SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5bop'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1N13_B_AG2B7011_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE ALPHA
CHAIN
PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE BETA
CHAIN)		 5bop NANOBODY
OCTARELLIN V.1
(Lama
glama;
synthetic
construct) 		4 / 5 ARG A  99
LEU B 156
ASP B 152
LEU A 102
 None
 1.15A 1n13B-5bopA:
undetectable
1n13C-5bopA:
undetectable		 1n13B-5bopA:
15.71
1n13C-5bopA:
20.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YGQ_A_PCFA1275_0
(WNT INHIBITORY
FACTOR 1)		 5bop OCTARELLIN V.1
(synthetic
construct) 		5 / 12 ILE B 129
LEU B   4
ILE B 100
ILE B   5
PHE B  45
 None
 1.06A 2ygqA-5bopB:
undetectable		 2ygqA-5bopB:
18.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CCF_A_BEZA261_0
(CYCLOPROPANE-FATTY-A
CYL-PHOSPHOLIPID
SYNTHASE)		 5bop NANOBODY
(Lama
glama) 		4 / 8 GLY A 104
ASN A 111
PHE A  47
TYR A 112
 None
 1.30A 3ccfA-5bopA:
undetectable		 3ccfA-5bopA:
20.63
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3QXV_A_MTXA2000_1
(ANTI-METHOTREXATE
CDR1-4 GRAFT VHH)		 5bop NANOBODY
(Lama
glama) 		5 / 12 MET A  34
ARG A  72
ASN A  74
VAL A  79
ALA A  98
 None
 0.48A 3qxvA-5bopA:
22.3		 3qxvA-5bopA:
69.60
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3QXV_C_MTXC2000_1
(ANTI-METHOTREXATE
CDR1-4 GRAFT VHH)		 5bop NANOBODY
(Lama
glama) 		5 / 11 MET A  34
ARG A  72
ASN A  74
VAL A  79
ALA A  98
 None
 0.53A 3qxvC-5bopA:
22.6		 3qxvC-5bopA:
69.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VW1_B_CVIB301_0
(PUTATIVE REGULATORY
PROTEIN)		 5bop NANOBODY
OCTARELLIN V.1
(Lama
glama;
synthetic
construct) 		5 / 12 LEU A 102
THR A  54
ILE B   5
ALA B 110
LEU B  49
 None
 1.45A 3vw1B-5bopA:
undetectable		 3vw1B-5bopA:
21.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WIP_F_ACHF301_0
(ACETYLCHOLINE-BINDIN
G PROTEIN)		 5bop NANOBODY
OCTARELLIN V.1
(Lama
glama;
synthetic
construct) 		4 / 7 TYR A 106
THR A  54
TYR A  32
ARG B 159
 None
 1.49A 3wipF-5bopA:
undetectable
3wipG-5bopA:
undetectable		 3wipF-5bopA:
20.60
3wipG-5bopA:
20.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KHP_A_PARA1606_1
(16S RIBOSOMAL RNA
30S RIBOSOMAL
PROTEIN S9
30S RIBOSOMAL
PROTEIN S10)		 5bop NANOBODY
(Lama
glama) 		3 / 3 TYR A 106
ARG A  72
SER A  51
 None
 0.96A 4khpI-5bopA:
undetectable
4khpJ-5bopA:
undetectable		 4khpI-5bopA:
23.68
4khpJ-5bopA:
17.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4N09_C_ADNC401_2
(ADENOSINE KINASE)		 5bop OCTARELLIN V.1
(synthetic
construct) 		4 / 5 LEU B 122
SER B 140
LEU B 137
ASN B  38
 None
 1.16A 4n09C-5bopB:
4.6		 4n09C-5bopB:
20.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TWD_C_377C402_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 5bop NANOBODY
OCTARELLIN V.1
(Lama
glama;
synthetic
construct) 		4 / 5 TYR A 106
ASN B 149
GLU B 155
TYR A  32
 None
 1.43A 4twdC-5bopA:
undetectable
4twdD-5bopA:
undetectable		 4twdC-5bopA:
17.69
4twdD-5bopA:
17.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TWD_H_377H401_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 5bop NANOBODY
OCTARELLIN V.1
(Lama
glama;
synthetic
construct) 		4 / 6 TYR A 106
ASN B 149
GLU B 155
TYR A  32
 None
 1.39A 4twdG-5bopA:
undetectable
4twdH-5bopA:
undetectable		 4twdG-5bopA:
17.69
4twdH-5bopA:
17.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UYM_B_VORB590_1
(14-ALPHA STEROL
DEMETHYLASE)		 5bop OCTARELLIN V.1
(synthetic
construct) 		4 / 7 PHE B  45
ALA B 110
ILE B  99
PHE B 103
 None
 1.07A 4uymB-5bopB:
undetectable		 4uymB-5bopB:
18.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZJL_A_ERYA1101_0
(MULTIDRUG EFFLUX
PUMP SUBUNIT ACRB)		 5bop NANOBODY
OCTARELLIN V.1
(Lama
glama;
synthetic
construct) 		5 / 12 PHE A  37
GLU B 146
GLU B 119
LEU A 102
GLY B 141
 None
 1.27A 4zjlA-5bopA:
undetectable		 4zjlA-5bopA:
9.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_4_BEZ4801_0
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 1
ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 2
BEZ-LEU-LEU)		 5bop OCTARELLIN V.1
(synthetic
construct) 		4 / 5 LEU B   4
PHE B 139
ILE B 112
ILE B 153
 None
 1.05A 5dzk4-5bopB:
undetectable
5dzkg-5bopB:
1.5
5dzkm-5bopB:
undetectable
5dzkn-5bopB:
undetectable		 5dzk4-5bopB:
4.08
5dzkg-5bopB:
22.58
5dzkm-5bopB:
23.01
5dzkn-5bopB:
23.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JSD_A_1GNA607_1
(PHIAB6 TAILSPIKE)		 5bop NANOBODY
(Lama
glama) 		3 / 3 THR A  54
SER A  52
TYR A  32
 None
 0.75A 5jsdA-5bopA:
undetectable		 5jsdA-5bopA:
11.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JSD_B_1GNB618_1
(PHIAB6 TAILSPIKE)		 5bop NANOBODY
(Lama
glama) 		3 / 3 THR A  54
SER A  52
TYR A  32
 None
 0.76A 5jsdB-5bopA:
undetectable		 5jsdB-5bopA:
11.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JSD_C_1GNC608_1
(PHIAB6 TAILSPIKE)		 5bop NANOBODY
(Lama
glama) 		3 / 3 THR A  54
SER A  52
TYR A  32
 None
 0.75A 5jsdC-5bopA:
undetectable		 5jsdC-5bopA:
11.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JSE_A_1GNA608_1
(PHIAB6 TAILSPIKE)		 5bop NANOBODY
(Lama
glama) 		3 / 3 THR A  54
SER A  52
TYR A  32
 None
 0.77A 5jseA-5bopA:
2.4		 5jseA-5bopA:
11.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JSE_B_1GNB611_1
(PHIAB6 TAILSPIKE)		 5bop NANOBODY
(Lama
glama) 		3 / 3 THR A  54
SER A  52
TYR A  32
 None
 0.74A 5jseB-5bopA:
undetectable		 5jseB-5bopA:
11.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JSE_C_1GNC611_1
(PHIAB6 TAILSPIKE)		 5bop NANOBODY
(Lama
glama) 		3 / 3 THR A  54
SER A  52
TYR A  32
 None
 0.75A 5jseC-5bopA:
undetectable		 5jseC-5bopA:
11.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MDQ_A_TESA604_0
(SERUM ALBUMIN)		 5bop NANOBODY
OCTARELLIN V.1
(Lama
glama;
synthetic
construct) 		4 / 8 GLY A 103
LEU A 102
ALA B  42
LYS B  41
 None
 0.81A 6mdqA-5bopA:
undetectable		 6mdqA-5bopA:
18.90