SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5bo6'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JFF_B_TA1B601_1
(TUBULIN BETA CHAIN)		 5bo6 SIA-ALPHA-2,3-GAL-BE
TA-1,4-GLCNAC-R:ALPH
A
2,8-SIALYLTRANSFERAS
E
(Homo
sapiens) 		5 / 12 LEU A 376
SER A 300
PHE A 321
LEU A 374
THR A 375
 None
CDP  A 411 (-2.7A)
CDP  A 411 (-4.4A)
None
None
 1.23A 1jffB-5bo6A:
undetectable		 1jffB-5bo6A:
22.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XF1_B_ACTB1108_0
(C5A PEPTIDASE)		 5bo6 SIA-ALPHA-2,3-GAL-BE
TA-1,4-GLCNAC-R:ALPH
A
2,8-SIALYLTRANSFERAS
E
(Homo
sapiens) 		4 / 6 LEU A 260
ASN A 211
ILE A 245
PHE A 191
 None
 0.87A 1xf1B-5bo6A:
undetectable		 1xf1B-5bo6A:
16.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HXF_B_TA1B601_1
(TUBULIN BETA CHAIN)		 5bo6 SIA-ALPHA-2,3-GAL-BE
TA-1,4-GLCNAC-R:ALPH
A
2,8-SIALYLTRANSFERAS
E
(Homo
sapiens) 		5 / 12 LEU A 376
SER A 300
PHE A 321
LEU A 374
THR A 375
 None
CDP  A 411 (-2.7A)
CDP  A 411 (-4.4A)
None
None
 1.23A 2hxfB-5bo6A:
undetectable		 2hxfB-5bo6A:
22.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HXH_B_TA1B601_1
(TUBULIN BETA CHAIN)		 5bo6 SIA-ALPHA-2,3-GAL-BE
TA-1,4-GLCNAC-R:ALPH
A
2,8-SIALYLTRANSFERAS
E
(Homo
sapiens) 		5 / 12 LEU A 376
SER A 300
PHE A 321
LEU A 374
THR A 375
 None
CDP  A 411 (-2.7A)
CDP  A 411 (-4.4A)
None
None
 1.23A 2hxhB-5bo6A:
undetectable		 2hxhB-5bo6A:
22.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OXT_A_SAMA300_1
(NUCLEOSIDE-2'-O-METH
YLTRANSFERASE)		 5bo6 SIA-ALPHA-2,3-GAL-BE
TA-1,4-GLCNAC-R:ALPH
A
2,8-SIALYLTRANSFERAS
E
(Homo
sapiens) 		3 / 3 SER A 174
HIS A 317
ASP A 184
 None
FUC  A 408 (-4.7A)
None
 0.82A 2oxtA-5bo6A:
undetectable		 2oxtA-5bo6A:
20.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2P4N_B_TA1B601_1
(TUBULIN BETA CHAIN)		 5bo6 SIA-ALPHA-2,3-GAL-BE
TA-1,4-GLCNAC-R:ALPH
A
2,8-SIALYLTRANSFERAS
E
(Homo
sapiens) 		5 / 12 LEU A 376
SER A 300
PHE A 321
LEU A 374
THR A 375
 None
CDP  A 411 (-2.7A)
CDP  A 411 (-4.4A)
None
None
 1.23A 2p4nB-5bo6A:
undetectable		 2p4nB-5bo6A:
22.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WBE_B_TA1B1439_1
(TUBULIN BETA-2B
CHAIN)		 5bo6 SIA-ALPHA-2,3-GAL-BE
TA-1,4-GLCNAC-R:ALPH
A
2,8-SIALYLTRANSFERAS
E
(Homo
sapiens) 		5 / 12 LEU A 376
SER A 300
PHE A 321
LEU A 374
THR A 375
 None
CDP  A 411 (-2.7A)
CDP  A 411 (-4.4A)
None
None
 1.23A 2wbeB-5bo6A:
undetectable		 2wbeB-5bo6A:
22.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XZ5_B_ACHB1211_0
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 5bo6 SIA-ALPHA-2,3-GAL-BE
TA-1,4-GLCNAC-R:ALPH
A
2,8-SIALYLTRANSFERAS
E
(Homo
sapiens) 		4 / 8 SER A 120
GLN A 125
ILE A 140
SER A 115
 None
 1.03A 2xz5B-5bo6A:
undetectable
2xz5E-5bo6A:
undetectable		 2xz5B-5bo6A:
20.00
2xz5E-5bo6A:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DCO_B_TA1B601_1
(BOVINE BETA TUBULIN)		 5bo6 SIA-ALPHA-2,3-GAL-BE
TA-1,4-GLCNAC-R:ALPH
A
2,8-SIALYLTRANSFERAS
E
(Homo
sapiens) 		5 / 12 LEU A 376
SER A 300
PHE A 321
LEU A 374
THR A 375
 None
CDP  A 411 (-2.7A)
CDP  A 411 (-4.4A)
None
None
 1.23A 3dcoB-5bo6A:
undetectable		 3dcoB-5bo6A:
22.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K2H_B_LYAB514_1
(DIHYDROFOLATE
REDUCTASE/THYMIDYLAT
E SYNTHASE)		 5bo6 SIA-ALPHA-2,3-GAL-BE
TA-1,4-GLCNAC-R:ALPH
A
2,8-SIALYLTRANSFERAS
E
(Homo
sapiens) 		5 / 12 PHE A 187
ARG A 188
SER A 310
ILE A 316
LEU A 318
 None
 1.18A 3k2hB-5bo6A:
undetectable		 3k2hB-5bo6A:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P6X_G_HCYG900_1
(GLUCOCORTICOID
RECEPTOR)		 5bo6 SIA-ALPHA-2,3-GAL-BE
TA-1,4-GLCNAC-R:ALPH
A
2,8-SIALYLTRANSFERAS
E
(Homo
sapiens) 		5 / 12 GLY A 302
LEU A 299
GLN A 100
THR A 372
ILE A 316
 CDP  A 411 (-3.3A)
None
None
None
None
 1.37A 4p6xG-5bo6A:
undetectable		 4p6xG-5bo6A:
21.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P6X_I_HCYI900_1
(GLUCOCORTICOID
RECEPTOR)		 5bo6 SIA-ALPHA-2,3-GAL-BE
TA-1,4-GLCNAC-R:ALPH
A
2,8-SIALYLTRANSFERAS
E
(Homo
sapiens) 		5 / 12 GLY A 302
LEU A 299
GLN A 100
THR A 372
ILE A 316
 CDP  A 411 (-3.3A)
None
None
None
None
 1.39A 4p6xI-5bo6A:
undetectable		 4p6xI-5bo6A:
21.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKQ_A_JMSA602_2
(PROSTAGLANDIN G/H
SYNTHASE 2)		 5bo6 SIA-ALPHA-2,3-GAL-BE
TA-1,4-GLCNAC-R:ALPH
A
2,8-SIALYLTRANSFERAS
E
(Homo
sapiens) 		3 / 3 VAL A 121
SER A 115
MET A 282
 None
 0.92A 5ikqA-5bo6A:
undetectable		 5ikqA-5bo6A:
17.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5W4Z_B_RBFB502_2
(RIBOFLAVIN LYASE)		 5bo6 SIA-ALPHA-2,3-GAL-BE
TA-1,4-GLCNAC-R:ALPH
A
2,8-SIALYLTRANSFERAS
E
(Homo
sapiens) 		4 / 4 ASN A 230
GLN A 226
ASP A 227
THR A 259
 None
 1.41A 5w4zB-5bo6A:
undetectable		 5w4zB-5bo6A:
11.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AYC_A_1YNA502_2
(PROTEIN CYP51)		 5bo6 SIA-ALPHA-2,3-GAL-BE
TA-1,4-GLCNAC-R:ALPH
A
2,8-SIALYLTRANSFERAS
E
(Homo
sapiens) 		4 / 7 VAL A 265
PRO A 246
PHE A 210
PHE A 144
 None
 0.87A 6aycA-5bo6A:
undetectable		 6aycA-5bo6A:
13.31