SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5bsh'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DYR_A_TOPA407_1
(DIHYDROFOLATE
REDUCTASE)		 5bsh PYRROLINE-5-CARBOXYL
ATE REDUCTASE
(Medicago
truncatula) 		5 / 11 ILE A 161
ALA A  29
LEU A  13
ILE A 154
PHE A 158
 None
 0.99A 1dyrA-5bshA:
undetectable		 1dyrA-5bshA:
24.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1G5Y_B_9CRB501_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 5bsh PYRROLINE-5-CARBOXYL
ATE REDUCTASE
(Medicago
truncatula) 		5 / 12 ILE A 186
ALA A 189
LEU A 208
ALA A 207
ILE A 190
 None
 1.28A 1g5yB-5bshA:
undetectable		 1g5yB-5bshA:
24.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NH8_A_HISA289_0
(ATP
PHOSPHORIBOSYLTRANSF
ERASE)		 5bsh PYRROLINE-5-CARBOXYL
ATE REDUCTASE
(Medicago
truncatula) 		4 / 5 ASP A  67
LEU A  91
ALA A  43
LEU A  62
 None
 1.02A 1nh8A-5bshA:
undetectable		 1nh8A-5bshA:
23.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2UXP_B_CLMB1211_0
(HTH-TYPE
TRANSCRIPTIONAL
REGULATOR TTGR)		 5bsh PYRROLINE-5-CARBOXYL
ATE REDUCTASE
(Medicago
truncatula) 		5 / 11 ALA A  26
MET A  21
VAL A  76
ILE A 161
VAL A 125
 None
 1.22A 2uxpB-5bshA:
3.6		 2uxpB-5bshA:
22.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2UXP_B_CLMB1211_0
(HTH-TYPE
TRANSCRIPTIONAL
REGULATOR TTGR)		 5bsh PYRROLINE-5-CARBOXYL
ATE REDUCTASE
(Medicago
truncatula) 		5 / 11 MET A  21
VAL A  76
GLY A  28
ILE A 161
VAL A 125
 None
 1.20A 2uxpB-5bshA:
3.6		 2uxpB-5bshA:
22.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YGN_A_PCFA1179_1
(WNT INHIBITORY
FACTOR 1)		 5bsh PYRROLINE-5-CARBOXYL
ATE REDUCTASE
(Medicago
truncatula) 		4 / 5 ILE A  57
PHE A  15
PRO A  37
VAL A 139
 None
 1.26A 2ygnA-5bshA:
undetectable		 2ygnA-5bshA:
17.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3M0W_E_P77E203_1
(PROTEIN S100-A4)		 5bsh PYRROLINE-5-CARBOXYL
ATE REDUCTASE
(Medicago
truncatula) 		4 / 8 ASP A 169
SER A 141
PHE A 122
SER A 103
 None
 0.87A 3m0wE-5bshA:
2.6
3m0wF-5bshA:
2.7
3m0wG-5bshA:
2.7
3m0wH-5bshA:
2.6		 3m0wE-5bshA:
15.75
3m0wF-5bshA:
15.75
3m0wG-5bshA:
15.75
3m0wH-5bshA:
15.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R21_A_STRA601_1
(CYTOCHROME P450
FAMILY 17
POLYPEPTIDE 2)		 5bsh PYRROLINE-5-CARBOXYL
ATE REDUCTASE
(Medicago
truncatula) 		4 / 6 ALA A  26
ILE A  44
SER A  72
ILE A  40
 None
 0.83A 4r21A-5bshA:
undetectable		 4r21A-5bshA:
20.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R21_A_STRA601_1
(CYTOCHROME P450
FAMILY 17
POLYPEPTIDE 2)		 5bsh PYRROLINE-5-CARBOXYL
ATE REDUCTASE
(Medicago
truncatula) 		4 / 6 ILE A  44
GLY A  17
SER A  72
ILE A  40
 None
 0.65A 4r21A-5bshA:
undetectable		 4r21A-5bshA:
20.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R21_B_STRB601_1
(CYTOCHROME P450
FAMILY 17
POLYPEPTIDE 2)		 5bsh PYRROLINE-5-CARBOXYL
ATE REDUCTASE
(Medicago
truncatula) 		5 / 9 ALA A  26
ILE A  44
GLY A  17
SER A  72
ILE A  40
 None
 1.08A 4r21B-5bshA:
2.5		 4r21B-5bshA:
20.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ECN_A_LEUA602_0
(JASMONIC ACID-AMIDO
SYNTHETASE JAR1)		 5bsh PYRROLINE-5-CARBOXYL
ATE REDUCTASE
(Medicago
truncatula) 		4 / 7 ALA A 131
THR A 132
LYS A  20
GLU A  23
 None
 1.17A 5ecnA-5bshA:
3.0		 5ecnA-5bshA:
19.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6QGB_A_BEZA701_0
(MONO(2-HYDROXYETHYL)
TEREPHTHALATE
HYDROLASE)		 5bsh PYRROLINE-5-CARBOXYL
ATE REDUCTASE
(Medicago
truncatula) 		5 / 11 LEU A  13
ALA A  26
PHE A 158
ALA A  22
PHE A  15
 None
 1.28A 6qgbA-5bshA:
undetectable		 6qgbA-5bshA:
20.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6QGB_E_BEZE701_0
(MONO(2-HYDROXYETHYL)
TEREPHTHALATE
HYDROLASE)		 5bsh PYRROLINE-5-CARBOXYL
ATE REDUCTASE
(Medicago
truncatula) 		5 / 11 LEU A  13
ALA A  26
PHE A 158
ALA A  22
PHE A  15
 None
 1.31A 6qgbE-5bshA:
undetectable		 6qgbE-5bshA:
20.10