SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5brq'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1C4D_B_DVAB8_0
(GRAMICIDIN A)		 5brq GLYCOSIDE HYDROLASE
FAMILY 13
(Bacillus
licheniformis) 		3 / 3 TRP A 320
VAL A  13
TRP A   9
 None
 1.21A 1c4dA-5brqA:
undetectable
1c4dB-5brqA:
undetectable		 1c4dA-5brqA:
7.43
1c4dB-5brqA:
7.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EE2_A_CHDA1150_0
(ALCOHOL
DEHYDROGENASE)		 5brq GLYCOSIDE HYDROLASE
FAMILY 13
(Bacillus
licheniformis) 		5 / 11 HIS A 462
LEU A 323
LEU A 466
VAL A 505
ILE A 355
 None
 1.33A 1ee2A-5brqA:
undetectable		 1ee2A-5brqA:
19.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EQB_A_FFOA1293_1
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 5brq GLYCOSIDE HYDROLASE
FAMILY 13
(Bacillus
licheniformis) 		3 / 3 GLU A  45
TYR A  42
PHE A 460
 None
 0.96A 1eqbB-5brqA:
undetectable		 1eqbB-5brqA:
21.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EQB_B_FFOB2293_0
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 5brq GLYCOSIDE HYDROLASE
FAMILY 13
(Bacillus
licheniformis) 		3 / 3 GLU A  45
TYR A  42
PHE A 460
 None
 0.95A 1eqbA-5brqA:
undetectable		 1eqbA-5brqA:
21.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EQB_C_FFOC3293_2
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 5brq GLYCOSIDE HYDROLASE
FAMILY 13
(Bacillus
licheniformis) 		3 / 3 GLU A  45
TYR A  42
PHE A 460
 None
 0.95A 1eqbD-5brqA:
undetectable		 1eqbD-5brqA:
21.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EQB_D_FFOD4293_0
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 5brq GLYCOSIDE HYDROLASE
FAMILY 13
(Bacillus
licheniformis) 		3 / 3 GLU A  45
TYR A  42
PHE A 460
 None
 0.96A 1eqbC-5brqA:
undetectable		 1eqbC-5brqA:
21.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ILQ_C_ACAC7_1
(INTERLEUKIN-8
PRECURSOR
INTERLEUKIN-8
RECEPTOR A)		 5brq GLYCOSIDE HYDROLASE
FAMILY 13
(Bacillus
licheniformis) 		4 / 6 PHE A 225
ASP A 217
ASP A 218
PRO A 215
 None
 1.50A 1ilqA-5brqA:
undetectable
1ilqC-5brqA:
undetectable		 1ilqA-5brqA:
8.10
1ilqC-5brqA:
2.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q64_B_1UNB1001_4
(PROTEASE RETROPEPSIN)		 5brq GLYCOSIDE HYDROLASE
FAMILY 13
(Bacillus
licheniformis) 		3 / 3 ASP A 378
THR A 419
PRO A 420
 None
 0.43A 2q64B-5brqA:
undetectable		 2q64B-5brqA:
11.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q64_B_1UNB1001_4
(PROTEASE RETROPEPSIN)		 5brq GLYCOSIDE HYDROLASE
FAMILY 13
(Bacillus
licheniformis) 		3 / 3 ASP A 379
THR A 419
PRO A 420
 None
 0.58A 2q64B-5brqA:
undetectable		 2q64B-5brqA:
11.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RCT_A_RTLA140_1
(RETINOL-BINDING
PROTEIN II, CELLULAR)		 5brq GLYCOSIDE HYDROLASE
FAMILY 13
(Bacillus
licheniformis) 		3 / 3 GLN A  58
THR A 107
TRP A 113
 None
 0.87A 2rctA-5brqA:
undetectable		 2rctA-5brqA:
12.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WEK_A_DIFA1373_1
(ZINC-BINDING ALCOHOL
DEHYDROGENASE
DOMAIN-CONTAINING
PROTEIN 2)		 5brq GLYCOSIDE HYDROLASE
FAMILY 13
(Bacillus
licheniformis) 		4 / 8 SER A  21
PHE A 431
VAL A 440
TYR A  18
 None
 0.94A 2wekA-5brqA:
undetectable		 2wekA-5brqA:
19.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WEK_B_DIFB1373_1
(ZINC-BINDING ALCOHOL
DEHYDROGENASE
DOMAIN-CONTAINING
PROTEIN 2)		 5brq GLYCOSIDE HYDROLASE
FAMILY 13
(Bacillus
licheniformis) 		4 / 8 SER A  21
PHE A 431
VAL A 440
TYR A  18
 None
 0.97A 2wekB-5brqA:
undetectable		 2wekB-5brqA:
19.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X7H_B_PFNB1372_1
(ZINC-BINDING ALCOHOL
DEHYDROGENASE
DOMAIN-CONTAINING
PROTEIN 2)		 5brq GLYCOSIDE HYDROLASE
FAMILY 13
(Bacillus
licheniformis) 		4 / 5 SER A  21
PHE A 431
VAL A 440
TYR A  18
 None
 0.99A 2x7hB-5brqA:
undetectable		 2x7hB-5brqA:
21.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A27_A_SAMA250_0
(UNCHARACTERIZED
PROTEIN MJ1557)		 5brq GLYCOSIDE HYDROLASE
FAMILY 13
(Bacillus
licheniformis) 		5 / 12 SER A 245
ASN A 240
GLY A 199
LYS A  97
ASP A  49
 None
 1.28A 3a27A-5brqA:
undetectable		 3a27A-5brqA:
18.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GSS_A_EAAA212_1
(GLUTATHIONE
S-TRANSFERASE P1-1)		 5brq GLYCOSIDE HYDROLASE
FAMILY 13
(Bacillus
licheniformis) 		4 / 7 VAL A 421
ILE A  43
TYR A  15
GLY A 367
 None
 0.98A 3gssA-5brqA:
undetectable		 3gssA-5brqA:
17.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GSS_B_EAAB211_1
(GLUTATHIONE
S-TRANSFERASE P1-1)		 5brq GLYCOSIDE HYDROLASE
FAMILY 13
(Bacillus
licheniformis) 		4 / 7 VAL A 421
ILE A  43
TYR A  15
GLY A 367
 None
 0.99A 3gssB-5brqA:
undetectable		 3gssB-5brqA:
17.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JZJ_A_ACRA405_1
(ACARBOSE/MALTOSE
BINDING PROTEIN GACH)		 5brq GLYCOSIDE HYDROLASE
FAMILY 13
(Bacillus
licheniformis) 		5 / 12 GLY A 149
GLU A 387
ASP A 329
ASP A 168
ASN A 390
 None
 1.42A 3jzjA-5brqA:
undetectable		 3jzjA-5brqA:
21.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K8M_A_ACRA720_1
(ALPHA-AMYLASE, SUSG)		 5brq GLYCOSIDE HYDROLASE
FAMILY 13
(Bacillus
licheniformis) 		4 / 7 TYR A 363
GLU A 254
LEU A 323
ASN A 321
 None
 1.33A 3k8mA-5brqA:
32.4		 3k8mA-5brqA:
27.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N9J_A_EAAA210_1
(GLUTATHIONE
S-TRANSFERASE P)		 5brq GLYCOSIDE HYDROLASE
FAMILY 13
(Bacillus
licheniformis) 		4 / 8 VAL A 421
ILE A  43
TYR A  15
GLY A 367
 None
 0.97A 3n9jA-5brqA:
undetectable		 3n9jA-5brqA:
18.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OXX_A_DR7A100_2
(HIV-1 PROTEASE)		 5brq GLYCOSIDE HYDROLASE
FAMILY 13
(Bacillus
licheniformis) 		5 / 11 ASP A  83
ILE A  36
GLY A  31
VAL A  30
ILE A  56
 None
None
MG  A 601 ( 4.6A)
MG  A 601 (-4.8A)
None
 0.92A 3oxxB-5brqA:
undetectable		 3oxxB-5brqA:
10.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OXX_C_DR7C100_2
(HIV-1 PROTEASE)		 5brq GLYCOSIDE HYDROLASE
FAMILY 13
(Bacillus
licheniformis) 		5 / 11 ASP A  83
ILE A  36
GLY A  31
VAL A  30
ILE A  56
 None
None
MG  A 601 ( 4.6A)
MG  A 601 (-4.8A)
None
 0.92A 3oxxD-5brqA:
undetectable		 3oxxD-5brqA:
10.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OZV_B_ECNB411_1
(FLAVOHEMOGLOBIN)		 5brq GLYCOSIDE HYDROLASE
FAMILY 13
(Bacillus
licheniformis) 		5 / 9 ILE A 476
ILE A 475
PHE A 473
LEU A 503
LEU A 469
 None
 0.99A 3ozvB-5brqA:
undetectable		 3ozvB-5brqA:
22.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TKG_C_ROCC901_3
(PROTEASE)		 5brq GLYCOSIDE HYDROLASE
FAMILY 13
(Bacillus
licheniformis) 		3 / 3 ASP A 378
THR A 419
PRO A 420
 None
 0.46A 3tkgD-5brqA:
undetectable		 3tkgD-5brqA:
13.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TKG_C_ROCC901_3
(PROTEASE)		 5brq GLYCOSIDE HYDROLASE
FAMILY 13
(Bacillus
licheniformis) 		3 / 3 ASP A 379
THR A 419
PRO A 420
 None
 0.56A 3tkgD-5brqA:
undetectable		 3tkgD-5brqA:
13.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DAJ_A_0HKA2000_1
(MUSCARINIC
ACETYLCHOLINE
RECEPTOR M3,
LYSOZYME)		 5brq GLYCOSIDE HYDROLASE
FAMILY 13
(Bacillus
licheniformis) 		5 / 12 ASP A 329
ASN A 416
ALA A 411
TRP A 293
TYR A 287
 None
 1.44A 4dajA-5brqA:
undetectable		 4dajA-5brqA:
23.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E7C_A_ACTA504_0
(UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE)		 5brq GLYCOSIDE HYDROLASE
FAMILY 13
(Bacillus
licheniformis) 		3 / 3 ARG A 224
TRP A 144
GLY A 222
 None
 0.98A 4e7cA-5brqA:
undetectable		 4e7cA-5brqA:
20.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KR4_C_AICC401_1
(OUTER MEMBRANE
PROTEIN F)		 5brq GLYCOSIDE HYDROLASE
FAMILY 13
(Bacillus
licheniformis) 		4 / 8 LYS A  20
ARG A 418
TYR A  18
GLU A 387
 None
 1.35A 4kr4C-5brqA:
undetectable		 4kr4C-5brqA:
19.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NDN_A_SAMA407_1
(S-ADENOSYLMETHIONINE
SYNTHASE ISOFORM
TYPE-2)		 5brq GLYCOSIDE HYDROLASE
FAMILY 13
(Bacillus
licheniformis) 		4 / 8 GLU A  86
ASP A  32
ILE A  33
ILE A  74
 None
MG  A 601 (-3.5A)
None
None
 0.92A 4ndnB-5brqA:
undetectable		 4ndnB-5brqA:
20.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O4D_A_ACTA406_0
(INOSITOL
HEXAKISPHOSPHATE
KINASE)		 5brq GLYCOSIDE HYDROLASE
FAMILY 13
(Bacillus
licheniformis) 		4 / 7 ASP A 168
PHE A 148
SER A 146
HIS A 165
 None
 1.45A 4o4dA-5brqA:
undetectable		 4o4dA-5brqA:
18.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5C0O_H_SAMH301_1
(TRNA
(ADENINE(58)-N(1))-M
ETHYLTRANSFERASE
TRMI)		 5brq GLYCOSIDE HYDROLASE
FAMILY 13
(Bacillus
licheniformis) 		4 / 5 THR A 432
GLY A 430
GLU A  38
ASP A  24
 None
None
None
MG  A 601 (-3.1A)
 0.98A 5c0oH-5brqA:
undetectable		 5c0oH-5brqA:
19.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CSY_B_ACRB601_1
(4-ALPHA-GLUCANOTRANS
FERASE DPE1,
CHLOROPLASTIC/AMYLOP
LASTIC)		 5brq GLYCOSIDE HYDROLASE
FAMILY 13
(Bacillus
licheniformis) 		5 / 12 ARG A 201
ASP A 203
GLU A 254
HIS A 282
HIS A 328
 None
 1.13A 5csyB-5brqA:
17.0		 5csyB-5brqA:
21.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CSY_B_ACRB601_1
(4-ALPHA-GLUCANOTRANS
FERASE DPE1,
CHLOROPLASTIC/AMYLOP
LASTIC)		 5brq GLYCOSIDE HYDROLASE
FAMILY 13
(Bacillus
licheniformis) 		5 / 12 ASP A 203
GLU A 254
HIS A 282
HIS A 328
ASP A 329
 None
 0.95A 5csyB-5brqA:
17.0		 5csyB-5brqA:
21.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5GTR_A_ESTA601_2
(ESTROGEN RECEPTOR)		 5brq GLYCOSIDE HYDROLASE
FAMILY 13
(Bacillus
licheniformis) 		4 / 5 LEU A  88
LEU A  40
PHE A  84
LEU A  53
 None
 0.99A 5gtrA-5brqA:
undetectable		 5gtrA-5brqA:
16.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JMN_A_FUAA1101_1
(MULTIDRUG EFFLUX
PUMP SUBUNIT ACRB)		 5brq GLYCOSIDE HYDROLASE
FAMILY 13
(Bacillus
licheniformis) 		4 / 5 ILE A  36
ILE A  96
HIS A  92
VAL A  98
 None
 0.66A 5jmnA-5brqA:
undetectable		 5jmnA-5brqA:
19.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JMN_A_FUAA1101_1
(MULTIDRUG EFFLUX
PUMP SUBUNIT ACRB)		 5brq GLYCOSIDE HYDROLASE
FAMILY 13
(Bacillus
licheniformis) 		4 / 5 ILE A  36
LYS A  93
HIS A  92
VAL A  98
 None
 0.95A 5jmnA-5brqA:
undetectable		 5jmnA-5brqA:
19.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L2T_A_6ZZA900_2
(CYCLIN-DEPENDENT
KINASE 6)		 5brq GLYCOSIDE HYDROLASE
FAMILY 13
(Bacillus
licheniformis) 		3 / 3 LYS A 304
GLN A 552
ASN A 508
 None
 1.07A 5l2tA-5brqA:
undetectable		 5l2tA-5brqA:
20.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LJC_A_RTLA201_1
(RETINOL-BINDING
PROTEIN 1)		 5brq GLYCOSIDE HYDROLASE
FAMILY 13
(Bacillus
licheniformis) 		4 / 7 LEU A 236
ILE A 260
MET A 314
MET A 255
 None
 1.28A 5ljcA-5brqA:
undetectable		 5ljcA-5brqA:
13.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AG0_A_ACRA610_0
(ALPHA-AMYLASE)		 5brq GLYCOSIDE HYDROLASE
FAMILY 13
(Bacillus
licheniformis) 		5 / 12 TYR A  66
HIS A 106
ASP A 203
HIS A 328
ASP A 329
 None
 0.76A 6ag0A-5brqA:
18.8		 6ag0A-5brqA:
9.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DWD_A_GLYA715_0
(DEOXYNUCLEOSIDE
TRIPHOSPHATE
TRIPHOSPHOHYDROLASE
SAMHD1)		 5brq GLYCOSIDE HYDROLASE
FAMILY 13
(Bacillus
licheniformis) 		4 / 6 ASN A 416
ASP A 415
SER A 388
ARG A 414
 None
 1.13A 6dwdA-5brqA:
undetectable
6dwdC-5brqA:
undetectable		 6dwdA-5brqA:
23.16
6dwdC-5brqA:
23.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DWJ_B_GLYB710_0
(DEOXYNUCLEOSIDE
TRIPHOSPHATE
TRIPHOSPHOHYDROLASE
SAMHD1)		 5brq GLYCOSIDE HYDROLASE
FAMILY 13
(Bacillus
licheniformis) 		4 / 5 ARG A 224
ARG A 223
GLY A 222
ASP A 221
 None
 1.39A 6dwjB-5brqA:
undetectable
6dwjD-5brqA:
undetectable		 6dwjB-5brqA:
23.16
6dwjD-5brqA:
23.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6N7F_A_RBFA502_0
(PUTATIVE GLUTATHIONE
REDUCTASE (GR))		 5brq GLYCOSIDE HYDROLASE
FAMILY 13
(Bacillus
licheniformis) 		4 / 7 GLY A 319
ASN A 279
GLU A 254
GLY A 253
 None
 0.94A 6n7fA-5brqA:
undetectable		 6n7fA-5brqA:
8.29