SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5bq1'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EKJ_A_ACTA3001_0
(BETA-CARBONIC
ANHYDRASE)		 5bq1 CARBONIC ANHYDRASE
(Pseudomonas
aeruginosa) 		6 / 8 CYH A  42
ASP A  44
HIS A  98
CYH A 101
GLY A 102
GLY A 103
 ZN  A 301 ( 2.2A)
CO2  A 302 ( 4.6A)
ZN  A 301 (-3.2A)
ZN  A 301 (-2.3A)
CO2  A 302 ( 4.5A)
CO2  A 302 (-3.7A)
 0.19A 1ekjA-5bq1A:
22.1
1ekjB-5bq1A:
21.8		 1ekjA-5bq1A:
28.63
1ekjB-5bq1A:
28.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EKJ_A_ACTA3003_0
(BETA-CARBONIC
ANHYDRASE)		 5bq1 CARBONIC ANHYDRASE
(Pseudomonas
aeruginosa) 		5 / 8 CYH A  42
ASP A  44
HIS A  98
CYH A 101
GLY A 103
 ZN  A 301 ( 2.2A)
CO2  A 302 ( 4.6A)
ZN  A 301 (-3.2A)
ZN  A 301 (-2.3A)
CO2  A 302 (-3.7A)
 0.96A 1ekjA-5bq1A:
22.1
1ekjB-5bq1A:
21.8		 1ekjA-5bq1A:
28.63
1ekjB-5bq1A:
28.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EKJ_A_ACTA3003_0
(BETA-CARBONIC
ANHYDRASE)		 5bq1 CARBONIC ANHYDRASE
(Pseudomonas
aeruginosa) 		6 / 8 CYH A  42
ASP A  44
VAL A  66
HIS A  98
CYH A 101
GLY A 102
 ZN  A 301 ( 2.2A)
CO2  A 302 ( 4.6A)
CO2  A 302 (-4.0A)
ZN  A 301 (-3.2A)
ZN  A 301 (-2.3A)
CO2  A 302 ( 4.5A)
 0.26A 1ekjA-5bq1A:
22.1
1ekjB-5bq1A:
21.8		 1ekjA-5bq1A:
28.63
1ekjB-5bq1A:
28.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EKJ_C_ACTC3004_0
(BETA-CARBONIC
ANHYDRASE)		 5bq1 CARBONIC ANHYDRASE
(Pseudomonas
aeruginosa) 		4 / 6 CYH A  42
ASP A  44
VAL A  66
GLY A 102
 ZN  A 301 ( 2.2A)
CO2  A 302 ( 4.6A)
CO2  A 302 (-4.0A)
CO2  A 302 ( 4.5A)
 0.19A 1ekjC-5bq1A:
22.0
1ekjD-5bq1A:
22.2		 1ekjC-5bq1A:
28.63
1ekjD-5bq1A:
28.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EKJ_C_ACTC3004_0
(BETA-CARBONIC
ANHYDRASE)		 5bq1 CARBONIC ANHYDRASE
(Pseudomonas
aeruginosa) 		4 / 6 CYH A  42
ASP A  44
VAL A  66
GLY A 103
 ZN  A 301 ( 2.2A)
CO2  A 302 ( 4.6A)
CO2  A 302 (-4.0A)
CO2  A 302 (-3.7A)
 0.98A 1ekjC-5bq1A:
22.0
1ekjD-5bq1A:
22.2		 1ekjC-5bq1A:
28.63
1ekjD-5bq1A:
28.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EKJ_C_ACTC3007_0
(BETA-CARBONIC
ANHYDRASE)		 5bq1 CARBONIC ANHYDRASE
(Pseudomonas
aeruginosa) 		4 / 6 CYH A  42
ASP A  44
VAL A  66
GLY A 102
 ZN  A 301 ( 2.2A)
CO2  A 302 ( 4.6A)
CO2  A 302 (-4.0A)
CO2  A 302 ( 4.5A)
 0.19A 1ekjC-5bq1A:
22.0
1ekjD-5bq1A:
22.2		 1ekjC-5bq1A:
28.63
1ekjD-5bq1A:
28.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EKJ_C_ACTC3007_0
(BETA-CARBONIC
ANHYDRASE)		 5bq1 CARBONIC ANHYDRASE
(Pseudomonas
aeruginosa) 		4 / 6 CYH A  42
ASP A  44
VAL A  66
GLY A 103
 ZN  A 301 ( 2.2A)
CO2  A 302 ( 4.6A)
CO2  A 302 (-4.0A)
CO2  A 302 (-3.7A)
 1.00A 1ekjC-5bq1A:
22.0
1ekjD-5bq1A:
22.2		 1ekjC-5bq1A:
28.63
1ekjD-5bq1A:
28.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EKJ_E_ACTE3005_0
(BETA-CARBONIC
ANHYDRASE)		 5bq1 CARBONIC ANHYDRASE
(Pseudomonas
aeruginosa) 		5 / 7 CYH A  42
ASP A  44
HIS A  98
GLY A 102
GLY A 103
 ZN  A 301 ( 2.2A)
CO2  A 302 ( 4.6A)
ZN  A 301 (-3.2A)
CO2  A 302 ( 4.5A)
CO2  A 302 (-3.7A)
 0.16A 1ekjE-5bq1A:
22.0
1ekjF-5bq1A:
21.9		 1ekjE-5bq1A:
28.63
1ekjF-5bq1A:
28.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EKJ_E_ACTE3005_0
(BETA-CARBONIC
ANHYDRASE)		 5bq1 CARBONIC ANHYDRASE
(Pseudomonas
aeruginosa) 		4 / 7 CYH A  42
ASP A  44
HIS A  98
GLY A 103
 ZN  A 301 ( 2.2A)
CO2  A 302 ( 4.6A)
ZN  A 301 (-3.2A)
CO2  A 302 (-3.7A)
 0.86A 1ekjE-5bq1A:
22.0
1ekjF-5bq1A:
21.9		 1ekjE-5bq1A:
28.63
1ekjF-5bq1A:
28.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EKJ_F_ACTF3008_0
(BETA-CARBONIC
ANHYDRASE)		 5bq1 CARBONIC ANHYDRASE
(Pseudomonas
aeruginosa) 		5 / 8 CYH A  42
ASP A  44
VAL A  66
GLY A 102
GLY A 103
 ZN  A 301 ( 2.2A)
CO2  A 302 ( 4.6A)
CO2  A 302 (-4.0A)
CO2  A 302 ( 4.5A)
CO2  A 302 (-3.7A)
 0.23A 1ekjE-5bq1A:
22.0
1ekjF-5bq1A:
21.9		 1ekjE-5bq1A:
28.63
1ekjF-5bq1A:
28.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EKJ_G_ACTG3002_0
(BETA-CARBONIC
ANHYDRASE)		 5bq1 CARBONIC ANHYDRASE
(Pseudomonas
aeruginosa) 		5 / 8 CYH A  42
ASP A  44
HIS A  98
CYH A 101
GLY A 102
 ZN  A 301 ( 2.2A)
CO2  A 302 ( 4.6A)
ZN  A 301 (-3.2A)
ZN  A 301 (-2.3A)
CO2  A 302 ( 4.5A)
 1.00A 1ekjG-5bq1A:
21.9
1ekjH-5bq1A:
22.3		 1ekjG-5bq1A:
28.63
1ekjH-5bq1A:
28.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EKJ_G_ACTG3002_0
(BETA-CARBONIC
ANHYDRASE)		 5bq1 CARBONIC ANHYDRASE
(Pseudomonas
aeruginosa) 		6 / 8 CYH A  42
ASP A  44
HIS A  98
CYH A 101
GLY A 102
GLY A 103
 ZN  A 301 ( 2.2A)
CO2  A 302 ( 4.6A)
ZN  A 301 (-3.2A)
ZN  A 301 (-2.3A)
CO2  A 302 ( 4.5A)
CO2  A 302 (-3.7A)
 0.16A 1ekjG-5bq1A:
21.9
1ekjH-5bq1A:
22.3		 1ekjG-5bq1A:
28.63
1ekjH-5bq1A:
28.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EKJ_H_ACTH3006_0
(BETA-CARBONIC
ANHYDRASE)		 5bq1 CARBONIC ANHYDRASE
(Pseudomonas
aeruginosa) 		5 / 6 CYH A  42
ASP A  44
VAL A  66
HIS A  98
CYH A 101
 ZN  A 301 ( 2.2A)
CO2  A 302 ( 4.6A)
CO2  A 302 (-4.0A)
ZN  A 301 (-3.2A)
ZN  A 301 (-2.3A)
 0.17A 1ekjG-5bq1A:
21.9
1ekjH-5bq1A:
22.3		 1ekjG-5bq1A:
28.63
1ekjH-5bq1A:
28.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WOP_A_FFOA2887_1
(AMINOMETHYLTRANSFERA
SE)		 5bq1 CARBONIC ANHYDRASE
(Pseudomonas
aeruginosa) 		3 / 3 ASP A 186
GLU A 149
ARG A 105
 None
 0.85A 1wopA-5bq1A:
undetectable		 1wopA-5bq1A:
21.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IW1_A_ASDA1223_1
(CYTOCHROME P450
CYP125)		 5bq1 CARBONIC ANHYDRASE
(Pseudomonas
aeruginosa) 		5 / 12 ILE A 153
VAL A 177
VAL A  95
ILE A  81
VAL A  70
 None
 1.17A 3iw1A-5bq1A:
undetectable		 3iw1A-5bq1A:
19.26
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3UCJ_A_AZMA229_1
(CARBONIC ANHYDRASE)		 5bq1 CARBONIC ANHYDRASE
(Pseudomonas
aeruginosa) 		7 / 10 CYH A  42
ASP A  44
VAL A  66
HIS A  98
CYH A 101
GLY A 102
ALA A 106
 ZN  A 301 ( 2.2A)
CO2  A 302 ( 4.6A)
CO2  A 302 (-4.0A)
ZN  A 301 (-3.2A)
ZN  A 301 (-2.3A)
CO2  A 302 ( 4.5A)
None
 0.23A 3ucjA-5bq1A:
27.1		 3ucjA-5bq1A:
39.82
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3UCJ_B_AZMB229_2
(CARBONIC ANHYDRASE)		 5bq1 CARBONIC ANHYDRASE
(Pseudomonas
aeruginosa) 		5 / 10 ASP A  44
HIS A  98
CYH A 101
GLY A 103
ALA A  67
 CO2  A 302 ( 4.6A)
ZN  A 301 (-3.2A)
ZN  A 301 (-2.3A)
CO2  A 302 (-3.7A)
CO2  A 302 ( 4.8A)
 1.19A 3ucjB-5bq1A:
27.3		 3ucjB-5bq1A:
39.82
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3UCJ_B_AZMB229_2
(CARBONIC ANHYDRASE)		 5bq1 CARBONIC ANHYDRASE
(Pseudomonas
aeruginosa) 		6 / 10 CYH A  42
ASP A  44
HIS A  98
CYH A 101
GLY A 103
ALA A 106
 ZN  A 301 ( 2.2A)
CO2  A 302 ( 4.6A)
ZN  A 301 (-3.2A)
ZN  A 301 (-2.3A)
CO2  A 302 (-3.7A)
None
 1.30A 3ucjB-5bq1A:
27.3		 3ucjB-5bq1A:
39.82
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3UCJ_B_AZMB229_2
(CARBONIC ANHYDRASE)		 5bq1 CARBONIC ANHYDRASE
(Pseudomonas
aeruginosa) 		7 / 10 CYH A  42
ASP A  44
VAL A  66
HIS A  98
CYH A 101
GLY A 102
ALA A 106
 ZN  A 301 ( 2.2A)
CO2  A 302 ( 4.6A)
CO2  A 302 (-4.0A)
ZN  A 301 (-3.2A)
ZN  A 301 (-2.3A)
CO2  A 302 ( 4.5A)
None
 0.26A 3ucjB-5bq1A:
27.3		 3ucjB-5bq1A:
39.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RFQ_A_SAMA401_1
(HISTIDINE PROTEIN
METHYLTRANSFERASE 1
HOMOLOG)		 5bq1 CARBONIC ANHYDRASE
(Pseudomonas
aeruginosa) 		4 / 4 THR A 195
GLY A 198
ASP A 200
SER A 176
 None
 1.35A 4rfqA-5bq1A:
undetectable		 4rfqA-5bq1A:
20.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CZM_E_HISE402_0
(ATP
PHOSPHORIBOSYLTRANSF
ERASE CATALYTIC
SUBUNIT)		 5bq1 CARBONIC ANHYDRASE
(Pseudomonas
aeruginosa) 		5 / 9 VAL A 104
VAL A 152
GLY A  41
VAL A  69
CYH A  42
 None
None
None
None
ZN  A 301 ( 2.2A)
 1.33A 6czmD-5bq1A:
undetectable
6czmE-5bq1A:
undetectable		 6czmD-5bq1A:
23.71
6czmE-5bq1A:
23.71