:
undetectable		 3i45A-5bn4A:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IA4_C_MTXC164_2
(DIHYDROFOLATE
REDUCTASE)		 5bn4 V-TYPE ATP SYNTHASE
ALPHA CHAIN
(Nanoarchaeum
equitans) 		4 / 4 ILE A 248
ARG A 309
ILE A 246
THR A 322
 None
 0.90A 3ia4C-5bn4A:
0.9		 3ia4C-5bn4A:
15.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KP2_A_PNNA5001_0
(TRANSCRIPTIONAL
REGULATOR TCAR)		 5bn4 NEQ263
(Nanoarchaeum
equitans) 		4 / 8 LEU B 125
GLN B 128
SER B 325
HIS B 122
 None
 1.13A 3kp2A-5bn4B:
undetectable
3kp2B-5bn4B:
undetectable		 3kp2A-5bn4B:
18.14
3kp2B-5bn4B:
18.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3O7W_A_SAMA801_1
(LEUCINE CARBOXYL
METHYLTRANSFERASE 1)		 5bn4 V-TYPE ATP SYNTHASE
ALPHA CHAIN
NEQ263
(Nanoarchaeum
equitans;
Nanoarchaeum
equitans) 		3 / 3 LYS A 411
ARG A 485
ASP B 369
 None
 1.19A 3o7wA-5bn4A:
undetectable		 3o7wA-5bn4A:
19.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RFM_A_CFFA330_1
(ADENOSINE RECEPTOR
A2A)		 5bn4 NEQ263
(Nanoarchaeum
equitans) 		4 / 7 VAL B 151
LEU B 224
MET B 279
ILE B 277
 None
 0.78A 3rfmA-5bn4B:
undetectable		 3rfmA-5bn4B:
21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W1W_A_CHDA1507_0
(FERROCHELATASE,
MITOCHONDRIAL)		 5bn4 V-TYPE ATP SYNTHASE
ALPHA CHAIN
NEQ263
(Nanoarchaeum
equitans;
Nanoarchaeum
equitans) 		3 / 3 ARG A 253
LYS B 129
ARG B 104
 ANP  A 601 ( 3.9A)
None
None
 0.96A 3w1wA-5bn4A:
2.0
3w1wB-5bn4A:
2.1		 3w1wA-5bn4A:
19.66
3w1wB-5bn4A:
19.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W1W_B_CHDB506_0
(FERROCHELATASE,
MITOCHONDRIAL)		 5bn4 V-TYPE ATP SYNTHASE
ALPHA CHAIN
NEQ263
(Nanoarchaeum
equitans;
Nanoarchaeum
equitans) 		3 / 3 ARG B 104
ARG A 253
LYS B 129
 None
ANP  A 601 ( 3.9A)
None
 1.01A 3w1wA-5bn4B:
2.8
3w1wB-5bn4B:
2.8		 3w1wA-5bn4B:
24.28
3w1wB-5bn4B:
24.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DF3_A_SAMA301_0
(FIBRILLARIN-LIKE
RRNA/TRNA
2'-O-METHYLTRANSFERA
SE)		 5bn4 V-TYPE ATP SYNTHASE
ALPHA CHAIN
(Nanoarchaeum
equitans) 		5 / 12 GLY A 228
ALA A 378
VAL A 221
VAL A 231
GLN A 234
 ANP  A 601 (-3.2A)
None
None
ANP  A 601 (-4.1A)
None
 1.38A 4df3A-5bn4A:
undetectable		 4df3A-5bn4A:
19.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DF3_B_SAMB301_0
(FIBRILLARIN-LIKE
RRNA/TRNA
2'-O-METHYLTRANSFERA
SE)		 5bn4 V-TYPE ATP SYNTHASE
ALPHA CHAIN
(Nanoarchaeum
equitans) 		5 / 12 GLY A 228
ALA A 378
VAL A 221
VAL A 231
GLN A 234
 ANP  A 601 (-3.2A)
None
None
ANP  A 601 (-4.1A)
None
 1.38A 4df3B-5bn4A:
2.0		 4df3B-5bn4A:
19.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DJF_A_C2FA300_0
(5-METHYLTETRAHYDROFO
LATE CORRINOID/IRON
SULFUR PROTEIN
METHYLTRANSFERASE)		 5bn4 V-TYPE ATP SYNTHASE
ALPHA CHAIN
NEQ263
(Nanoarchaeum
equitans;
Nanoarchaeum
equitans) 		5 / 12 GLU A 331
ILE A  36
ASN A   8
ARG B 242
ILE A 332
 None
 1.47A 4djfA-5bn4A:
undetectable		 4djfA-5bn4A:
18.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FOG_D_C2FD302_0
(THYMIDYLATE SYNTHASE)		 5bn4 V-TYPE ATP SYNTHASE
ALPHA CHAIN
(Nanoarchaeum
equitans) 		5 / 11 ILE A 184
LEU A  75
ASP A  81
LEU A  83
GLY A  82
 None
 1.18A 4fogD-5bn4A:
undetectable		 4fogD-5bn4A:
17.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FOX_G_D16G301_1
(THYMIDYLATE SYNTHASE)		 5bn4 V-TYPE ATP SYNTHASE
ALPHA CHAIN
(Nanoarchaeum
equitans) 		5 / 12 ILE A 184
LEU A  75
ASP A  81
LEU A  83
GLY A  82
 None
 1.19A 4foxG-5bn4A:
undetectable		 4foxG-5bn4A:
17.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JEC_B_478B401_2
(HIV-1 PROTEASE)		 5bn4 V-TYPE ATP SYNTHASE
ALPHA CHAIN
(Nanoarchaeum
equitans) 		5 / 12 ARG A 188
LEU A  71
ILE A 168
GLY A 133
ILE A 131
 None
 0.97A 4jecB-5bn4A:
undetectable		 4jecB-5bn4A:
14.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KSZ_A_CYSA620_0
(LACTOPEROXIDASE)		 5bn4 NEQ263
(Nanoarchaeum
equitans) 		3 / 3 ARG B 142
GLU B 141
PHE B 172
 None
 0.97A 4kszA-5bn4B:
undetectable		 4kszA-5bn4B:
23.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LB2_A_DM5A601_1
(SERUM ALBUMIN)		 5bn4 V-TYPE ATP SYNTHASE
ALPHA CHAIN
(Nanoarchaeum
equitans) 		4 / 7 LEU A 194
LYS A 191
TYR A 190
GLU A 192
 None
 0.99A 4lb2A-5bn4A:
undetectable		 4lb2A-5bn4A:
23.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LV9_A_20JA601_1
(NICOTINAMIDE
PHOSPHORIBOSYLTRANSF
ERASE)		 5bn4 NEQ263
V-TYPE ATP SYNTHASE
ALPHA CHAIN
(Nanoarchaeum
equitans) 		4 / 8 ARG A 294
SER A 334
ALA B 253
SER B 247
 None
 1.11A 4lv9A-5bn4A:
undetectable
4lv9B-5bn4A:
undetectable		 4lv9A-5bn4A:
24.60
4lv9B-5bn4A:
24.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R38_A_RBFA201_2
(BLUE-LIGHT-ACTIVATED
HISTIDINE KINASE 2)		 5bn4 NEQ263
(Nanoarchaeum
equitans) 		4 / 8 ILE B 162
LEU B 222
LEU B 207
ILE B 274
 None
 0.68A 4r38A-5bn4B:
undetectable		 4r38A-5bn4B:
15.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R7I_A_STIA1001_2
(MACROPHAGE
COLONY-STIMULATING
FACTOR 1 RECEPTOR)		 5bn4 V-TYPE ATP SYNTHASE
ALPHA CHAIN
(Nanoarchaeum
equitans) 		4 / 5 LEU A 408
VAL A 206
VAL A 221
TYR A 419
 None
 1.03A 4r7iA-5bn4A:
undetectable		 4r7iA-5bn4A:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B8I_C_FK5C201_3
(PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE)		 5bn4 NEQ263
V-TYPE ATP SYNTHASE
ALPHA CHAIN
(Nanoarchaeum
equitans) 		5 / 12 ARG A 335
VAL B  31
ILE B  30
LEU B 235
ILE B 200
 None
 0.94A 5b8iC-5bn4A:
undetectable		 5b8iC-5bn4A:
12.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FCT_A_C2FA402_0
(THYMIDYLATE SYNTHASE)		 5bn4 V-TYPE ATP SYNTHASE
ALPHA CHAIN
(Nanoarchaeum
equitans) 		5 / 11 ILE A 184
LEU A  75
ASP A  81
LEU A  83
GLY A  82
 None
 1.21A 5fctA-5bn4A:
undetectable		 5fctA-5bn4A:
20.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FHZ_D_READ602_1
(ALDEHYDE
DEHYDROGENASE FAMILY
1 MEMBER A3)		 5bn4 V-TYPE ATP SYNTHASE
ALPHA CHAIN
(Nanoarchaeum
equitans) 		5 / 12 ILE A 483
GLU A 486
GLY A 487
GLU A 508
LEU A 544
 None
 1.16A 5fhzD-5bn4A:
undetectable		 5fhzD-5bn4A:
23.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KR1_B_017B101_1
(PROTEASE PR5-DRV)		 5bn4 V-TYPE ATP SYNTHASE
ALPHA CHAIN
(Nanoarchaeum
equitans) 		5 / 10 ARG A 188
LEU A  71
ILE A 168
GLY A 133
ILE A 131
 None
 1.00A 5kr1A-5bn4A:
undetectable		 5kr1A-5bn4A:
13.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MSD_A_BEZA1202_0
(CARBOXYLIC ACID
REDUCTASE)		 5bn4 NEQ263
(Nanoarchaeum
equitans) 		4 / 5 ILE B 344
PHE B 383
SER B 117
ALA B 340
 None
 1.28A 5msdA-5bn4B:
undetectable		 5msdA-5bn4B:
17.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N0W_B_SAMB501_1
(PEPTIDE
N-METHYLTRANSFERASE)		 5bn4 V-TYPE ATP SYNTHASE
ALPHA CHAIN
(Nanoarchaeum
equitans) 		4 / 5 TYR A 423
ALA A 220
GLN A 392
THR A 394
 None
 0.96A 5n0wB-5bn4A:
2.2		 5n0wB-5bn4A:
21.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N4I_A_SAMA501_1
(PEPTIDE
N-METHYLTRANSFERASE)		 5bn4 V-TYPE ATP SYNTHASE
ALPHA CHAIN
(Nanoarchaeum
equitans) 		4 / 5 TYR A 423
ALA A 220
GLN A 392
THR A 394
 None
 1.01A 5n4iA-5bn4A:
1.4		 5n4iA-5bn4A:
21.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ODH_G_ACTG710_0
(HETERODISULFIDE
REDUCTASE, SUBUNIT A)		 5bn4 NEQ263
(Nanoarchaeum
equitans) 		4 / 4 ARG B 265
ILE B 262
TYR B 231
ILE B 200
 None
 1.46A 5odhG-5bn4B:
2.8		 5odhG-5bn4B:
21.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TE8_A_08JA602_1
(CYTOCHROME P450 3A4)		 5bn4 V-TYPE ATP SYNTHASE
ALPHA CHAIN
(Nanoarchaeum
equitans) 		4 / 7 ARG A 185
ALA A 292
ILE A  32
LEU A  83
 None
 0.94A 5te8A-5bn4A:
undetectable		 5te8A-5bn4A:
22.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DJZ_A_GMJA301_0
(SIGMA NON-OPIOID
INTRACELLULAR
RECEPTOR 1)		 5bn4 V-TYPE ATP SYNTHASE
ALPHA CHAIN
(Nanoarchaeum
equitans) 		5 / 12 LEU A 207
ILE A 376
VAL A 398
THR A 322
VAL A 379
 None
 1.24A 6djzA-5bn4A:
undetectable		 6djzA-5bn4A:
16.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6G1P_B_ACTB403_0
(ADP-RIBOSYLHYDROLASE
LIKE 2)		 5bn4 V-TYPE ATP SYNTHASE
ALPHA CHAIN
NEQ263
(Nanoarchaeum
equitans;
Nanoarchaeum
equitans) 		3 / 3 PHE A 225
ARG B 326
GLN B 302
 None
ANP  A 601 (-3.0A)
None
 0.95A 6g1pB-5bn4A:
undetectable		 6g1pB-5bn4A:
19.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6J20_A_GBQA1201_0
(SUBSTANCE-P
RECEPTOR,ENDOLYSIN)		 5bn4 V-TYPE ATP SYNTHASE
ALPHA CHAIN
(Nanoarchaeum
equitans) 		5 / 12 VAL A 441
ILE A 559
THR A 506
ILE A 507
PHE A 448
 None
 1.50A 6j20A-5bn4A:
undetectable		 6j20A-5bn4A:
19.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NCS_A_ACTA303_0
(N-ACETYLNEURAMINIC
ACID (SIALIC ACID)
SYNTHETASE)		 5bn4 V-TYPE ATP SYNTHASE
ALPHA CHAIN
(Nanoarchaeum
equitans) 		3 / 3 ILE A 164
THR A 163
PRO A  73
 None
 0.63A 6ncsA-5bn4A:
undetectable		 6ncsA-5bn4A:
20.45