SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5bqt'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SN5_C_T3C601_1
(TRANSTHYRETIN)		 5bqt PUTATIVE HTH-TYPE
TRANSCRIPTIONAL
REGULATOR TRMBL2
(Pyrococcus
furiosus) 		4 / 6 LEU A 215
GLU A 220
LEU A 152
VAL A 174
 None
 0.84A 1sn5A-5bqtA:
undetectable		 1sn5A-5bqtA:
21.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SN5_C_T3C601_2
(TRANSTHYRETIN)		 5bqt PUTATIVE HTH-TYPE
TRANSCRIPTIONAL
REGULATOR TRMBL2
(Pyrococcus
furiosus) 		4 / 8 LEU A 215
GLU A 220
LEU A 152
VAL A 174
 None
 0.86A 1sn5C-5bqtA:
undetectable		 1sn5C-5bqtA:
21.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0M_B_KLNB1499_1
(CYTOCHROME P450 3A4)		 5bqt PUTATIVE HTH-TYPE
TRANSCRIPTIONAL
REGULATOR TRMBL2
(Pyrococcus
furiosus) 		4 / 7 SER A 191
THR A 139
ILE A 194
GLY A 156
 None
 0.81A 2v0mB-5bqtA:
undetectable		 2v0mB-5bqtA:
22.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K4V_B_ROCB201_4
(HIV-1 PROTEASE)		 5bqt PUTATIVE HTH-TYPE
TRANSCRIPTIONAL
REGULATOR TRMBL2
(Pyrococcus
furiosus) 		4 / 4 ARG A 172
ASP A 195
GLY A 200
THR A 176
 None
 1.30A 3k4vB-5bqtA:
undetectable		 3k4vB-5bqtA:
17.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KMO_B_EAAB213_1
(GLUTATHIONE
S-TRANSFERASE P)		 5bqt PUTATIVE HTH-TYPE
TRANSCRIPTIONAL
REGULATOR TRMBL2
(Pyrococcus
furiosus) 		4 / 7 TYR A  24
PHE A  61
VAL A  75
ASN A  79
 None
 0.99A 3kmoB-5bqtA:
undetectable		 3kmoB-5bqtA:
21.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WDM_C_ADNC301_1
(4-PHOSPHOPANTOATE--B
ETA-ALANINE LIGASE)		 5bqt PUTATIVE HTH-TYPE
TRANSCRIPTIONAL
REGULATOR TRMBL2
(Pyrococcus
furiosus) 		5 / 9 ALA A 206
LEU A 188
LEU A 204
LEU A 152
ILE A 193
 None
 1.14A 3wdmC-5bqtA:
undetectable		 3wdmC-5bqtA:
25.90