SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5bo4'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)

Filter list by:

	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3LM8_C_VIBC223_1 (THIAMINE PYROPHOSPHOKINASE)	5bo4	SUPPRESSOR OF CYTOKINE SIGNALING 2 (Homo sapiens)	4 / 8	ASP A 74 LEU A 43 LEU A 82 SER A 85	None	1.00A	3lm8A-5bo4A: undetectable 3lm8C-5bo4A: undetectable	3lm8A-5bo4A: 21.52 3lm8C-5bo4A: 21.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5KI6_A_IPHA901_0 (PROTEIN ARGONAUTE-2)	5bo4	SUPPRESSOR OF CYTOKINE SIGNALING 2 (Homo sapiens)	4 / 5	LEU A 106 LYS A 117 LEU A 125 TYR A 129	CAS A 111 ( 4.4A) None None None	1.43A	5ki6A-5bo4A: undetectable	5ki6A-5bo4A: 12.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5UMW_B_RBFB201_1 (GLYOXALASE/BLEOMYCIN RESISANCE PROTEIN/DIOXYGENASE)	5bo4	SUPPRESSOR OF CYTOKINE SIGNALING 2 (Homo sapiens)	4 / 7	VAL A 122 GLU A 42 LEU A 169 TRP A 48	None	1.19A	5umwB-5bo4A: undetectable 5umwE-5bo4A: undetectable	5umwB-5bo4A: 19.65 5umwE-5bo4A: 19.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5UMW_F_RBFF201_1 (GLYOXALASE/BLEOMYCIN RESISANCE PROTEIN/DIOXYGENASE)	5bo4	SUPPRESSOR OF CYTOKINE SIGNALING 2 (Homo sapiens)	5 / 7	LEU A 169 TRP A 48 VAL A 122 GLU A 42 SER A 121	None	1.28A	5umwA-5bo4A: undetectable 5umwF-5bo4A: undetectable	5umwA-5bo4A: 19.65 5umwF-5bo4A: 19.65

[["DrReposER ID","Desc.","Hit PDB","Hit molecule","Hit organism","Res. no.","Interface","HETATM","RMSD","Z-score","Seq ID"],["3LM8_C_VIBC223_1","THIAMINE PYROPHOSPHOKINASE;THIAMINE PYROPHOSPHOKINASE","5bo4","SUPPRESSOR OF CYTOKINE SIGNALING 2","Homo sapiens",4,"ASP A  74;LEU A  43;LEU A  82;SER A  85","None","1.00A","3lm8A-5bo4A:undetectable;3lm8C-5bo4A:undetectable","3lm8A-5bo4A:21.52;3lm8C-5bo4A:21.52"],["5KI6_A_IPHA901_0","PROTEIN ARGONAUTE-2","5bo4","SUPPRESSOR OF CYTOKINE SIGNALING 2","Homo sapiens",4,"LEU A 106;LYS A 117;LEU A 125;TYR A 129","CAS A 111 ( 4.4A);None;None;None","1.43A","5ki6A-5bo4A:undetectable","5ki6A-5bo4A:12.76"],["5UMW_B_RBFB201_1","GLYOXALASE\/BLEOMYCIN RESISANCE PROTEIN\/DIOXYGENASE;GLYOXALASE\/BLEOMYCIN RESISANCE PROTEIN\/DIOXYGENASE","5bo4","SUPPRESSOR OF CYTOKINE SIGNALING 2","Homo sapiens",4,"VAL A 122;GLU A  42;LEU A 169;TRP A  48","None","1.19A","5umwB-5bo4A:undetectable;5umwE-5bo4A:undetectable","5umwB-5bo4A:19.65;5umwE-5bo4A:19.65"],["5UMW_F_RBFF201_1","GLYOXALASE\/BLEOMYCIN RESISANCE PROTEIN\/DIOXYGENASE;GLYOXALASE\/BLEOMYCIN RESISANCE PROTEIN\/DIOXYGENASE","5bo4","SUPPRESSOR OF CYTOKINE SIGNALING 2","Homo sapiens",5,"LEU A 169;TRP A  48;VAL A 122;GLU A  42;SER A 121","None","1.28A","5umwA-5bo4A:undetectable;5umwF-5bo4A:undetectable","5umwA-5bo4A:19.65;5umwF-5bo4A:19.65"]]