SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5brr'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1BCU_H_PRLH280_0
(ALPHA-THROMBIN)		 5brr TISSUE-TYPE
PLASMINOGEN
ACTIVATOR
(Homo
sapiens) 		5 / 9 ASP E 189
ALA E 190
TRP E 215
GLY E 216
GLY E 226
 None
 0.35A 1bcuH-5brrE:
35.6		 1bcuH-5brrE:
32.38
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1ETR_H_MITH1_1
(EPSILON-THROMBIN)		 5brr TISSUE-TYPE
PLASMINOGEN
ACTIVATOR
(Homo
sapiens) 		5 / 12 HIS E  57
ASP E 189
TRP E 215
GLY E 216
GLY E 226
 None
 0.50A 1etrH-5brrE:
34.9		 1etrH-5brrE:
32.35
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1F5L_A_AMRA301_1
(UROKINASE-TYPE
PLASMINOGEN
ACTIVATOR)		 5brr TISSUE-TYPE
PLASMINOGEN
ACTIVATOR
(Homo
sapiens) 		4 / 8 ASP E 189
GLN E 192
GLY E 216
GLY E 226
 None
 0.45A 1f5lA-5brrE:
38.1		 1f5lA-5brrE:
44.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OXR_A_AINA141_1
(PHOSPHOLIPASE A2
ISOFORM 3)		 5brr TISSUE-TYPE
PLASMINOGEN
ACTIVATOR
(Homo
sapiens) 		4 / 4 LEU E 199
GLY E 184
ASP E 189
TYR E 228
 None
 1.29A 1oxrA-5brrE:
undetectable		 1oxrA-5brrE:
18.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BR4_B_SAMB301_0
(CEPHALOSPORIN
HYDROXYLASE CMCI)		 5brr TISSUE-TYPE
PLASMINOGEN
ACTIVATOR
(Homo
sapiens) 		5 / 12 LYS E  16
GLY E 193
ASP E 194
ALA E 195
ALA E  55
 None
 1.00A 2br4B-5brrE:
undetectable		 2br4B-5brrE:
20.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CML_A_ZMRA1478_1
(NEURAMINIDASE)		 5brr TISSUE-TYPE
PLASMINOGEN
ACTIVATOR
(Homo
sapiens) 		4 / 7 SER E 110
ASP E 110
SER E 110
GLN E  81
 None
 1.12A 2cmlA-5brrE:
undetectable		 2cmlA-5brrE:
20.94
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2P16_A_GG2A298_1
(COAGULATION FACTOR X
(EC 3.4.21.6)
(STUART FACTOR)
(STUART-PROWER
FACTOR))		 5brr TISSUE-TYPE
PLASMINOGEN
ACTIVATOR
(Homo
sapiens) 		7 / 12 TYR E  99
ASP E 189
ALA E 190
TRP E 215
GLY E 216
GLY E 226
TYR E 228
 None
 0.43A 2p16A-5brrE:
34.1		 2p16A-5brrE:
38.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PXC_A_SAMA500_0
(GENOME POLYPROTEIN
[CONTAINS: CAPSID
PROTEIN C (CORE
PROTEIN)
ENVELOPE PROTEIN M
(MATRIX PROTEIN)
MAJOR ENVELOPE
PROTEIN E
NON-STRUCTURAL
PROTEIN 1 (NS1)
NON-STRUCTURAL
PROTEIN 2A (NS2A)
FLAVIVIRIN PROTEASE
NS2B REGULATORY
SUBUNIT
FLAVIVIRIN PROTEASE
NS3 CATALYTIC
SUBUNIT
NON-STRUCTURAL
PROTEIN 4A (NS4A)
NON-STRUCTURAL
PROTEIN 4B (NS4B)
RNA-DIRECTED RNA
POLYMERASE (EC
2.7.7.48) (NS5)])		 5brr TISSUE-TYPE
PLASMINOGEN
ACTIVATOR
(Homo
sapiens) 		5 / 12 GLY E 211
GLY E  44
GLY E 196
VAL E  66
ILE E  52
 None
 0.88A 2pxcA-5brrE:
undetectable		 2pxcA-5brrE:
20.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QD4_A_CHDA803_0
(FERROCHELATASE)		 5brr TISSUE-TYPE
PLASMINOGEN
ACTIVATOR
(Homo
sapiens) 		4 / 5 LEU E 123
PRO E 124
LEU E 235
ILE E 238
 None
 0.85A 2qd4A-5brrE:
undetectable		 2qd4A-5brrE:
22.34
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2W26_A_RIVA1001_1
(ACTIVATED FACTOR XA
HEAVY CHAIN)		 5brr TISSUE-TYPE
PLASMINOGEN
ACTIVATOR
(Homo
sapiens) 		7 / 12 TYR E  99
ASP E 189
ALA E 190
TRP E 215
GLY E 216
GLY E 226
TYR E 228
 None
 0.44A 2w26A-5brrE:
34.3		 2w26A-5brrE:
38.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XFH_A_CL6A1413_1
(ERYTHROMYCIN B/D
C-12 HYDROXYLASE)		 5brr TISSUE-TYPE
PLASMINOGEN
ACTIVATOR
(Homo
sapiens) 		4 / 6 GLN E  30
ALA E  55
ALA E 195
PHE E  40
 None
 0.92A 2xfhA-5brrE:
undetectable		 2xfhA-5brrE:
20.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CLA_A_CLMA221_0
(TYPE III
CHLORAMPHENICOL
ACETYLTRANSFERASE)		 5brr TISSUE-TYPE
PLASMINOGEN
ACTIVATOR
(Homo
sapiens) 		5 / 9 ALA E 190
SER E 139
LEU E 209
VAL E 231
ILE E  45
 None
 1.27A 3claA-5brrE:
undetectable		 3claA-5brrE:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EMB_A_SAMA4633_0
(METHYLTRANSFERASE)		 5brr TISSUE-TYPE
PLASMINOGEN
ACTIVATOR
(Homo
sapiens) 		5 / 12 GLY E 211
GLY E  44
GLY E 196
VAL E  66
ILE E  52
 None
 0.90A 3embA-5brrE:
undetectable		 3embA-5brrE:
undetectable
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3GY3_A_PNTA246_0
(CATIONIC TRYPSIN)		 5brr TISSUE-TYPE
PLASMINOGEN
ACTIVATOR
(Homo
sapiens) 		5 / 11 HIS E  57
ASP E 189
TRP E 215
GLY E 216
GLY E 226
 None
 0.44A 3gy3A-5brrE:
15.4		 3gy3A-5brrE:
37.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NS1_C_PM6C1_1
(XANTHINE
DEHYDROGENASE/OXIDAS
E)		 5brr TISSUE-TYPE
PLASMINOGEN
ACTIVATOR
(Homo
sapiens) 		4 / 6 ARG E  60
PHE E  59
ALA E  55
ALA E  56
 None
 1.20A 3ns1C-5brrE:
undetectable		 3ns1C-5brrE:
15.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P97_A_SAMA263_0
(NON-STRUCTURAL
PROTEIN 5)		 5brr TISSUE-TYPE
PLASMINOGEN
ACTIVATOR
(Homo
sapiens) 		5 / 12 GLY E 211
GLY E  44
GLY E 196
VAL E  66
ILE E  52
 None
 0.86A 3p97A-5brrE:
undetectable		 3p97A-5brrE:
23.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VAQ_A_ADNA401_1
(PUTATIVE ADENOSINE
KINASE)		 5brr TISSUE-TYPE
PLASMINOGEN
ACTIVATOR
(Homo
sapiens) 		5 / 12 LEU E  64
GLY E 197
GLY E 196
LEU E 106
GLY E 142
 None
 0.91A 3vaqA-5brrE:
undetectable		 3vaqA-5brrE:
18.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BUP_B_SAMB500_1
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SUV420H1)		 5brr TISSUE-TYPE
PLASMINOGEN
ACTIVATOR
(Homo
sapiens) 		3 / 3 HIS E 144
GLU E 145
ASN E 186
 PGE  E 305 (-4.3A)
None
None
 0.92A 4bupB-5brrE:
undetectable		 4bupB-5brrE:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CTJ_A_SAMA1263_0
(NON-STRUCTURAL
PROTEIN 5)		 5brr TISSUE-TYPE
PLASMINOGEN
ACTIVATOR
(Homo
sapiens) 		5 / 12 GLY E 211
GLY E  44
GLY E 196
VAL E  66
ILE E  52
 None
 0.85A 4ctjA-5brrE:
undetectable		 4ctjA-5brrE:
21.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CTK_A_SAMA1263_0
(POLYPROTEIN)		 5brr TISSUE-TYPE
PLASMINOGEN
ACTIVATOR
(Homo
sapiens) 		5 / 12 GLY E 211
GLY E  44
GLY E 196
VAL E  66
ILE E  52
 None
 0.84A 4ctkA-5brrE:
undetectable		 4ctkA-5brrE:
21.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DUB_A_LDPA501_1
(CYTOCHROME P450 BM3
VARIANT 9D7)		 5brr TISSUE-TYPE
PLASMINOGEN
ACTIVATOR
(Homo
sapiens) 		4 / 6 PHE E  59
ALA E 104
GLY E  44
LEU E 106
 None
 0.74A 4dubA-5brrE:
undetectable		 4dubA-5brrE:
21.40
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4FU8_A_ACTA302_0
(UROKINASE-TYPE
PLASMINOGEN
ACTIVATOR)		 5brr TISSUE-TYPE
PLASMINOGEN
ACTIVATOR
(Homo
sapiens) 		4 / 5 HIS E  57
TYR E 151
GLN E 192
GLY E 193
 None
GOL  E 301 ( 4.9A)
None
None
 0.68A 4fu8A-5brrE:
38.2		 4fu8A-5brrE:
45.06
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4HFP_D_15UD402_1
(PROTHROMBIN)		 5brr TISSUE-TYPE
PLASMINOGEN
ACTIVATOR
(Homo
sapiens) 		6 / 12 HIS E  57
ASP E 189
ALA E 190
ALA E 195
TRP E 215
GLY E 226
 None
 0.46A 4hfpD-5brrE:
34.9		 4hfpD-5brrE:
32.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4I41_A_MIXA500_2
(SERINE/THREONINE-PRO
TEIN KINASE PIM-1)		 5brr TISSUE-TYPE
PLASMINOGEN
ACTIVATOR
(Homo
sapiens) 		4 / 4 LEU E  46
LEU E 106
GLN E 113
GLU E  80
 None
 1.19A 4i41A-5brrE:
undetectable		 4i41A-5brrE:
23.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KRH_B_SAMB900_1
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE
2)		 5brr TISSUE-TYPE
PLASMINOGEN
ACTIVATOR
(Homo
sapiens) 		4 / 4 ILE E 213
SER E 214
ASP E 189
ASP E 223
 None
 1.46A 4krhB-5brrE:
undetectable		 4krhB-5brrE:
20.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NPT_A_017A401_1
(PROTEASE)		 5brr TISSUE-TYPE
PLASMINOGEN
ACTIVATOR
(Homo
sapiens) 		5 / 9 ALA E  56
ILE E  33
GLY E  44
ILE E  45
ILE E  89
 None
 1.08A 4nptA-5brrE:
undetectable		 4nptA-5brrE:
16.67
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4RN6_B_15UB301_1
(THROMBIN HEAVY CHAIN)		 5brr TISSUE-TYPE
PLASMINOGEN
ACTIVATOR
(Homo
sapiens) 		5 / 12 HIS E  57
ALA E 190
ALA E 195
TRP E 215
GLY E 216
 None
 0.98A 4rn6B-5brrE:
29.2		 4rn6B-5brrE:
32.63
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4RN6_B_15UB301_1
(THROMBIN HEAVY CHAIN)		 5brr TISSUE-TYPE
PLASMINOGEN
ACTIVATOR
(Homo
sapiens) 		5 / 12 HIS E  57
ALA E 195
TRP E 215
GLY E 216
GLY E 226
 None
 0.52A 4rn6B-5brrE:
29.2		 4rn6B-5brrE:
32.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E9Q_A_SAMA301_0
(GENOME POLYPROTEIN)		 5brr TISSUE-TYPE
PLASMINOGEN
ACTIVATOR
(Homo
sapiens) 		5 / 12 GLY E 211
GLY E  44
GLY E 196
VAL E  66
ILE E  52
 None
 0.83A 5e9qA-5brrE:
undetectable		 5e9qA-5brrE:
22.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EC8_A_SAMA301_0
(GENOME POLYPROTEIN)		 5brr TISSUE-TYPE
PLASMINOGEN
ACTIVATOR
(Homo
sapiens) 		5 / 12 GLY E 211
GLY E  44
GLY E 196
VAL E  66
ILE E  52
 None
 0.80A 5ec8A-5brrE:
undetectable		 5ec8A-5brrE:
21.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ECL_A_ILEA602_0
(JASMONIC ACID-AMIDO
SYNTHETASE JAR1)		 5brr TISSUE-TYPE
PLASMINOGEN
ACTIVATOR
(Homo
sapiens) 		4 / 6 ALA E  56
VAL E  90
TYR E  88
HIS E  57
 None
 0.94A 5eclA-5brrE:
undetectable		 5eclA-5brrE:
17.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EHG_A_SAMA301_0
(RNA-DIRECTED RNA
POLYMERASE NS5)		 5brr TISSUE-TYPE
PLASMINOGEN
ACTIVATOR
(Homo
sapiens) 		5 / 12 GLY E 211
GLY E  44
GLY E 196
VAL E  66
ILE E  52
 None
 0.81A 5ehgA-5brrE:
undetectable		 5ehgA-5brrE:
21.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EHG_C_SAMC4001_0
(RNA-DIRECTED RNA
POLYMERASE NS5)		 5brr TISSUE-TYPE
PLASMINOGEN
ACTIVATOR
(Homo
sapiens) 		5 / 12 GLY E 211
GLY E  44
GLY E 196
VAL E  66
ILE E  52
 None
 0.96A 5ehgC-5brrE:
undetectable		 5ehgC-5brrE:
21.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EHI_A_SAMA4001_0
(NS5
METHYLTRANSFERASE
DENGUE VIRUS)		 5brr TISSUE-TYPE
PLASMINOGEN
ACTIVATOR
(Homo
sapiens) 		5 / 12 GLY E 211
GLY E  44
GLY E 196
VAL E  66
ILE E  52
 None
 0.84A 5ehiA-5brrE:
undetectable		 5ehiA-5brrE:
21.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EIF_A_SAMA301_0
(GENOME POLYPROTEIN)		 5brr TISSUE-TYPE
PLASMINOGEN
ACTIVATOR
(Homo
sapiens) 		5 / 12 GLY E 211
GLY E  44
GLY E 196
VAL E  66
ILE E  52
 None
 0.86A 5eifA-5brrE:
undetectable		 5eifA-5brrE:
21.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EIW_A_SAMA301_0
(NS5
METHYLTRANSFERASE)		 5brr TISSUE-TYPE
PLASMINOGEN
ACTIVATOR
(Homo
sapiens) 		5 / 12 GLY E 211
GLY E  44
GLY E 196
VAL E  66
ILE E  52
 None
 0.81A 5eiwA-5brrE:
undetectable		 5eiwA-5brrE:
21.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EKX_A_SAMA301_0
(NS5
METHYLTRANSFERASE)		 5brr TISSUE-TYPE
PLASMINOGEN
ACTIVATOR
(Homo
sapiens) 		5 / 12 GLY E 211
GLY E  44
GLY E 196
VAL E  66
ILE E  52
 None
 0.83A 5ekxA-5brrE:
undetectable		 5ekxA-5brrE:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EKX_B_SAMB4000_0
(NS5
METHYLTRANSFERASE)		 5brr TISSUE-TYPE
PLASMINOGEN
ACTIVATOR
(Homo
sapiens) 		5 / 12 GLY E 211
GLY E  44
GLY E 196
VAL E  66
ILE E  52
 None
 0.87A 5ekxB-5brrE:
undetectable		 5ekxB-5brrE:
21.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KQR_A_SAMA301_0
(METHYLTRANSFERASE)		 5brr TISSUE-TYPE
PLASMINOGEN
ACTIVATOR
(Homo
sapiens) 		5 / 12 GLY E 211
GLY E  44
GLY E 196
VAL E  66
ILE E  52
 None
 0.91A 5kqrA-5brrE:
undetectable		 5kqrA-5brrE:
23.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KQS_A_SAMA307_0
(GENOME POLYPROTEIN)		 5brr TISSUE-TYPE
PLASMINOGEN
ACTIVATOR
(Homo
sapiens) 		5 / 12 GLY E 211
GLY E  44
GLY E 196
VAL E  66
ILE E  52
 None
 0.89A 5kqsA-5brrE:
undetectable		 5kqsA-5brrE:
23.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NJV_B_SAMB301_0
(NS5)		 5brr TISSUE-TYPE
PLASMINOGEN
ACTIVATOR
(Homo
sapiens) 		5 / 12 GLY E 211
GLY E  44
GLY E 196
VAL E  66
ILE E  52
 None
 0.89A 5njvB-5brrE:
undetectable		 5njvB-5brrE:
22.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NJV_D_SAMD301_0
(NS5)		 5brr TISSUE-TYPE
PLASMINOGEN
ACTIVATOR
(Homo
sapiens) 		5 / 12 GLY E 211
GLY E  44
GLY E 196
VAL E  66
ILE E  52
 None
 1.00A 5njvD-5brrE:
undetectable		 5njvD-5brrE:
22.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5O96_B_SAMB501_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE E)		 5brr TISSUE-TYPE
PLASMINOGEN
ACTIVATOR
(Homo
sapiens) 		5 / 9 LEU E  53
GLY E 196
GLY E  43
LEU E 105
ALA E 104
 None
 0.97A 5o96A-5brrE:
undetectable
5o96B-5brrE:
undetectable		 5o96A-5brrE:
18.11
5o96B-5brrE:
18.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UL4_A_SAMA803_0
(OXSB PROTEIN)		 5brr TISSUE-TYPE
PLASMINOGEN
ACTIVATOR
(Homo
sapiens) 		5 / 12 PHE E  40
GLY E 142
LYS E  16
GLY E 193
ILE E 213
 None
 1.12A 5ul4A-5brrE:
undetectable		 5ul4A-5brrE:
16.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VIM_A_SAMA301_0
(METHYLTRANSFERASE)		 5brr TISSUE-TYPE
PLASMINOGEN
ACTIVATOR
(Homo
sapiens) 		5 / 12 GLY E 211
GLY E  44
GLY E 196
VAL E  66
ILE E  52
 None
 0.89A 5vimA-5brrE:
undetectable		 5vimA-5brrE:
24.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VIM_B_SAMB301_0
(METHYLTRANSFERASE)		 5brr TISSUE-TYPE
PLASMINOGEN
ACTIVATOR
(Homo
sapiens) 		5 / 12 GLY E 211
GLY E  44
GLY E 196
VAL E  66
ILE E  52
 None
 0.87A 5vimB-5brrE:
undetectable		 5vimB-5brrE:
24.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WBV_A_SAMA402_1
(HISTONE-LYSINE
N-METHYLTRANSFERASE
KMT5B)		 5brr TISSUE-TYPE
PLASMINOGEN
ACTIVATOR
(Homo
sapiens) 		3 / 3 HIS E 144
GLU E 145
ASN E 186
 PGE  E 305 (-4.3A)
None
None
 0.96A 5wbvA-5brrE:
undetectable		 5wbvA-5brrE:
19.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WBV_B_SAMB402_1
(HISTONE-LYSINE
N-METHYLTRANSFERASE
KMT5B)		 5brr TISSUE-TYPE
PLASMINOGEN
ACTIVATOR
(Homo
sapiens) 		3 / 3 HIS E 144
GLU E 145
ASN E 186
 PGE  E 305 (-4.3A)
None
None
 0.96A 5wbvB-5brrE:
undetectable		 5wbvB-5brrE:
19.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WZ2_A_SAMA601_0
(NS5 MTASE)		 5brr TISSUE-TYPE
PLASMINOGEN
ACTIVATOR
(Homo
sapiens) 		5 / 12 GLY E 211
GLY E  44
GLY E 196
VAL E  66
ILE E  52
 None
 0.86A 5wz2A-5brrE:
undetectable		 5wz2A-5brrE:
23.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WZ2_B_SAMB601_0
(NS5 MTASE)		 5brr TISSUE-TYPE
PLASMINOGEN
ACTIVATOR
(Homo
sapiens) 		5 / 12 GLY E 211
GLY E  44
GLY E 196
VAL E  66
ILE E  52
 None
 0.84A 5wz2B-5brrE:
undetectable		 5wz2B-5brrE:
23.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WZ2_C_SAMC601_0
(NS5 MTASE)		 5brr TISSUE-TYPE
PLASMINOGEN
ACTIVATOR
(Homo
sapiens) 		5 / 12 GLY E 211
GLY E  44
GLY E 196
VAL E  66
ILE E  52
 None
 0.87A 5wz2C-5brrE:
undetectable		 5wz2C-5brrE:
23.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BPY_A_ACTA408_0
(THIOREDOXIN
REDUCTASE)		 5brr TISSUE-TYPE
PLASMINOGEN
ACTIVATOR
(Homo
sapiens) 		3 / 3 PRO E 164
SER E 165
SER E 166
 GOL  E 303 ( 4.6A)
None
GOL  E 303 ( 4.0A)
 0.69A 6bpyA-5brrE:
undetectable		 6bpyA-5brrE:
21.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ECE_C_DVAC3010_0
(VLM2
DODECADEPSIPEPTIDE)		 5brr TISSUE-TYPE
PLASMINOGEN
ACTIVATOR
(Homo
sapiens) 		3 / 3 ALA E  55
PHE E  94
GLN E  60
 None
 0.75A 6eceA-5brrE:
undetectable		 6eceA-5brrE:
22.26