SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5bob'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IJX_B_HCZB800_1
(GLUTAMATE RECEPTOR 2)		 5bob TRANSLATION
INITIATION FACTOR 2
(IF-2 GTPASE)
(Streptococcus
suis) 		5 / 10 LEU A 293
ILE A 287
SER A 317
SER A 189
GLY A 195
 None
 1.34A 3ijxB-5bobA:
undetectable
3ijxD-5bobA:
undetectable		 3ijxB-5bobA:
21.30
3ijxD-5bobA:
21.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IK6_B_HCZB262_1
(GLUTAMATE RECEPTOR 2)		 5bob TRANSLATION
INITIATION FACTOR 2
(IF-2 GTPASE)
(Streptococcus
suis) 		5 / 10 ILE A 287
SER A 317
SER A 189
GLY A 195
LEU A 293
 None
 1.40A 3ik6B-5bobA:
undetectable
3ik6E-5bobA:
undetectable		 3ik6B-5bobA:
21.30
3ik6E-5bobA:
21.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IK6_B_HCZB800_1
(GLUTAMATE RECEPTOR 2)		 5bob TRANSLATION
INITIATION FACTOR 2
(IF-2 GTPASE)
(Streptococcus
suis) 		5 / 10 LEU A 293
ILE A 287
SER A 317
SER A 189
GLY A 195
 None
 1.27A 3ik6B-5bobA:
undetectable
3ik6E-5bobA:
undetectable		 3ik6B-5bobA:
21.30
3ik6E-5bobA:
21.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ILU_B_HFZB800_1
(GLUTAMATE RECEPTOR 2)		 5bob TRANSLATION
INITIATION FACTOR 2
(IF-2 GTPASE)
(Streptococcus
suis) 		5 / 10 LEU A 293
ILE A 287
SER A 317
SER A 189
GLY A 195
 None
 1.31A 3iluB-5bobA:
undetectable
3iluE-5bobA:
undetectable		 3iluB-5bobA:
21.30
3iluE-5bobA:
21.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ILU_E_HFZE800_1
(GLUTAMATE RECEPTOR 2)		 5bob TRANSLATION
INITIATION FACTOR 2
(IF-2 GTPASE)
(Streptococcus
suis) 		5 / 11 ILE A 287
SER A 317
SER A 189
GLY A 195
LEU A 293
 None
 1.30A 3iluB-5bobA:
undetectable
3iluE-5bobA:
undetectable		 3iluB-5bobA:
21.30
3iluE-5bobA:
21.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N23_C_OBNC1_1
(SODIUM/POTASSIUM-TRA
NSPORTING ATPASE
SUBUNIT ALPHA-1)		 5bob TRANSLATION
INITIATION FACTOR 2
(IF-2 GTPASE)
(Streptococcus
suis) 		5 / 11 GLN A 215
ASP A 217
ALA A 299
PHE A 199
THR A 219
 None
 1.43A 3n23C-5bobA:
undetectable		 3n23C-5bobA:
12.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E7C_D_ACTD504_0
(UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE)		 5bob TRANSLATION
INITIATION FACTOR 2
(IF-2 GTPASE)
(Streptococcus
suis) 		3 / 3 GLY A 251
SER A 254
TRP A 258
 None
None
GOL  A 402 (-3.9A)
 0.93A 4e7cD-5bobA:
undetectable		 4e7cD-5bobA:
19.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UAC_A_ACRA501_2
(CARBOHYDRATE ABC
TRANSPORTER
SUBSTRATE-BINDING
PROTEIN, CUT1 FAMILY
(TC 3.A.1.1.-))		 5bob TRANSLATION
INITIATION FACTOR 2
(IF-2 GTPASE)
(Streptococcus
suis) 		4 / 7 SER A 154
TRP A 188
ASP A 184
THR A 163
 None
 1.07A 4uacA-5bobA:
undetectable		 4uacA-5bobA:
19.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z3J_A_NCAA302_0
(ABRIN A-CHAIN)		 5bob TRANSLATION
INITIATION FACTOR 2
(IF-2 GTPASE)
(Streptococcus
suis) 		4 / 6 TYR A 295
VAL A 211
TYR A 237
ILE A 218
 None
 1.07A 5z3jA-5bobA:
undetectable		 5z3jA-5bobA:
23.93