SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5brl'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EQB_A_FFOA1293_2
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 5brl STAR-RELATED LIPID
TRANSFER PROTEIN 4
(Mus
musculus) 		3 / 3 SER A  61
GLU A  62
GLU A  63
 None
 0.68A 1eqbD-5brlA:
undetectable		 1eqbD-5brlA:
19.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EQB_C_FFOC3293_0
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 5brl STAR-RELATED LIPID
TRANSFER PROTEIN 4
(Mus
musculus) 		3 / 3 SER A  61
GLU A  62
GLU A  63
 None
 0.69A 1eqbB-5brlA:
undetectable		 1eqbB-5brlA:
19.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HRK_B_CHDB2503_0
(FERROCHELATASE)		 5brl STAR-RELATED LIPID
TRANSFER PROTEIN 4
(Mus
musculus) 		4 / 4 LEU A  93
PRO A  90
LEU A 102
ARG A 116
 None
 1.40A 1hrkB-5brlA:
undetectable		 1hrkB-5brlA:
19.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QD2_A_CHDA426_0
(FERROCHELATASE)		 5brl STAR-RELATED LIPID
TRANSFER PROTEIN 4
(Mus
musculus) 		4 / 4 LEU A  93
PRO A  90
LEU A 102
ARG A 116
 None
 1.18A 2qd2A-5brlA:
undetectable		 2qd2A-5brlA:
19.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XFS_A_J01A500_1
(ORF12)		 5brl STAR-RELATED LIPID
TRANSFER PROTEIN 4
(Mus
musculus) 		4 / 8 VAL A  82
LEU A 210
GLY A 187
ALA A  71
 None
 0.90A 2xfsA-5brlA:
2.1		 2xfsA-5brlA:
18.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XH9_A_J01A1436_1
(ORF12)		 5brl STAR-RELATED LIPID
TRANSFER PROTEIN 4
(Mus
musculus) 		4 / 8 VAL A  82
LEU A 210
GLY A 187
ALA A  71
 None
 0.89A 2xh9A-5brlA:
1.8		 2xh9A-5brlA:
18.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DZY_A_9CRA463_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 5brl STAR-RELATED LIPID
TRANSFER PROTEIN 4
(Mus
musculus) 		5 / 12 ILE A 189
ALA A  71
PHE A 213
LEU A 210
LEU A  34
 None
 1.13A 3dzyA-5brlA:
undetectable		 3dzyA-5brlA:
17.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HCO_A_CHDA3_0
(FERROCHELATASE,
MITOCHONDRIAL)		 5brl STAR-RELATED LIPID
TRANSFER PROTEIN 4
(Mus
musculus) 		4 / 4 LEU A  93
PRO A  90
LEU A 102
ARG A 116
 None
 1.15A 3hcoA-5brlA:
undetectable		 3hcoA-5brlA:
19.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KHM_A_TPFA501_1
(STEROL 14
ALPHA-DEMETHYLASE)		 5brl STAR-RELATED LIPID
TRANSFER PROTEIN 4
(Mus
musculus) 		4 / 8 ALA A 201
ALA A 205
THR A 209
LEU A  98
 None
 0.92A 3khmA-5brlA:
undetectable		 3khmA-5brlA:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MBH_B_PXLB400_1
(PUTATIVE
PHOSPHOMETHYLPYRIMID
INE KINASE)		 5brl STAR-RELATED LIPID
TRANSFER PROTEIN 4
(Mus
musculus) 		5 / 12 ASP A 134
SER A 151
HIS A 167
THR A 191
GLN A 190
 None
 1.32A 3mbhB-5brlA:
undetectable		 3mbhB-5brlA:
24.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PSS_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 5brl STAR-RELATED LIPID
TRANSFER PROTEIN 4
(Mus
musculus) 		5 / 12 LEU A 210
ALA A 211
PHE A 213
LEU A 185
ILE A  86
 None
 0.87A 4pssA-5brlA:
undetectable		 4pssA-5brlA:
19.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QWP_A_GCSA303_1
(CHITOSANASE)		 5brl STAR-RELATED LIPID
TRANSFER PROTEIN 4
(Mus
musculus) 		4 / 6 GLU A  63
TYR A  37
THR A  33
TYR A 165
 None
 1.43A 4qwpA-5brlA:
undetectable		 4qwpA-5brlA:
20.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QWP_B_GCSB302_1
(CHITOSANASE)		 5brl STAR-RELATED LIPID
TRANSFER PROTEIN 4
(Mus
musculus) 		4 / 5 GLU A  63
TYR A  37
THR A  33
TYR A 165
 None
 1.38A 4qwpB-5brlA:
undetectable		 4qwpB-5brlA:
20.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YDQ_B_HFGB802_1
(PROLINE--TRNA LIGASE)		 5brl STAR-RELATED LIPID
TRANSFER PROTEIN 4
(Mus
musculus) 		3 / 3 GLU A 142
THR A 186
HIS A  38
 None
 0.81A 4ydqB-5brlA:
2.8		 4ydqB-5brlA:
16.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TL8_A_X2NA502_2
(PROTEIN CYP51)		 5brl STAR-RELATED LIPID
TRANSFER PROTEIN 4
(Mus
musculus) 		4 / 6 TYR A 188
LEU A 145
PHE A 172
LEU A 185
 None
 1.15A 5tl8A-5brlA:
undetectable		 5tl8A-5brlA:
18.28