SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5bnt'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1D4Y_A_TPVA501_1
(PROTEIN (HIV-1
PROTEASE))		 5bnt ASPARTATE-SEMIALDEHY
DE DEHYDROGENASE
(Pseudomonas
aeruginosa) 		5 / 10 LEU C 352
ALA C  97
ASP C  96
GLY C   8
VAL C  16
 None
NAP  C 500 ( 4.2A)
None
NAP  C 500 (-3.2A)
None
 1.02A 1d4yA-5bntC:
undetectable		 1d4yA-5bntC:
14.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UOB_A_PNNA1311_1
(DEACETOXYCEPHALOSPOR
IN C SYNTHETASE)		 5bnt ASPARTATE-SEMIALDEHY
DE DEHYDROGENASE
(Pseudomonas
aeruginosa) 		3 / 3 ARG C 362
ARG C 361
ILE C  95
 None
 0.67A 1uobA-5bntC:
undetectable		 1uobA-5bntC:
24.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XF1_A_ACTA1107_0
(C5A PEPTIDASE)		 5bnt ASPARTATE-SEMIALDEHY
DE DEHYDROGENASE
(Pseudomonas
aeruginosa) 		4 / 5 LEU C 144
GLY C 145
HIS C 299
ILE C 296
 None
 0.97A 1xf1A-5bntC:
undetectable		 1xf1A-5bntC:
17.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AOH_C_FRDC305_1
(POL POLYPROTEIN
PEPTIDE INHIBITOR)		 5bnt ASPARTATE-SEMIALDEHY
DE DEHYDROGENASE
(Pseudomonas
aeruginosa) 		4 / 5 LEU C 353
ASP C 350
GLY C 166
ALA C 357
 None
 0.97A 2aohA-5bntC:
undetectable		 2aohA-5bntC:
15.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FK8_A_SAMA302_1
(METHOXY MYCOLIC ACID
SYNTHASE 4)		 5bnt ASPARTATE-SEMIALDEHY
DE DEHYDROGENASE
(Pseudomonas
aeruginosa) 		3 / 3 SER C  15
THR C  37
GLN C  73
 None
NAP  C 500 (-3.0A)
NAP  C 500 (-3.2A)
 0.69A 2fk8A-5bntC:
undetectable		 2fk8A-5bntC:
23.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HC4_A_VDXA525_2
(VITAMIN D RECEPTOR)		 5bnt ASPARTATE-SEMIALDEHY
DE DEHYDROGENASE
(Pseudomonas
aeruginosa) 		4 / 7 LEU C   6
ILE C 131
ARG C 102
SER C 100
 None
 1.19A 2hc4A-5bntC:
undetectable		 2hc4A-5bntC:
23.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2O4P_A_TPVA300_1
(PROTEASE)		 5bnt ASPARTATE-SEMIALDEHY
DE DEHYDROGENASE
(Pseudomonas
aeruginosa) 		5 / 11 LEU C 352
ALA C  97
ASP C  96
GLY C   8
VAL C  16
 None
NAP  C 500 ( 4.2A)
None
NAP  C 500 (-3.2A)
None
 1.04A 2o4pA-5bntC:
undetectable		 2o4pA-5bntC:
16.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2R2V_D_ACTD36_0
(GCN4 LEUCINE ZIPPER)		 5bnt ASPARTATE-SEMIALDEHY
DE DEHYDROGENASE
(Pseudomonas
aeruginosa) 		3 / 3 SER C 276
TYR C 161
HIS C 275
 None
 0.73A 2r2vD-5bntC:
undetectable		 2r2vD-5bntC:
6.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZGW_B_ADNB1302_1
(BIOTIN--[ACETYL-COA-
CARBOXYLASE] LIGASE)		 5bnt ASPARTATE-SEMIALDEHY
DE DEHYDROGENASE
(Pseudomonas
aeruginosa) 		4 / 6 GLU C 174
ALA C 182
PRO C 214
ALA C 181
 None
 1.17A 2zgwB-5bntC:
undetectable		 2zgwB-5bntC:
20.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DEU_B_SALB306_1
(TRANSCRIPTIONAL
REGULATOR SLYA)		 5bnt ASPARTATE-SEMIALDEHY
DE DEHYDROGENASE
(Pseudomonas
aeruginosa) 		4 / 6 THR C  71
ILE C 131
LEU C 101
THR C  78
 None
 0.95A 3deuB-5bntC:
undetectable		 3deuB-5bntC:
19.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T3Z_A_9PLA501_1
(CYTOCHROME P450 2E1)		 5bnt ASPARTATE-SEMIALDEHY
DE DEHYDROGENASE
(Pseudomonas
aeruginosa) 		4 / 6 LEU C 139
ALA C 245
THR C 249
LEU C 279
 None
 0.92A 3t3zA-5bntC:
undetectable		 3t3zA-5bntC:
22.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T3Z_B_9PLB501_1
(CYTOCHROME P450 2E1)		 5bnt ASPARTATE-SEMIALDEHY
DE DEHYDROGENASE
(Pseudomonas
aeruginosa) 		4 / 6 LEU C 139
ALA C 245
THR C 249
LEU C 279
 None
 0.90A 3t3zB-5bntC:
undetectable		 3t3zB-5bntC:
22.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T3Z_D_9PLD501_1
(CYTOCHROME P450 2E1)		 5bnt ASPARTATE-SEMIALDEHY
DE DEHYDROGENASE
(Pseudomonas
aeruginosa) 		4 / 6 LEU C 139
ALA C 245
THR C 249
LEU C 279
 None
 0.92A 3t3zD-5bntC:
undetectable		 3t3zD-5bntC:
22.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FGJ_A_1PQA304_0
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 5bnt ASPARTATE-SEMIALDEHY
DE DEHYDROGENASE
(Pseudomonas
aeruginosa) 		4 / 8 ILE C  95
TRP C 354
GLY C 133
ASN C 115
 None
 0.95A 4fgjA-5bntC:
3.6
4fgjB-5bntC:
3.9		 4fgjA-5bntC:
21.19
4fgjB-5bntC:
21.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L6E_B_ACTB401_0
(N6-ADENOSINE-METHYLT
RANSFERASE 70 KDA
SUBUNIT
N6-ADENOSINE-METHYLT
RANSFERASE SUBUNIT
METTL14)		 5bnt ASPARTATE-SEMIALDEHY
DE DEHYDROGENASE
(Pseudomonas
aeruginosa) 		4 / 6 GLU C 358
ARG C  20
LEU C  17
ARG C 361
 None
 1.18A 5l6eA-5bntC:
undetectable
5l6eB-5bntC:
undetectable		 5l6eA-5bntC:
20.00
5l6eB-5bntC:
22.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N0O_A_SAMA501_1
(PEPTIDE
N-METHYLTRANSFERASE)		 5bnt ASPARTATE-SEMIALDEHY
DE DEHYDROGENASE
(Pseudomonas
aeruginosa) 		3 / 3 ALA C  98
GLN C  73
THR C  78
 NAP  C 500 ( 4.0A)
NAP  C 500 (-3.2A)
None
 0.59A 5n0oA-5bntC:
undetectable		 5n0oA-5bntC:
22.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5QGK_A_ACTA301_0
(PEROXISOMAL COENZYME
A DIPHOSPHATASE
NUDT7)		 5bnt ASPARTATE-SEMIALDEHY
DE DEHYDROGENASE
(Pseudomonas
aeruginosa) 		3 / 3 VAL C 269
TYR C 161
GLN C 162
 None
 0.58A 5qgkA-5bntC:
undetectable		 5qgkA-5bntC:
21.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5QGR_A_ACTA301_0
(PEROXISOMAL COENZYME
A DIPHOSPHATASE
NUDT7)		 5bnt ASPARTATE-SEMIALDEHY
DE DEHYDROGENASE
(Pseudomonas
aeruginosa) 		3 / 3 VAL C 269
TYR C 161
GLN C 162
 None
 0.56A 5qgrA-5bntC:
undetectable		 5qgrA-5bntC:
21.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5QGT_A_ACTA301_0
(PEROXISOMAL COENZYME
A DIPHOSPHATASE
NUDT7)		 5bnt ASPARTATE-SEMIALDEHY
DE DEHYDROGENASE
(Pseudomonas
aeruginosa) 		3 / 3 VAL C 269
TYR C 161
GLN C 162
 None
 0.56A 5qgtA-5bntC:
undetectable		 5qgtA-5bntC:
21.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z6K_A_FOLA201_1
(DIHYDROFOLATE
REDUCTASE)		 5bnt ASPARTATE-SEMIALDEHY
DE DEHYDROGENASE
(Pseudomonas
aeruginosa) 		3 / 3 MET C 142
ASP C 112
ARG C  20
 None
 1.14A 5z6kA-5bntC:
undetectable		 5z6kA-5bntC:
17.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EU9_D_READ601_1
(RETINOIC ACID
RECEPTOR)		 5bnt ASPARTATE-SEMIALDEHY
DE DEHYDROGENASE
(Pseudomonas
aeruginosa) 		4 / 7 VAL C  16
LEU C 326
GLY C 324
GLY C 166
 None
 0.75A 6eu9D-5bntC:
undetectable		 6eu9D-5bntC:
13.03