SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5bpv'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KT0_A_PQNA2001_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A1
PHOTOSYSTEM I
REACTION CENTER
SUBUNIT IX)		 5bpv POLYMERASE COFACTOR
VP35
(Zaire
ebolavirus) 		5 / 11 PHE A 328
ARG A 312
GLY A 337
ILE A 259
LEU A 256
 None
 1.00A 4kt0A-5bpvA:
undetectable
4kt0J-5bpvA:
undetectable		 4kt0A-5bpvA:
10.97
4kt0J-5bpvA:
11.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NQA_A_9CRA501_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 5bpv POLYMERASE COFACTOR
VP35
(Zaire
ebolavirus) 		5 / 11 ILE A 246
GLN A 244
LEU A 242
VAL A 284
LEU A 256
 None
 1.18A 4nqaA-5bpvA:
undetectable		 4nqaA-5bpvA:
18.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R3A_A_RBFA402_1
(BLUE-LIGHT-ACTIVATED
HISTIDINE KINASE 2)		 5bpv POLYMERASE COFACTOR
VP35
(Zaire
ebolavirus) 		5 / 12 ALA A 276
ILE A 246
ILE A 219
MET A 228
GLN A 264
 None
 1.21A 4r3aA-5bpvA:
undetectable		 4r3aA-5bpvA:
18.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LJD_A_RTLA201_0
(RETINOL-BINDING
PROTEIN 1)		 5bpv POLYMERASE COFACTOR
VP35
(Zaire
ebolavirus) 		5 / 9 LEU A 242
LEU A 249
ILE A 219
ILE A 280
MET A 228
 None
 1.43A 5ljdA-5bpvA:
undetectable		 5ljdA-5bpvA:
23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6G2P_A_TRPA502_0
(FLAVIN-DEPENDENT
L-TRYPTOPHAN OXIDASE
VIOA)		 5bpv POLYMERASE COFACTOR
VP35
(Zaire
ebolavirus) 		4 / 7 ARG A 312
LEU A 242
VAL A 325
TRP A 324
 None
 1.13A 6g2pA-5bpvA:
undetectable		 6g2pA-5bpvA:
17.20