SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5bqk'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LQT_A_ACTA1871_0
(FPRA)		 5bqk ICP27
(Human
alphaherpesvirus
1) 		4 / 7 PHE A 285
PRO A 378
ALA A 332
PHE A 280
 None
 1.30A 1lqtA-5bqkA:
undetectable		 1lqtA-5bqkA:
22.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LQU_A_ACTA1428_0
(FPRA)		 5bqk ICP27
(Human
alphaherpesvirus
1) 		4 / 7 PHE A 285
PRO A 378
ALA A 332
PHE A 280
 None
 1.29A 1lquA-5bqkA:
undetectable		 1lquA-5bqkA:
22.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IWK_A_CUA1599_0
(NITROUS OXIDE
REDUCTASE)		 5bqk ICP27
(Human
alphaherpesvirus
1) 		3 / 3 CYH A 400
CYH A 483
HIS A 479
 ZN  A 601 (-2.1A)
ZN  A 601 (-2.3A)
ZN  A 601 (-3.2A)
 0.79A 2iwkA-5bqkA:
undetectable		 2iwkA-5bqkA:
18.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IWK_B_CUB1599_0
(NITROUS OXIDE
REDUCTASE)		 5bqk ICP27
(Human
alphaherpesvirus
1) 		3 / 3 CYH A 400
CYH A 483
HIS A 479
 ZN  A 601 (-2.1A)
ZN  A 601 (-2.3A)
ZN  A 601 (-3.2A)
 0.80A 2iwkB-5bqkA:
undetectable		 2iwkB-5bqkA:
18.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JFA_B_RALB600_1
(ESTROGEN RECEPTOR)		 5bqk ICP27
(Human
alphaherpesvirus
1) 		5 / 12 ALA A 356
ASP A 357
LEU A 360
LEU A 433
LEU A 472
 None
 1.12A 2jfaB-5bqkA:
undetectable		 2jfaB-5bqkA:
22.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NPN_A_SAMA4633_0
(PUTATIVE COBALAMIN
SYNTHESIS RELATED
PROTEIN)		 5bqk ICP27
(Human
alphaherpesvirus
1) 		5 / 9 LEU A 344
THR A 382
ALA A 383
LEU A 390
LEU A 436
 None
 1.26A 2npnA-5bqkA:
undetectable		 2npnA-5bqkA:
22.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QO5_A_CHDA131_0
(LIVER-BASIC FATTY
ACID BINDING PROTEIN)		 5bqk ICP27
(Human
alphaherpesvirus
1) 		5 / 12 ILE A 422
ILE A 425
LEU A 472
CYH A 468
LEU A 387
 None
 1.20A 2qo5A-5bqkA:
undetectable		 2qo5A-5bqkA:
20.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DTU_B_CUB1022_0
(CYTOCHROME C OXIDASE
SUBUNIT 2)		 5bqk ICP27
(Human
alphaherpesvirus
1) 		3 / 3 CYH A 400
CYH A 483
HIS A 479
 ZN  A 601 (-2.1A)
ZN  A 601 (-2.3A)
ZN  A 601 (-3.2A)
 0.81A 3dtuB-5bqkA:
undetectable		 3dtuB-5bqkA:
22.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DTU_D_CUD3_0
(CYTOCHROME C OXIDASE
SUBUNIT 2)		 5bqk ICP27
(Human
alphaherpesvirus
1) 		3 / 3 CYH A 400
CYH A 483
HIS A 479
 ZN  A 601 (-2.1A)
ZN  A 601 (-2.3A)
ZN  A 601 (-3.2A)
 0.79A 3dtuD-5bqkA:
undetectable		 3dtuD-5bqkA:
22.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3L35_H_DHIH3_0
(GP41 N-PEPTIDE
HIV ENTRY INHIBITOR
PIE12)		 5bqk ICP27
(Human
alphaherpesvirus
1) 		3 / 3 LEU A 296
TRP A 292
GLY A 319
 None
 0.72A 3l35A-5bqkA:
undetectable
3l35H-5bqkA:
undetectable		 3l35A-5bqkA:
8.12
3l35H-5bqkA:
5.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3L35_K_DHIK3_0
(GP41 N-PEPTIDE
HIV ENTRY INHIBITOR
PIE12)		 5bqk ICP27
(Human
alphaherpesvirus
1) 		3 / 3 LEU A 296
TRP A 292
GLY A 319
 None
 0.73A 3l35B-5bqkA:
undetectable
3l35K-5bqkA:
undetectable		 3l35B-5bqkA:
8.12
3l35K-5bqkA:
5.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T3R_A_9PLA501_1
(CYTOCHROME P450 2A6)		 5bqk ICP27
(Human
alphaherpesvirus
1) 		6 / 11 VAL A 429
PHE A 430
ILE A 475
GLY A 471
LEU A 390
PHE A 349
 None
 1.44A 3t3rA-5bqkA:
undetectable		 3t3rA-5bqkA:
19.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T3R_D_9PLD501_1
(CYTOCHROME P450 2A6)		 5bqk ICP27
(Human
alphaherpesvirus
1) 		5 / 10 VAL A 429
PHE A 430
ILE A 475
GLY A 471
PHE A 349
 None
 1.15A 3t3rD-5bqkA:
undetectable		 3t3rD-5bqkA:
19.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U9F_P_CLMP221_1
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 5bqk ICP27
(Human
alphaherpesvirus
1) 		4 / 4 PHE A 397
ALA A 492
CYH A 488
HIS A 479
 None
None
ZN  A 601 (-2.3A)
ZN  A 601 (-3.2A)
 1.33A 3u9fR-5bqkA:
undetectable		 3u9fR-5bqkA:
18.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R21_B_STRB601_1
(CYTOCHROME P450
FAMILY 17
POLYPEPTIDE 2)		 5bqk ICP27
(Human
alphaherpesvirus
1) 		5 / 9 ALA A 426
ILE A 495
VAL A 496
THR A 478
ILE A 425
 None
 1.10A 4r21B-5bqkA:
undetectable		 4r21B-5bqkA:
22.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TVT_A_ASCA303_0
(THAUMATIN-1)		 5bqk ICP27
(Human
alphaherpesvirus
1) 		4 / 7 LEU A 407
SER A 427
ILE A 422
LYS A 423
 None
 1.14A 4tvtA-5bqkA:
undetectable		 4tvtA-5bqkA:
23.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B1B_W_CHDW101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 5bqk ICP27
(Human
alphaherpesvirus
1) 		4 / 7 ILE A 379
PHE A 326
ARG A 308
LEU A 315
 None
 0.86A 5b1bN-5bqkA:
1.9
5b1bW-5bqkA:
undetectable		 5b1bN-5bqkA:
17.83
5b1bW-5bqkA:
12.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DQF_A_CZEA613_1
(SERUM ALBUMIN)		 5bqk ICP27
(Human
alphaherpesvirus
1) 		5 / 9 ARG A 405
ALA A 426
GLY A 471
LEU A 472
LEU A 398
 None
 1.13A 5dqfA-5bqkA:
undetectable		 5dqfA-5bqkA:
18.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IEN_B_VDYB201_2
(CDL2.2)		 5bqk ICP27
(Human
alphaherpesvirus
1) 		5 / 12 LEU A 407
LEU A 390
LEU A 402
ILE A 495
LEU A 476
 None
 1.12A 5ienB-5bqkA:
undetectable		 5ienB-5bqkA:
19.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KKZ_O_ASCO1004_0
(CYTOCHROME B
UBIQUINOL-CYTOCHROME
C REDUCTASE
IRON-SULFUR SUBUNIT)		 5bqk ICP27
(Human
alphaherpesvirus
1) 		4 / 7 HIS A 494
ILE A 495
VAL A 496
ARG A 480
 None
 1.27A 5kkzM-5bqkA:
undetectable
5kkzO-5bqkA:
undetectable		 5kkzM-5bqkA:
19.41
5kkzO-5bqkA:
22.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MAF_A_XINA403_2
(MATERNAL EMBRYONIC
LEUCINE ZIPPER
KINASE)		 5bqk ICP27
(Human
alphaherpesvirus
1) 		4 / 5 LEU A 472
CYH A 414
LEU A 413
ASP A 424
 None
 1.20A 5mafA-5bqkA:
undetectable		 5mafA-5bqkA:
16.02