SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5bq2'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FBM_B_RTLB951_1
(PROTEIN (CARTILAGE
OLIGOMERIC MATRIX
PROTEIN))		 5bq2 UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE
(Pseudomonas
aeruginosa) 		4 / 4 THR A 248
LEU A 384
VAL A 380
LEU A   4
 None
 1.01A 1fbmB-5bq2A:
undetectable		 1fbmB-5bq2A:
7.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IE4_A_T44A128_1
(TRANSTHYRETIN)		 5bq2 UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE
(Pseudomonas
aeruginosa) 		5 / 10 LEU A 412
GLU A  15
LEU A 409
LEU A 242
ALA A 245
 None
 1.35A 1ie4A-5bq2A:
undetectable
1ie4C-5bq2A:
undetectable		 1ie4A-5bq2A:
14.22
1ie4C-5bq2A:
14.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SN0_B_T44B602_1
(TRANSTHYRETIN)		 5bq2 UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE
(Pseudomonas
aeruginosa) 		4 / 7 LEU A 412
GLU A  15
LEU A 242
ALA A 245
 None
 1.08A 1sn0B-5bq2A:
undetectable
1sn0D-5bq2A:
undetectable		 1sn0B-5bq2A:
16.55
1sn0D-5bq2A:
16.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TW4_B_CHDB1131_0
(FATTY ACID-BINDING
PROTEIN)		 5bq2 UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE
(Pseudomonas
aeruginosa) 		5 / 10 LEU A 254
ILE A 381
THR A 240
VAL A 385
THR A 248
 None
 1.34A 1tw4B-5bq2A:
undetectable		 1tw4B-5bq2A:
15.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XP0_A_VDNA201_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		 5bq2 UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE
(Pseudomonas
aeruginosa) 		5 / 10 LEU A 384
ALA A 382
ILE A 381
VAL A 319
ALA A 320
 None
 1.12A 1xp0A-5bq2A:
undetectable		 1xp0A-5bq2A:
22.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YAJ_B_BEZB12_0
(CES1 PROTEIN)		 5bq2 UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE
(Pseudomonas
aeruginosa) 		4 / 4 GLY A 168
SER A 165
VAL A 194
LEU A  97
 None
EPU  A 501 (-2.8A)
None
None
 1.24A 1yajB-5bq2A:
undetectable		 1yajB-5bq2A:
22.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QHF_A_ACTA509_0
(CHORISMATE SYNTHASE)		 5bq2 UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE
(Pseudomonas
aeruginosa) 		3 / 3 ARG A 155
GLN A 137
PRO A 150
 None
 0.73A 2qhfA-5bq2A:
undetectable		 2qhfA-5bq2A:
25.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EL0_A_1UNA201_2
(PROTEASE)		 5bq2 UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE
(Pseudomonas
aeruginosa) 		5 / 9 VAL A 380
ILE A 398
ILE A 236
ALA A 244
ILE A 381
 None
 1.05A 3el0B-5bq2A:
undetectable		 3el0B-5bq2A:
13.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3H52_C_486C4_2
(GLUCOCORTICOID
RECEPTOR)		 5bq2 UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE
(Pseudomonas
aeruginosa) 		3 / 3 MET A 173
CYH A 200
PRO A  27
 None
 1.29A 3h52C-5bq2A:
undetectable		 3h52C-5bq2A:
21.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HEG_A_BAXA1_2
(MITOGEN-ACTIVATED
PROTEIN KINASE 14)		 5bq2 UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE
(Pseudomonas
aeruginosa) 		4 / 6 MET A 344
VAL A 368
ILE A 392
LEU A 391
 None
 0.73A 3hegA-5bq2A:
undetectable		 3hegA-5bq2A:
22.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3R9C_A_ECLA452_1
(CYTOCHROME P450
164A2)		 5bq2 UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE
(Pseudomonas
aeruginosa) 		5 / 12 SER A 315
LEU A 384
LEU A  12
VAL A 252
LEU A 285
 None
 1.17A 3r9cA-5bq2A:
undetectable		 3r9cA-5bq2A:
23.01
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3V4T_E_ACTE502_0
(UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE)		 5bq2 UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE
(Pseudomonas
aeruginosa) 		3 / 3 LYS A  22
ARG A 122
LEU A 373
 EPU  A 501 (-2.6A)
EPU  A 501 (-3.9A)
EPU  A 501 (-4.5A)
 0.60A 3v4tE-5bq2A:
63.6		 3v4tE-5bq2A:
60.14
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3V4T_E_ACTE502_0
(UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE)		 5bq2 UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE
(Pseudomonas
aeruginosa) 		3 / 3 LYS A  22
ARG A 334
LEU A 373
 EPU  A 501 (-2.6A)
EPU  A 501 ( 4.2A)
EPU  A 501 (-4.5A)
 1.08A 3v4tE-5bq2A:
63.6		 3v4tE-5bq2A:
60.14
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3V4T_H_ACTH503_0
(UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE)		 5bq2 UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE
(Pseudomonas
aeruginosa) 		5 / 7 ARG A  93
ALA A  94
ILE A  96
ARG A 122
HIS A 127
 QPA  A 117 ( 4.3A)
EPU  A 501 ( 3.7A)
None
EPU  A 501 (-3.9A)
EPU  A 501 ( 4.8A)
 0.57A 3v4tH-5bq2A:
63.7		 3v4tH-5bq2A:
60.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FGL_C_CLQC303_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 5bq2 UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE
(Pseudomonas
aeruginosa) 		4 / 8 ASN A 317
GLY A 324
VAL A 357
ILE A 327
 None
 0.96A 4fglD-5bq2A:
undetectable		 4fglD-5bq2A:
19.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IJI_F_BEZF501_0
(GLUTATHIONE
S-TRANSFERASE-LIKE
PROTEIN YIBF)		 5bq2 UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE
(Pseudomonas
aeruginosa) 		4 / 8 ALA A 318
SER A 315
LEU A 363
ARG A 291
 None
 1.16A 4ijiF-5bq2A:
undetectable		 4ijiF-5bq2A:
21.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NDN_C_SAMC405_1
(S-ADENOSYLMETHIONINE
SYNTHASE ISOFORM
TYPE-2)		 5bq2 UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE
(Pseudomonas
aeruginosa) 		4 / 8 ALA A 382
ASP A 393
ILE A 392
ILE A 398
 None
 0.95A 4ndnD-5bq2A:
undetectable		 4ndnD-5bq2A:
23.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NKV_B_AERB601_2
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 5bq2 UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE
(Pseudomonas
aeruginosa) 		4 / 5 ARG A 235
ASP A 308
GLU A 237
VAL A 380
 None
EPU  A 501 (-2.9A)
None
None
 1.41A 4nkvB-5bq2A:
undetectable		 4nkvB-5bq2A:
21.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OQR_A_2UOA502_1
(CYP105AS1)		 5bq2 UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE
(Pseudomonas
aeruginosa) 		5 / 9 VAL A 357
VAL A 243
ALA A 244
THR A 248
ALA A 318
 None
 1.08A 4oqrA-5bq2A:
undetectable		 4oqrA-5bq2A:
25.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4U8V_B_MIYB1103_1
(MULTIDRUG EFFLUX
PUMP SUBUNIT ACRB)		 5bq2 UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE
(Pseudomonas
aeruginosa) 		5 / 12 GLY A 401
ILE A 398
ALA A 377
VAL A 380
ARG A 418
 None
 1.15A 4u8vB-5bq2A:
undetectable		 4u8vB-5bq2A:
18.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4U8Y_B_MIYB1102_1
(MULTIDRUG EFFLUX
PUMP SUBUNIT ACRB)		 5bq2 UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE
(Pseudomonas
aeruginosa) 		5 / 12 GLY A 401
ILE A 398
ALA A 377
VAL A 380
ARG A 418
 None
 1.15A 4u8yB-5bq2A:
undetectable		 4u8yB-5bq2A:
18.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CF9_B_NCAB302_0
(RIBOSOME-INACTIVATIN
G PROTEIN MOMORDIN I)		 5bq2 UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE
(Pseudomonas
aeruginosa) 		5 / 9 ILE A 398
GLY A 401
ILE A 405
GLU A 406
ARG A 418
 None
 1.14A 5cf9B-5bq2A:
undetectable		 5cf9B-5bq2A:
21.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HS6_A_J3ZA302_1
(17-BETA-HYDROXYSTERO
ID DEHYDROGENASE 14)		 5bq2 UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE
(Pseudomonas
aeruginosa) 		4 / 8 HIS A 337
GLN A 310
LEU A 379
THR A 240
 None
 1.00A 5hs6A-5bq2A:
undetectable		 5hs6A-5bq2A:
22.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKR_A_ID8A601_2
(PROSTAGLANDIN G/H
SYNTHASE 2)		 5bq2 UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE
(Pseudomonas
aeruginosa) 		3 / 3 VAL A 140
LEU A 154
MET A 134
 None
 0.89A 5ikrA-5bq2A:
undetectable		 5ikrA-5bq2A:
22.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LJB_A_RTLA201_1
(RETINOL-BINDING
PROTEIN 1)		 5bq2 UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE
(Pseudomonas
aeruginosa) 		4 / 8 LEU A   4
LEU A 384
ILE A 236
THR A 240
 None
 0.95A 5ljbA-5bq2A:
undetectable		 5ljbA-5bq2A:
14.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UMD_A_YMZA3801_1
(60S RIBOSOMAL
PROTEIN L28
28S RIBOSOMAL RNA
60S RIBOSOMAL
PROTEIN L4)		 5bq2 UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE
(Pseudomonas
aeruginosa) 		4 / 6 ALA A  94
PRO A 114
VAL A  89
ASP A  49
 EPU  A 501 ( 3.7A)
None
None
None
 0.92A 5umd2-5bq2A:
undetectable
5umdF-5bq2A:
undetectable		 5umd2-5bq2A:
10.50
5umdF-5bq2A:
12.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZNI_A_YMZA302_0
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 5bq2 UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE
(Pseudomonas
aeruginosa) 		5 / 9 VAL A  62
GLY A 226
VAL A  39
ASP A  36
GLY A 225
 None
 1.29A 5zniA-5bq2A:
undetectable		 5zniA-5bq2A:
10.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZNI_A_YMZA302_0
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 5bq2 UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE
(Pseudomonas
aeruginosa) 		5 / 9 VAL A  62
GLY A 226
VAL A  39
GLU A  73
GLY A 225
 None
 1.30A 5zniA-5bq2A:
undetectable		 5zniA-5bq2A:
10.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AK3_B_P2EB1201_1
(PROSTAGLANDIN E2
RECEPTOR EP3
SUBTYPE,SOLUBLE
CYTOCHROME B562)		 5bq2 UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE
(Pseudomonas
aeruginosa) 		4 / 5 PRO A 301
VAL A 164
GLY A 210
VAL A 194
 None
 1.01A 6ak3B-5bq2A:
undetectable		 6ak3B-5bq2A:
8.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EKU_A_ZMRA901_1
(SIALIDASE)		 5bq2 UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE
(Pseudomonas
aeruginosa) 		5 / 12 ARG A 122
ILE A 119
ASN A  23
ARG A 400
ASP A  49
 EPU  A 501 (-3.9A)
QPA  A 117 ( 3.9A)
EPU  A 501 (-3.1A)
QPA  A 117 ( 3.0A)
None
 1.34A 6ekuA-5bq2A:
undetectable		 6ekuA-5bq2A:
20.58