SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5bpx'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DTT_E_H4BE1004_1
(HYPOTHETICAL PROTEIN
PH0634)		 5bpx 2,4'-DIHYDROXYACETOP
HENONE DIOXYGENASE
(Alcaligenes
sp.) 		5 / 11 LEU A  65
HIS A  78
VAL A  82
HIS A 114
HIS A  76
 None
FE  A 201 ( 3.2A)
None
FE  A 201 ( 3.2A)
FE  A 201 ( 3.1A)
 1.06A 2dttD-5bpxA:
undetectable
2dttE-5bpxA:
undetectable		 2dttD-5bpxA:
22.15
2dttE-5bpxA:
22.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2GEH_A_NHYA300_1
(CARBONIC ANHYDRASE 2)		 5bpx 2,4'-DIHYDROXYACETOP
HENONE DIOXYGENASE
(Alcaligenes
sp.) 		4 / 8 HIS A 114
HIS A  76
HIS A  78
VAL A  82
 FE  A 201 ( 3.2A)
FE  A 201 ( 3.1A)
FE  A 201 ( 3.2A)
None
 0.87A 2gehA-5bpxA:
undetectable		 2gehA-5bpxA:
18.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZBU_B_ADNB502_1
(UNCHARACTERIZED
CONSERVED PROTEIN)		 5bpx 2,4'-DIHYDROXYACETOP
HENONE DIOXYGENASE
(Alcaligenes
sp.) 		4 / 5 ASP A  63
TRP A  61
PHE A 128
VAL A  82
 GOL  A 203 (-3.0A)
GOL  A 203 (-4.3A)
None
None
 1.23A 2zbuB-5bpxA:
0.0		 2zbuB-5bpxA:
18.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CZV_B_AZMB263_1
(CARBONIC ANHYDRASE
13)		 5bpx 2,4'-DIHYDROXYACETOP
HENONE DIOXYGENASE
(Alcaligenes
sp.) 		5 / 10 HIS A 114
HIS A  76
HIS A  78
VAL A  82
VAL A  73
 FE  A 201 ( 3.2A)
FE  A 201 ( 3.1A)
FE  A 201 ( 3.2A)
None
None
 1.46A 3czvB-5bpxA:
undetectable		 3czvB-5bpxA:
18.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3L35_K_DHIK3_0
(GP41 N-PEPTIDE
HIV ENTRY INHIBITOR
PIE12)		 5bpx 2,4'-DIHYDROXYACETOP
HENONE DIOXYGENASE
(Alcaligenes
sp.) 		3 / 3 LEU A  65
TRP A  91
GLY A  92
 None
 0.80A 3l35B-5bpxA:
undetectable
3l35K-5bpxA:
undetectable		 3l35B-5bpxA:
11.84
3l35K-5bpxA:
7.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEI_A_SHHA2004_1
(HDAC6 PROTEIN)		 5bpx 2,4'-DIHYDROXYACETOP
HENONE DIOXYGENASE
(Alcaligenes
sp.) 		5 / 12 PRO A  79
SER A 144
GLY A 146
ASP A 152
ASP A 149
 None
 1.45A 5eeiA-5bpxA:
undetectable		 5eeiA-5bpxA:
16.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEI_B_SHHB801_1
(HDAC6 PROTEIN)		 5bpx 2,4'-DIHYDROXYACETOP
HENONE DIOXYGENASE
(Alcaligenes
sp.) 		5 / 12 PRO A  79
SER A 144
GLY A 146
ASP A 152
ASP A 149
 None
 1.43A 5eeiB-5bpxA:
undetectable		 5eeiB-5bpxA:
16.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5O96_E_SAME501_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE E)		 5bpx 2,4'-DIHYDROXYACETOP
HENONE DIOXYGENASE
(Alcaligenes
sp.) 		5 / 9 LEU A  94
HIS A 114
GLY A  92
VAL A  73
LEU A  72
 None
FE  A 201 ( 3.2A)
None
None
None
 1.27A 5o96E-5bpxA:
undetectable
5o96F-5bpxA:
undetectable		 5o96E-5bpxA:
19.20
5o96F-5bpxA:
19.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZRD_A_CUA607_0
(TYROSINASE)		 5bpx 2,4'-DIHYDROXYACETOP
HENONE DIOXYGENASE
(Alcaligenes
sp.) 		3 / 3 HIS A  76
HIS A 114
HIS A  78
 FE  A 201 ( 3.1A)
FE  A 201 ( 3.2A)
FE  A 201 ( 3.2A)
 0.39A 5zrdA-5bpxA:
undetectable		 5zrdA-5bpxA:
15.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B0C_D_TA1D502_1
(TUBULIN BETA CHAIN)		 5bpx 2,4'-DIHYDROXYACETOP
HENONE DIOXYGENASE
(Alcaligenes
sp.) 		5 / 12 GLU A  69
LEU A  65
ALA A  67
LEU A 116
THR A 115
 None
 0.97A 6b0cD-5bpxA:
undetectable		 6b0cD-5bpxA:
18.62