SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5boe'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1L2I_A_CCSA417_0
(ESTROGEN RECEPTOR)		 5boe ENOLASE
(Staphylococcus
aureus) 		3 / 3 GLU A  11
LYS A  66
VAL A  64
 None
 0.90A 1l2iA-5boeA:
undetectable		 1l2iA-5boeA:
21.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RG9_A_SAMA385_1
(S-ADENOSYLMETHIONINE
SYNTHETASE)		 5boe ENOLASE
(Staphylococcus
aureus) 		4 / 8 GLU A 358
GLN A 361
ILE A 357
ILE A 384
 None
 0.92A 1rg9B-5boeA:
undetectable		 1rg9B-5boeA:
21.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RG9_B_SAMB485_0
(S-ADENOSYLMETHIONINE
SYNTHETASE)		 5boe ENOLASE
(Staphylococcus
aureus) 		4 / 8 GLU A 358
GLN A 361
ILE A 357
ILE A 384
 None
 0.92A 1rg9A-5boeA:
undetectable		 1rg9A-5boeA:
21.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RG9_C_SAMC585_1
(S-ADENOSYLMETHIONINE
SYNTHETASE)		 5boe ENOLASE
(Staphylococcus
aureus) 		4 / 8 GLU A 358
GLN A 361
ILE A 357
ILE A 384
 None
 0.93A 1rg9D-5boeA:
undetectable		 1rg9D-5boeA:
21.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RG9_C_SAMC685_0
(S-ADENOSYLMETHIONINE
SYNTHETASE)		 5boe ENOLASE
(Staphylococcus
aureus) 		4 / 8 GLU A 358
GLN A 361
ILE A 357
ILE A 384
 None
 0.93A 1rg9C-5boeA:
undetectable		 1rg9C-5boeA:
21.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1VPT_A_SAMA400_1
(VP39)		 5boe ENOLASE
(Staphylococcus
aureus) 		3 / 3 ASP A 402
ARG A 400
ASP A  14
 None
 0.87A 1vptA-5boeA:
undetectable		 1vptA-5boeA:
19.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YAJ_A_BEZA11_0
(CES1 PROTEIN)		 5boe ENOLASE
(Staphylococcus
aureus) 		4 / 4 LEU A 278
SER A 247
LEU A 315
LEU A 305
 None
 0.92A 1yajA-5boeA:
undetectable		 1yajA-5boeA:
21.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AVO_B_MK1B902_1
(POL POLYPROTEIN)		 5boe ENOLASE
(Staphylococcus
aureus) 		5 / 9 ILE A 384
ILE A 347
PRO A  38
VAL A  37
ILE A 118
 None
 1.04A 2avoA-5boeA:
undetectable		 2avoA-5boeA:
15.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NYR_B_SVRB401_4
(NAD-DEPENDENT
DEACETYLASE
SIRTUIN-5)		 5boe ENOLASE
(Staphylococcus
aureus) 		4 / 5 ALA A  76
ALA A 119
ALA A  35
VAL A  21
 None
 0.89A 2nyrB-5boeA:
undetectable		 2nyrB-5boeA:
20.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BXO_A_SAMA238_1
(N,N-DIMETHYLTRANSFER
ASE)		 5boe ENOLASE
(Staphylococcus
aureus) 		3 / 3 TYR A   8
GLU A  11
ASP A  55
 None
 0.85A 3bxoA-5boeA:
undetectable		 3bxoA-5boeA:
21.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3D1Y_A_ROCA201_2
(HIV-1 PROTEASE)		 5boe ENOLASE
(Staphylococcus
aureus) 		5 / 9 ILE A 384
ILE A 347
PRO A  38
VAL A  37
ILE A 118
 None
 1.14A 3d1yB-5boeA:
undetectable		 3d1yB-5boeA:
15.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3E23_A_SAMA221_0
(UNCHARACTERIZED
PROTEIN RPA2492)		 5boe ENOLASE
(Staphylococcus
aureus) 		5 / 12 LEU A 305
GLY A 317
GLY A 293
LEU A 320
LEU A 278
 None
 1.20A 3e23A-5boeA:
undetectable		 3e23A-5boeA:
22.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GSS_A_EAAA212_1
(GLUTATHIONE
S-TRANSFERASE P1-1)		 5boe ENOLASE
(Staphylococcus
aureus) 		4 / 7 VAL A  23
ILE A  92
THR A 351
GLY A 115
 None
 0.98A 3gssA-5boeA:
undetectable		 3gssA-5boeA:
19.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NU4_B_478B401_1
(PROTEASE)		 5boe ENOLASE
(Staphylococcus
aureus) 		5 / 9 ILE A  79
GLY A 115
ILE A 118
VAL A  86
ILE A   4
 None
 1.09A 3nu4A-5boeA:
undetectable		 3nu4A-5boeA:
15.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QEL_D_QELD2_2
(GLUTAMATE [NMDA]
RECEPTOR SUBUNIT
EPSILON-2)		 5boe ENOLASE
(Staphylococcus
aureus) 		5 / 9 ALA A 382
ILE A 381
THR A 176
PHE A 177
GLU A 414
 None
 1.22A 3qelD-5boeA:
undetectable		 3qelD-5boeA:
22.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T7S_C_SAMC300_0
(PUTATIVE
METHYLTRANSFERASE)		 5boe ENOLASE
(Staphylococcus
aureus) 		5 / 12 GLY A 109
GLY A 106
GLU A  50
ALA A  67
ASN A  70
 None
 1.34A 3t7sC-5boeA:
undetectable		 3t7sC-5boeA:
20.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TL9_A_ROCA401_4
(PROTEASE)		 5boe ENOLASE
(Staphylococcus
aureus) 		4 / 4 ASP A 295
ASP A 298
GLY A 293
THR A 306
 None
 1.23A 3tl9B-5boeA:
undetectable		 3tl9B-5boeA:
15.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KCN_B_MTLB806_0
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5boe ENOLASE
(Staphylococcus
aureus) 		4 / 7 SER A 339
PHE A 321
ASN A 338
TRP A 302
 None
 1.39A 4kcnB-5boeA:
undetectable		 4kcnB-5boeA:
21.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KOW_A_CFXA204_1
(UNCHARACTERIZED
PROTEIN)		 5boe ENOLASE
(Staphylococcus
aureus) 		5 / 12 GLY A 396
ASN A 150
MET A 149
SER A 370
LEU A 341
 None
None
None
PEP  A 501 ( 4.7A)
None
 1.25A 4kowA-5boeA:
undetectable		 4kowA-5boeA:
15.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MMA_A_CXXA603_1
(TRANSPORTER)		 5boe ENOLASE
(Staphylococcus
aureus) 		5 / 11 ASP A  88
VAL A  25
ALA A 119
SER A 117
THR A  27
 None
 1.29A 4mmaA-5boeA:
undetectable		 4mmaA-5boeA:
21.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NKV_C_AERC601_2
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 5boe ENOLASE
(Staphylococcus
aureus) 		4 / 6 LEU A 350
ASP A 378
VAL A 386
ALA A 385
 None
 1.12A 4nkvC-5boeA:
undetectable		 4nkvC-5boeA:
22.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OAD_A_CLMA205_0
(GNAT SUPERFAMILY
ACETYLTRANSFERASE
PA4794)		 5boe ENOLASE
(Staphylococcus
aureus) 		5 / 12 PHE A 354
GLU A 358
ALA A 363
GLY A 364
TYR A 430
 None
 1.39A 4oadA-5boeA:
undetectable		 4oadA-5boeA:
15.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X3U_B_SVRB102_1
(CHROMOBOX PROTEIN
HOMOLOG 7)		 5boe ENOLASE
(Staphylococcus
aureus) 		3 / 3 LYS A 105
ARG A 372
VAL A 344
 None
PEP  A 501 (-3.7A)
None
 1.07A 4x3uA-5boeA:
undetectable
4x3uB-5boeA:
undetectable		 4x3uA-5boeA:
11.20
4x3uB-5boeA:
11.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B8H_A_PAUA302_0
(TYPE III
PANTOTHENATE KINASE)		 5boe ENOLASE
(Staphylococcus
aureus) 		5 / 12 LEU A 114
THR A 380
ILE A 384
GLN A  89
THR A 353
 None
 1.22A 5b8hA-5boeA:
undetectable
5b8hB-5boeA:
undetectable		 5b8hA-5boeA:
21.38
5b8hB-5boeA:
21.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CDP_H_EVPH2101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B)		 5boe ENOLASE
(Staphylococcus
aureus) 		4 / 6 GLU A 249
ASP A 402
ARG A 400
GLY A 396
 None
 0.97A 5cdpA-5boeA:
undetectable
5cdpB-5boeA:
undetectable		 5cdpA-5boeA:
22.33
5cdpB-5boeA:
18.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E26_A_PAUA602_0
(PANTOTHENATE KINASE
2, MITOCHONDRIAL)		 5boe ENOLASE
(Staphylococcus
aureus) 		4 / 7 GLU A 416
GLY A 129
TYR A 133
ALA A 125
 GOL  A 503 (-3.0A)
None
GOL  A 503 (-4.9A)
None
 0.82A 5e26A-5boeA:
undetectable
5e26B-5boeA:
undetectable		 5e26A-5boeA:
23.09
5e26B-5boeA:
23.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E26_B_PAUB601_0
(PANTOTHENATE KINASE
2, MITOCHONDRIAL)		 5boe ENOLASE
(Staphylococcus
aureus) 		4 / 7 TYR A 133
ALA A 125
GLU A 416
GLY A 129
 GOL  A 503 (-4.9A)
None
GOL  A 503 (-3.0A)
None
 0.84A 5e26A-5boeA:
undetectable
5e26B-5boeA:
undetectable		 5e26A-5boeA:
23.09
5e26B-5boeA:
23.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E26_C_PAUC602_0
(PANTOTHENATE KINASE
2, MITOCHONDRIAL)		 5boe ENOLASE
(Staphylococcus
aureus) 		4 / 7 GLU A 416
GLY A 129
TYR A 133
ALA A 125
 GOL  A 503 (-3.0A)
None
GOL  A 503 (-4.9A)
None
 0.82A 5e26C-5boeA:
undetectable
5e26D-5boeA:
undetectable		 5e26C-5boeA:
23.09
5e26D-5boeA:
23.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HFJ_D_SAMD301_0
(ADENINE SPECIFIC DNA
METHYLTRANSFERASE
(DPNA))		 5boe ENOLASE
(Staphylococcus
aureus) 		5 / 12 ALA A 220
ASP A 244
GLY A 155
SER A 156
GLU A 262
 None
MG  A 502 ( 2.9A)
None
None
None
 0.94A 5hfjD-5boeA:
undetectable		 5hfjD-5boeA:
19.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKT_A_TLFA601_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 5boe ENOLASE
(Staphylococcus
aureus) 		3 / 3 LEU A 278
TYR A 258
SER A 247
 None
 0.78A 5iktA-5boeA:
undetectable		 5iktA-5boeA:
23.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KB5_A_ADNA401_2
(ADENOSINE KINASE)		 5boe ENOLASE
(Staphylococcus
aureus) 		4 / 4 ASN A  18
LEU A  13
SER A  15
LEU A  36
 None
 1.37A 5kb5A-5boeA:
undetectable		 5kb5A-5boeA:
22.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VLM_G_CVIG301_0
(REGULATORY PROTEIN
TETR)		 5boe ENOLASE
(Staphylococcus
aureus) 		5 / 12 GLN A 274
ALA A 272
LEU A 278
ILE A 309
ARG A 312
 None
 1.14A 5vlmG-5boeA:
undetectable		 5vlmG-5boeA:
19.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VUN_B_MTLB805_0
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5boe ENOLASE
(Staphylococcus
aureus) 		4 / 8 SER A 339
PHE A 321
ASN A 338
TRP A 302
 None
 1.35A 5vunB-5boeA:
undetectable		 5vunB-5boeA:
21.84